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21.03.2018 | Original Article

Voxel-wise correlation of functional imaging parameters in HNSCC patients receiving PET/MRI in an irradiation setup

verfasst von: Kerstin Zwirner, M.D., Daniela Thorwarth, René M. Winter, Stefan Welz, Jakob Weiss, Nina F. Schwenzer, Holger Schmidt, Christian la Fougère, Konstantin Nikolaou, Daniel Zips, Sergios Gatidis

Erschienen in: Strahlentherapie und Onkologie | Ausgabe 8/2018

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Abstract

Purpose

The purpose of this study was to demonstrate the feasibility of voxel-wise multiparametric characterization of head and neck squamous cell carcinomas (HNSCC) using hybrid multiparametric magnetic resonance imaging and positron emission tomography with [¹⁸F]-fluorodesoxyglucose (FDG-PET/MRI) in a radiation treatment planning setup.

Methods

Ten patients with locally advanced HNSCC were examined with a combined FDG-PET/MRI in an irradiation planning setup. The multiparametric imaging protocol consisted of FDG-PET, T2-weighted transverse short tau inversion recovery sequence (STIR) and diffusion-weighted MRI (DWI). Primary tumours were manually segmented and quantitative imaging parameters were extracted. PET standardized uptake values (SUV) and DWI apparent diffusion coefficients (ADC) were correlated on a voxel-wise level.

Results

Images acquired in this specialised radiotherapy planning setup achieved good diagnostic quality. Median tumour volume was 4.9 [1.1–42.1] ml. Mean PET SUV and ADC of the primary tumours were 5 ± 2.5 and 1.2 ± 0.3 10⁻³ mm²/s, respectively. In voxel-wise correlation between ADC values and corresponding FDG SUV of the tumours, a significant negative correlation was observed (r = −0.31 ± 0.27, p < 0.05).

Conclusion

Multiparametric voxel-wise characterization of HNSCC is feasible using combined PET/MRI in a radiation planning setup. This technique may provide novel insights into tumour biology with regard to radiation therapy in the future.

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Titel: Voxel-wise correlation of functional imaging parameters in HNSCC patients receiving PET/MRI in an irradiation setup
verfasst von: Kerstin Zwirner, M.D.
Daniela Thorwarth
René M. Winter
Stefan Welz
Jakob Weiss
Nina F. Schwenzer
Holger Schmidt
Christian la Fougère
Konstantin Nikolaou
Daniel Zips
Sergios Gatidis
Publikationsdatum: 21.03.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Strahlentherapie und Onkologie / Ausgabe 8/2018
Print ISSN: 0179-7158
Elektronische ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-018-1292-4

Springer Medizin

Voxel-wise correlation of functional imaging parameters in HNSCC patients receiving PET/MRI in an irradiation setup