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Translational Stroke Research

Erschienen in:

01.03.2010 | Review Article

Pharmacologic Preconditioning: Translating the Promise

verfasst von: Jeffrey M. Gidday

Erschienen in: Translational Stroke Research | Ausgabe 1/2010

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Abstract

A transient, ischemia-resistant phenotype known as “ischemic tolerance” can be established in brain in a rapid or delayed fashion by a preceding noninjurious “preconditioning” stimulus. Initial preclinical studies of this phenomenon relied primarily on brief periods of ischemia or hypoxia as preconditioning stimuli, but it was later realized that many other stressors, including pharmacologic ones, are also effective. This review highlights the surprisingly wide variety of drugs now known to promote ischemic tolerance, documented and to some extent mechanistically characterized in preclinical animal models of stroke. Although considerably more experimentation is needed to thoroughly validate the ability of any currently identified preconditioning agent to protect ischemic brain, the fact that some of these drugs are already clinically approved for other indications implies that the growing enthusiasm for translational success in the field of pharmacologic preconditioning may be well justified.

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Titel: Pharmacologic Preconditioning: Translating the Promise
verfasst von: Jeffrey M. Gidday
Publikationsdatum: 01.03.2010
Verlag: Springer-Verlag
Erschienen in: Translational Stroke Research / Ausgabe 1/2010
Print ISSN: 1868-4483
Elektronische ISSN: 1868-601X
DOI: https://doi.org/10.1007/s12975-010-0011-y

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Thrombektomie auch bei großen Infarkten von Vorteil

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Update Neurologie

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Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

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