Erschienen in:
01.04.2014 | Research Article
Association of IL-6 polymorphisms with hepatocellular carcinoma risk: evidences from a meta-analysis
verfasst von:
Ying Liu, Su-jun Gao, Bo-xiang Du, Jie-jun Wang
Erschienen in:
Tumor Biology
|
Ausgabe 4/2014
Einloggen, um Zugang zu erhalten
Abstract
The associations between IL-6 gene single nucleotide polymorphisms (SNPs) and risk of hepatocellular carcinoma (HCC) are controversial. We performed a meta-analysis to provide more credible evidence. We searched for relevant studies published up to 2013 by performing an efficient searching strategy. Odds ratios (OR) with 95 % confidence interval (95 % CI) was used to estimate the strength of the associations between IL-6 polymorphisms and HCC risk. We identified eight case–control studies involving 1,448 HCC cases and 3,160 controls. Our estimation specifically focused on two SNPs of the IL-6 gene, −174 G/C and −572 G/C. The combined results showed that association between IL-6-174 G/C polymorphism and risk of HCC was significant under additive model (CC vs. GG: OR 0.36; 95 % CI, 0.16, 0.85) and recessive model (GG+CG vs. CC: OR 2.82; 95 % CI 1.26, 6.28). However, the IL-6-572 G/C polymorphism was not associated with HCC risk. In conclusion, IL-6-174 G/C, but not −572 G/C polymorphism could be a candidate for susceptibility to HCC. However, the results should be cautiously interpreted due to the limited number of the included studies.