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Current Behavioral Neuroscience Reports

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01.09.2015 | Mood and Anxiety Disorders (D Iosifescu, Section Editor)

Anhedonia and the Brain Reward Circuitry in Depression

verfasst von: Mitra Heshmati, Scott J. Russo

Erschienen in: Current Behavioral Neuroscience Reports | Ausgabe 3/2015

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Abstract

Anhedonia, or the loss of pleasure in previously rewarding stimuli, is a core symptom of major depressive disorder that may reflect an underlying dysregulation in reward processing. The mesolimbic dopamine circuit, also known as the brain’s reward circuit, is integral to processing the rewarding salience of stimuli to guide actions. Manifestation of anhedonia and associated depression symptoms, like feelings of sadness, changes in appetite, and psychomotor effects, may reflect changes in the brain reward circuitry as a common underlying disease process. This review will synthesize the recent literature from human and rodent studies providing a circuit-level framework for understanding anhedonia in depression, with emphasis on the nucleus accumbens.

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Titel: Anhedonia and the Brain Reward Circuitry in Depression
verfasst von: Mitra Heshmati
Scott J. Russo
Publikationsdatum: 01.09.2015
Verlag: Springer International Publishing
Erschienen in: Current Behavioral Neuroscience Reports / Ausgabe 3/2015
Elektronische ISSN: 2196-2979
DOI: https://doi.org/10.1007/s40473-015-0044-3

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