Erschienen in:
01.08.2019 | Systematic Review
Effect of Biological Treatment on Fatigue in Psoriasis: A Systematic Review and Meta-Analysis
verfasst von:
Inger Marie Skoie, Ingvild Dalen, Roald Omdal
Erschienen in:
American Journal of Clinical Dermatology
|
Ausgabe 4/2019
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Abstract
Background
Fatigue is frequent in patients with psoriasis. Though conventional drugs in general have no effect on fatigue, biological agents have demonstrated beneficial effects in several other chronic inflammatory diseases.
Objective
The objective of the present study was to evaluate the effect of biological drugs on fatigue in patients with psoriasis vulgaris.
Methods
We conducted a meta-analysis of randomized controlled trials in which anti-interleukin-12/23, anti-interleukin-23, anti-interleukin-17, or anti-tumor necrosis factor-α agents were used for psoriasis vulgaris and fatigue was an outcome measure.
Results
A total of eight randomized controlled trials fulfilled criteria for inclusion in the meta-analysis. The studies used two fatigue reporting scales: the Functional Assessment of Chronic Illness Therapy-Fatigue and the Short Form 36 Health Survey Vitality Subscale. Treatment by biological agents in general compared with placebo led to a significant reduction in fatigue, with a standardized mean difference of − 0.40 (95% confidence interval − 0.46 to − 0.34; p < 0.001).
Conclusion
Biological drugs used for the treatment of psoriasis vulgaris have a consistently small-to-moderate beneficial effect on fatigue independent of the type of drug.