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Current Obesity Reports
Erschienen in: Current Obesity Reports 3/2021

05.05.2021 | Childhood Obesity (A Kelly and C Fox, Section Editor)

Adolescent and Childhood Obesity and Excess Morbidity and Mortality in Young Adulthood—a Systematic Review

verfasst von: Adi Horesh, Avishai M. Tsur, Aya Bardugo, Gilad Twig

Erschienen in: Current Obesity Reports | Ausgabe 3/2021

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Abstract

Purpose of Review

Rates of childhood obesity have been soaring in recent decades. The association between obesity in adulthood and excess morbidity and mortality has been readily established, whereas the association of childhood and adolescent obesity has not. The purpose of this review is to summarize existing data regarding the association of the presence of obesity in childhood/adolescence and early-onset adverse outcomes in adulthood, with specific focus on young adults under the age of 45 years.

Recent Findings

Diabetes, cancer, and cardiometabolic outcomes in midlife are closely linked to childhood and adolescent obesity.

Summary

Childhood and adolescent obesity confer major risks of excess and premature morbidity and mortality, which may be evident before age 30 years in both sexes. The scientific literature is mixed regarding the independent risk of illness, which may be attributed to childhood BMI regardless of adult BMI, and additional data is required to establish causality between the two. Nonetheless, the increasing prevalence of childhood and adolescent obesity may impose an increase of disease burden in midlife, emphasizing the need for effective interventions to be implemented at a young age.
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Literatur
1.
2.
3.
4.
5.
6.
American KR, Diabetes Association. Type 2 diabetes in children and adolescents: consensus conference report. Diabetes Care. 2000;105:671–80.
7.
8.
• Twig G, Zucker I, Afek A, Cukierman-Yaffe T, Bendor CD, Derazne E, et al. Adolescent obesity and early-onset type 2 diabetes. Diabetes Care. 2020;43:1487–95 A nationwide study that assessed type 2 diabetes risk for different degrees of adolescent obesity during the third and fourth decades of life. It shows a substantial risk of incident diabetes for both sexes regardless socioeconomic status and other coexisting morbidities.CrossRefPubMed
9.
Tanamas SK, Reddy SP, Chambers MA, Clark EJ, Dunnigan DL, Hanson RL, et al. Effect of severe obesity in childhood and adolescence on risk of type 2 diabetes in youth and early adulthood in an American Indian population. Pediatr Diabetes. 2018;19:622–9.CrossRefPubMed
10.
Zimmermann E, Bjerregaard LG, Gamborg M, Vaag AA, Sørensen TIA, Baker JL. Childhood body mass index and development of type 2 diabetes throughout adult life—a large-scale danish cohort study. Obesity. 2017;25:965–71.CrossRefPubMed
11.
Twig G, Afek A, Derazne E, Tzur D, Cukierman-Yaffe T, Gerstein HC, et al. Diabetes risk among overweight and obese metabolically healthy young adults. Diabetes Care. 2014;37:2989–95.CrossRefPubMed
12.
Tirosh A, Shai I, Tekes-Manova D, Israeli E, Pereg D, Shochat T, et al. Normal fasting plasma glucose levels and type 2 diabetes in young men. N Engl J Med. 2005;353:1454–62.CrossRefPubMed
13.
Magnussen CG, Koskinen J, Chen W, Thomson R, Schmidt MD, Srinivasan SR, et al. Pediatric metabolic syndrome predicts adulthood metabolic syndrome, subclinical atherosclerosis, and type 2 diabetes mellitus but is no better than body mass index alone: the Bogalusa Heart Study and the Cardiovascular Risk in Young Finns Study. Circulation. 2010;122:1604–11.PubMedCentralCrossRefPubMed
14.
Hillier TA, Pedula KL. Characteristics of an adult population with newly diagnosed type 2 diabetes. Diabetes Care. 2001;24:1522–7.CrossRefPubMed
15.
Skinner AC, Perrin EM, Moss LA, Skelton JA. Cardiometabolic risks and severity of obesity in children and young adults. N Engl J Med. 2015;373:1307–17.CrossRefPubMed
16.
Zhang T, Xu J, Li S, Bazzano LA, He J, Whelton PK, et al. Trajectories of childhood BMI and adult diabetes : the Bogalusa Heart Study. Diabetologia. 2019;62:70–7.CrossRefPubMed
17.
Tirosh A, Shai I, Afek A, Dubnov-Raz G, Ayalon N, Gordon B, et al. Adolescent BMI trajectory and risk of diabetes versus coronary disease. N Engl J Med. 2011;55:296–7.
18.
Juonala M, Magnussen CG, Berenson GS, Venn A, Burns TL, Sabin MA, et al. Childhood adiposity, adult adiposity, and cardiovascular risk factors. N Engl J Med. 2011;365:1876–85.CrossRefPubMed
19.
Bjerregaard LG, Jensen BW, Ängquist L, Osler M, Sørensen TIA, Baker JL. Change in overweight from childhood to early adulthood and risk of type 2 diabetes. N Engl J Med. 2018;378:1302–12.CrossRefPubMed
20.
The NS, Richardson AS, Gordon-Larsen P. Timing and duration of obesity in relation to diabetes: findings from an ethnically diverse, nationally representative sample. Diabetes Care. 2013;36:865–72.PubMedCentralCrossRefPubMed
21.
22.
• Geng T, Smith CE, Li C, Huang T. Childhood BMI and adult type 2 diabetes, coronary artery diseases, chronic kidney disease, and cardiometabolic traits: a Mendelian randomization analysis. Diabetes Care. 2018;41:dc172141 The first Mendelian randomization study that proves causality between obesity and deleterious cardiovascular metabolic comorbidities.CrossRef
23.
Viitasalo A, Schnurr TM, Pitkänen N, Hollensted M, Nielsen TRH, Pahkala K, et al. Abdominal adiposity and cardiometabolic risk factors in children and adolescents: a Mendelian randomization analysis. Am J Clin Nutr. 2019;110:1079–87.PubMedCentralCrossRefPubMed
24.
25.
Zhang T, Zhang H, Li Y, Li S, Fernandez C, Bazzano L, et al. Long-term impact of temporal sequence from childhood obesity to hyperinsulinemia on adult metabolic syndrome and diabetes: the Bogalusa Heart Study. Sci Rep. 2017;7:1–7.
26.
Hillier TA, Pedula KL. Complications in young adults with early-onset type 2 diabetes: losing the relative protection of youth. Diabetes Care. 2003;26:2999–3005.CrossRefPubMed
27.
Pinhas-Hamiel O, Zeitler P. Acute and chronic complications of type 2 diabetes mellitus in children and adolescents. Lancet. 2007;369:1823–31.CrossRefPubMed
28.
29.
Matthews DR, Cull CA, Stratton IM, Holman RR, Turner RC. UKPDS 26: sulphonylurea failure in non-insulin-dependent diabetic patients over six years. Diabet Med. 1998;15:297–303.CrossRefPubMed
30.
Gungor N, Bacha F, Saad R, Janosky J, Arslanian S. Youth type 2 diabetes: insulin resistance, β-cell failure, or both? Diabetes Care. 2005;28:638–44.CrossRefPubMed
31.
Constantino MI, Molyneaux L, Limacher-Gisler F, Al-Saeed A, Luo C, Wu T, et al. Long-term complications and mortality in young-onset diabetes: type 2 diabetes is more hazardous and lethal than type 1 diabetes. Diabetes Care. 2013;36:3863–9.PubMedCentralCrossRefPubMed
32.
Twig G, Tirosh A, Leiba A, Levine H, Shor DBA, Derazne E, et al. BMI at age 17 years and diabetes mortality in midlife: a nationwide cohort of 2.3 million adolescents. Diabetes Care. 2016;39:1996–2003.CrossRefPubMed
33.
Iyengar NM, Hudis CA, Dannenberg AJ. Obesity and cancer: local and systemic mechanisms. Annu Rev Med. 2015;66:297–309.CrossRefPubMed
34.
WRCF. Body fatness and weight gain and the risk of cancer. Contin Updat Proj Expert Rep. 2018;2018:3–141 Available from: Available at dietcancerreport​.​org.
35.
36.
• Furer A, Afek A, Sommer A, Keinan-Boker L, Derazne E, Levi Z, et al. Adolescent obesity and midlife cancer risk: a population-based cohort study of 2·3 million adolescents in Israel. Lancet Diabetes Endocrinol. 2020;8:216–25. https://​doi.​org/​10.​1016/​S2213-8587(20)30019-XA nationwide study that assessed cancer-specific risk for various groups of adolescent BMI. It shows a substantial risk of incident cancer among adolescents with overweight and obesity that was apparent before age 30 years. Cancer risk for the latter persisted when the study sample was limited to overweight and obese adolescents who had unimpaired health at baseline.CrossRefPubMed
37.
Baer HJ, Colditz GA, Rosner B, Michels KB, Rich-Edwards JW, Hunter DJ, et al. Body fatness during childhood and adolescence and incidence of breast cancer in premenopausal women: a prospective cohort study. Breast Cancer Res. 2005;7:R314–25.PubMedCentralCrossRefPubMed
38.
Keinan-Boker L, Levine H, Derazne E, Molina-Hazan V, Kark JD. Measured adolescent body mass index and adult breast cancer in a cohort of 951,480 women. Breast Cancer Res Treat. 2016;158:157–67.CrossRefPubMed
39.
Levi Z, Kark JD, Shamiss A, Derazne E, Tzur D, Keinan-Boker L, et al. Body mass index and socioeconomic status measured in adolescence, country of origin, and the incidence of gastroesophageal adenocarcinoma in a cohort of 1 million men. Cancer. 2013;119:4086–93.CrossRefPubMed
40.
Keinan-Boker L, Levine H, Leiba A, Derazne E, Kark JD. Adolescent obesity and adult male breast cancer in a cohort of 1,382,093 men. Int J Cancer. 2018;142:910–8.CrossRefPubMed
41.
42.
Zohar L, Rottenberg Y, Twig G, Katz L, Leiba A, Derazne E, et al. Adolescent overweight and obesity and the risk for pancreatic cancer among men and women: a nationwide study of 1.79 million Israeli adolescents. Cancer. 2019;125:118–26.CrossRefPubMed
43.
Levi Z, Kark JD, Twig G, Katz L, Leiba A, Derazne E, et al. Body mass index at adolescence and risk of noncardia gastric cancer in a cohort of 1.79 million men and women. Cancer. 2018;124:356–63.CrossRefPubMed
44.
Levi Z, Kark JD, Katz LH, Twig G, Derazne E, Tzur D, et al. Adolescent body mass index and risk of colon and rectal cancer in a cohort of 1.79 million Israeli men and women: a population-based study. Cancer. 2017;123:4022–30.CrossRefPubMed
45.
Leiba M, Leiba A, Keinan-Boker L, Avigdor A, Derazne E, Levine H, et al. Adolescent weight and height are predictors of specific non-Hodgkin lymphoma subtypes among a cohort of 2,352,988 individuals aged 16 to 19 years. Cancer. 2016;122:1068–77.CrossRefPubMed
46.
Kitahara CM, Gamborg M, De González AB, Sørensen TIA, Baker JL. Childhood height and body mass index were associated with risk of adult thyroid cancer in a large cohort study. Cancer Res. 2014;74:235–42.CrossRefPubMed
47.
Sommer A, Twig G. The impact of childhood and adolescent obesity on cardiovascular risk in adulthood: a systematic review. Curr Diab Rep. 2018;18:91.CrossRefPubMed
48.
Würtz P, Wang Q, Kangas AJ, Richmond RC, Skarp J, Tiainen M, et al. Metabolic signatures of adiposity in young adults: Mendelian randomization analysis and effects of weight change. PLoS Med. 2014;11:e1001765.PubMedCentralCrossRefPubMed
49.
Mattsson N, Rönnemaa T, Juonala M, Viikari JSA, Raitakari OT. Childhood predictors of the metabolic syndrome in adulthood. The Cardiovascular Risk in Young Finns Study. Ann Med. 2008;40:542–52.CrossRefPubMed
50.
Morrison JA, Friedman LA, Gray-McGuire C. Metabolic syndrome in childhood predicts adult cardiovascular disease 25 years later: the Princeton lipid research clinics follow-up study. Pediatrics. 2007;120:340–5.CrossRefPubMed
51.
Sundaram MES, Berg RL, Economos C, Coleman LA. The relationship between childhood BMI and adult serum cholesterol, LDL, And ankle brachial index. Clin Med Res. 2014;12:33–9.PubMedCentralCrossRefPubMed
52.
Rademacher ER, Jacobs DR, Moran A, Steinberger J, Prineas RJ, Sinaiko A. Relation of blood pressure and body mass index during childhood to cardiovascular risk factor levels in young adults. J Hypertens. 2009;27:1766–74.PubMedCentralCrossRefPubMed
53.
Kelly RK, Magnussen CG, Sabin MA, Cheung M, Juonala M. Development of hypertension in overweight adolescents: a review. Adolesc Health Med Ther. 2015;6:171–87.PubMedCentralPubMed
54.
Movahed MR, Bates S, Strootman D, Sattur S. Obesity in adolescence is associated with left ventricular hypertrophy and hypertension. Echocardiography. 2011;28:150–3.CrossRefPubMed
55.
56.
Pereira PF, Serrano HMS, Carvalho GQ, Lamounier JA, Peluzio MDCG, Franceschini SDCC, et al. Body fat location and cardiovascular disease risk factors in overweight female adolescents and eutrophic female adolescents with a high percentage of body fat. Cardiol Young. 2012;22:162–9.CrossRefPubMed
57.
Sabo RT, Lu Z, Daniels S, SSS. Serial childhood body mass index and associations with adult hypertension and obesity: the Fels Longitudinal Study. Physiol Behav. 2017;176:139–48.
58.
Chorin E, Hassidim A, Hartal M, Havakuk O, Flint N, Ziv-Baran T, et al. Trends in adolescents obesity and the association between BMI and blood pressure: a cross-sectional study in 714,922 healthy teenagers. Am J Hypertens. 2015;28:1157–63.CrossRefPubMed
59.
Park MH, Sovio U, Viner RM, Hardy RJ, Kinra S. Overweight in childhood, adolescence and adulthood and cardiovascular risk in later life: pooled analysis of three British birth cohorts. PLoS One. 2013;8:3–8.
60.
Su TC, Liao CC, Chien KL, Hsu SHJ, Sung FC. An overweight or obese status in childhood predicts subclinical atherosclerosis and prehypertension/hypertension in young adults. J Atheroscler Thromb. 2014;21:1170–82.CrossRefPubMed
61.
Tirosh A, Afek A, Rudich A, Percik R, Gordon B, Ayalon N, et al. Progression of normotensive adolescents to hypertensive adults a study of 26 980 teenagers. Hypertension. 2010;56:203–9.CrossRefPubMed
62.
Twig G, Ben-Ami Shor D, Furer A, Levine H, Derazne E, Goldberger N, et al. Adolescent body mass index and cardiovascular disease-specific mortality by midlife. J Clin Endocrinol Metab. 2017;102:3011–20.CrossRefPubMed
63.
Twig G, Gerstein HC, Shor DBA, Derazne E, Tzur D, Afek A, et al. Coronary artery disease risk among obese metabolically healthy young men. Eur J Endocrinol. 2015;173:305–12.CrossRefPubMed
64.
Williams MJA, Milne BJ, Ambler A, Theodore R, Ramrakha S, Caspi A, et al. Childhood body mass index and endothelial dysfunction evaluated by peripheral arterial tonometry in early midlife. Int J Obes. 2017;41:1355–60.CrossRef
65.
Hao G, Wang X, Treiber FA, Harshfield G, Kapuku G, Su S. Body mass index trajectories in childhood is predictive of cardiovascular risk: results from the 23-year longitudinal Georgia Stress and Heart study. Int J Obes. 2018;42:923–5.CrossRef
66.
Juonala M, Magnussen CG, Venn A, Dwyer T, Burns TL, Davis PH, et al. Influence of age on associations between childhood risk factors and carotid intima-media thickness in adulthood. Circulation. 2010;122:2514–20.CrossRefPubMed
67.
Yan Y, Hou D, Liu J, Zhao X, Cheng H, Xi B, et al. Childhood body mass index and blood pressure in prediction of subclinical vascular damage in adulthood: Beijing blood pressure cohort. J Hypertens. 2017;35:47–54.CrossRefPubMed
68.
Andersen LG, Ängquist L, Eriksson JG, Forsen T, Gamborg M, Osmond C, et al. Birth weight, childhood body mass index and risk of coronary heart disease in adults: combined historical cohort studies. PLoS One. 2010;5:20–2.CrossRef
69.
Falkstedt D, Hemmingsson T, Rasmussen F, Lundberg I. Body mass index in late adolescence and its association with coronary heart disease and stroke in middle age among Swedish men. Int J Obes. 2007;31:777–83.CrossRef
70.
Fang X, Zuo J, Zhou J, Cai J, Chen C, Xiang E, et al. Childhood obesity leads to adult type 2 diabetes and coronary artery diseases: a 2-sample Mendelian randomization study. Med (United States). 2019;98:e16825.
71.
Must A, Jacques PF, Dallal GE, Bajema CJ, Dietz WH. Long-term morbidity and mortality of overweight adolescents. N Engl J Med. 1992;326:653–7.
72.
Baker JL, Olsen LW, Sørensen TIA. Childhood body-mass index and the risk of coronary heart disease in adulthood. N Engl J Med. 2007:687–96.
73.
• Twig G, Yaniv G, Levine H, Leiba A, Goldberger N, Derazne E, et al. Body-mass index in 2.3 million adolescents and cardiovascular death in adulthood. N Engl J Med. 2016;374:2430–40 A nationwide study that assessed the association between adolescent BMI and midlife mortality. It showed that the risk of mortality due to cardiovascular disease was nearly 2- and 4-fold among adolescents with overweight and obesity respectively and was evident before age 30 years. The mortality risk for the latter persisted with extensive sensitivity analyses including limiting the study sample to overweight and obese adolescents who had unimpaired health at baseline.CrossRefPubMed
74.
75.
Barasa A, Schaufelberger M, Lappas G, Swedberg K, Dellborg M, Rosengren A. Heart failure in young adults: 20-year trends in hospitalization, aetiology, and case fatality in Sweden. Eur Heart J. 2014;35:25–32.CrossRefPubMed
76.
Aune D, Sen A, Norat T, Janszky I, Romundstad P, Tonstad S, et al. Body mass index, abdominal fatness, and heart failure incidence and mortality: a systematic review and dose-response meta-analysis of prospective studies. Circulation. 2016;133:639–49.CrossRefPubMed
77.
Rosengren A, Åberg M, Robertson J, Waern M, Schaufelberger M, Kuhn G, et al. Body weight in adolescence and long-term risk of early heart failure in adulthood among men in Sweden. Eur Heart J. 2017;38:1926–33.PubMed
78.
Robertson J, Schaufelberger M, Lindgren M, Adiels M, Schiöler L, Torén K, et al. Higher body mass index in adolescence predicts cardiomyopathy risk in midlife: long-term follow-up among Swedish men. Circulation. 2019;140:117–25.PubMedCentralCrossRefPubMed
79.
Mangner N, Scheuermann K, Winzer E, Wagner I, Hoellriegel R, Sandri M, et al. Childhood obesity: impact on cardiac geometry and function. JACC Cardiovasc Imaging. 2014;7:1198–205.CrossRefPubMed
80.
Twig G, Vivante A, Bader T, Derazne E, Tsur AM, Levi M, et al. Body mass index and kidney disease-related mortality in midlife: a nationwide cohort of 2.3 million adolescents. Obesity. 2018;26:776–81.CrossRefPubMed
81.
Metadaten
Titel
Adolescent and Childhood Obesity and Excess Morbidity and Mortality in Young Adulthood—a Systematic Review
verfasst von
Adi Horesh
Avishai M. Tsur
Aya Bardugo
Gilad Twig
Publikationsdatum
05.05.2021
Verlag
Springer US
Erschienen in
Current Obesity Reports / Ausgabe 3/2021
Elektronische ISSN: 2162-4968
DOI
https://doi.org/10.1007/s13679-021-00439-9

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