nach oben

Erschienen in:

01.08.2007

Euler_strut.cavity, a New Histomorphometric Parameter of Connectivity Reflects Bone Strength and Speed of Sound in Trabecular Bone from Human Os Calcis

verfasst von: Nathalie R. Portero-Muzy, Pascale M. Chavassieux, David Mitton, François Duboeuf, Pierre D. Delmas, Pierre J. Meunier

Erschienen in: Calcified Tissue International | Ausgabe 2/2007

Einloggen, um Zugang zu erhalten

Abstract

The amount of bone and the trabecular microarchitecture are two determinants of bone strength which can be quantified by bone histomorphometry. Among the parameters of bone microarchitecture, the Euler number developed in our laboratory (E_strut.cavity) and trabecular bone pattern factor (TBPf) evaluate the connectivity and complexity independently of the bone quantity, and the speed of sound (SOS) measured by quantitative ultrasound (QUS) corroborates E_strut.cavity. The aim of the present study was to validate E_strut.cavity, TBPf, and SOS as parameters of bone microarchitecture and their contribution to bone strength. We examined 20 right os calcis taken after necropsy in 11 males and 9 females, aged 52–95 years. At the same anatomic location, we measured SOS and broadband ultrasound attenuation (BUA) using a Hologic Sahara device and bone mineral density (BMD) using a Hologic QDR 1000W. At this site a transcortical cylinder was cut for both apparent density measurement (Ap.Dens) and biomechanical tests (maximum compressive stress (σ_max) and Young’s modulus (E)), and histomorphometry was performed with an automatic image analyzer (Visiolab, Explora Nova, France). E and σ_max were significantly correlated with the parameters of bone quantity, microarchitecture, and QUS. However, after adjustment for the bone quantity, E correlated only with E_strut.cavity, TBPf, and SOS, and σ_max with BUA. In conclusion, the bone connectivity and complexity evaluated by E_strut.cavity and TBPf contribute to bone strength, independently of the bone quantity. The bone mechanical properties may be assessed, in os calcis, in the elastic domain by SOS and in the plastic domain by BUA.

Ammann P (2003) Determining factors of bone mechanical resistance. Therapie 58:403–407PubMedCrossRef

Ammann P, Rizzoli R (2003) Bone strength and its determinants. Osteoporos Int 14:13–18CrossRef

Bouxsein ML (2004) Bone quality: Where do we go from here? Osteoporos Int 14(Suppl 5):S118–S127

Bruce MR, Sharkey NA (2001) Mechanical effects of post-mortem changes, preservation, and allograft bone treatments. In: Cowin SC (ed) Bone mechanics handbook, 2nd edn. CRC Press, Boca Raton, FL pp 20–24

Chappard D, Legrand E, Basle MF, Fromont P, Racineux JL, Rebel A, Audran M (1996) Altered trabecular architecture induced by corticosteroids: A bone histomorphometric study. J Bone Miner Res 11:676–685PubMed

Chappard D, Legrand E, Baslé MF, Audran M (1997) Measuring trabecular bone architecture by image analysis of histological sections. Eur Micros Anal 50:13–15

Chavassieux P, Arlot M, Meunier PJ (2001) Clinical use of bone biopsy. In: Marcus R, Feldman D, Kelsey J (eds) Osteoporosis, 2nd edn. Academic Press, San Diego, CA, pp 501–509

Cheng S, Njeh CF, Fan B, Cheng X, Hans D, Wang L, Fuerts T, Genant HK (2002) Influence of region of interest and bone size on calcaneal BMD: Implications for the accuracy of quantitative ultrasound assessments at the calcaneus. Br J Radiol 75:59–68PubMed

Compston JE (1994) Connectivity of cancellous bone: Assessment and mechanical implications. Bone 15:463-466PubMedCrossRef

10.

Coster M, Chermant JL (1989) Précis d’analyse d’images. Presses du CNRS, Paris, pp 22–27

11.

Croucher PI, Garrahan NJ, Compston JE (1996) Assessment of cancellous bone structure: Comparison of strut analysis, trabecular bone pattern factor and marrow space star volume. J Bone Miner Res 11:955–961PubMed

12.

Dalle Carbonare L, Giannini S (2004) Bone microarchitecture as an important determinant of bone strength. J Endocrinol Invest 27:99–105PubMed

13.

Dempster DW, Ferguson-Pell MW, Mellish RWK, Cochran GVB, Xie F, Fey C, Horben W, Parisien M, Lindsay R (1993) Relationship between bone structure in the iliac crest and bone structure and strength in the lumbar spine. Osteoporos Int 3:90–96PubMedCrossRef

14.

Feldkamp LA, Goldstein SA, Parfitt AM, Jesion G, Kleerekoper M (1989) The direct examination of three-dimensional bone architecture in vitro by computed tomography. J Bone Miner Res 4:3–11PubMed

15.

Follet H, Boivin G, Rumelhart C, Meunier PJ (2004) The degree of mineralization is a determinant of bone strength: A study on human calcanei. Bone 34:783–789PubMedCrossRef

16.

Follet H, Bruyère-Garnier F, Peyrin F, Roux JP, Arlot ME, Burt-Pichat B, Rumelhart C, Meunier PJ (2005) Relationship between compressive properties of human os calcis cancellous bone and microarchitecture assessed from 2D and 3D synchrotron microtomography. Bone 36:340–351PubMedCrossRef

17.

Garrahan NJ, Mellish RWE, Compston JE (1986) A new method for the two-dimensional analysis of bone structure in human iliac crest biopsies. J Microsc 142:341–349PubMed

18.

Genant HK, Engelke K, Fuerst T, Glüer CC, Grampp S, Harris ST, Jergas M, Lang T, Lu Y, Majumdar S, Mathur A, Takada M (1996) Non-invasive assessment of bone mineral and structure: State of the art. J Bone Miner Res 11:707–730PubMed

19.

Glüer CC, Wu CY, Jergas M, Goldstein SA, Genant HK (1994) Three quantitative ultrasound parameters reflect bone structure. Calcif Tissue Int 55:46–52PubMedCrossRef

20.

Gonnelli S, Cepollaro C, Montagnani A, Martini S, Gennari L, Mangeri M, Gennari C (2002) Heel ultrasonography in monitoring alendronate therapy: A four-year longitudinal study. Osteoporos Int 13:415–421PubMedCrossRef

21.

Hahn M, Vogel M, Pompesius-Kempa M, Delling G (1992) Trabecular bone pattern factor: A new parameter for simple quantification of bone microarchitecture. Bone 13:327–330PubMedCrossRef

22.

Hans D, Arlot ME, Schott AM, Roux JP, Kotzki PO, Meunier PJ (1995) Do ultrasound measurements on the os calcis reflect more the bone microarchitecture than the bone mass?: A two-dimensional histomorphometric study. Bone 16:295-300PubMedCrossRef

23.

Kang C, Paley M, Ordidge R, Speller R (1999) In vivo MRI measurements of bone quality in the calcaneus: A comparison with DXA and ultrasound. Osteoporos Int 9:65–74PubMedCrossRef

24.

Kaufman JJ, Einhorn TA (1993) Perspectives: Ultrasound assessment of bone. J Bone Miner Res 8:517-525PubMed

25.

Legrand E, Chappard D, Pascaretti C, Duquenne M, Rohmer V, Basle MF, Audran M (1999) Trabecular bone microarchitecture and male osteoporosis. Morphologie 83:35–40PubMed

26.

Le Ha M, Holmes RE, Shors EC, Rosenstein DA (1992) Computerized quantitative analysis of the interconnectivity of porous biomaterials. Acta Stereol 11:267–272

27.

Leichter I, Margulies JY, Weinreb A, Mizrahi J, Robin GC, Conforty B, Makin M, Bloch B (1982) The relationship between bone density, mineral content, and mechanical strength in the femoral neck. Clin Orthop 163:272–281PubMed

28.

Levitz P, Tchoubar D (1992) Disordered porous solids: From chord distributions to small angle scattering. J Phys I France 2:771–790CrossRef

29.

Mellish RWE, Ferguson-Pell MW, Cochran GVB, Lindsay R, Dempster DW (1991) A new manual method for assessing two-dimensional cancellous bone structure: Comparison between iliac crest and lumbar vertebra. J Bone Miner Res 6:689–696PubMedCrossRef

30.

Meunier PJ (1983) Histomorphometry of the skeleton. In: Peck WA (ed) Bone and mineral research annual: A yearly review of developments in the field of bone and mineral metabolism. Excerpta Medica, Amsterdam, pp 191–222

31.

Mitton D, Rumelhart C, Hans D, Meunier PJ (2001) The effects of density and test conditions on measured compression and shear strength of cancellous bone from the lumbar vertebrae of ewes. Med Eng Phys 1997 19:464–474CrossRef

32.

Nicholson PHF, Müller R, Cheng XG, Rüegsegger P, Van Der Perre G, Dequeker J, Boonen S (2001) Quantitative ultrasound and trabecular architecture in the human calcaneus. J Bone Miner Res 16:1886–1892PubMedCrossRef

33.

Nicholson PHF, Bouxsein ML (2000) Quantitative ultrasound does not reflect mechanically induced damage in human cancellous bone. J Bone Miner Res 15:2467–2472PubMedCrossRef

34.

Nicholson PHF, Bouxsein ML (2002) Bone marrow influences quantitative ultrasound measurements in human cancellous bone. Ultrasound Med Biol 28:369–375PubMedCrossRef

35.

Njeh CF, Hans D, Wu C, Kantorovich E, Sister M, Fuerst T, Genant HK (1999) An in vitro investigation of the dependence on sample thickness of the speed of sound along the specimen. Med Eng Phys 21:651–659PubMedCrossRef

36.

Njeh CF, Fuerst T, Diessel E, Genant HK (2001) Is quantitative ultrasound dependent on bone structure? A reflection. Osteoporos Int 12:1–15PubMed

37.

Njeh CF, Saeed I, Grigorian M, Kendler DL, Fan B, Shepherd J, McClung M, Drake WM, Genant HK (2001) Assessment of bone status using speed of sound at multiple anatomical sites. Ultrasound Med Biol 27:1337–1345PubMedCrossRef

38.

Odgaard A (1997) Three-dimensional methods for quantification of cancellous bone architecture. Bone 20:315–328PubMedCrossRef

39.

Parfitt A, Mathews CHE, Villanueva AR, Kleerekoper M, Frame B, Rao DS (1983) Relationships between surface, volume and thickness of iliac trabecular bone in aging and in osteoporosis: Implications for the microanatomic and cellular mechanisms of bone loss. J Clin Invest 72:1396–1409PubMedCrossRef

40.

Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR (1987) Bone histomorphometry: Standardization of nomenclature, symbols and units. J Bone Miner Res 2:595–610PubMed

41.

Portero NR, Arlot ME, Roux JP, Duboeuf F, Meunier PJ (2000) Do quantitative ultrasounds reflect microarchitecture in human os calcis?. J Bone Miner Res 15:808

42.

Portero NR, Arlot ME, Roux JP, Duboeuf F, Chavassieux PM, Meunier PJ (2005) Evaluation and development of automatic 2-D measurements of histomorphometric parameters reflecting trabecular bone connectivity. Correlations with dual-energy x-ray absorptiometry and quantitative ultrasound in human calcaneum. Calcif Tissue Int 77:195–204PubMedCrossRef

43.

Szucs J, Jonson R, Granhed H, Hansson T (1992) Accuracy, precision and homogeneity effects in the determination of the bone mineral content with dual photon absorptiometry in the heel bone. Bone 13:179–183PubMedCrossRef

44.

Thomsen JS, Ebbesen EN, Mosekilde LI (1998) Relationships between static histomorphometry and bone strength measurements in human iliac crest bone biopsies. Bone 22:153–163PubMedCrossRef

45.

Thomsen JS, Ebbesen EN, Mosekilde Li (2002) Predicting human vertebral bone strength by vertebral static histomorphometry. Bone 30:502–508PubMedCrossRef

46.

Trebacz H, Natali A (1999) Ultrasound velocity and attenuation in cancellous bone samples from lumbar vertebra and calcaneus. Osteoporos Int 9:99–105PubMedCrossRef

47.

Tribl B, Vogelsang H, Pohanka E, Grampp S, Gangl A, Hörl WH (1998) Broadband ultrasound attenuation of the calcaneus: A tool for assessing bone status in patients with chronic renal failure. Acta Radiol 39:637–641PubMedCrossRef

48.

Turner CH, Burr DB (1993) Basic biomechanical measurements of bone: A tutorial. Bone 14:595–608PubMedCrossRef

Titel: Euler strut.cavity , a New Histomorphometric Parameter of Connectivity Reflects Bone Strength and Speed of Sound in Trabecular Bone from Human Os Calcis
verfasst von: Nathalie R. Portero-Muzy
Pascale M. Chavassieux
David Mitton
François Duboeuf
Pierre D. Delmas
Pierre J. Meunier
Publikationsdatum: 01.08.2007
Verlag: Springer-Verlag
Erschienen in: Calcified Tissue International / Ausgabe 2/2007
Print ISSN: 0171-967X
Elektronische ISSN: 1432-0827
DOI: https://doi.org/10.1007/s00223-007-9044-y

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Neue S3-Leitlinie zur unkomplizierten Zystitis: Auf Antibiotika verzichten?

15.05.2024 Harnwegsinfektionen Nachrichten

Welche Antibiotika darf man bei unkomplizierter Zystitis verwenden und wovon sollte man die Finger lassen? Welche pflanzlichen Präparate können helfen? Was taugt der zugelassene Impfstoff? Antworten vom Koordinator der frisch überarbeiteten S3-Leitlinie, Prof. Florian Wagenlehner.

Schadet Ärger den Gefäßen?

14.05.2024 Arteriosklerose Nachrichten

In einer Studie aus New York wirkte sich Ärger kurzfristig deutlich negativ auf die Endothelfunktion gesunder Probanden aus. Möglicherweise hat dies Einfluss auf die kardiovaskuläre Gesundheit.

Intervallfasten zur Regeneration des Herzmuskels?

14.05.2024 Herzinfarkt Nachrichten

Die Nahrungsaufnahme auf wenige Stunden am Tag zu beschränken, hat möglicherweise einen günstigen Einfluss auf die Prognose nach akutem ST-Hebungsinfarkt. Darauf deutet eine Studie an der Uniklinik in Halle an der Saale hin.

Klimaschutz beginnt bei der Wahl des Inhalators

14.05.2024 Klimawandel Podcast

Auch kleine Entscheidungen im Alltag einer Praxis können einen großen Beitrag zum Klimaschutz leisten. Die neue Leitlinie zur "klimabewussten Verordnung von Inhalativa" geht mit gutem Beispiel voran, denn der Wechsel vom klimaschädlichen Dosieraerosol zum Pulverinhalator spart viele Tonnen CO₂. Leitlinienautor PD Dr. Guido Schmiemann erklärt, warum nicht nur die Umwelt, sondern auch Patientinnen und Patienten davon profitieren.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2007

Evidence that Treatment with Risedronate in Women with Postmenopausal Osteoporosis Affects Bone Mineralization and Bone Volume

Effects of a Single Percutaneous Injection of Basic Fibroblast Growth Factor on the Healing of a Closed Femoral Shaft Fracture in the Rat

Adaptations in the Mandible and Appendicular Skeleton of High and Low Bone Density Inbred Mice

Conversion of Immunosuppressive Monotherapy from Cyclosporin A to Tacrolimus Reverses Bone Loss in Rats

Circulating Sex Steroids, Sex Hormone-Binding Globulin, and Longitudinal Changes in Forearm Bone Mineral Density in Postmenopausal Women and Men: The Tromsø Study