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06.06.2019 | Review

Ten years of chest MRI for patients with cystic fibrosis

Translation from the bench to clinical routine

verfasst von: Dr. med. Patricia Leutz-Schmidt, Monika Eichinger, Mirjam Stahl, Olaf Sommerburg, Jürgen Biederer, Hans-Ulrich Kauczor, Michael U. Puderbach, Marcus A. Mall, Mark O. Wielpütz

Erschienen in: Die Radiologie | Sonderheft 1/2019

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Abstract

Background

Despite recent advances in our knowledge about the pathophysiology and treatment of cystic fibrosis (CF), pulmonary involvement remains the most important determinant of morbidity and mortality in patients with CF. Since lung function testing may not be sensitive enough for subclinical disease progression, and because young children may have normal spirometry results over a longer period of time, imaging today plays an increasingly important role in clinical routine and research for the monitoring of CF lung disease. In this regard, chest magnetic resonance imaging (MRI) could serve as a radiation-free modality for structural and functional lung imaging.

Methods

Our research agenda encompassed the entire process of development, implementation, and validation of appropriate chest MRI protocols for use with infant and adult CF patients alike.

Results

After establishing a general MRI protocol for state-of-the-art clinical 1.5-T scanners based on the available sequence technology, a semiquantitative scoring system was developed followed by cross-validation of the method against the established modalities of computed tomography, radiography, and lung function testing. Cross-sectional studies were then set up to determine the sensitivity of the method for the interindividual variation of the disease and for changes in disease severity after treatment. Finally, the MRI protocol was implemented at multiple sites to be validated in a multicenter setting.

Conclusion

After more than a decade, lung MRI has become a valuable tool for monitoring CF in clinical routine application and as an endpoint for clinical studies.

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Titel: Ten years of chest MRI for patients with cystic fibrosis
Translation from the bench to clinical routine
verfasst von: Dr. med. Patricia Leutz-Schmidt
Monika Eichinger
Mirjam Stahl
Olaf Sommerburg
Jürgen Biederer
Hans-Ulrich Kauczor
Michael U. Puderbach
Marcus A. Mall
Mark O. Wielpütz
Publikationsdatum: 06.06.2019
Verlag: Springer Medizin
Erschienen in: Die Radiologie / Ausgabe Sonderheft 1/2019
Print ISSN: 2731-7048
Elektronische ISSN: 2731-7056
DOI: https://doi.org/10.1007/s00117-019-0553-2

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Ten years of chest MRI for patients with cystic fibrosis

Translation from the bench to clinical routine