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Current Obesity Reports

Erschienen in:

01.03.2012 | Etiology of Obesity (D Allison, Section Editor)

Effects of Chronic Social Stress on Obesity

verfasst von: Karen A. Scott, Susan J. Melhorn, Randall R. Sakai

Erschienen in: Current Obesity Reports | Ausgabe 1/2012

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Abstract

The prevalence of overweight and obesity has markedly increased during the past few decades. Stress has been suggested as one environmental factor that may contribute to the development of obesity. In this review, we discuss the role that exposure to chronic stress may play in the development of obesity, with particular attention to the effects of chronic psychosocial stress. Of particular importance is the effect that social stress has on dietary preference, food consumption, and regional distribution of adipose tissue. We present evidence from human and animal studies that links sympathetic nervous system and hypothalamic-pituitary-adrenal axis hyperactivity with visceral obesity, and that stress tends to alter the pattern of food consumption, and promotes craving of nutrient-dense “comfort foods.” Lastly, we discuss the visible burrow system, a model of chronic social stress used in our laboratory to assess the effects of social subordination on behavioral and metabolic profile.

Flegal KM, Carroll MD, Ogden CL, Curtin LR. Prevalence and trends in obesity among US adults, 1999–2008. JAMA. 2010;303(3):235–41.PubMedCrossRef

Selassie M, Sinha AC. The epidemiology and aetiology of obesity: a global challenge. Best Pract Res Clin Anaesthesiol. 2011;25(1):1–9.PubMedCrossRef

Keith SW, Redden DT, Katzmarzyk PT, et al. Putative contributors to the secular increase in obesity: exploring the roads less traveled. Int J Obes (Lond). 2006;30(11):1585–94.CrossRef

McAllister EJ, Dhurandhar NV, Keith SW, et al. Ten putative contributors to the obesity epidemic. Crit Rev Food Sci Nutr. 2009;49(10):868–913.PubMedCrossRef

Siervo M, Wells JC, Cizza G. The contribution of psychosocial stress to the obesity epidemic: an evolutionary approach. Horm Metab Res. 2009;41(4):261–70.PubMedCrossRef

Speakman JR. A nonadaptive scenario explaining the genetic predisposition to obesity: the “predation release” hypothesis. Cell Metab. 2007;6(1):5–12.PubMedCrossRef

Speakman JR. Thrifty genes for obesity, an attractive but flawed idea, and an alternative perspective: the ‘drifty gene’ hypothesis. Int J Obes (Lond). 2008;32(11):1611–7.CrossRef

McEwen BS, Gianaros PJ. Central role of the brain in stress and adaptation: links to socioeconomic status, health, and disease. Ann N Y Acad Sci. 2010;1186:190–222.PubMedCrossRef

McEwen BS, Stellar E. Stress and the individual. Mechanisms leading to disease. Arch Intern Med. 1993;153(18):2093–101.PubMedCrossRef

10.

Bjorntorp P. Adipose tissue distribution and function. Int J Obes. 1991;15 Suppl 2:67–81.PubMed

11.

Bjorntorp P. The regulation of adipose tissue distribution in humans. Int J Obes Relat Metab Disord. 1996;20(4):291–302.PubMed

12.

Chrousos GP. The role of stress and the hypothalamic-pituitary-adrenal axis in the pathogenesis of the metabolic syndrome: neuro-endocrine and target tissue-related causes. Int J Obes Relat Metab Disord. 2000;24 Suppl 2:S50–5.PubMedCrossRef

13.

Rebuffe-Scrive M, Walsh UA, McEwen B, Rodin J. Effect of chronic stress and exogenous glucocorticoids on regional fat distribution and metabolism. Physiol Behav. 1992;52(3):583–90.PubMedCrossRef

14.

Goldstein DS, Kopin IJ. Evolution of concepts of stress. Stress. 2007;10(2):109–20.PubMedCrossRef

15.

McEwen BS. Protective and damaging effects of stress mediators. N Engl J Med. 1998;338(3):171–9.PubMedCrossRef

16.

Lambert GW, Straznicky NE, Lambert EA, Dixon JB, Schlaich MP. Sympathetic nervous activation in obesity and the metabolic syndrome–causes, consequences and therapeutic implications. Pharmacol Ther. 2010;126(2):159–72.PubMedCrossRef

17.

de Kloet ER, Joels M, Holsboer F. Stress and the brain: from adaptation to disease. Nat Rev Neurosci. 2005;6(6):463–75.PubMedCrossRef

18.

Herman JP, Cullinan WE. Neurocircuitry of stress: central control of the hypothalamo-pituitary-adrenocortical axis. Trends Neurosci. 1997;20(2):78–84.PubMedCrossRef

19.

Lundgren M, Buren J, Ruge T, Myrnas T, Eriksson JW. Glucocorticoids down-regulate glucose uptake capacity and insulin-signaling proteins in omental but not subcutaneous human adipocytes. J Clin Endocrinol Metab. 2004;89(6):2989–97.PubMedCrossRef

20.

Cohen S. Keynote Presentation at the Eight International Congress of Behavioral Medicine: the Pittsburgh common cold studies: psychosocial predictors of susceptibility to respiratory infectious illness. Int J Behav Med. 2005;12(3):123–31.PubMedCrossRef

21.

Steptoe A, Feldman PJ, Kunz S, Owen N, Willemsen G, Marmot M. Stress responsivity and socioeconomic status: a mechanism for increased cardiovascular disease risk? Eur Heart J. 2002;23(22):1757–63.PubMedCrossRef

22.

Wang JL. Perceived work stress, imbalance between work and family/personal lives, and mental disorders. Soc Psychiatry Psychiatr Epidemiol. 2006;41(7):541–8.PubMedCrossRef

23.

Marmot MG. Status syndrome: a challenge to medicine. Jama. 2006;295(11):1304–7.PubMedCrossRef

24.

Matthews KA, Gallo LC, Taylor SE: Are psychosocial factors mediators of socioeconomic status and health connections? A progress report and blueprint for the future. Ann N Y Acad Sci, 1186:146–173.

25.

Pecoraro N, Reyes F, Gomez F, Bhargava A, Dallman MF. Chronic stress promotes palatable feeding, which reduces signs of stress: feedforward and feedback effects of chronic stress. Endocrinology. 2004;145(8):3754–62.PubMedCrossRef

26.

Adam TC, Epel ES. Stress, eating and the reward system. Physiol Behav. 2007;91(4):449–58.PubMedCrossRef

27.

• Dallman MF: Stress-induced obesity and the emotional nervous system. Trends Endocrinol Metab 2009, 21(3):159–165. This is a review of the comfort food hypothesis and how stress can influence food intake and weight gain. PubMed

28.

Block JP, He Y, Zaslavsky AM, Ding L, Ayanian JZ. Psychosocial stress and change in weight among US adults. Am J Epidemiol. 2009;170(2):181–92.PubMedCrossRef

29.

• Volkow ND, Wang GJ, Baler RD: Reward, dopamine and the control of food intake: implications for obesity. Trends Cogn Sci 2011, 15(1):37–46. This outlines how consumption of palatable foods activates reward pathways, and how obesity may relate to addiction. PubMedCrossRef

30.

Ravussin E, Tataranni PA. The role of altered sympathetic nervous system activity in the pathogenesis of obesity. Proc Nutr Soc. 1996;55(3):793–802.PubMedCrossRef

31.

Spraul M, Anderson EA, Bogardus C, Ravussin E. Muscle sympathetic nerve activity in response to glucose ingestion Impact of plasma insulin and body fat. Diabetes. 1994;43(2):191–6.PubMedCrossRef

32.

Lambert EA, Lambert GW. Stress and its role in sympathetic nervous system activation in hypertension and the metabolic syndrome. Curr Hypertens Rep. 2011;13(3):244–8.PubMedCrossRef

33.

Greenfield JR, Campbell LV. Role of the autonomic nervous system and neuropeptides in the development of obesity in humans: targets for therapy? Curr Pharm Des. 2008;14(18):1815–20.PubMedCrossRef

34.

Brunner EJ, Hemingway H, Walker BR, et al. Adrenocortical, autonomic, and inflammatory causes of the metabolic syndrome: nested case-control study. Circulation. 2002;106(21):2659–65.PubMedCrossRef

35.

Palatini P, Mos L, Santonastaso M, et al. Resting heart rate as a predictor of body weight gain in the early stage of hypertension. Obesity (Silver Spring). 2011;19(3):618–23.CrossRef

36.

Masuo K, Kawaguchi H, Mikami H, Ogihara T, Tuck ML. Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation. Hypertension. 2003;42(4):474–80.PubMedCrossRef

37.

Rosmond R. Role of stress in the pathogenesis of the metabolic syndrome. Psychoneuroendocrinology. 2005;30(1):1–10.PubMedCrossRef

38.

Bjorntorp P. Do stress reactions cause abdominal obesity and comorbidities? Obes Rev. 2001;2(2):73–86.PubMedCrossRef

39.

Macfarlane DP, Forbes S, Walker BR. Glucocorticoids and fatty acid metabolism in humans: fuelling fat redistribution in the metabolic syndrome. J Endocrinol. 2008;197(2):189–204.PubMedCrossRef

40.

Karatsoreos IN, Bhagat SM, Bowles NP, Weil ZM, Pfaff DW, McEwen BS. Endocrine and physiological changes in response to chronic corticosterone: a potential model of the metabolic syndrome in mouse. Endocrinology. 2010;151(5):2117–27.PubMedCrossRef

41.

Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab. 2004;89(6):2548–56.PubMedCrossRef

42.

Nieuwenhuizen AG, Rutters F. The hypothalamic-pituitary-adrenal-axis in the regulation of energy balance. Physiol Behav. 2008;94(2):169–77.PubMedCrossRef

43.

Kouvonen A, Stafford M, De Vogli R, et al. Negative aspects of close relationships as a predictor of increased body mass index and waist circumference: the Whitehall II study. Am J Public Health. 2011;101(8):1474–80.PubMedCrossRef

44.

Puustinen PJ, Koponen H, Kautiainen H, Mantyselka P, Vanhala M. Psychological distress predicts the development of the metabolic syndrome: a prospective population-based study. Psychosom Med. 2011;73(2):158–65.PubMedCrossRef

45.

Lee JM, Lee H. Obesity reduction within a generation: the dual roles of prevention and treatment. Obesity (Silver Spring). 2011;19(10):2107–10.CrossRef

46.

Reilly JJ, Kelly J. Long-term impact of overweight and obesity in childhood and adolescence on morbidity and premature mortality in adulthood: systematic review. Int J Obes (Lond). 2011;35(7):891–8.CrossRef

47.

Gundersen C, Mahatmya D, Garasky S, Lohman B. Linking psychosocial stressors and childhood obesity. Obes Rev. 2010;12(5):e54–63.PubMedCrossRef

48.

Olds T, Maher C, Zumin S, et al. Evidence that the prevalence of childhood overweight is plateauing: data from nine countries. Int J Pediatr Obes. 2011;6(5–6):342–60.PubMedCrossRef

49.

O’Dea JA, Nguyen Hoang TD, Dibley MJ: Plateau in obesity and overweight in a cross sectional study of low, middle and high socioeconomic status schoolchildren between 2004 and 2009. Int J Public Health 2011.

50.

Lohman BJ, Stewart S, Gundersen C, Garasky S, Eisenmann JC. Adolescent overweight and obesity: links to food insecurity and individual, maternal, and family stressors. J Adolesc Health. 2009;45(3):230–7.PubMedCrossRef

51.

Fontaine KR, Robertson HT, Holst C, Desmond R, Stunkard AJ, Sorensen TIA: Is socioeconomic status of the rearing environment causally related to obesity in the offspring. PloS One 2011, In press.

52.

Ludwig J, Sanbonmatsu L, Gennetian L, et al. Neighborhoods, obesity, and diabetes–a randomized social experiment. N Engl J Med. 2011;365(16):1509–19.PubMedCrossRef

53.

•• Stamatakis E, Wardle J, Cole TJ: Childhood obesity and overweight prevalence trends in England: evidence for growing socioeconomic disparities. Int J Obes (Lond) 2010, 34(1):41–47. This highlights the impact that low socioeconomic status plays in vulnerability to develop overweight and obesity. CrossRef

54.

Pacak K, Palkovits M. Stressor specificity of central neuroendocrine responses: implications for stress-related disorders. Endocr Rev. 2001;22(4):502–48.PubMedCrossRef

55.

Pacak K, Palkovits M, Kvetnansky R, Yadid G, Kopin IJ, Goldstein DS. Effects of various stressors on in vivo norepinephrine release in the hypothalamic paraventricular nucleus and on the pituitary-adrenocortical axis. Ann N Y Acad Sci. 1995;771:115–30.PubMedCrossRef

56.

Koolhaas JM, de Boer SF, Coppens CM, Buwalda B. Neuroendocrinology of coping styles: towards understanding the biology of individual variation. Front Neuroendocrinol. 2010;31(3):307–21.PubMedCrossRef

57.

Koolhaas JM, Korte SM, De Boer SF, et al. Coping styles in animals: current status in behavior and stress-physiology. Neurosci Biobehav Rev. 1999;23(7):925–35.PubMedCrossRef

58.

Levin BE. Metabolic imprinting on genetically predisposed neural circuits perpetuates obesity. Nutrition. 2000;16(10):909–15.PubMedCrossRef

59.

• Boersma GJ, Benthem L, van Dijk G, Scheurink AJ: Individual variation in the (patho)physiology of energy balance. Physiol Behav 2011, 103(1):89–97. This stresses the importance of individual differences in vulnerability and resilience, and how these differences also should be taken into consideration in prevention and treatment of disease. PubMedCrossRef

60.

Boersma G, Benthem L, van Dijk G, Steimer TJ, Scheurink AJ. Pharmacological treatment of hyperinsulineamia in rats depends on coping style. Eur J Pharmacol. 2011;654(1):122–7.PubMedCrossRef

61.

Grillo CA, Piroli GG, Hendry RM, Reagan LP. Insulin-stimulated translocation of GLUT4 to the plasma membrane in rat hippocampus is PI3-kinase dependent. Brain Res. 2009;1296:35–45.PubMedCrossRef

62.

Masuzaki H, Paterson J, Shinyama H, et al. A transgenic model of visceral obesity and the metabolic syndrome. Science. 2001;294(5549):2166–70.PubMedCrossRef

63.

Cowley MA, Smart JL, Rubinstein M, et al. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature. 2001;411(6836):480–4.PubMedCrossRef

64.

Bi S, Scott KA, Kopin AS, Moran TH. Differential roles for cholecystokinin A receptors in energy balance in rats and mice. Endocrinology. 2004;145(8):3873–80.PubMedCrossRef

65.

Chua Jr SC, Chung WK, Wupeng XS, et al. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science. 1996;271(5251):994–6.PubMedCrossRef

66.

Clark KJ, Boczek NJ, Ekker SC. Stressing zebrafish for behavioral genetics. Rev Neurosci. 2011;22(1):49–62.PubMedCrossRef

67.

Norton WH, Stumpenhorst K, Faus-Kessler T, et al. Modulation of Fgfr1a signaling in zebrafish reveals a genetic basis for the aggression-boldness syndrome. J Neurosci. 2011;31(39):13796–807.PubMedCrossRef

68.

Pavlidis M, Sundvik M, Chen YC, Panula P. Adaptive changes in zebrafish brain in dominant-subordinate behavioral context. Behav Brain Res. 2011;225(2):529–37.PubMedCrossRef

69.

Manuck SB, Kaplan JR, Adams MR, Clarkson TB. Effects of stress and the sympathetic nervous system on coronary artery atherosclerosis in the cynomolgus macaque. Am Heart J. 1988;116(1 Pt 2):328–33.PubMedCrossRef

70.

Jayo JM, Shively CA, Kaplan JR, Manuck SB. Effects of exercise and stress on body fat distribution in male cynomolgus monkeys. Int J Obes Relat Metab Disord. 1993;17(10):597–604.PubMed

71.

Shively CA, Register TC, Clarkson TB. Social stress, visceral obesity, and coronary artery atherosclerosis in female primates. Obesity (Silver Spring). 2009;17(8):1513–20.CrossRef

72.

Shively CA, Register TC, Clarkson TB. Social stress, visceral obesity, and coronary artery atherosclerosis: product of a primate adaptation. Am J Primatol. 2009;71(9):742–51.PubMedCrossRef

73.

Arce M, Michopoulos V, Shepard KN, Ha QC, Wilson ME. Diet choice, cortisol reactivity, and emotional feeding in socially housed rhesus monkeys. Physiol Behav. 2010;101(4):446–55.PubMedCrossRef

74.

Christiansen AM, Dekloet AD, Ulrich-Lai YM, Herman JP. “Snacking” causes long term attenuation of HPA axis stress responses and enhancement of brain FosB/deltaFosB expression in rats. Physiol Behav. 2011;103(1):111–6.PubMedCrossRef

75.

• Ulrich-Lai YM, Christiansen AM, Ostrander MM, et al: Pleasurable behaviors reduce stress via brain reward pathways. Proc Natl Acad Sci U S A 2010, 107(47):20529–20534. This is a study suggesting that access to palatable food and drink can dampen the HPA axis response to stress. PubMedCrossRef

76.

Blanchard DC, Spencer RL, Weiss SM, Blanchard RJ, McEwen B, Sakai RR. Visible burrow system as a model of chronic social stress: behavioral and neuroendocrine correlates. Psychoneuroendocrinology. 1995;20(2):117–34.PubMedCrossRef

77.

Tamashiro KL, Nguyen MM, Fujikawa T, et al. Metabolic and endocrine consequences of social stress in a visible burrow system. Physiol Behav. 2004;80(5):683–93.PubMedCrossRef

78.

Nguyen MM, Tamashiro KL, Melhorn SJ, Ma LY, Gardner SR, Sakai RR. Androgenic influences on behavior, body weight, and body composition in a model of chronic social stress. Endocrinology. 2007;148(12):6145–56.PubMedCrossRef

79.

Hardy MP, Sottas CM, Ge R, et al. Trends of reproductive hormones in male rats during psychosocial stress: role of glucocorticoid metabolism in behavioral dominance. Biol Reprod. 2002;67(6):1750–5.PubMedCrossRef

80.

Tamashiro KL, Nguyen MM, Ostrander MM, et al. Social stress and recovery: implications for body weight and body composition. Am J Physiol Regul Integr Comp Physiol. 2007;293(5):R1864–74.PubMedCrossRef

81.

Tamashiro KL, Hegeman MA, Sakai RR. Chronic social stress in a changing dietary environment. Physiol Behav. 2006;89(4):536–42.PubMedCrossRef

82.

Yamamoto K, Irie M, Sakamoto Y, Ohmori S, Yoshinari M. The relationship between IMPS-measured stress score and biomedical parameters regarding health status among public school workers. J Physiol Anthropol. 2007;26(2):149–58.PubMedCrossRef

83.

• Melhorn SJ, Krause EG, Scott KA, et al: Meal patterns and hypothalamic NPY expression during chronic social stress and recovery. Am J Physiol Regul Integr Comp Physiol 2010, 299(3):R813–822. This is a study of feeding behavior and meal patterns of SUB rats during and following chronic social stress exposure. PubMedCrossRef

84.

Fabry P, Tepperman J. Meal frequency–a possible factor in human pathology. Am J Clin Nutr. 1970;23(8):1059–68.PubMed

85.

Wheeler J, Martin R, Lin D, Yakubu F, Hill JO. Weight cycling in female rats subjected to varying meal patterns. Am J Physiol. 1990;258(1 Pt 2):R124–9.PubMed

86.

Chapelot D, Marmonier C, Aubert R, et al. Consequence of omitting or adding a meal in man on body composition, food intake, and metabolism. Obesity (Silver Spring). 2006;14(2):215–27.CrossRef

87.

Rybkin II, Zhou Y, Volaufova J, Smagin GN, Ryan DH, Harris RB. Effect of restraint stress on food intake and body weight is determined by time of day. Am J Physiol. 1997;273(5 Pt 2):R1612–22.PubMed

88.

Arble DM, Bass J, Laposky AD, Vitaterna MH, Turek FW. Circadian timing of food intake contributes to weight gain. Obesity (Silver Spring). 2009;17(11):2100–2.CrossRef

89.

Inui A, Kitaoka H, Majima M, et al. Effect of the Kobe earthquake on stress and glycemic control in patients with diabetes mellitus. Arch Intern Med. 1998;158(3):274–8.PubMedCrossRef

90.

Goodyear LJ, Kahn BB. Exercise, glucose transport, and insulin sensitivity. Annu Rev Med. 1998;49:235–61.PubMedCrossRef

91.

Gathercole LL, Bujalska IJ, Stewart PM, Tomlinson JW. Glucocorticoid modulation of insulin signaling in human subcutaneous adipose tissue. J Clin Endocrinol Metab. 2007;92(11):4332–9.PubMedCrossRef

Titel: Effects of Chronic Social Stress on Obesity
verfasst von: Karen A. Scott
Susan J. Melhorn
Randall R. Sakai
Publikationsdatum: 01.03.2012
Verlag: Current Science Inc.
Erschienen in: Current Obesity Reports / Ausgabe 1/2012
Elektronische ISSN: 2162-4968
DOI: https://doi.org/10.1007/s13679-011-0006-3

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