Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Typ-2-Diabetes und Adipositas Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Häufige urologisch-sexualmedizinische Themen in der Praxis sind das Thema des MMW-Webinars am 5. Juni von 17.30 bis 19 Uhr. Konkret geht es um die Frage, wann bei Harnwegsinfektionen auf Antibiotika verzichtet werden kann, und um ein Update zur Therapie von Libido- und Potenzstörungen des Mannes. Der dritte Vortrag behandelt sexuell übertragbare Krankheiten. Stellen Sie Ihre Fragen an die Experten und sammeln Sie 2 CME-Punkte. Jetzt gleich anmelden!
Erweiterte Suche
Anmelden
nach oben
Sports Medicine
Erschienen in: Sports Medicine 11/2014

01.11.2014 | Current Opinion

A Neuroinflammatory Model for Acute Fatigue During Exercise

verfasst von: Nicole T. Vargas, Frank Marino

Erschienen in: Sports Medicine | Ausgabe 11/2014

Einloggen, um Zugang zu erhalten

Abstract

A common emotional human anomaly is the manifestation of fatigue which is felt as an overall symptom in times of sickness and disease, but also during and after exercise as a specific or general symptom of exhaustion and over exertion. The main culprit of fatigue during illness is thought to be the immune/inflammatory response that occurs as the body attempts to fight off the invading virus or bacteria. Numerous models of fatigue have been developed to help us understand its mechanisms in both disease and exercise, but none so far have specifically discussed the interactions between cytokine release during exercise and its effects on afferent feedback and processing of signals in the brain that might lead to sensations and feelings of fatigue. Therefore, this article examines the literature in a range of disciplines spanning exercise, disease, immunology, and neurology, in order to develop a neuroinflammatory model for acute fatigue during exercise, similar to that which we often feel during illness.
Literatur
1.
Johnson AK, Gross PM. Sensory circumventricular organs and brain homeostatic pathways. FASEB J. 1993;7(8):678–86.PubMed
2.
Coghill R, Talbot J, Evans A, et al. Distributed processing of pain and vibration by the human brain. J Neurosci. 1994;14(7):4095–108.PubMed
3.
Liang M, Mouraux A, Iannetti GD. Parallel processing of nociceptive and non-nociceptive somatosensory information in the human primary and secondary somatosensory cortices: evidence from dynamic causal modeling of functional magnetic resonance imaging data. J Neurosci. 2011;31(24):8976–85.PubMedCrossRef
4.
Ploner M, Schmitz F, Freund H-J, et al. Parallel activation of primary and secondary somatosensory cortices in human pain processing. J Neurophysiol. 1999;81(6):3100–4.PubMed
5.
Maier SF, Watkins LR. Cytokines for psychologists: implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition. Psychol Rev. 1998;105(1):83.PubMedCrossRef
6.
St Gibson A, Lambert E, Rauch LG, et al. The role of information processing between the brain and peripheral physiological systems in pacing and perception of effort. Sports Med. 2006;36(8):705–22.CrossRef
7.
Olofsson PS, Rosas-Ballina M, Levine YA, et al. Rethinking inflammation: neural circuits in the regulation of immunity. Immunol Rev. 2012;248(1):188–204.PubMedCrossRef
8.
Watkins LR, Maier SF, Goehler LE. Cytokine-to-brain communication: a review and analysis of alternative mechanisms. Life Sci. 1995;57(11):1011–26.PubMedCrossRef
9.
Vitkovic L, Konsman JP, Bockaert J, et al. Cytokine signals propagate through the brain. Mol Psychiatry. 2000;5(6):604.PubMedCrossRef
10.
St Clair Gibson A, Noakes TD. Evidence for complex system integration and dynamic neural regulation of skeletal muscle recruitment during exercise in humans. Br J Sports Med. 2004;38(6):797–806.PubMedCrossRef
11.
Lambert EV, St Clair Gibson A, TD Noakes. Complex systems model of fatigue: integrative homoeostatic control of peripheral physiological systems during exercise in humans. Br J Sports Med. 2005;39(1):52–62.PubMedPubMedCentralCrossRef
12.
Dantzer R, O’Conner JC, Freund GG, et al. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci. 2008;9(1):46–56.PubMedPubMedCentralCrossRef
13.
Heesen C, Nawrath L, Reich C, et al. Fatigue in multiple sclerosis: an example of cytokine mediated sickness behaviour? J Neurol Neurosurg Psychiatry. 2006;77(1):34–9.PubMedPubMedCentralCrossRef
14.
Eccles R. Understanding the symptoms of the common cold and influenza. Lancet Infect Dis. 2005;5(11):718–25.PubMedCrossRef
15.
Hubbard JL, Mechan DJ. The physiology of health and illness: with related anatomy. UK: Stanley Thornes Ltd; 1997. p. 361–6.
16.
Skoner DP, Gentile DA, Patel A, et al. Evidence for cytokine mediation of disease expression in adults experimentally infected with influenza A virus. J Infect Dis. 1999;180(1):10–4.PubMedCrossRef
17.
Van Reeth K. Cytokines in the pathogenesis of influenza. Vet Microbiol. 2000;74(1–2):109–16.PubMedCrossRef
18.
Borish L, Schmaling K, DiClementi JD, et al. Chronic fatigue syndrome: identification of distinct subgroups on the basis of allergy and psychologic variables. J Allergy Clin Immunol. 1998;102(2):222–30.PubMedCrossRef
19.
Buchwald D, Wener MH, Pearlman T, et al. Markers of inflammation and immune activation in chronic fatigue and chronic fatigue syndrome. J Rheumatol. 1997;24(2):372–6.PubMed
20.
Gupta S, Aggarwal S, See D, et al. Cytokine production by adherent and non-adherent mononuclear cells in chronic fatigue syndrome. J Psychiatr Res. 1997;31(1):149–56.PubMedCrossRef
21.
Chao CC, Gallagher M, Phair J, et al. Serum neopterin and interleukin-6 levels in chronic fatigue syndrome. J Infect Dis. 1990;162(6):1412–3.PubMedCrossRef
22.
Moss R, Mercandetti A, Vojdani A. TNF-α and chronic fatigue syndrome. J Clin Immunol. 1999;19(5):314–6.PubMedCrossRef
23.
Patarca R, Klimas N, Sandler D, et al. Interindividual immune status variation patterns in patients with chronic fatigue syndrome. J Chronic Fatigue Syndr. 1996;2(1):13–39.CrossRef
24.
Robson-Ansley P, Cockburn E, Walshe I, et al. The effect of exercise on plasma soluble IL-6 receptor concentration: a dichotomous response. Exerc Immunol Rev. 2010;16:56–76.PubMed
25.
Ishihara K, Hirano T. IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev. 2002;13(4–5):357–68.PubMedCrossRef
26.
Rovaris M, Barnes D, Woodrofe N, et al. Patterns of disease activity in multiple sclerosis patients: a study with quantitative gadolinium-enhanced brain MRI and cytokine measurement in different clinical subgroups. J Neurol. 1996;243(7):536–42.PubMedCrossRef
27.
Robson-Ansley P, Barwood M, Canavan J, et al. The effect of repeated endurance exercise on IL-6 and sIL-6R and their relationship with sensations of fatigue at rest. Cytokine. 2009;45(2):111–6.PubMedCrossRef
28.
Gray SR, Clifford M, Lancaster R, et al. The response of circulating levels of the interleukin-6/interleukin-6 receptor complex to exercise in young men. Cytokine. 2009;47(2):98–102.PubMedCrossRef
29.
Kreher JB, Schwartz JB. Overtraining syndrome: a practical guide. Sports health: a multidisciplinary approach. 2012;4(2):128–38.
30.
Robson-Ansley P, Blannin A, Gleeson M. Elevated plasma interleukin-6 levels in trained male triathletes following an acute period of intense interval training. Eur J Appl Physiol. 2007;99(4):353–60.PubMedCrossRef
31.
Allen DG, Lamb GD, Westerblad H. Skeletal muscle fatigue: cellular mechanisms. Physiol Rev. 2008;88(1):287–332.PubMedCrossRef
32.
Grange RW, Houston ME. Simultaneous potentiation and fatigue in quadriceps after a 60-second maximal voluntary isometric contraction. J Appl Physiol. 1991;70(2):726–31.PubMed
33.
Kent-Braun JA. Central and peripheral contributions to muscle fatigue in humans during sustained maximal effort. Euro J Appl Physiol. 1999;80(1):57–63.CrossRef
34.
Gandevia SC, Allen GM, Butler JE, et al. Supraspinal factors in human muscle fatigue: evidence for suboptimal output from the motor cortex. J Physiol. 1996;490:529–36.PubMedPubMedCentral
35.
Martin PG, Smith JL, Butler JE, et al. Fatigue-sensitive afferents inhibit extensor but not flexor motoneurons in humans. J Neurosci. 2006;26(18):4796–802.PubMedCrossRef
36.
Wiles CM, Edwards RHT. The effect of temperature, ischaemia and contractile activity on the relaxation rate of human muscle. Clin Physiol. 1982;2(6):485–97.PubMedCrossRef
37.
Kennedy DS, McNeil CJ, Gandevia SC, et al. Firing of antagonist small-diameter muscle afferents reduces voluntary activation and torque of elbow flexors. J Physiol. 2013;591(14):3591–604.PubMedPubMedCentral
38.
Holloszy J. Regulation by exercise of skeletal muscle content of mitochondria and GLUT4. J Physiol Pharmacol. 2008;59(Suppl 7):5–18.PubMed
39.
Febbraio MA, Hiscock N, Sacchetti M, et al. Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction. Diabetes. 2004;53(7):1643–8.PubMedCrossRef
40.
Mendham A, Donges C, Liberts E, et al. Effects of mode and intensity on the acute exercise-induced IL-6 and CRP responses in a sedentary, overweight population. Eur J Appl Physiol. 2011;111(6):1035–45.PubMedCrossRef
41.
Mendham A, Coutts A, Duffield R. The acute effects of aerobic exercise and modified rugby on inflammation and glucose homeostasis within Indigenous Australians. Eur J Appl Physiol. 2012;112(11):3787–95.PubMedCrossRef
42.
Starkie RL, Arkinstall MJ, Koukoulas I, et al. Carbohydrate ingestion attenuates the increase in plasma interleukin-6, but not skeletal muscle interleukin-6 mRNA, during exercise in humans. J Physiol. 2001;533(2):585–91.PubMedPubMedCentralCrossRef
43.
Ostrowski K, Rohde T, Zacho M, et al. Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running. J Physiol. 1998;508(3):949–53.PubMedPubMedCentralCrossRef
44.
Robson-Ansley PJ, Milander Ld, Collins M, et al. Acute Interleukin-6 administration impairs athletic performance in healthy, trained male runners. Can J Appl Physiol. 2004;29(4):411–8.PubMedCrossRef
45.
Taga T, Kishimoto T. gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol. 1997;15(1):797.PubMedCrossRef
46.
Andratsch M, Mair N, Constantin CE, et al. A key role for gp130 expressed on peripheral sensory nerves in pathological pain. J Neurosci. 2009;29(43):13473–83.PubMedCrossRef
47.
Jones SA, Richards PJ, Scheller J, et al. Review: IL-6 transsignaling: the in vivo consequences. J Interferon Cytokine Res. 2005;25(5):241–53.PubMedCrossRef
48.
Gleeson M. Anti-inflammatory effects of exercise. Obesity, inflammation and cancer. New York: Springer; 2013. p. 401–24.
49.
Papanicolaou DA, Wilder RL, Manolagas SC, et al. The pathophysiologic roles of interleukin-6 in human disease. Ann Intern Med. 1998;128(2):127–37.PubMedCrossRef
50.
Sommer C, Kress M. Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia. Neurosci Lett. 2004;361(1–3):184–7.PubMedCrossRef
51.
Gray SR, Robinson M, Nimmo MA. Response of plasma IL-6 and its soluble receptors during submaximal exercise to fatigue in sedentary middle-aged men. Cell Stress Chaperones. 2008;13(2):247–51.PubMedPubMedCentralCrossRef
52.
Patterson S, Reid S, Gray S, et al. The response of plasma interleukin-6 and its soluble receptors to exercise in the cold in humans. J Sports Sci. 2008;26(9):927–33.PubMedCrossRef
53.
Robinson M, Gray SR, Watson MS, et al. Plasma IL-6, its soluble receptors and F2-isoprostanes at rest and during exercise in chronic fatigue syndrome. Scand J Med Sci Sports. 2010;20(2):282–90.PubMedCrossRef
54.
Brenn D, Richter F, Schaible H-G. Sensitization of unmyelinated sensory fibers of the joint nerve to mechanical stimuli by interleukin-6 in the rat: an inflammatory mechanism of joint pain. Arthritis Rheum. 2007;56(1):351–9.PubMedCrossRef
55.
Chichorro JG, Lorenzetti BB, Zampronio AR. Involvement of bradykinin, cytokines, sympathetic amines and prostaglandins in formalin-induced orofacial nociception in rats. Br J Pharmacol. 2004;141(7):1175–84.PubMedPubMedCentralCrossRef
56.
Cunha JM, Cunha FQ, Poole S, et al. Cytokine-mediated inflammatory hyperalgesia limited by interleukin-1 receptor antagonist. Br J Pharmacol. 2000;130(6):1418–24.PubMedPubMedCentralCrossRef
57.
Albrecht PJ, Rice FL. Role of small-fiber afferents in pain mechanisms with implications on diagnosis and treatment. Curr Pain Headache Rep. 2010;14(3):179–88.PubMedCrossRef
58.
Roth J, Harre EM, Rummel C, et al. Signaling the brain in systemic inflammation: role of sensory circumventricular organs. Front Biosci. 2004;1(9):290–300.CrossRef
59.
Bear MF, Connors BW, Paradiso MA. Neuroscience: exploring the brain. 3rd ed. USA: Lippincott Williams and Wilkins; 2006. p. 413–4.
60.
Luc Darques J, Decherchi P, Jammes Y. Mechanisms of fatigue-induced activation of group IV muscle afferents: the roles played by lactic acid and inflammatory mediators. Neurosci Lett. 1998;257(2):109–12.CrossRef
61.
Chester AR, Kathryn HG. Augmentation of exercise-induced muscle sympathetic nerve activity during muscle heating. J Appl Physiol. 1997;82(6):1719–33.
62.
Goehler LE, Gaykema RPA, Hansen MK, et al. Vagal immune-to-brain communication: a visceral chemosensory pathway. Auton Neurosci. 2000;85(1–3):49–59.PubMedCrossRef
63.
Immke DC, McCleskey EW. Lactate enhances the acid-sensing Na+ channel on ischemia-sensing neurons. Nat Neurosci. 2001;4(9):869–70.PubMedCrossRef
64.
Gautam M, Benson CJ, Sluka KA. Increased response of muscle sensory neurons to decreases in pH after muscle inflammation. Neurosci. 2010;170(3):893–900.CrossRef
65.
66.
Yquel RJ, Arsac LM, Thiaudiere E, et al. Effect of creatine supplementation on phosphocreatine resynthesis, inorganic phosphate accumulation and pH during intermittent maximal exercise. J Sports Sci. 2002;20(5):427–37.PubMedCrossRef
67.
Cunha FQ, Poole S, Lorenzetti BB, et al. The pivotal role of tumour necrosis factor α in the development of inflammatory hyperalgesia. Br J Pharmacol. 1992;107(3):660–4.PubMedPubMedCentralCrossRef
68.
Hoheisel U, Unger T, Mense S. Excitatory and modulatory effects of inflammatory cytokines and neurotrophins on mechanosensitive group IV muscle afferents in the rat. Pain. 2005;114(1–2):168–76.PubMedCrossRef
69.
Vissers KC, De Jongh RF, Hoffmann VL, et al. Exogenous interleukin-6 increases cold allodynia in rats with a mononeuropathy. Cytokine. 2005;30(4):154–9.PubMedCrossRef
70.
Vallières L, Rivest S. Regulation of the genes encoding interleukin-6, its receptor, and gp130 in the rat brain in response to the immune activator lipopolysaccharide and the proinflammatory cytokine interleukin-1β. J Neurochem. 1997;69(4):1668–83.PubMedCrossRef
71.
Quan N, Stern EL, Whiteside MB, et al. Induction of pro-inflammatory cytokine mRNAs in the brain after peripheral injection of subseptic doses of lipopolysaccharide in the rat. J Neuroimmunol. 1999;93(1–2):72–80.PubMedCrossRef
72.
Nybo L, Nielsen B, Pedersen BK, et al. Interleukin-6 release from the human brain during prolonged exercise. J Physiol. 2002;1(542):991–5.CrossRef
73.
Phelps EA, LeDoux JE. Contributions of the amygdala to emotion processing: from animal models to human behavior. Neuron. 2005;48(2):175–87.PubMedCrossRef
74.
Hall EE, Ekkekakis P, Petruzzello SJ. Regional brain activity and strenuous exercise: predicting affective responses using EEG asymmetry. Biol Psychol. 2007;75(2):194–200.PubMedCrossRef
75.
Nielsen B, Hyldig T, Bidstrup F, et al. Brain activity and fatigue during prolonged exercise in the heat. Pflügers Arch. 2001;442(1):41–8.PubMedCrossRef
76.
Nybo L, Nielsen B. Perceived exertion is associated with an altered brain activity during exercise with progressive hyperthermia. J Appl Physiol. 2001;91(5):2017–23.PubMed
Metadaten
Titel
A Neuroinflammatory Model for Acute Fatigue During Exercise
verfasst von
Nicole T. Vargas
Frank Marino
Publikationsdatum
01.11.2014
Verlag
Springer International Publishing
Erschienen in
Sports Medicine / Ausgabe 11/2014
Print ISSN: 0112-1642
Elektronische ISSN: 1179-2035
DOI
https://doi.org/10.1007/s40279-014-0232-4

Weitere Artikel der Ausgabe 11/2014

Sports Medicine 11/2014 Zur Ausgabe

Review Article

McArdle Disease: A Unique Study Model in Sports Medicine

Systematic Review

Chronic Ankle Instability in Sporting Populations

Review Article

The Effects of Statin Medications on Aerobic Exercise Capacity and Training Adaptations

Systematic Review

Knee Mechanics During Planned and Unplanned Sidestepping: A Systematic Review and Meta-Analysis

Letter to the Editor

Dr. Boullosa’s Forgotten Pieces Don’t Fit the Puzzle: A Response to Dr. Buchheit and Dr. Laursen

Systematic Review

Physical Activity and Physical Self-Concept in Youth: Systematic Review and Meta-Analysis

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Häusliche Gewalt in der orthopädischen Notaufnahme oft nicht erkannt

28.05.2024 Traumatologische Notfälle Nachrichten

In der Notaufnahme wird die Chance, Opfer von häuslicher Gewalt zu identifizieren, von Orthopäden und Orthopädinnen offenbar zu wenig genutzt. Darauf deuten die Ergebnisse einer Fragebogenstudie an der Sahlgrenska-Universität in Schweden hin.

Fehlerkultur in der Medizin – Offenheit zählt!

28.05.2024 Internistische Arzneimitteltherapie Podcast

Darüber reden und aus Fehlern lernen, sollte das Motto in der Medizin lauten. Und zwar nicht nur im Sinne der Patientensicherheit. Eine negative Fehlerkultur kann auch die Behandelnden ernsthaft krank machen, warnt Prof. Dr. Reinhard Strametz. Ein Plädoyer und ein Leitfaden für den offenen Umgang mit kritischen Ereignissen in Medizin und Pflege.

Mehr Frauen im OP – weniger postoperative Komplikationen

21.05.2024 Allgemeine Chirurgie Nachrichten

Ein Frauenanteil von mindestens einem Drittel im ärztlichen Op.-Team war in einer großen retrospektiven Studie aus Kanada mit einer signifikanten Reduktion der postoperativen Morbidität assoziiert.

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

17.05.2024 Klinik aktuell Nachrichten

Sie sei „ethisch geboten“, meint Gesundheitsminister Karl Lauterbach: mehr Transparenz über die Qualität von Klinikbehandlungen. Um sie abzubilden, lässt er gegen den Widerstand vieler Länder einen virtuellen Klinik-Atlas freischalten.

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise