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Sports Medicine

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01.11.2013 | Systematic Review

Effects of Exercise Training on Arterial Function in Type 2 Diabetes Mellitus

A Systematic Review and Meta-Analysis

verfasst von: David Montero, Guillaume Walther, Eric Benamo, Antonia Perez-Martin, Agnès Vinet

Erschienen in: Sports Medicine | Ausgabe 11/2013

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Abstract

Background and Objective

Controversy exists among trials assessing whether exercise can improve arterial function in type 2 diabetes mellitus (T2DM) subjects. Therefore the aim of this study was to systematically review and quantify the effects of exercise on arterial function in T2DM subjects.

Methods

MEDLINE, Cochrane, Scopus and Web of Science were searched up until January 2013 for randomized controlled trials evaluating the effects of exercise interventions lasting 4 weeks or more on arterial function in T2DM subjects. Flow-mediated dilation (FMD) and nitrate-mediated dilation (NMD) of the brachial conduit artery were considered for assessment of arterial endothelial function and smooth muscle function, respectively.

Results

Five randomized trials comparing exercise and control groups (overall n = 217) met the inclusion criteria. The mean exercise characteristics were as follows: 3.6 sessions per week, 67.5 min per session, intensity at 74.4 % of the maximum heart rate (HR_max), for 14 weeks. The post-intervention mean difference in FMD favoured the exercise groups over the control groups (2.23 %; P < 0.0001). No significant post-intervention mean difference in NMD (1.22 %; P = 0.29) was found between the groups. Neither heterogeneity nor publication bias was detected among the trials.

Conclusion

Exercise training alone improved FMD, showing its capacity to restore arterial endothelial function in T2DM subjects. However, further research is needed to determine whether longer and/or more intense exercise interventions could enhance arterial smooth muscle function in this population.

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Titel: Effects of Exercise Training on Arterial Function in Type 2 Diabetes Mellitus
A Systematic Review and Meta-Analysis
verfasst von: David Montero
Guillaume Walther
Eric Benamo
Antonia Perez-Martin
Agnès Vinet
Publikationsdatum: 01.11.2013
Verlag: Springer International Publishing
Erschienen in: Sports Medicine / Ausgabe 11/2013
Print ISSN: 0112-1642
Elektronische ISSN: 1179-2035
DOI: https://doi.org/10.1007/s40279-013-0085-2

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Abstract

Background and Objective

Methods

Results

Conclusion

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