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Erschienen in:

01.07.2009

The ANKK1 Kinase Gene and Psychiatric Disorders

verfasst von: Guillermo Ponce, Rocío Pérez-González, María Aragüés, Tomás Palomo, Roberto Rodríguez-Jiménez, Miguel Angel Jiménez-Arriero, Janet Hoenicka

Erschienen in: Neurotoxicity Research | Ausgabe 1/2009

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Abstract

The TaqIA single nucleotide polymorphism (SNP, rs1800497), which is located in the gene that codes for the putative kinase ANKK1 (ANKK1) near the termination codon of the D2 dopamine receptor gene (DRD2; chromosome 11q22–q23), is the most studied genetic variation in a broad range of psychiatric disorders and personality traits. A large number of individual genetic association studies have found that the TaqIA SNP is linked to alcoholism and antisocial traits. In addition, it has also been related to other conditions such as schizophrenia, eating disorders, and some behavioral childhood disorders. The TaqIA A1 allele is mainly associated with addictions, antisocial disorders, eating disorders, and attention-deficit/hyperactivity disorders, while the A2 allele occurs more frequently in schizophrenic and obsessive-compulsive patients. Current data show that the TaqIA polymorphism may be a marker of both DRD2 and ANKK1 genetic variants. ANKK1 would belong to a family of kinases involved in signal transduction. This raises the question of whether signaling players intervene in the pathophysiology of psychiatric disorders. Basic research on the ANKK1 protein and its putative interaction with the D2 dopamine receptor could shed light on this issue.

Arinami T, Itokawa M, Komiyama T, Mitsushio H, Mori H, Mifune H, Hamaguchi H, Toru M (1993) Association between severity of alcoholism and the A1 allele of the dopamine D2 receptor gene TaqI A RFLP in Japanese. Biol Psychiatry 33:108–114PubMedCrossRef

Audrain-McGovern J, Lerman C, Wileyto EP, Rodriguez D, Shields PG (2004) Interacting effects of genetic predisposition and depression on adolescent smoking progression. Am J Psychiatry 161(7):1224–1230PubMedCrossRef

Blair RJ (2003) Neurobiological basis of psychopathy. Br J Psychiatry 182:5–7PubMedCrossRef

Blum K, Noble EP, Sheridan PJ, Montgomery A, Ritchie T, Jagadeeswaran P, Nogami H, Briggs AH, Cohn JB (1990) Allelic association of human dopamine D2 receptor gene in alcoholism. Jama 263:2055–2060PubMedCrossRef

Blum K, Noble EP, Sheridan PJ, Finley O, Montgomery A, Ritchie T, Ozkaragoz T, Fitch RJ, Sadlack F, Sheffield D et al (1991) Association of the A1 allele of the D2 dopamine receptor gene with severe alcoholism. Alcohol 8:409–416PubMedCrossRef

Blum K, Braverman ER, Dinardo MJ, Wood RC, Sheridan PJ (1994) Prolonged P300 latency in a neuropsychiatric population with the D2 dopamine receptor A1 allele. Pharmacogenetics 4:313–322PubMedCrossRef

Blum K, Braverman ER, Wood RC, Gill J, Li C, Chen TJ, Taub M, Montgomery AR, Sheridan PJ, Cull JG (1996) Increased prevalence of the Taq I A1 allele of the dopamine receptor gene (DRD2) in obesity with comorbid substance use disorder: a preliminary report. Pharmacogenetics 6:297–305PubMedCrossRef

Bolos AM, Dean M, Lucas-Derse S, Ramsburg M, Brown GL, Goldman D (1990) Population and pedigree studies reveal a lack of association between the dopamine D2 receptor gene and alcoholism. Jama 264:3156–3160PubMedCrossRef

Chen CH, Chien SH, Hwu HG (1996) Lack of association between TaqI A1 allele of dopamine D2 receptor gene and alcohol-use disorders in atayal natives of Taiwan. Am J Med Genet 67:488–490PubMedCrossRef

Chen WJ, Lu ML, Hsu YP, Chen CC, Yu JM, Cheng AT (1997) Dopamine D2 receptor gene and alcoholism among four aboriginal groups and Han in Taiwan. Am J Med Genet 74:129–136PubMedCrossRef

Chen WJ, Chen CH, Huang J, Hsu YP, Seow SV, Chen CC, Cheng AT (2001) Genetic polymorphisms of the promoter region of dopamine D2 receptor and dopamine transporter genes and alcoholism among four aboriginal groups and Han Chinese in Taiwan. Psychiatr Genet 11:187–195PubMedCrossRef

Chen CK, Hu X, Lin SK, Sham PC, Loh el W, Li T, Murray RM, Ball DM (2004) Association analysis of dopamine D2-like receptor genes and methamphetamine abuse. Psychiatr Genet 14:223–226PubMedCrossRef

Comings DE, Comings BG, Muhleman D, Dietz G, Shahbahrami B, Tast D, Knell E, Kocsis P, Baumgarten R, Kovacs BW et al (1991) The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders. Jama 266:1793–1800PubMedCrossRef

Comings DE, Rosenthal RJ, Lesieur HR, Rugle LJ, Muhleman D, Chiu C, Dietz G, Gade R (1996) A study of the dopamine D2 receptor gene in pathological gambling. Pharmacogenetics 6:223–234PubMedCrossRef

Connor JP, Young RM, Lawford BR, Saunders JB, Ritchie TL, Noble EP (2007) Heavy nicotine and alcohol use in alcohol dependence is associated with D2 dopamine receptor (DRD2) polymorphism. Addict Behav 32(2):310–319PubMedCrossRef

Costa-Mallen P, Costa LG, Smith-Weller T, Franklin GM, Swanson PD, Checkoway H (2000) Genetic polymorphism of dopamine D2 receptors in Parkinson’s disease and interactions with cigarette smoking and MAO-B intron 13 polymorphism. J Neurol Neurosurg Psychiatry 69:535–537PubMedCrossRef

Cruz C, Camarena B, Mejia JM, Paez F, Eroza V, Ramon De La Fuente J, Kershenobich D, Nicolini H (1995) The dopamine D2 receptor gene TaqI A1 polymorphism and alcoholism in a Mexican population. Arch Med Res 26:421–426PubMed

David SP, Niaura R, Papandonatos GD, Shadel WG, Burkholder GJ, Britt DM, Day A, Stumpff J, Hutchison K, Murphy M, Johnstone E, Griffiths SE, Walton RT (2003) Does the DRD2-Taq1 A polymorphism influence treatment response to bupropion hydrochloride for reduction of the nicotine withdrawal syndrome? Nicotine Tob Res 5(6):935–942PubMedCrossRef

Davis C, Levitan RD, Kaplan AS, Carter J, Reid C, Curtis C, Patte K, Hwang R, Kennedy JL (2008) Reward sensitivity and the D2 dopamine receptor gene: A case-control study of binge eating disorder. Prog Neuropsychopharmacol Biol Psychiatry 32(3):620–628PubMedCrossRef

Denys D, Van Nieuwerburgh F, Deforce D, Westenberg H (2006) Association between the dopamine D2 receptor TaqI A2 allele and low activity COMT allele with obsessive-compulsive disorder in males. Eur Neuropsychopharmacol 16:446–450PubMedCrossRef

Di Chiara G, Imperato A (1998) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci U S A 85:5274–5278CrossRef

Dick DM, Wang JC, Plunkett J, Aliev F, Hinrichs A, Bertelsen S, Budde JP, Goldstein EL, Kaplan D, Edenberg HJ, Nurnberger J Jr, Hesselbrock V, Schuckit M, Kuperman S, Tischfield J, Porjesz B, Begleiter H, Bierut LJ, Goate A (2007) Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1. Alcohol Clin Exp Res 31(10):1645–1653PubMedCrossRef

Drtilkova I, Sery O, Theiner P, Uhrova A, Zackova M, Balastikova B, Znojil V (2008) Clinical and molecular-genetic markers of ADHD in children. Neuro Endocrinol Lett 29:320–327PubMed

Duan J, Wainwright MS, Comeron JM, Saitou N, Sanders AR, Gelernter J, Gejman PV (2003) Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. Hum Mol Genet 12(3):205–216PubMedCrossRef

Dubertret C, Gorwood P, Gouya L, Deybach JC, Ades J (2001) Association and excess of transmission of a DRD2 haplotype in a sample of French schizophrenic patients. Schizophr Res 49:203–212PubMedCrossRef

Dubertret C, Gouya L, Hanoun N, Deybach JC, Ades J, Hamon M, Gorwood P (2004) The 3′ region of the DRD2 gene is involved in genetic susceptibility to schizophrenia. Schizophr Res 67:75–85PubMedCrossRef

Edenberg HJ, Foroud T, Koller DL, Goate A, Rice J, Van Eerdewegh P, Reich T, Cloninger CR, Nurnberger JI Jr, Kowalczuk M, Wu B, Li TK, Conneally PM, Tischfield JA, Wu W, Shears S, Crowe R, Hesselbrock V, Schuckit M, Porjesz B, Begleiter H (1998) A family-based analysis of the association of the dopamine D2 receptor (DRD2) with alcoholism. Alcohol Clin Exp Res 22:505–512PubMed

Epstein LH, Temple JL, Neaderhiser BJ, Salis RJ, Erbe RW, Leddy JJ (2007) Food reinforcement, the dopamine D2 receptor genotype, and energy intake in obese and nonobese humans. Behav Neurosci 121:877–886PubMedCrossRef

Foley PF, Loh EW, Innes DJ, Williams SM, Tannenberg AE, Harper CG, Dodd PR (2004) Association studies of neurotransmitter gene polymorphisms in alcoholic Caucasians. Ann N Y Acad Sci 1025:39–46PubMedCrossRef

Gelernter J, Kranzler H (1999) D2 dopamine receptor gene (DRD2) allele and haplotype frequencies in alcohol dependent and control subjects: no association with phenotype or severity of phenotype. Neuropsychopharmacology 20:640–649PubMedCrossRef

Gelernter J, O’Malley S, Risch N, Kranzler HR, Krystal J, Merikangas K, Kennedy JL, Kidd KK (1991) No association between an allele at the D2 dopamine receptor gene (DRD2) and alcoholism. Jama 266:1801–1807PubMedCrossRef

Gelernter J, Pauls DL, Leckman J, Kidd KK, Kurlan R (1994) D2 dopamine receptor alleles do not influence severity of Tourette’s syndrome. Results from four large kindreds. Arch Neurol 51:397–400PubMed

Gelernter J, Yu Y, Weiss R, Brady K, Panhuysen C, Yang BZ, Kranzler HR, Farrer L (2006) Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations. Hum Mol Genet 15(24):3498–3507PubMedCrossRef

Gilbert D, McClernon J, Rabinovich N, Sugai C, Plath L, Asgaard G, Zuo Y, Huggenvik J, Botros N (2004) Effects of quitting smoking on EEG activation and attention last for more than 31 days and are more severe with stress, dependence, DRD2 A1 allele, and depressive traits. Nicotine Tob Res 6(2):249–267PubMedCrossRef

Goldman D, Urbanek M, Guenther D, Robin R, Long JC (1997) Linkage and association of a functional DRD2 variant [Ser311Cys] and DRD2 markers to alcoholism, substance abuse and schizophrenia in Southwestern American Indians. Am J Med Genet 74:386–394PubMedCrossRef

Golimbet VE, Aksenova MG, Abramova LI, Kaleda VG, Orlova VA, Braga EA, Nosikov VV, Trubnikov VI (1998) Association of allele polymorphism of dopamine d2 receptors with schizophrenic and affective disorders. Zh Nevrol Psikhiatr Im S S Korsakova 98:32–35PubMed

Golimbet V, Aksenova M, Nosikov V, Orlova V, Kaleda V (2003) Analysis of the linkage of the Taq1A and Taq1B loci of the dopamine D2 receptor gene with schizophrenia in patients and their siblings. Neurosci Behav Physiol 33:223–225PubMedCrossRef

Grevle L, Guzey C, Hadidi H, Brennersted R, Idle JR, Aasly J (2000) Allelic association between the DRD2 TaqI A polymorphism and Parkinson’s disease. Mov Disord 15:1070–1074PubMedCrossRef

Hietala J, Pohjalainen T, Heikkila-Kallio U, West C, Salaspuro M, Syvalahti E (1997) Allelic association between D2 but not D1 dopamine receptor gene and alcoholism in Finland. Psychiatr Genet 7:19–25PubMedCrossRef

Hill SY, Locke J, Zezza N, Kaplan B, Neiswanger K, Steinhauer SR, Wipprecht G, Xu J (1998) Genetic association between reduced P300 amplitude and the DRD2 dopamine receptor A1 allele in children at high risk for alcoholism. Biol Psychiatry 43:40–51PubMedCrossRef

Hirvonen M, Laakso A, Någren K, Rinne JO, Pohjalainen T, Hietala J (2004) C957T polymorphism of the dopamine D2 receptor (DRD2) gene affects striatal DRD2 availability in vivo. Mol Psychiatry 9(12):1060–1061PubMedCrossRef

Hirvonen J, van Erp TG, Huttunen J, Aalto S, Någren K, Huttunen M, Lönnqvist J, Kaprio J, Hietala J, Cannon TD (2005) Increased caudate dopamine D2 receptor availability as a genetic marker for schizophrenia. Arch Gen Psychiatry 62(4):371–378PubMedCrossRef

Hoenicka J, Ponce G, Jimenez-Arriero MA, Ampuero I, Rodriguez-Jimenez R, Rubio G, Aragues M, Ramos JA, Palomo T (2007) Association in alcoholic patients between psychopathic traits and the additive effect of allelic forms of the CNR1 and FAAH endocannabinoid genes, and the 3′ region of the DRD2 gene. Neurotox Res 11:51–60PubMedCrossRef

Huang YS, Lin SK, Wu YY, Chao CC, Chen CK (2003) A family-based association study of attention-deficit hyperactivity disorder and dopamine D2 receptor TaqI A alleles. Chang Gung Med J 26:897–903PubMed

Huang W, Payne TJ, Ma JZ, Beuten J, Dupont RT, Inohara N, Li MD (2009) Significant association of ANKK1 and detection of a functional polymorphism with nicotine dependence in an African-American sample. Neuropsychopharmacology 34(2):319–330

Inoue K, Lupski JR (2003) Genetics and genomics of behavioral and psychiatric disorders. Curr Opin Genet Dev 13:303–309PubMedCrossRef

Ishiguro H, Arinami T, Saito T, Akazawa S, Enomoto M, Mitushio H, Fujishiro H, Tada K, Akimoto Y, Mifune H, Shioduka S, Hamaguchi H, Toru M, Shibuya H (1998) Association study between the −141C Ins/Del and TaqI A polymorphisms of the dopamine D2 receptor gene and alcoholism. Alcohol Clin Exp Res 22:845–848PubMed

Jimenez-Arriero M, Ponce G, Rodriguez-Jimenez RMA, Galvan A, Rubio G, Hoenicka J, Palomo T (2006) TaqI-A polymorphism linked to the DRD2 gene and P300 in alcoholic patients. Eur J Psych 20:45–53

Kono Y, Yoneda H, Sakai T, Nonomura Y, Inayama Y, Koh J, Sakai J, Inada Y, Imamichi H, Asaba H (1997) Association between early-onset alcoholism and the dopamine D2 receptor gene. Am J Med Genet 74:179–182PubMedCrossRef

Kumar S, Tamura K, Jakobsen IB, Nei M (2001) MEGA2: molecular evolutionary genetics analysis software. Bioinformatics 17:1244–1245PubMedCrossRef

Laakso A, Pohjalainen T, Bergman J, Kajander J, Haaparanta M, Solin O, Syvalahti E, Hietala J (2005) The A1 allele of the human D2 dopamine receptor gene is associated with increased activity of striatal l-amino acid decarboxylase in healthy subjects. Pharmacogenet Genomics 15:387–391PubMedCrossRef

Laruelle M (1998) Imaging dopamine transmission in schizophrenia. A review and meta-analysis. Q J Nucl Med 42:211–221PubMed

Lawford BR, Young RM, Noble EP, Sargent J, Rowell J, Shadforth S, Zhang X, Ritchie T (2000) The D(2) dopamine receptor A(1) allele and opioid dependence: association with heroin use and response to methadone treatment. Am J Med Genet 96:592–598PubMedCrossRef

Lobos EA, Todd RD (1998) Association analysis in an evolutionary context: cladistic analysis of the DRD2 locus to test for association with alcoholism. Am J Med Genet 81:411–419PubMedCrossRef

Lu RB, Ko HC, Chang FM, Castiglione CM, Schoolfield G, Pakstis AJ, Kidd JR, Kidd KK (1996) No association between alcoholism and multiple polymorphisms at the dopamine D2 receptor gene (DRD2) in three distinct Taiwanese populations. Biol Psychiatry 39:419–429PubMedCrossRef

Magro F, Cunha E, Araujo F, Meireles E, Pereira P, Dinis-Ribeiro M, Veloso FT, Medeiros R, Soares-da-Silva P (2006) Dopamine D2 receptor polymorphisms in inflammatory bowel disease and the refractory response to treatment. Dig Dis Sci 51:2039–2044PubMedCrossRef

Meylan E, Tschopp J (2005) The RIP kinases: crucial integrators of cellular stress. Trends Biochem Sci 30:151–159PubMedCrossRef

Moldin S (1999) Report of the national institute of mental health’s genetics workgroup: summary of research. Biol Psychiatry 45:573–602CrossRef

Morens DM, Grandinetti A, Reed D, White LR, Ross GW (1995) Cigarette smoking and protection from Parkinson’s disease: false association or etiologic clue? Neurology 45:1041–1051PubMed

Morton LM, Wang SS, Bergen AW, Chatterjee N, Kvale P, Welch R, Yeager M, Hayes RB, Chanock SJ, Caporaso NE (2006) DRD2 genetic variation in relation to smoking and obesity in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Pharmacogenet Genomics 16(12):901–910PubMedCrossRef

Munafo M, Clark T, Johnstone E, Murphy M, Walton R (2004) The genetic basis for smoking behavior: a systematic review and meta-analysis. Nicotine Tob Res 6(4):583–597PubMedCrossRef

Munafo MR, Matheson IJ, Flint J (2007) Association of the DRD2 gene Taq1A polymorphism and alcoholism: a meta-analysis of case-control studies and evidence of publication bias. Mol Psychiatry 12:454–461PubMed

Neiswanger K, Hill SY, Kaplan BB (1995) Association and linkage studies of the TAQI A1 allele at the dopamine D2 receptor gene in samples of female and male alcoholics. Am J Med Genet 60:267–271PubMedCrossRef

Neville MJ, Johnstone EC, Walton RT (2004) Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1. Hum Mutat 23:540–545PubMedCrossRef

Newman JP, Kosson DS, Patterson CM (1992) Delay of gratification in psychopathic and nonpsychopathic offenders. Abnorm Psychol 101(4):630–636CrossRef

Nicolini H, Cruz C, Camarena B, Orozco B, Kennedy JL, King N, Weissbecker K, de la Fuente JR, Sidenberg D (1996) DRD2, DRD3 and 5HT2A receptor genes polymorphisms in obsessive-compulsive disorder. Mol Psychiatry 1:461–465PubMed

Nicolini H, Cruz C, Paez F, Camarena B (1998) Dopamine D2 and D4 receptor genes distinguish the clinical presence of tics in obsessive-compulsive disorder. Gac Med Mex 134:521–527PubMed

Nisoli E, Brunani A, Borgomainerio E, Tonello C, Dioni L, Briscini L, Redaelli G, Molinari E, Cavagnini F, Carruba MO (2007) D2 dopamine receptor (DRD2) gene Taq1A polymorphism and the eating-related psychological traits in eating disorders (anorexia nervosa and bulimia) and obesity. Eat Weight Disord 12:91–96PubMed

Noble EP (1994) Polymorphisms of the D2 dopamine receptor gene and alcoholism and other substance use disorders. Alcohol Alcohol Suppl 2:35–43PubMed

Noble EP (2003) D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. Am J Med Genet B Neuropsychiatr Genet 116:103–125CrossRef

Noble EP, Blum K, Ritchie T, Montgomery A, Sheridan PJ (1991) Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism. Arch Gen Psychiatry 48(7):648–654PubMed

Noble EP, Blum K, Khalsa ME, Ritchie T, Montgomery A, Wood RC, Fitch RJ, Ozkaragoz T, Sheridan PJ, Anglin MD et al (1993) Allelic association of the D2 dopamine receptor gene with cocaine dependence. Drug Alcohol Depend 33(3):271–285PubMedCrossRef

Nothen MM, Hebebrand J, Knapp M, Hebebrand K, Camps A, von Gontard A, Wettke-Schafer R, Lisch S, Cichon S, Poustka F et al (1994) Association analysis of the dopamine D2 receptor gene in Tourette’s syndrome using the haplotype relative risk method. Am J Med Genet 54:249–252PubMedCrossRef

Oliveri RL, Annesi G, Zappia M, Civitelli D, De Marco EV, Pasqua AA, Annesi F, Spadafora P, Gambardella A, Nicoletti G, Branca D, Caracciolo M, Aguglia U, Quattrone A (2000) The dopamine D2 receptor gene is a susceptibility locus for Parkinson’s disease. Mov Disord 15:127–131PubMedCrossRef

Parsian A, Todd RD, Devor EJ, O’Malley KL, Suarez BK, Reich T, Cloninger CR (1991) Alcoholism and alleles of the human D2 dopamine receptor locus. Studies of association and linkage. Arch Gen Psychiatry 48:655–663PubMed

Parsons MJ, Mata I, Beperet M, Iribarren-Iriso F, Arroyo B, Sainz R, Arranz MJ, Kerwin R (2007) A dopamine D2 receptor gene-related polymorphism is associated with schizophrenia in a Spanish population isolate. Psychiatr Genet 17:159–163PubMedCrossRef

Perez de los Cobos J, Baiget M, Trujols J, Sinol N, Volpini V, Banuls E, Calafell F, Luquero E, del Rio E, Alvarez E (2007) Allelic and genotypic associations of DRD2 TaqI A polymorphism with heroin dependence in Spanish subjects: a case control study. Behav Brain Funct 3:25PubMedCrossRef

Persico AM, Bird G, Gabbay FH, Uhl GR (1996) D2 dopamine receptor gene TaqI A1 and B1 restriction fragment length polymorphisms: enhanced frequencies in psychostimulant-preferring polysubstance abusers. Biol Psychiatry 40:776–784PubMedCrossRef

Pohjalainen T, Rinne JO, Nagren K, Lehikoinen P, Anttila K, Syvalahti EK, Hietala J (1998) The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers. Mol Psychiatry 3:256–260PubMedCrossRef

Ponce G, Jimenez-Arriero MA, Rubio G, Hoenicka J, Ampuero I, Ramos JA, Palomo T (2003) The A1 allele of the DRD2 gene (TaqI A polymorphisms) is associated with antisocial personality in a sample of alcohol-dependent patients. Eur Psychiatry 18(7):356–360PubMedCrossRef

Ponce G, Hoenicka J, Jimenez-Arriero MA, Rodriguez-Jimenez R, Aragues M, Martin-Sune N, Huertas E, Palomo T (2008) DRD2 and ANKK1 genotype in alcohol-dependent patients with psychopathic traits: association and interaction study. Br J Psychiatry 193:121–125PubMedCrossRef

Ratsma JE, van der Stelt O, Schoffelmeer AN, Westerveld A, Gunning WB (2001) P3 event-related potential, dopamine D2 receptor A1 allele, and sensation-seeking in adult children of alcoholics. Alcohol Clin Exp Res 25:960–967PubMedCrossRef

Ritchie T, Noble EP (2003) Association of seven polymorphisms of the D2 dopamine receptor gene with brain receptor-binding characteristics. Neurochem Res 28:73–82PubMedCrossRef

Rodríguez-Jiménez R, Aragüés M, Hoenicka J, Martinez-Gras I, Ponce G, Cubillo A, Bagney A, Jiménez-Arriero M, Rubio G, Palomo T, Psychosis and addictions research group P (2005) The TaqIA polymorphism, linked to the DRD2 gene, is associated with substance use disorders in schizophrenic patients (dual diagnosis). Implications of comorbidity for etiology and treatment of neuropsychiatric disorders—Mazagón (Huelva), October 19–23 2005

Rowe DC, Van den Oord EJ, Stever C, Giedinghagen LN, Gard JM, Cleveland HH, Gilson M, Terris ST, Mohr JH, Sherman S, Abramowitz A, Waldman ID (1999) The DRD2 TaqI polymorphism and symptoms of attention deficit hyperactivity disorder. Mol Psychiatry 4:580–586PubMedCrossRef

Sander T, Harms H, Podschus J, Finckh U, Nickel B, Rolfs A, Rommelspacher H, Schmidt LG (1995) Dopamine D1, D2 and D3 receptor genes in alcohol dependence. Psychiatr Genet 5:171–176PubMedCrossRef

Sander T, Ladehoff M, Samochowiec J, Finckh U, Rommelspacher H, Schmidt LG (1999) Lack of an allelic association between polymorphisms of the dopamine D2 receptor gene and alcohol dependence in the German population. Alcohol Clin Exp Res 23:578–581PubMed

Seeman P, Bzowej NH, Guan HC, Bergeron C, Reynolds GP, Bird ED, Riederer P, Jellinger K, Tourtellotte WW (1987) Human brain D1 and D2 dopamine receptors in schizophrenia, Alzheimer’s, Parkinson’s, and Huntington’s diseases. Neuropsychopharmacology 1:5–15PubMedCrossRef

Sery O, Drtilkova I, Theiner P, Pitelova R, Staif R, Znojil V, Lochman J, Didden W (2006) Polymorphism of DRD2 gene and ADHD. Neuro Endocrinol Lett 27:236–240PubMed

Smith L, Watson M, Gates S, Ball D, Foxcroft D (2008) Meta-analysis of the association of the Taq1A polymorphism with the risk of alcohol dependency: a HuGE gene-disease association review. Am J Epidemiol 167:125–138PubMedCrossRef

Stice E, Spoor S, Bohon C, Small DM (2008) Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele. Science 322:449–452PubMedCrossRef

Suarez BK, Parsian A, Hampe CL, Todd RD, Reich T, Cloninger CR (1994) Linkage disequilibria at the D2 dopamine receptor locus (DRD2) in alcoholics and controls. Genomics 19:12–20PubMedCrossRef

Thompson J, Thomas N, Singleton A, Piggott M, Lloyd S, Perry EK, Morris CM, Perry RH, Ferrier IN, Court JA (1997) D2 dopamine receptor gene (DRD2) Taq1 A polymorphism: reduced dopamine D2 receptor binding in the human striatum associated with the A1 allele. Pharmacogenetics 7:479–484PubMedCrossRef

Turner E, Ewing J, Shilling P, Smith TL, Irwin M, Schuckit M, Kelsoe JR (1992) Lack of association between an RFLP near the D2 dopamine receptor gene and severe alcoholism. Biol Psychiatry 31:285–290PubMedCrossRef

Vijayan NN, Bhaskaran S, Koshy LV, Natarajan C, Srinivas L, Nair CM, Allencherry PM, Banerjee M (2007) Association of dopamine receptor polymorphisms with schizophrenia and antipsychotic response in a South Indian population. Behav Brain Funct 3:34PubMedCrossRef

Waldman ID, Robinson BF, Rhee SH (1999) A logistic regression extension of the transmission disequilibrium test for continuous traits: application to linkage disequilibrium between alcoholism and the candidate genes DRD2 and ADH3. Genet Epidemiol 17(Suppl 1):S379–S384PubMed

Wong AH, Gottesman II, Petronis A (2005) Phenotypic differences in genetically identical organisms: the epigenetic perspective. Hum Mol Genet 14 Spec No 1:R11-18

Yang BZ, Kranzler HR, Zhao H, Gruen JR, Luo X, Gelernter J (2007) Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples. Hum Mol Genet 16:2844–2853PubMedCrossRef

Yang BZ, Kranzler HR, Zhao H, Gruen JR, Luo X, Gelernter J (2008) Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence. Alcohol Clin Exp Res 32(12):2117–2127

Zhang Y, Bertolino A, Fazio L, Blasi G, Rampino A, Romano R, Lee ML, Xiao T, Papp A, Wang D, Sadee W (2007) Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory. Proc Natl Acad Sci U S A 104:20552–20557PubMedCrossRef

Titel: The ANKK1 Kinase Gene and Psychiatric Disorders
verfasst von: Guillermo Ponce
Rocío Pérez-González
María Aragüés
Tomás Palomo
Roberto Rodríguez-Jiménez
Miguel Angel Jiménez-Arriero
Janet Hoenicka
Publikationsdatum: 01.07.2009
Verlag: Springer-Verlag
Erschienen in: Neurotoxicity Research / Ausgabe 1/2009
Print ISSN: 1029-8428
Elektronische ISSN: 1476-3524
DOI: https://doi.org/10.1007/s12640-009-9046-9

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Ein hohes soziales Niveau ist mit die beste Versicherung gegen eine Demenz. Noch geringer ist das Demenzrisiko für Menschen, die sozial aufsteigen: Sie gewinnen fast zwei demenzfreie Lebensjahre. Umgekehrt steigt die Demenzgefahr beim sozialen Abstieg.

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Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

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