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Drugs
Erschienen in: Drugs 11/2016

01.07.2016 | Review Article

Psychosis in Parkinson’s Disease: Epidemiology, Pathophysiology, and Management

verfasst von: Anna Chang, Susan H. Fox

Erschienen in: Drugs | Ausgabe 11/2016

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Abstract

Psychotic symptoms are common in Parkinson’s disease (PD) and are associated with poorer quality of life and increased caregiver burden. PD psychosis is correlated with several factors, such as more advanced disease, cognitive impairment, depression, and sleep disorders. The underlying causes of psychosis in PD thus involve a complex interplay between exogenous (e.g., drugs, intercurrent illnesses) and endogenous (e.g., PD disease pathology) factors. Current theories of the pathophysiology of PD psychosis have come from several neuropathological and neuroimaging studies that implicate pathways involving visual processing and executive function, including temporo-limbic structures and neocortical gray matter with altered neurotransmitter functioning (e.g., dopamine, serotonin, and acetylcholine). Treatment of PD psychosis requires a step-wise process, including initial careful investigation of treatable triggering conditions and a comprehensive evaluation with adjustment of PD medications and/or initiation of specific antipsychotic therapies. Clozapine remains the only recommended drug for the treatment of PD psychosis; however, because of regular blood monitoring, quetiapine is usually first-line therapy, although less efficacious. Emerging studies have focused on agents involving other neurotransmitters, including the serotonin 5-HT2A receptor inverse agonist pimavanserin, cholinesterase inhibitors, and antidepressants and anxiolytics.
Literatur
1.
Martinez-Martin P, Rodriguez-Blazquez C, Forjaz MJ, Frades-Payo B, Aguera-Ortiz L, Weintraub D, et al. Neuropsychiatric symptoms and caregiver’s burden in Parkinson’s disease. Parkinsonism Relat Disord. 2015;21:629–34.PubMedCrossRef
2.
de Lau LM, Verbaan D, van Rooden SM, Marinus J, van Hilten JJ. Relation of clinical subtypes in Parkinson’s disease with survival. Mov Disord. 2014;29:150–1.PubMedCrossRef
3.
Ravina B, Marder K, Fernandez HH, Friedman JH, McDonald W, Murphy D, et al. Diagnostic criteria for psychosis in Parkinson’s disease: report of an NINDS, NIMH work group. Mov Disord. 2007;22:1061–8.PubMedCrossRef
4.
Miyasaki JM, Shannon K, Voon V, Ravina B, Kleiner-Fisman G, Anderson K, et al. Practice parameter: evaluation and treatment of depression, psychosis, and dementia in Parkinson disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2006;66:996–1002.PubMedCrossRef
5.
Fernandez HH, Aarsland D, Fenelon G, Friedman JH, Marsh L, Troster AI, et al. Scales to assess psychosis in Parkinson’s disease: critique and recommendations. Mov Disord. 2008;23:484–500.PubMedCrossRef
6.
Friedberg G, Zoldan J, Weizman A, Melamed E. Parkinson Psychosis Rating Scale: a practical instrument for grading psychosis in Parkinson’s disease. Clin Neuropharmacol. 1998;21:280–4.PubMed
7.
Brandstaedter D, Spieker S, Ulm G, Siebert U, Eichhorn TE, Krieg JC, et al. Development and evaluation of the Parkinson Psychosis Questionnaire A screening-instrument for the early diagnosis of drug-induced psychosis in Parkinson’s disease. J Neurol. 2005;252:1060–6.PubMedCrossRef
8.
Goetz CG, Leurgans S, Pappert EJ, Raman R, Stemer AB. Prospective longitudinal assessment of hallucinations in Parkinson’s disease. Neurology. 2001;57:2078–82.PubMedCrossRef
9.
Ondo WG, Tintner R, Voung KD, Lai D, Ringholz G. Double-blind, placebo-controlled, unforced titration parallel trial of quetiapine for dopaminergic-induced hallucinations in Parkinson’s disease. Mov Disord. 2005;20:958–63.PubMedCrossRef
10.
Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology. 1994;44:2308–14.PubMedCrossRef
11.
Reisberg B, Borenstein J, Salob SP, Ferris SH, Franssen E, Georgotas A. Behavioral symptoms in Alzheimer’s disease: phenomenology and treatment. J Clin Psychiatry. 1987;48:S9–15.
12.
Beller SA, Overall JE. The Brief Psychiatric Rating Scale (BPRS) in geropsychiatric research: II. Representative profile patterns. J Gerontol. 1984;39:194–200.PubMedCrossRef
13.
Kay SR, Opler LA, Lindenmayer JP. The Positive and Negative Syndrome Scale (PANSS): rationale and standardisation. Br J Psychiatry Suppl. 1989;7:59–67.
14.
Minas IH, Klimidis S, Stuart GW, Copolov DL, Singh BS. Positive and negative symptoms in the psychoses: principal components analysis of items from the Scale for the Assessment of Positive Symptoms and the Scale for the Assessment of Negative Symptoms. Compr Psychiatry. 1994;35:135–44.PubMedCrossRef
15.
Honigfeld G, Gillis RD, Klett CJ. NOSIE-30: a treatment-sensitive ward behavior scale. Psychol Rep. 1966;19:180–2.PubMedCrossRef
16.
Guy W. Clinical Global Impressions (CGI). In: ECDEU assessment manual for psychopharmacology, revised. Rockville, MD: US Department of Health, Education and Welfare, NIMH;1976. p. 217–22.
17.
Fahn S, Elton RL, UPDRS program members. Unified Parkinsons Disease Rating Scale. In: Fahn S, Marsden CD, Goldstein M, Calne DB, editors. Recent developments in Parkinsons disease, vol. 2. Florham Park: Macmillan Healthcare Information; 1987. p. 153–63.
18.
Martinez-Martin P, Leentjens AF, de Pedro-Cuesta J, Chaudhuri KR, Schrag AE, Weintraub D. Accuracy of screening instruments for detection of neuropsychiatric syndromes in Parkinson’s disease. Mov Disord. 2016;31:270–9.PubMedCrossRef
19.
Fenelon G, Mahieux F, Huon R, Ziegler M. Hallucinations in Parkinson’s disease: prevalence, phenomenology and risk factors. Brain. 2000;123:733–45.PubMedCrossRef
20.
Holroyd S, Currie L, Wooten GF. Prospective study of hallucinations and delusions in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2001;70:734–8.PubMedPubMedCentralCrossRef
21.
Schrag A, Ben-Shlomo Y, Quinn N. How common are complications of Parkinson’s disease? J Neurol. 2002;249:419–23.PubMedCrossRef
22.
Marsh L, Williams JR, Rocco M, Grill S, Munro C, Dawson TM. Psychiatric comorbidities in patients with Parkinson disease and psychosis. Neurology. 2004;63:293–300.PubMedCrossRef
23.
Pacchetti C, Manni R, Zangaglia R, Mancini F, Marchioni E, Tassorelli C, et al. Relationship between hallucinations, delusions, and rapid eye movement sleep behavior disorder in Parkinson’s disease. Mov Disord. 2005;20:1439–48.PubMedCrossRef
24.
Paleacu D, Schechtman E, Inzelberg R. Association between family history of dementia and hallucinations in Parkinson disease. Neurology. 2005;64:1712–5.PubMedCrossRef
25.
Papapetropoulos S, Katzen H, Schrag A, Singer C, Scanlon BK, Nation D, et al. A questionnaire-based (UM-PDHQ) study of hallucinations in Parkinson’s disease. BMC Neurol. 2008;8:21.PubMedPubMedCentralCrossRef
26.
Williams DR, Warren JD, Lees AJ. Using the presence of visual hallucinations to differentiate Parkinson’s disease from atypical parkinsonism. J Neurol Neurosurg Psychiatry. 2008;79:652–5.PubMedCrossRef
27.
Fenelon G, Soulas T, Zenasni F, Cleret de Langavant L. The changing face of Parkinson’s disease-associated psychosis: a cross-sectional study based on the new NINDS-NIMH criteria. Mov Disord. 2010;25:763–6.PubMedCrossRef
28.
Mack J, Rabins P, Anderson K, Goldstein S, Grill S, Hirsch ES, et al. Prevalence of psychotic symptoms in a community-based Parkinson disease sample. Am J Geriatr Psychiatry. 2012;20:123–32.PubMedPubMedCentralCrossRef
29.
Fenelon G, Alves G. Epidemiology of psychosis in Parkinson’s disease. J Neurol Sci. 2010;289:12–7.PubMedCrossRef
30.
Goetz CG, Fan W, Leurgans S, Bernard B, Stebbins GT. The malignant course of “benign hallucinations” in Parkinson disease. Arch Neurol. 2006;63:713–6.PubMedCrossRef
31.
Pagonabarraga J, Martinez-Horta S, Fernandez de Bobadilla R, Perez J, Ribosa-Nogue R, Marin J, et al. Minor hallucinations occur in drug-naive Parkinson’s disease patients, even from the premotor phase. Mov Disord. 2016;31:45–52.PubMedCrossRef
32.
de Maindreville AD, Fenelon G, Mahieux F. Hallucinations in Parkinson’s disease: a follow-up study. Mov Disord. 2005;20:212–7.PubMedCrossRef
33.
Wood RA, Hopkins SA, Moodley KK, Chan D. Fifty percent prevalence of extracampine hallucinations in Parkinson’s disease patients. Front Neurol. 2015;6:263.PubMedPubMedCentralCrossRef
34.
Forsaa EB, Larsen JP, Wentzel-Larsen T, Goetz CG, Stebbins GT, Aarsland D, et al. A 12-year population-based study of psychosis in Parkinson disease. Arch Neurol. 2010;67:996–1001.PubMedCrossRef
35.
Goetz CG, Stebbins GT, Ouyang B. Visual plus nonvisual hallucinations in Parkinson’s disease: development and evolution over 10 years. Mov Disord. 2011;26:2196–200.PubMedCrossRef
36.
Dotchin CL, Jusabani A, Walker RW. Non-motor symptoms in a prevalent population with Parkinson’s disease in Tanzania. Parkinsonism Relat Disord. 2009;15:457–60.PubMedCrossRef
37.
Biousse V, Skibell BC, Watts RL, Loupe DN, Drews-Botsch C, Newman NJ. Ophthalmologic features of Parkinson’s disease. Neurology. 2004;62:177–80.PubMedCrossRef
38.
Aarsland D, Bronnick K, Alves G, Tysnes OB, Pedersen KF, Ehrt U, et al. The spectrum of neuropsychiatric symptoms in patients with early untreated Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2009;80:928–30.PubMedCrossRef
39.
de la Riva P, Smith K, Xie SX, Weintraub D. Course of psychiatric symptoms and global cognition in early Parkinson disease. Neurology. 2014;83:1096–103.PubMedPubMedCentralCrossRef
40.
Weintraub D, Simuni T, Caspell-Garcia C, Coffey C, Lasch S, Siderowf A, et al. Cognitive performance and neuropsychiatric symptoms in early, untreated Parkinson’s disease. Mov Disord. 2015;30:919–27.PubMedPubMedCentralCrossRef
41.
42.
Rascol O, Brooks DJ, Korczyn AD, De Deyn PP, Clarke CE, Lang AE. A five-year study of the incidence of dyskinesia in patients with early Parkinson’s disease who were treated with ropinirole or levodopa. N Engl J Med. 2000;342:1484–91.PubMedCrossRef
43.
Herzog J, Reiff J, Krack P, Witt K, Schrader B, Muller D, et al. Manic episode with psychotic symptoms induced by subthalamic nucleus stimulation in a patient with Parkinson’s disease. Mov Disord. 2003;18:1382–4.PubMedCrossRef
44.
Parkinson Study Group. Pramipexole vs levodopa as initial treatment for Parkinson disease: A randomized controlled trial. Parkinson Study Group. JAMA. 2000;284:1931–8.CrossRef
45.
Merims D, Shabtai H, Korczyn AD, Peretz C, Weizman N, Giladi N. Antiparkinsonian medication is not a risk factor for the development of hallucinations in Parkinson’s disease. J Neural Transm (Vienna). 2004;111:1447–53.PubMedCrossRef
46.
Papapetropoulos S, Argyriou AA, Ellul J. Factors associated with drug-induced visual hallucinations in Parkinson’s disease. J Neurol. 2005;252:1223–8.PubMedCrossRef
47.
Fenelon G, Goetz CG, Karenberg A. Hallucinations in Parkinson disease in the prelevodopa era. Neurology. 2006;66:93–8.PubMedCrossRef
48.
Aarsland D, Larsen JP, Cummins JL, Laake K. Prevalence and clinical correlates of psychotic symptoms in Parkinson disease: a community-based study. Arch Neurol. 1999;56:595–601.PubMedCrossRef
49.
Goetz CG, Pappert EJ, Blasucci LM, Stebbins GT, Ling ZD, Nora MV, et al. Intravenous levodopa in hallucinating Parkinson’s disease patients: high-dose challenge does not precipitate hallucinations. Neurology. 1998;50:515–7.PubMedCrossRef
50.
Fenelon G, Soulas T, Cleret de Langavant L, Trinkler I, Bachoud-Levi AC. Feeling of presence in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2011;82:1219–24.PubMedPubMedCentralCrossRef
51.
Williams DR, Lees AJ. Visual hallucinations in the diagnosis of idiopathic Parkinson’s disease: a retrospective autopsy study. Lancet Neurol. 2005;4:605–10.PubMedCrossRef
52.
Ecker D, Unrath A, Kassubek J, Sabolek M. Dopamine Agonists and their risk to induce psychotic episodes in Parkinson’s disease: a case-control study. BMC Neurol. 2009;9:23.PubMedPubMedCentralCrossRef
53.
Baker WL, Silver D, White CM, Kluger J, Aberle J, Patel AA, et al. Dopamine agonists in the treatment of early Parkinson’s disease: a meta-analysis. Parkinsonism Relat Disord. 2009;15:287–94.PubMedCrossRef
54.
Stowe RL, Ives NJ, Clarke C, van Hilten J, Ferreira J, Hawker RJ, et al. Dopamine agonist therapy in early Parkinson’s disease. Cochrane Database Syst Rev. 2008;2:CD006564.PubMed
55.
Poletti M, Perugi G, Logi C, Romano A, Del Dotto P, Ceravolo R, et al. Dopamine agonists and delusional jealousy in Parkinson’s disease: a cross-sectional prevalence study. Mov Disord. 2012;27:1679–82.PubMedCrossRef
56.
Poletti M, Lucetti C, Baldacci F, Del Dotto P, Bonuccelli U. Concomitant development of hypersexuality and delusional jealousy in patients with Parkinson’s disease: a case series. Parkinsonism Relat Disord. 2014;20:1290–2.PubMedCrossRef
57.
Munhoz RP, Teive HA, Eleftherohorinou H, Coin LJ, Lees AJ, Silveira-Moriyama L. Demographic and motor features associated with the occurrence of neuropsychiatric and sleep complications of Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2013;84:883–7.PubMedCrossRef
58.
Barnes J, David AS. Visual hallucinations in Parkinson’s disease: a review and phenomenological survey. J Neurol Neurosurg Psychiatry. 2001;70:727–33.PubMedPubMedCentralCrossRef
59.
Yoritaka A, Shimo Y, Takanashi M, Fukae J, Hatano T, Nakahara T, et al. Motor and non-motor symptoms of 1453 patients with Parkinson’s disease: prevalence and risks. Parkinsonism Relat Disord. 2013;19:725–31.PubMedCrossRef
60.
Factor SA, Steenland NK, Higgins DS, Molho ES, Kay DM, Montimurro J, et al. Disease-related and genetic correlates of psychotic symptoms in Parkinson’s disease. Mov Disord. 2011;26:2190–5.PubMedPubMedCentralCrossRef
61.
Shergill SS, Walker Z, Le Katona C. A preliminary investigation of laterality in Parkinson’s disease and susceptibility to psychosis. J Neurol Neurosurg Psychiatry. 1998;65:610–1.PubMedPubMedCentralCrossRef
62.
Goetz CG, Vogel C, Tanner CM, Stebbins GT. Early dopaminergic drug-induced hallucinations in parkinsonian patients. Neurology. 1998;51:811–4.PubMedCrossRef
63.
Goetz CG, Wuu J, Curgian LM, Leurgans S. Hallucinations and sleep disorders in PD: six-year prospective longitudinal study. Neurology. 2005;64:81–6.PubMedCrossRef
64.
Hely MA, Reid WG, Adena MA, Halliday GM, Morris JG. The Sydney multicenter study of Parkinson’s disease: the inevitability of dementia at 20 years. Mov Disord. 2008;23:837–44.PubMedCrossRef
65.
Schrag A, Dodel R, Spottke A, Bornschein B, Siebert U, Quinn NP. Rate of clinical progression in Parkinson’s disease. A prospective study. Mov Disord. 2007;22:938–45.PubMedCrossRef
66.
Lee AH, Weintraub D. Psychosis in Parkinson’s disease without dementia: common and comorbid with other non-motor symptoms. Mov Disord. 2012;27:858–63.PubMedPubMedCentralCrossRef
67.
van Rooden SM, Visser M, Verbaan D, Marinus J, van Hilten JJ. Motor patterns in Parkinson’s disease: a data-driven approach. Mov Disord. 2009;24:1042–7.PubMedCrossRef
68.
Forsaa EB, Larsen JP, Wentzel-Larsen T, Alves G. A 12-year population-based study of freezing of gait in Parkinson’s disease. Parkinsonism Relat Disord. 2015;21:254–8.PubMedCrossRef
69.
Baumann CR, Held U, Valko PO, Wienecke M, Waldvogel D. Body side and predominant motor features at the onset of Parkinson’s disease are linked to motor and nonmotor progression. Mov Disord. 2014;29:207–13.PubMedCrossRef
70.
Rana AQ, Vaid HM, Edun A, Dogu O, Rana MA. Relationship of dementia and visual hallucinations in tremor and non-tremor dominant Parkinson’s disease. J Neurol Sci. 2012;323:158–61.PubMedCrossRef
71.
Cubo E, Martin PM, Martin-Gonzalez JA, Rodriguez-Blazquez C, Kulisevsky J, Members EG. Motor laterality asymmetry and nonmotor symptoms in Parkinson’s disease. Mov Disord. 2010;25:70–5.PubMedCrossRef
72.
Stavitsky K, McNamara P, Durso R, Harris E, Auerbach S, Cronin-Golomb A. Hallucinations, dreaming, and frequent dozing in Parkinson disease: impact of right-hemisphere neural networks. Cogn Behav Neurol. 2008;21:143–9.PubMedPubMedCentralCrossRef
73.
Sawada H, Oeda T, Yamamoto K, Umemura A, Tomita S, Hayashi R, et al. Trigger medications and patient-related risk factors for Parkinson disease psychosis requiring anti-psychotic drugs: a retrospective cohort study. BMC Neurol. 2013;13:145.PubMedPubMedCentralCrossRef
74.
Goetz CG, Wuu J, Curgian L, Leurgans S. Age-related influences on the clinical characteristics of new-onset hallucinations in Parkinson’s disease patients. Mov Disord. 2006;21:267–70.PubMedCrossRef
75.
Kiziltan G, Ozekmekci S, Ertan S, Ertan T, Erginoz E. Relationship between age and subtypes of psychotic symptoms in Parkinson’s disease. J Neurol. 2007;254:448–52.PubMedCrossRef
76.
Spica V, Pekmezovic T, Svetel M, Kostic VS. Prevalence of non-motor symptoms in young-onset versus late-onset Parkinson’s disease. J Neurol. 2013;260:131–7.PubMedCrossRef
77.
Khan NL, Graham E, Critchley P, Schrag AE, Wood NW, Lees AJ, et al. Parkin disease: a phenotypic study of a large case series. Brain. 2003;126:1279–92.PubMedCrossRef
78.
Lohmann E, Thobois S, Lesage S, Broussolle E, du Montcel ST, Ribeiro MJ, et al. A multidisciplinary study of patients with early-onset PD with and without parkin mutations. Neurology. 2009;72:110–6.PubMedPubMedCentralCrossRef
79.
Steinlechner S, Stahlberg J, Volkel B, Djarmati A, Hagenah J, Hiller A, et al. Co-occurrence of affective and schizophrenia spectrum disorders with PINK1 mutations. J Neurol Neurosurg Psychiatry. 2007;78:532–5.PubMedPubMedCentralCrossRef
80.
Ross OA, Braithwaite AT, Skipper LM, Kachergus J, Hulihan MM, Middleton FA, et al. Genomic investigation of alpha-synuclein multiplication and parkinsonism. Ann Neurol. 2008;63:743–50.PubMedCrossRef
81.
Nishioka K, Hayashi S, Farrer MJ, Singleton AB, Yoshino H, Imai H, et al. Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson’s disease. Ann Neurol. 2006;59:298–309.PubMedCrossRef
82.
83.
Belarbi S, Hecham N, Lesage S, Kediha MI, Smail N, Benhassine T, et al. LRRK2 G2019S mutation in Parkinson’s disease: a neuropsychological and neuropsychiatric study in a large Algerian cohort. Parkinsonism Relat Disord. 2010;16:676–9.PubMedCrossRef
84.
Goldwurm S, Zini M, Di Fonzo A, De Gaspari D, Siri C, Simons EJ, et al. LRRK2 G2019S mutation and Parkinson’s disease: a clinical, neuropsychological and neuropsychiatric study in a large Italian sample. Parkinsonism Relat Disord. 2006;12:410–9.PubMedCrossRef
85.
Somme JH, Molano Salazar A, Gonzalez A, Tijero B, Berganzo K, Lezcano E, et al. Cognitive and behavioral symptoms in Parkinson’s disease patients with the G2019S and R1441G mutations of the LRRK2 gene. Parkinsonism Relat Disord. 2015;21:494–9.PubMedCrossRef
86.
Oeda T, Umemura A, Mori Y, Tomita S, Kohsaka M, Park K, et al. Impact of glucocerebrosidase mutations on motor and nonmotor complications in Parkinson’s disease. Neurobiol Aging. 2015;36:3306–13.PubMedCrossRef
87.
Kitayama M, Wada-Isoe K, Nakaso K, Irizawa Y, Nakashima K. Clinical evaluation of Parkinson’s disease dementia: association with aging and visual hallucination. Acta Neurol Scand. 2007;116:190–5.PubMedCrossRef
88.
89.
Zhu K, van Hilten JJ, Putter H, Marinus J. Risk factors for hallucinations in Parkinson’s disease: results from a large prospective cohort study. Mov Disord. 2013;28:755–62.PubMedCrossRef
90.
Aarsland D, Ballard C, Larsen JP, McKeith I. A comparative study of psychiatric symptoms in dementia with Lewy bodies and Parkinson’s disease with and without dementia. Int J Geriatr Psychiatry. 2001;16:528–36.PubMedCrossRef
91.
Biglan KM, Holloway RG Jr, McDermott MP, Richard IH, Parkinson Study Group C-PDI. Risk factors for somnolence, edema, and hallucinations in early Parkinson disease. Neurology. 2007;69:187–95.PubMedCrossRef
92.
Archibald NK, Clarke MP, Mosimann UP, Burn DJ. Visual symptoms in Parkinson’s disease and Parkinson’s disease dementia. Mov Disord. 2011;26:2387–95.PubMedCrossRef
93.
Aarsland D, Kurz MW. The epidemiology of dementia associated with Parkinson disease. J Neurol Sci. 2010;289:18–22.PubMedCrossRef
94.
Aarsland D, Andersen K, Larsen JP, Perry R, Wentzel-Larsen T, Lolk A, et al. The rate of cognitive decline in Parkinson disease. Arch Neurol. 2004;61:1906–11.PubMedCrossRef
95.
Ibarretxe-Bilbao N, Ramirez-Ruiz B, Junque C, Marti MJ, Valldeoriola F, Bargallo N, et al. Differential progression of brain atrophy in Parkinson’s disease with and without visual hallucinations. J Neurol Neurosurg Psychiatry. 2010;81:650–7.PubMedCrossRef
96.
Hepp DH, da Hora CC, Koene T, Uitdehaag BM, van den Heuvel OA, Klein M, et al. Cognitive correlates of visual hallucinations in non-demented Parkinson’s disease patients. Parkinsonism Relat Disord. 2013;19:795–9.PubMedCrossRef
97.
Meppelink AM, Koerts J, Borg M, Leenders KL, van Laar T. Visual object recognition and attention in Parkinson’s disease patients with visual hallucinations. Mov Disord. 2008;23:1906–12.PubMedCrossRef
98.
Barnes J, Boubert L. Executive functions are impaired in patients with Parkinson’s disease with visual hallucinations. J Neurol Neurosurg Psychiatry. 2008;79:190–2.PubMedCrossRef
99.
Llebaria G, Pagonabarraga J, Martinez-Corral M, Garcia-Sanchez C, Pascual-Sedano B, Gironell A, et al. Neuropsychological correlates of mild to severe hallucinations in Parkinson’s disease. Mov Disord. 2010;25:2785–91.PubMedCrossRef
100.
Bronnick K, Emre M, Tekin S, Haugen SB, Aarsland D. Cognitive correlates of visual hallucinations in dementia associated with Parkinson’s disease. Mov Disord. 2011;26:824–9.PubMedCrossRef
101.
Ramirez-Ruiz B, Junque C, Marti MJ, Valldeoriola F, Tolosa E. Neuropsychological deficits in Parkinson’s disease patients with visual hallucinations. Mov Disord. 2006;21:1483–7.PubMedCrossRef
102.
Shin S, Lee JE, Hong JY, Sunwoo MK, Sohn YH, Lee PH. Neuroanatomical substrates of visual hallucinations in patients with non-demented Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2012;83:1155–61.PubMedCrossRef
103.
Ozer F, Meral H, Hanoglu L, Ozturk O, Aydemir T, Cetin S, et al. Cognitive impairment patterns in Parkinson’s disease with visual hallucinations. J Clin Neurosci. 2007;14:742–6.PubMedCrossRef
104.
Grossi D, Trojano L, Pellecchia MT, Amboni M, Fragassi NA, Barone P. Frontal dysfunction contributes to the genesis of hallucinations in non-demented Parkinsonian patients. Int J Geriatr Psychiatry. 2005;20:668–73.PubMedCrossRef
105.
Collerton D, Perry E, McKeith I. Why people see things that are not there: a novel Perception and Attention Deficit model for recurrent complex visual hallucinations. Behav Brain Sci. 2005;28:737–57.PubMed
106.
Diederich NJ, Goetz CG, Stebbins GT. Repeated visual hallucinations in Parkinson’s disease as disturbed external/internal perceptions: focused review and a new integrative model. Mov Disord. 2005;20:130–40.PubMedCrossRef
107.
Alzahrani H, Venneri A. Cognitive and neuroanatomical correlates of neuropsychiatric symptoms in Parkinson’s disease: a systematic review. J Neurol Sci. 2015;356:32–44.PubMedCrossRef
108.
Goldman JG, Stebbins GT, Dinh V, Bernard B, Merkitch D, deToledo-Morrell L, et al. Visuoperceptive region atrophy independent of cognitive status in patients with Parkinson’s disease with hallucinations. Brain. 2014;137:849–59.PubMedPubMedCentralCrossRef
109.
Gasca-Salas C, Clavero P, Garcia-Garcia D, Obeso JA, Rodriguez-Oroz MC. Significance of visual hallucinations and cerebral hypometabolism in the risk of dementia in Parkinson’s disease patients with mild cognitive impairment. Hum Brain Mapp. 2016;37:968–77.PubMedCrossRef
110.
Factor SA, Scullin MK, Sollinger AB, Land JO, Wood-Siverio C, Zanders L, et al. Cognitive correlates of hallucinations and delusions in Parkinson’s disease. J Neurol Sci. 2014;347:316–21.PubMedCrossRef
111.
Stefanis N, Bozi M, Christodoulou C, Douzenis A, Gasparinatos G, Stamboulis E, et al. Isolated delusional syndrome in Parkinson’s Disease. Parkinsonism Relat Disord. 2010;16:550–2.PubMedCrossRef
112.
Pappert EJ, Goetz CG, Niederman FG, Raman R, Leurgans S. Hallucinations, sleep fragmentation, and altered dream phenomena in Parkinson’s disease. Mov Disord. 1999;14:117–21.PubMedCrossRef
113.
Gama RL, de Bruin VM, de Bruin PF, Tavora DG, Lopes EM, Jorge IF, et al. Risk factors for visual hallucinations in patients with Parkinson’s disease. Neurol Res. 2015;37:112–6.PubMedCrossRef
114.
Nomura T, Inoue Y, Mitani H, Kawahara R, Miyake M, Nakashima K. Visual hallucinations as REM sleep behavior disorders in patients with Parkinson’s disease. Mov Disord. 2003;18:812–7.PubMedCrossRef
115.
Manni R, Pacchetti C, Terzaghi M, Sartori I, Mancini F, Nappi G. Hallucinations and sleep-wake cycle in PD: a 24-hour continuous polysomnographic study. Neurology. 2002;59:1979–81.PubMedCrossRef
116.
Comella CL, Tanner CM, Ristanovic RK. Polysomnographic sleep measures in Parkinson’s disease patients with treatment-induced hallucinations. Ann Neurol. 1993;34:710–4.PubMedCrossRef
117.
Gjerstad MD, Boeve B, Wentzel-Larsen T, Aarsland D, Larsen JP. Occurrence and clinical correlates of REM sleep behaviour disorder in patients with Parkinson’s disease over time. J Neurol Neurosurg Psychiatry. 2008;79:387–91.PubMedCrossRef
118.
Arnulf I, Bonnet AM, Damier P, Bejjani BP, Seilhean D, Derenne JP, et al. Hallucinations, REM sleep, and Parkinson’s disease: a medical hypothesis. Neurology. 2000;55:281–8.PubMedCrossRef
119.
Benbir G, Ozekmekci S, Cinar M, Beskardes F, Apaydin H, Erginoz E. Features associated with the development of hallucinations in Parkinson’s disease. Acta Neurol Scand. 2006;114:239–43.PubMedCrossRef
120.
Sinforiani E, Pacchetti C, Zangaglia R, Pasotti C, Manni R, Nappi G. REM behavior disorder, hallucinations and cognitive impairment in Parkinson’s disease: a two-year follow up. Mov Disord. 2008;23:1441–5.PubMedCrossRef
121.
Lenka A, Hegde S, Jhunjhunwala KR, Pal PK. Interactions of visual hallucinations, rapid eye movement sleep behavior disorder and cognitive impairment in Parkinson’s disease: a review. Parkinsonism Relat Disord. 2016;22:1–8.PubMedCrossRef
122.
Matsui H, Udaka F, Tamura A, Oda M, Kubori T, Nishinaka K, et al. Impaired visual acuity as a risk factor for visual hallucinations in Parkinson’s disease. J Geriatr Psychiatry Neurol. 2006;19:36–40.PubMedCrossRef
123.
Diederich NJ, Goetz CG, Raman R, Pappert EJ, Leurgans S, Piery V. Poor visual discrimination and visual hallucinations in Parkinson’s disease. Clin Neuropharmacol. 1998;21:289–95.PubMed
124.
Lee JY, Kim JM, Ahn J, Kim HJ, Jeon BS, Kim TW. Retinal nerve fiber layer thickness and visual hallucinations in Parkinson’s Disease. Mov Disord. 2014;29:61–7.PubMedCrossRef
125.
Jimenez B, Ascaso FJ, Cristobal JA, Lopez del Val J. Development of a prediction formula of Parkinson disease severity by optical coherence tomography. Mov Disord. 2014;29:68–74.PubMedCrossRef
126.
Bodis-Wollner I, Kozlowski PB, Glazman S, Miri S. alpha-synuclein in the inner retina in parkinson disease. Ann Neurol. 2014;75:964–6.PubMedCrossRef
127.
128.
Lee JY, Yoon EJ, Lee WW, Kim YK, Lee JY, Jeon B. Lateral geniculate atrophy in Parkinson’s with visual hallucination: a trans-synaptic degeneration? Mov Disord. 2016. doi:10.​1002/​mds.​26533.
129.
Sanchez-Ramos JR, Ortoll R, Paulson GW. Visual hallucinations associated with Parkinson disease. Arch Neurol. 1996;53:1265–8.PubMedCrossRef
130.
131.
Giladi N, Treves TA, Paleacu D, Shabtai H, Orlov Y, Kandinov B, et al. Risk factors for dementia, depression and psychosis in long-standing Parkinson’s disease. J Neural Transm. 2000;107:59–71.PubMedCrossRef
132.
Weintraub D, Morales KH, Duda JE, Moberg PJ, Stern MB. Frequency and correlates of co-morbid psychosis and depression in Parkinson’s disease. Parkinsonism Relat Disord. 2006;12:427–31.PubMedPubMedCentralCrossRef
133.
Morgante L, Colosimo C, Antonini A, Marconi R, Meco G, Pederzoli M, et al. Psychosis associated to Parkinson’s disease in the early stages: relevance of cognitive decline and depression. J Neurol Neurosurg Psychiatry. 2012;83:76–82.PubMedCrossRef
134.
Stuebner E, Vichayanrat E, Low DA, Mathias CJ, Isenmann S, Haensch CA. Non-dipping nocturnal blood pressure and psychosis parameters in Parkinson disease. Clin Auton Res. 2015;25:109–16.PubMedCrossRef
135.
Morley JF, Weintraub D, Mamikonyan E, Moberg PJ, Siderowf AD, Duda JE. Olfactory dysfunction is associated with neuropsychiatric manifestations in Parkinson’s disease. Mov Disord. 2011;26:2051–7.PubMedPubMedCentralCrossRef
136.
Damholdt MF, Borghammer P, Larsen L, Ostergaard K. Odor identification deficits identify Parkinson’s disease patients with poor cognitive performance. Mov Disord. 2011;26:2045–50.PubMedCrossRef
137.
Makoff AJ, Graham JM, Arranz MJ, Forsyth J, Li T, Aitchison KJ, et al. Association study of dopamine receptor gene polymorphisms with drug-induced hallucinations in patients with idiopathic Parkinson’s disease. Pharmacogenetics. 2000;10:43–8.PubMedCrossRef
138.
Goetz CG, Burke PF, Leurgans S, Berry-Kravis E, Blasucci LM, Raman R, et al. Genetic variation analysis in parkinson disease patients with and without hallucinations: case-control study. Arch Neurol. 2001;58:209–13.PubMedCrossRef
139.
Wang J, Si YM, Liu ZL, Yu L. Cholecystokinin, cholecystokinin-A receptor and cholecystokinin-B receptor gene polymorphisms in Parkinson’s disease. Pharmacogenetics. 2003;13:365–9.PubMedCrossRef
140.
Kiferle L, Ceravolo R, Petrozzi L, Rossi C, Frosini D, Rocchi A, et al. Visual hallucinations in Parkinson’s disease are not influenced by polymorphisms of serotonin 5-HT2A receptor and transporter genes. Neurosci Lett. 2007;422:228–31.PubMedCrossRef
141.
Onofrj M, Luciano AL, Iacono D, Thomas A, Stocchi F, Papola F, et al. HLA typing does not predict REM sleep behaviour disorder and hallucinations in Parkinson’s disease. Mov Disord. 2003;18:337–40.PubMedCrossRef
142.
Camicioli R, Rajput A, Rajput M, Reece C, Payami H, Hao C, et al. Apolipoprotein E epsilon4 and catechol-O-methyltransferase alleles in autopsy-proven Parkinson’s disease: relationship to dementia and hallucinations. Mov Disord. 2005;20:989–94.PubMedCrossRef
143.
Monsell SE, Besser LM, Heller KB, Checkoway H, Litvan I, Kukull WA. Clinical and pathologic presentation in Parkinson’s disease by apolipoprotein e4 allele status. Parkinsonism Relat Disord. 2014;20:503–7.PubMedPubMedCentralCrossRef
144.
Wang J, Zhao C, Chen B, Liu ZL. Polymorphisms of dopamine receptor and transporter genes and hallucinations in Parkinson’s disease. Neurosci Lett. 2004;355:193–6.PubMedCrossRef
145.
Goldman JG, Goetz CG, Berry-Kravis E, Leurgans S, Zhou L. Genetic polymorphisms in Parkinson disease subjects with and without hallucinations: an analysis of the cholecystokinin system. Arch Neurol. 2004;61:1280–4.PubMed
146.
Solla P, Cannas A, Floris GL, Orofino G, Costantino E, Boi A, et al. Behavioral, neuropsychiatric and cognitive disorders in Parkinson’s disease patients with and without motor complications. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35:1009–13.PubMedCrossRef
147.
Lubomski M, Rushworth RL, Tisch S. Hospitalisation and comorbidities in Parkinson’s disease: a large Australian retrospective study. J Neurol Neurosurg Psychiatry. 2015;86:324–30.PubMedCrossRef
148.
Aminoff MJ, Christine CW, Friedman JH, Chou KL, Lyons KE, Pahwa R, et al. Management of the hospitalized patient with Parkinson’s disease: current state of the field and need for guidelines. Parkinsonism Relat Disord. 2011;17:139–45.PubMedCrossRef
149.
Fong TG, Davis D, Growdon ME, Albuquerque A, Inouye SK. The interface between delirium and dementia in elderly adults. Lancet Neurol. 2015;14:823–32.PubMedPubMedCentralCrossRef
150.
Vardy ER, Teodorczuk A, Yarnall AJ. Review of delirium in patients with Parkinson’s disease. J Neurol. 2015;262:2401–10.PubMedCrossRef
151.
van Munster BC, Korevaar JC, Zwinderman AH, Levi M, Wiersinga WJ, De Rooij SE. Time-course of cytokines during delirium in elderly patients with hip fractures. J Am Geriatr Soc. 2008;56:1704–9.PubMedCrossRef
152.
Kouti L, Noroozian M, Akhondzadeh S, Abdollahi M, Javadi MR, Faramarzi MA, et al. Nitric oxide and peroxynitrite serum levels in Parkinson’s disease: correlation of oxidative stress and the severity of the disease. Eur Rev Med Pharmacol Sci. 2013;17:964–70.PubMed
153.
Sawada H, Oeda T, Umemura A, Tomita S, Hayashi R, Kohsaka M, et al. Subclinical elevation of plasma C-reactive protein and illusions/hallucinations in subjects with Parkinson’s disease: case–control study. PLoS One. 2014;9:e85886.PubMedPubMedCentralCrossRef
154.
Cunningham C, Maclullich AM. At the extreme end of the psychoneuroimmunological spectrum: delirium as a maladaptive sickness behaviour response. Brain Behav Immun. 2013;28:1–13.PubMedCrossRef
155.
Flacker JM, Cummings V, Mach JR Jr, Bettin K, Kiely DK, Wei J. The association of serum anticholinergic activity with delirium in elderly medical patients. Am J Geriatr Psychiatry. 1998;6:31–41.PubMedCrossRef
156.
Inouye SK, Westendorp RG, Saczynski JS. Delirium in elderly people. Lancet. 2014;383:911–22.PubMedCrossRef
157.
Visanji NP, Gomez-Ramirez J, Johnston TH, Pires D, Voon V, Brotchie JM, et al. Pharmacological characterization of psychosis-like behavior in the MPTP-lesioned nonhuman primate model of Parkinson’s disease. Mov Disord. 2006;21:1879–91.PubMedCrossRef
158.
Harding AJ, Broe GA, Halliday GM. Visual hallucinations in Lewy body disease relate to Lewy bodies in the temporal lobe. Brain. 2002;125:391–403.PubMedCrossRef
159.
Goodale MA, Milner AD. Separate visual pathways for perception and action. Trends Neurosci. 1992;15:20–5.PubMedCrossRef
160.
Halgren E, Dale AM, Sereno MI, Tootell RB, Marinkovic K, Rosen BR. Location of human face-selective cortex with respect to retinotopic areas. Hum Brain Mapp. 1999;7:29–37.PubMedCrossRef
161.
Beauchamp MS, Lee KE, Argall BD, Martin A. Integration of auditory and visual information about objects in superior temporal sulcus. Neuron. 2004;41:809–23.PubMedCrossRef
162.
Beauchamp MS, Argall BD, Bodurka J, Duyn JH, Martin A. Unraveling multisensory integration: patchy organization within human STS multisensory cortex. Nat Neurosci. 2004;7:1190–2.PubMedCrossRef
163.
Papapetropoulos S, McCorquodale DS, Gonzalez J, Jean-Gilles L, Mash DC. Cortical and amygdalar Lewy body burden in Parkinson’s disease patients with visual hallucinations. Parkinsonism Relat Disord. 2006;12:253–6.PubMedCrossRef
164.
Kalaitzakis ME, Christian LM, Moran LB, Graeber MB, Pearce RK, Gentleman SM. Dementia and visual hallucinations associated with limbic pathology in Parkinson’s disease. Parkinsonism Relat Disord. 2009;15:196–204.PubMedCrossRef
165.
Harding AJ, Stimson E, Henderson JM, Halliday GM. Clinical correlates of selective pathology in the amygdala of patients with Parkinson’s disease. Brain. 2002;125:2431–45.PubMedCrossRef
166.
Jacobson SA, Morshed T, Dugger BN, Beach TG, Hentz JG, Adler CH, et al. Plaques and tangles as well as Lewy-type alpha synucleinopathy are associated with formed visual hallucinations. Parkinsonism Relat Disord. 2014;20:1009–14.PubMedPubMedCentralCrossRef
167.
Homma T, Mochizuki Y, Takahashi K, Komori T. Medial temporal regional argyrophilic grain as a possible important factor affecting dementia in Parkinson’s disease. Neuropathology. 2015;35:441–51.PubMedCrossRef
168.
Grau-Rivera O, Gelpi E, Rey MJ, Valldeoriola F, Tolosa E, Compta Y, et al. Prominent psychiatric symptoms in patients with Parkinson’s disease and concomitant argyrophilic grain disease. J Neurol. 2013;260:3002–9.PubMedCrossRef
169.
Seno H, Kobayashi S, Inagaki T, Yamamori C, Miyaoka T, Horiguchi J, et al. Parkinson’s disease associated with argyrophilic grains clinically resembling progressive supranuclear palsy: an autopsy case. J Neurol Sci. 2000;178:70–4.PubMedCrossRef
170.
Hurley MJ, Durrenberger PF, Gentleman SM, Walls AF, Dexter DT. Altered expression of brain proteinase-activated receptor-2, trypsin-2 and serpin proteinase inhibitors in Parkinson’s disease. J Mol Neurosci. 2015;57:48–62.PubMedCrossRef
171.
Ramírez-Ruiz B, Martí MJ, Tolosa E, Giménez M, Bargalló N, Valldeoriola F, et al. Cerebral atrophy in Parkinson’s disease patients with visual hallucinations. Eur J Neurol. 2007;14:750–6.PubMedCrossRef
172.
Ibarretxe-Bilbao N, Ramírez-Ruiz B, Tolosa E, Martí MJ, Valldeoriola F, Bargalló N, et al. Hippocampal head atrophy predominance in Parkinson’s disease with hallucinations and with dementia. J Neurol. 2008;255:1324–31.PubMedCrossRef
173.
Ibarretxe-Bilbao N, Ramirez-Ruiz B, Junque C, Marti MJ, Valldeoriola F, Bargallo N, et al. Differential progression of brain atrophy in Parkinson’s disease with and without visual hallucinations. J Neurol Neurosurg Psychiatry. 2010;81:650–7.PubMedCrossRef
174.
Meppelink AM, de Jong BM, Teune LK, van Laar T. Regional cortical grey matter loss in Parkinson’s disease without dementia is independent from visual hallucinations. Mov Disord. 2011;26:142–7.PubMedCrossRef
175.
Janzen J, van’t Ent D, Lemstra AW, Berendse HW, Barkhof F, Foncke EM. The pedunculopontine nucleus is related to visual hallucinations in Parkinson’s disease: preliminary results of a voxel-based morphometry study. J Neurol. 2012;259:147–54.
176.
Shin S, Lee JE, Hong JY, Sunwoo M, Sohn YH, Lee PH. Neuroanatomical substrates of visual hallucinations in patients with non-demented Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2012;83:1155–61.PubMedCrossRef
177.
Watanabe H, Senda J, Kato S, Ito M, Atsuta N, Hara K, et al. Cortical and subcortical brain atrophy in Parkinson’s disease with visual hallucination. Mov Disord. 2013;28:1732–6.PubMedCrossRef
178.
Pagonabarraga J, Soriano-Mas C, Llebaria G, López-Solà M, Pujol J, Kulisevsky J. Neural correlates of minor hallucinations in non-demented patients with Parkinson’s disease. Parkinsonism Relat Disord. 2014;20:290–6.PubMedCrossRef
179.
Gama RL, Bruin VM, Távora DG, Duran FL, Bittencourt L, Tufik S. Structural brain abnormalities in patients with Parkinson’s disease with visual hallucinations: a comparative voxel-based analysis. Brain Cogn. 2014;87:97–103.PubMedCrossRef
180.
Goldman JG, Stebbins GT, Dinh V, Bernard B, Merkitch D, Detoledo-Morrell L, et al. Visuoperceptive region atrophy independent of cognitive status in patients with Parkinson’s disease with hallucinations. Brain. 2014;137:849–59.PubMedPubMedCentralCrossRef
181.
Fioravanti V, Benuzzi F, Codeluppi L, Contardi S, Cavallieri F, Nichelli P, et al. MRI correlates of Parkinson’s disease progression: a voxel based morphometry study. Parkinsons Dis. 2015;2015:378032.PubMedPubMedCentral
182.
Nagano-Saito A, Washimi Y, Arahata Y, Iwai K, Kawatsu S, Ito K, et al. Visual hallucination in Parkinson’s disease with FDG PET. Mov Disord. 2004;19:801–6.PubMedCrossRef
183.
Boecker H, Ceballos-Baumann AO, Volk D, Conrad B, Forstl H, Haussermann P. Metabolic alterations in patients with Parkinson disease and visual hallucinations. Arch Neurol. 2007;64:984–8.PubMedCrossRef
184.
Park HK, Kim JS, Im KC, Kim MJ, Lee J-H, Lee MC, et al. Visual hallucinations and cognitive impairment in Parkinson’s disease. Can J Neurol Sci. 2013;40:657–62.PubMedCrossRef
185.
Okada K, Suyama N, Kobayashi S, Oguro H, Yamaguchi S. Medication-induced hallucination and cerebral blood flow in Parkinson’s disease. J Neurol. 1999;246:365–8.PubMedCrossRef
186.
Oishi N, Udaka F, Kameyama M, Sawamoto N, Hashikawa K, Fukuyama H. Regional cerebral blood flow in Parkinson disease with nonpsychotic visual hallucinations. Neurology. 2005;65:1708–15.PubMedCrossRef
187.
Matsui H, Nishinaka K, Oda M, Hara N, Komatsu K, Kubori T, et al. Hypoperfusion of the visual pathway in parkinsonian patients with visual hallucinations. Mov Disord. 2006;21:2140–4.PubMedCrossRef
188.
Kiferle L, Ceravolo R, Giuntini M, Linsalata G, Puccini G, Volterrani D, et al. Caudate dopaminergic denervation and visual hallucinations: evidence from a 123I-FP-CIT SPECT study. Parkinsonism Relat Disord. 2014;20:761–5.PubMedCrossRef
189.
Stebbins GT, Goetz CG, Carrillo MC, Bangen KJ, Turner DA, Glover GH, et al. Altered cortical visual processing in PD with hallucinations: an fMRI study. Neurology. 2004;63:1409–16.PubMedCrossRef
190.
Holroyd S, Wooten GF. Preliminary FMRI evidence of visual system dysfunction in Parkinson’s disease patients with visual hallucinations. J Neuropsychiatry Clin Neurosci. 2006;18:402–4.
191.
Ramírez-Ruiz B, Martí MJ, Tolosa E, Falcón C, Bargalló N, Valldeoriola F, et al. Brain response to complex visual stimuli in Parkinson’s patients with hallucinations: a functional magnetic resonance imaging study. Mov Disord. 2008;23:2335–43.PubMedCrossRef
192.
Meppelink AM, de Jong BM, Renken R, Leenders KL, Cornelissen FW, van Laar T. Impaired visual processing preceding image recognition in Parkinson’s disease patients with visual hallucinations. Brain. 2009;132:2980–93.PubMedCrossRef
193.
Yao N, Shek-Kwan Chang R, Cheung C, Pang S, Lau KK, Suckling J, et al. The default mode network is disrupted in Parkinson’s disease with visual hallucinations. Hum Brain Mapp. 2014;35:5658–66.PubMedPubMedCentralCrossRef
194.
Yao N, Pang S, Cheung C, Chang RS, Lau KK, Suckling J, et al. Resting activity in visual and corticostriatal pathways in Parkinson’s disease with hallucinations. Parkinsonism Relat Disord. 2015;21:131–7.PubMedCrossRef
195.
Franciotti R, Delli Pizzi S, Perfetti B, Tartaro A, Bonanni L, Thomas A, et al. Default mode network links to visual hallucinations: a comparison between Parkinson’s disease and multiple system atrophy. Mov Disord. 2015;30:1237–47.PubMedCrossRef
196.
Yao N, Cheung C, Pang S, Shek-kwan Chang R, Lau KK, Suckling J, et al. Multimodal MRI of the hippocampus in Parkinson’s disease with visual hallucinations. Brain Struct Funct. 2016;221:287–300.PubMedCrossRef
197.
Carlsson A. The occurrence, distribution and physiological role of catecholamines in the nervous system. Pharmacol Rev. 1959;11:490–3.PubMed
198.
Goetz CG, Tanner CM, Klawans HL. Pharmacology of hallucinations induced by long-term drug therapy. Am J Psychiatry. 1982;139:494–7.PubMedCrossRef
199.
Wolters EC. Dopaminomimetic psychosis in Parkinson’s disease patients: diagnosis and treatment. Neurology. 1999;52:S10–3.PubMedCrossRef
200.
Moskovitz C, Moses H 3rd, Klawans HL. Levodopa-induced psychosis: a kindling phenomenon. Am J Psychiatry. 1978;135:669–75.PubMedCrossRef
201.
Snyder SH. The dopamine hypothesis of schizophrenia: focus on the dopamine receptor. Am J Psychiatry. 1976;133:197–202.PubMedCrossRef
202.
Seeman P. All roads to schizophrenia lead to dopamine supersensitivity and elevated dopamine D2(high) receptors. CNS Neurosci Ther. 2011;17:118–32.PubMedCrossRef
203.
Seeman P. Dopamine agonist radioligand binds to both D2High and D2Low receptors, explaining why alterations in D2High are not detected in human brain scans. Synapse. 2012;66:88–93.PubMedCrossRef
204.
Albin RL, Young AB, Penney JB. The functional anatomy of basal ganglia disorders. Trends Neurosci. 1989;12:366–75.PubMedCrossRef
205.
Gingrich JA, Caron MG. Recent advances in the molecular biology of dopamine receptors. Annu Rev Neurosci. 1993;16:299–321.PubMedCrossRef
206.
Vallone D, Picetti R, Borrelli E. Structure and function of dopamine receptors. Neurosci Biobehav Rev. 2000;24:125–32.PubMedCrossRef
207.
Seeman P. Targeting the dopamine D2 receptor in schizophrenia. Expert Opin Ther Targets. 2006;10:515–31.PubMedCrossRef
208.
Bezard E, Ferry S, Mach U, Stark H, Leriche L, Boraud T, et al. Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function. Nat Med. 2003;9:762–7.PubMedCrossRef
209.
Sokoloff P, Diaz J, Le Foll B, Guillin O, Leriche L, Bezard E, et al. The dopamine D3 receptor: a therapeutic target for the treatment of neuropsychiatric disorders. CNS Neurol Disord Drug Targets. 2006;5:25–43.PubMedCrossRef
210.
Rondou P, Haegeman G, Van Craenenbroeck K. The dopamine D4 receptor: biochemical and signalling properties. Cell Mol Life Sci. 2010;67:1971–86.PubMedCrossRef
211.
Sun J, Cairns NJ, Perlmutter JS, Mach RH, Xu J. Regulation of dopamine D(3) receptor in the striatal regions and substantia nigra in diffuse Lewy body disease. Neuroscience. 2013;248:112–26.PubMedCrossRef
212.
Veselinovic T, Paulzen M, Grunder G. Cariprazine, a new, orally active dopamine D2/3 receptor partial agonist for the treatment of schizophrenia, bipolar mania and depression. Expert Rev Neurother. 2013;13:1141–59.PubMedCrossRef
213.
Missale C, Nash SR, Robinson SW, Jaber M, Caron MG. Dopamine receptors: from structure to function. Physiol Rev. 1998;78:189–225.PubMed
214.
Oak JN, Oldenhof J, Van Tol HH. The dopamine D(4) receptor: one decade of research. Eur J Pharmacol. 2000;405:303–27.PubMedCrossRef
215.
Beaulieu JM, Espinoza S, Gainetdinov RR. Dopamine receptors—IUPHAR Review 13. Br J Pharmacol. 2015;172:1–23.PubMedCrossRef
216.
Birkmayer W, Riederer P. Responsibility of extrastriatal areas for the appearance of psychotic symptoms (clinical and biochemical human post-mortem findings). J Neural Transm. 1975;37:175–82.PubMedCrossRef
217.
Glennon RA, Titeler M, McKenney JD. Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents. Life Sci. 1984;35:2505–11.PubMedCrossRef
218.
Titeler M, Lyon RA, Glennon RA. Radioligand binding evidence implicates the brain 5-HT2 receptor as a site of action for LSD and phenylisopropylamine hallucinogens. Psychopharmacology (Berl). 1988;94:213–6.PubMedCrossRef
219.
Pollak P, Tison F, Rascol O, Destee A, Pere JJ, Senard JM, et al. Clozapine in drug induced psychosis in Parkinson’s disease: a randomised, placebo controlled study with open follow up. J Neurol Neurosurg Psychiatry. 2004;75:689–95.PubMedPubMedCentralCrossRef
220.
Fernandez HH, Donnelly EM, Friedman JH. Long-term outcome of clozapine use for psychosis in parkinsonian patients. Mov Disord. 2004;19:831–3.PubMedCrossRef
221.
Kapur S, Seeman P. Does fast dissociation from the dopamine d(2) receptor explain the action of atypical antipsychotics?: a new hypothesis. Am J Psychiatry. 2001;158:360–9.PubMedCrossRef
222.
Seeman P. Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002;47:27–38.PubMed
223.
Meltzer HY, Matsubara S, Lee JC. Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values. J Pharmacol Exp Ther. 1989;251:238–46.PubMed
224.
Ballanger B, Strafella AP, van Eimeren T, Zurowski M, Rusjan PM, Houle S, et al. Serotonin 2A receptors and visual hallucinations in Parkinson disease. Arch Neurol. 2010;67:416–21.PubMedCrossRef
225.
Huot P, Johnston TH, Darr T, Hazrati LN, Visanji NP, Pires D, et al. Increased 5-HT2A receptors in the temporal cortex of parkinsonian patients with visual hallucinations. Mov Disord. 2010;25:1399–408.PubMedCrossRef
226.
Fahn S, Libsch LR, Cutler RW. Monoamines in the human neostriatum: topographic distribution in normals and in Parkinson’s disease and their role in akinesia, rigidity, chorea, and tremor. J Neurol Sci. 1971;14:427–55.PubMedCrossRef
227.
Halliday GM, Blumbergs PC, Cotton RG, Blessing WW, Geffen LB. Loss of brainstem serotonin- and substance P-containing neurons in Parkinson’s disease. Brain Res. 1990;510:104–7.PubMedCrossRef
228.
Hillarp NA, Fuxe K, Dahlstrom A. Demonstration and mapping of central neurons containing dopamine, noradrenaline, and 5-hydroxytryptamine and their reactions to psychopharmaca. Pharmacol Rev. 1966;18:727–41.PubMed
229.
Carta M, Carlsson T, Kirik D, Bjorklund A. Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats. Brain. 2007;130:1819–33.PubMedCrossRef
230.
Laprade N, Radja F, Reader TA, Soghomonian JJ. Dopamine receptor agonists regulate levels of the serotonin 5-HT2A receptor and its mRNA in a subpopulation of rat striatal neurons. J Neurosci. 1996;16:3727–36.PubMed
231.
Radja F, Descarries L, Dewar KM, Reader TA. Serotonin 5-HT1 and 5-HT2 receptors in adult rat brain after neonatal destruction of nigrostriatal dopamine neurons: a quantitative autoradiographic study. Brain Res. 1993;606:273–85.PubMedCrossRef
232.
Nausieda PA, Tanner CM, Klawans HL. Serotonergically active agents in levodopa-induced psychiatric toxicity reactions. Adv Neurol. 1983;37:23–32.PubMed
233.
Burn D, Emre M, McKeith I, De Deyn PP, Aarsland D, Hsu C, et al. Effects of rivastigmine in patients with and without visual hallucinations in dementia associated with Parkinson’s disease. Mov Disord. 2006;21:1899–907.PubMedCrossRef
234.
Perry EK, Perry RH. Acetylcholine and hallucinations: disease-related compared to drug-induced alterations in human consciousness. Brain Cogn. 1995;28:240–58.PubMedCrossRef
235.
Bosboom JL, Stoffers D, Wolters E. The role of acetylcholine and dopamine in dementia and psychosis in Parkinson’s disease. J Neural Transm Suppl. 2003;65:185–95.
236.
Perry EK, Irving D, Kerwin JM, McKeith IG, Thompson P, Collerton D, et al. Cholinergic transmitter and neurotrophic activities in Lewy body dementia: similarity to Parkinson’s and distinction from Alzheimer disease. Alzheimer Dis Assoc Disord. 1993;7:69–79.PubMedCrossRef
237.
Fioravanti V, Benuzzi F, Codeluppi L, Contardi S, Cavallieri F, Nichelli P, et al. MRI correlates of Parkinson’s disease progression: a voxel based morphometry study. Parkinsons Dis. 2015;2015:378032.PubMedPubMedCentral
238.
Riederer P, Lange KW, Kornhuber J, Danielczyk W. Glutamatergic-dopaminergic balance in the brain. Its importance in motor disorders and schizophrenia. Arzneimittelforschung. 1992;42:265–8.PubMed
239.
Rodríguez-Violante M, Cervantes-Arriaga A, González-Latapí P, León-Ortiz P, de la Fuente-Sandoval C, Corona T. Proton magnetic resonance spectroscopy changes in Parkinson’s disease with and without psychosis. Rev Invest Clin. 2015;67:227–34.PubMed
240.
Amalric M. Targeting metabotropic glutamate receptors (mGluRs) in Parkinson’s disease. Curr Opin Pharmacol. 2015;20:29–34.PubMedCrossRef
241.
Barnes J, Boubert L, Harris J, Lee A, David AS. Reality monitoring and visual hallucinations in Parkinson’s disease. Neuropsychologia. 2003;41:565–74.PubMedCrossRef
242.
Shine JM, Halliday GM, Naismith SL, Lewis SJ. Visual misperceptions and hallucinations in Parkinson’s disease: dysfunction of attentional control networks? Mov Disord. 2011;26:2154–9.PubMedCrossRef
243.
Stebbins GT, Goetz CG, Carrillo MC, Bangen KJ, Turner DA, Glover GH, et al. Altered cortical visual processing in PD with hallucinations: an fMRI study. Neurology. 2004;63:1409–16.PubMedCrossRef
244.
Meppelink AM, de Jong BM, Renken R, Leenders KL, Cornelissen FW, van Laar T. Impaired visual processing preceding image recognition in Parkinson’s disease patients with visual hallucinations. Brain. 2009;132:2980–93.PubMedCrossRef
245.
Gallagher DA, Parkkinen L, O’Sullivan SS, Spratt A, Shah A, Davey CC, et al. Testing an aetiological model of visual hallucinations in Parkinson’s disease. Brain. 2011;134:3299–309.PubMedCrossRef
246.
Straughan S, Collerton D, Bruce V. Visual priming and visual hallucinations in Parkinson’s disease. Evidence for normal top-down processes. J Geriatr Psychiatry Neurol. 2016;29:25–30.PubMedCrossRef
247.
248.
Goldman JG, Vaughan CL, Goetz CG. An update expert opinion on management and research strategies in Parkinson’s disease psychosis. Expert Opin Pharmacother. 2011;12:2009–24.PubMedPubMedCentralCrossRef
249.
Olanow CW, Watts RL, Koller WC. An algorithm (decision tree) for the management of Parkinson’s disease (2001): treatment guidelines. Neurology. 2001;56:S1–88.PubMedCrossRef
250.
Thomsen TR, Panisset M, Suchowersky O, Goodridge A, Mendis T, Lang AE. Impact of standard of care for psychosis in Parkinson disease. J Neurol Neurosurg Psychiatry. 2008;79:1413–5.PubMedCrossRef
251.
Factor SA, Molho ES, Friedman JH. Risperidone and Parkinson’s disease. Mov Disord. 2002;17:221–2.PubMedCrossRef
252.
253.
Ondo WG, Levy JK, Vuong KD, Hunter C, Jankovic J. Olanzapine treatment for dopaminergic-induced hallucinations. Mov Disord. 2002;17:1031–5.PubMedCrossRef
254.
Breier A, Sutton VK, Feldman PD, Kadam DL, Ferchland I, Wright P, et al. Olanzapine in the treatment of dopamimetic-induced psychosis in patients with Parkinson’s disease. Biol Psychiatry. 2002;52:438–45.PubMedCrossRef
255.
Schindehutte J, Trenkwalder C. Treatment of drug-induced psychosis in Parkinson’s disease with ziprasidone can induce severe dose-dependent off-periods and pathological laughing. Clin Neurol Neurosurg. 2007;109:188–91.PubMedCrossRef
256.
Pintor L, Valldeoriola F, Bailles E, Marti MJ, Muniz A, Tolosa E. Ziprasidone versus clozapine in the treatment of psychotic symptoms in Parkinson disease: a randomized open clinical trial. Clin Neuropharmacol. 2012;35:61–6.PubMedCrossRef
257.
Friedman JH. Atypical antipsychotic drugs in the treatment of Parkinson’s disease. J Pharm Pract. 2011;24:534–40.PubMedCrossRef
258.
Friedman JH, Berman RM, Goetz CG, Factor SA, Ondo WG, Wojcieszek J, et al. Open-label flexible-dose pilot study to evaluate the safety and tolerability of aripiprazole in patients with psychosis associated with Parkinson’s disease. Mov Disord. 2006;21:2078–81.PubMedCrossRef
259.
Fernandez HH, Trieschmann ME, Friedman JH. Aripiprazole for drug-induced psychosis in Parkinson disease: preliminary experience. Clin Neuropharmacol. 2004;27:4–5.PubMedCrossRef
260.
261.
Trifiro G, Verhamme KM, Ziere G, Caputi AP, Ch Stricker BH, Sturkenboom MC. All-cause mortality associated with atypical and typical antipsychotics in demented outpatients. Pharmacoepidemiol Drug Saf. 2007;16:538–44.PubMedCrossRef
262.
Wu CS, Tsai YT, Tsai HJ. Antipsychotic drugs and the risk of ventricular arrhythmia and/or sudden cardiac death: a nation-wide case-crossover study. J Am Heart Assoc. 2015;4:e001568.PubMedPubMedCentralCrossRef
263.
McKeith I, Mintzer J, Aarsland D, Burn D, Chiu H, Cohen-Mansfield J, et al. Dementia with Lewy bodies. Lancet Neurol. 2004;3:19–28.PubMedCrossRef
264.
Ballard C, Isaacson S, Mills R, Williams H, Corbett A, Coate B, et al. Impact of current antipsychotic medications on comparative mortality and adverse events in people with Parkinson disease psychosis. J Am Med Dir Assoc. 2015;16:898.PubMedCrossRef
265.
Forsaa EB, Larsen JP, Wentzel-Larsen T, Alves G. What predicts mortality in Parkinson disease?: a prospective population-based long-term study. Neurology. 2010;75:1270–6.PubMedCrossRef
266.
Goetz CG, Fan W, Leurgans S. Antipsychotic medication treatment for mild hallucinations in Parkinson’s disease: positive impact on long-term worsening. Mov Disord. 2008;23:1541–5.PubMedCrossRef
267.
Leucht S, Corves C, Arbter D, Engel RR, Li C, Davis JM. Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis. Lancet. 2009;373:31–41.PubMedCrossRef
268.
The Parkinson Study Group. Low-dose clozapine for the treatment of drug-induced psychosis in Parkinson’s disease. N Engl J Med. 1999;340:757–63.
269.
The French Clozapine Parkinson Study Group. Clozapine in drug-induced psychosis in Parkinson’s disease. Lancet. 1999;353:2041–2.
270.
Frieling H, Hillemacher T, Ziegenbein M, Neundorfer B, Bleich S. Treating dopamimetic psychosis in Parkinson’s disease: structured review and meta-analysis. Eur Neuropsychopharmacol. 2007;17:165–71.PubMedCrossRef
271.
Seppi K, Weintraub D, Coelho M, Perez-Lloret S, Fox SH, Katzenschlager R, et al. The movement disorder society evidence-based medicine review update: treatments for the non-motor symptoms of Parkinson’s disease. Mov Disord. 2011;26:S42–80.PubMedPubMedCentralCrossRef
272.
Kapur S, Seeman P. Antipsychotic agents differ in how fast they come off the dopamine D2 receptors. Implications for atypical antipsychotic action. J Psychiatry Neurosci. 2000;25:161–6.PubMedPubMedCentral
273.
Kessler RM, Ansari MS, Riccardi P, Li R, Jayathilake K, Dawant B, et al. Occupancy of striatal and extrastriatal dopamine D2 receptors by clozapine and quetiapine. Neuropsychopharmacology. 2006;31:1991–2001.PubMedCrossRef
274.
Honigfeld G, Arellano F, Sethi J, Bianchini A, Schein J. Reducing clozapine-related morbidity and mortality: 5 years of experience with the Clozaril National Registry. J Clin Psychiatry. 1998;59:3–7.PubMedCrossRef
275.
Hack N, Fayad SM, Monari EH, Akbar U, Hardwick A, Rodriguez RL, et al. An eight-year clinic experience with clozapine use in a Parkinson’s disease clinic setting. PLoS One. 2014;9:e91545.PubMedPubMedCentralCrossRef
276.
Thomas AA, Friedman JH. Current use of clozapine in Parkinson disease and related disorders. Clin Neuropharmacol. 2010;33:14–6.PubMedCrossRef
277.
Richelson E. Preclinical pharmacology of neuroleptics: focus on new generation compounds. J Clin Psychiatry. 1996;57:4–11.PubMed
278.
Shotbolt P, Samuel M, Fox C, David AS. A randomized controlled trial of quetiapine for psychosis in Parkinson’s disease. Neuropsychiatr Dis Treat. 2009;5:327–32.PubMedPubMedCentralCrossRef
279.
Fernandez HH, Okun MS, Rodriguez RL, Malaty IA, Romrell J, Sun A, et al. Quetiapine improves visual hallucinations in Parkinson disease but not through normalization of sleep architecture: results from a double-blind clinical-polysomnography study. Int J Neurosci. 2009;119:2196–205.PubMedCrossRef
280.
Rabey JM, Prokhorov T, Miniovitz A, Dobronevsky E, Klein C. Effect of quetiapine in psychotic Parkinson’s disease patients: a double-blind labeled study of 3 months’ duration. Mov Disord. 2007;22:313–8.PubMedCrossRef
281.
Morgante L, Epifanio A, Spina E, Zappia M, Di Rosa AE, Marconi R, et al. Quetiapine and clozapine in parkinsonian patients with dopaminergic psychosis. Clin Neuropharmacol. 2004;27:153–6.PubMedCrossRef
282.
Merims D, Balas M, Peretz C, Shabtai H, Giladi N. Rater-blinded, prospective comparison: quetiapine versus clozapine for Parkinson’s disease psychosis. Clin Neuropharmacol. 2006;29:331–7.PubMedCrossRef
283.
Friedman JH. Melperone is ineffective in treating Parkinson’s disease psychosis. Mov Disord. 2012;27:803–4.PubMedCrossRef
284.
Horacek J, Bubenikova-Valesova V, Kopecek M, et al. Mechanism of action of atypical antipsychotic drugs and the neurobiology of schizophrenia. CNS Drugs. 2006;20:389–409.PubMedCrossRef
285.
Weiner DM, Burstein ES, Nash N, Croston GE, Currier EA, Vanover KE, et al. 5-hydroxytryptamine2A receptor inverse agonists as antipsychotics. J Pharmacol Exp Ther. 2001;299:268–76.PubMed
286.
Vanover KE, Weiner DM, Makhay M, Veinbergs I, Gardell LR, Lameh J, et al. Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N’-(4-(2-methylpropyloxy)phen ylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine(2A) receptor inverse agonist. J Pharmacol Exp Ther. 2006;317:910–8.PubMedCrossRef
287.
Meltzer HY, Mills R, Revell S, Williams H, Johnson A, Bahr D, et al. Pimavanserin, a serotonin(2A) receptor inverse agonist, for the treatment of parkinson’s disease psychosis. Neuropsychopharmacology. 2010;35:881–92.PubMedCrossRef
288.
Cummings J, Isaacson S, Mills R, Williams H, Chi-Burris K, Corbett A, et al. Pimavanserin for patients with Parkinson’s disease psychosis: a randomised, placebo-controlled phase 3 trial. Lancet. 2014;383:533–40.PubMedCrossRef
289.
Yasue I, Matsunaga S, Kishi T, Fujita K, Iwata N. Serotonin 2A receptor inverse agonist as a treatment for Parkinson’s disease psychosis: a systematic review and meta-analysis of serotonin 2A receptor negative modulators. J Alzheimers Dis. 2016;50:733–40.CrossRef
290.
George M, Amrutheshwar R, Rajkumar RP, Kattimani S, Dkhar SA. Newer antipsychotics and upcoming molecules for schizophrenia. Eur J Clin Pharmacol. 2013;69:1497–509.PubMedCrossRef
291.
Fabbrini G, Barbanti P, Aurilia C, Pauletti C, Lenzi GL, Meco G. Donepezil in the treatment of hallucinations and delusions in Parkinson’s disease. Neurol Sci. 2002;23:41–3.PubMedCrossRef
292.
Kurita A, Ochiai Y, Kono Y, Suzuki M, Inoue K. The beneficial effect of donepezil on visual hallucinations in three patients with Parkinson’s disease. J Geriatr Psychiatry Neurol. 2003;16:184–8.PubMedCrossRef
293.
Bergman J, Lerner V. Successful use of donepezil for the treatment of psychotic symptoms in patients with Parkinson’s disease. Clin Neuropharmacol. 2002;25:107–10.PubMedCrossRef
294.
Rovers JM, Dautzenberg PL, ter Bruggen JP. Rivastigmine as adjunctive therapy in the therapeutic dilemma for the treatment of hallucinations due to Parkinson disease. Tijdschr Gerontol Geriatr. 2006;37:117–20.PubMedCrossRef
295.
Bullock R, Cameron A. Rivastigmine for the treatment of dementia and visual hallucinations associated with Parkinson’s disease: a case series. Curr Med Res Opin. 2002;18:258–64.PubMedCrossRef
296.
Ravina B, Putt M, Siderowf A, Farrar JT, Gillespie M, Crawley A, et al. Donepezil for dementia in Parkinson’s disease: a randomised, double blind, placebo controlled, crossover study. J Neurol Neurosurg Psychiatry. 2005;76:934–9.PubMedPubMedCentralCrossRef
297.
Aarsland D, Hutchinson M, Larsen JP. Cognitive, psychiatric and motor response to galantamine in Parkinson’s disease with dementia. Int J Geriatr Psychiatry. 2003;18:937–41.PubMedCrossRef
298.
Dubois B, Tolosa E, Katzenschlager R, Emre M, Lees AJ, Schumann G, et al. Donepezil in Parkinson’s disease dementia: a randomized, double-blind efficacy and safety study. Mov Disord. 2012;27:1230–8.PubMedCrossRef
299.
Reading PJ, Luce AK, McKeith IG. Rivastigmine in the treatment of parkinsonian psychosis and cognitive impairment: preliminary findings from an open trial. Mov Disord. 2001;16:1171–4.PubMedCrossRef
300.
Riederer P, Lange KW, Kornhuber J, Danielczyk W. Pharmacotoxic psychosis after memantine in Parkinson’s disease. Lancet. 1991;338:1022–3.PubMedCrossRef
301.
Menendez-Gonzalez M, Calatayud MT, Blazquez-Menes B. Exacerbation of Lewy bodies dementia due to memantine. J Alzheimers Dis. 2005;8:289–91.PubMed
302.
Voon V, Fox S, Butler TR, Lang AE. Antidepressants and psychosis in Parkinson disease: a case series. Int J Geriatr Psychiatry. 2007;22:601–4.PubMedCrossRef
303.
Tagai K, Nagata T, Shinagawa S, Tsuno N, Ozone M, Nakayama K. Mirtazapine improves visual hallucinations in Parkinson’s disease: a case report. Psychogeriatrics. 2013;13:103–7.PubMedCrossRef
304.
Godschalx-Dekker JA, Siegers HP. Reduction of parkinsonism and psychosis with mirtazapine: a case report. Pharmacopsychiatry. 2014;47:81–3.PubMedCrossRef
305.
Meco G, Bernardi S. Antidepressant use in treatment of psychosis with comorbid depression in Parkinson’s disease. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31:311–3.PubMedCrossRef
306.
Lauterbach EC. Dopaminergic hallucinosis with fluoxetine in Parkinson’s disease. Am J Psychiatry. 1993;150:1750.PubMed
307.
Normann C, Hesslinger B, Frauenknecht S, Berger M, Walden J. Psychosis during chronic levodopa therapy triggered by the new antidepressive drug mirtazapine. Pharmacopsychiatry. 1997;30:263–5.PubMedCrossRef
308.
Yu CH, Ishii R, Yu SC, Takeda M. Yokukansan and its ingredients as possible treatment options for schizophrenia. Neuropsychiatr Dis Treat. 2014;10:1629–34.PubMedPubMedCentral
309.
Matsuda Y, Kishi T, Shibayama H, Iwata N. Yokukansan in the treatment of behavioral and psychological symptoms of dementia: a systematic review and meta-analysis of randomized controlled trials. Hum Psychopharmacol. 2013;28:80–6.PubMedCrossRef
310.
Hatano T, Hattori N, Kawanabe T, Terayama Y, Suzuki N, Iwasaki Y, et al. An exploratory study of the efficacy and safety of yokukansan for neuropsychiatric symptoms in patients with Parkinson’s disease. J Neural Transm. 2014;121:275–81.PubMedCrossRef
311.
Abe K, Chiba Y, Katsuse O, Hirayasu Y. A case of Parkinson disease with both visual hallucination and pain improved by gabapentin. Clin Neuropharmacol. 2016;39:55–6.PubMedCrossRef
312.
Ueda S, Koyama K, Okubo Y. Marked improvement of psychotic symptoms after electroconvulsive therapy in Parkinson disease. J ECT. 2010;26:111–5.PubMedCrossRef
313.
Nishioka K, Tanaka R, Shimura H, Hirano K, Hatano T, Miyakawa K, et al. Quantitative evaluation of electroconvulsive therapy for Parkinson’s disease with refractory psychiatric symptoms. J Neural Transm. 2014;121:1405–10.PubMedCrossRef
314.
Kennedy R, Mittal D, O’Jile J. Electroconvulsive therapy in movement disorders: an update. J Neuropsychiatry Clin Neurosci. 2003;15:407–21.PubMedCrossRef
315.
Usui C, Hatta K, Doi N, Kubo S, Kamigaichi R, Nakanishi A, et al. Improvements in both psychosis and motor signs in Parkinson’s disease, and changes in regional cerebral blood flow after electroconvulsive therapy. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35:1704–8.
Metadaten
Titel
Psychosis in Parkinson’s Disease: Epidemiology, Pathophysiology, and Management
verfasst von
Anna Chang
Susan H. Fox
Publikationsdatum
01.07.2016
Verlag
Springer International Publishing
Erschienen in
Drugs / Ausgabe 11/2016
Print ISSN: 0012-6667
Elektronische ISSN: 1179-1950
DOI
https://doi.org/10.1007/s40265-016-0600-5

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