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09.06.2016 | Functional Neuroradiology

Functional connectivity change of brain default mode network in breast cancer patients after chemotherapy

verfasst von: Hui Miao, Xingui Chen, Yunwen Yan, Xiaoxuan He, Sheng Hu, Jian Kong, Meiqi Wu, Yarui Wei, Yawen Zhou, Lu Wang, Kai Wang, Bensheng Qiu

Erschienen in: Neuroradiology | Ausgabe 9/2016

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Abstract

Introduction

Complaint about attention disorders is common among breast cancer patients who have undergone chemotherapy, which may be associated with the default mode network (DMN). To validate this hypothesis, we investigated the DMN functional connectivity (FC) change and its relationship with the attention function in breast cancer patients (BC) using resting-state functional magnetic resonance imaging (rs-fMRI).

Methods

Twenty-two BC treated with chemotherapy and 22 healthy controls (HC) were recruited into this study. The FC between the DMN’s hubs and regions of the dorsal medial prefrontal cortex (dMPFC) and medial temporal lobe (MTL) subsystems was respectively calculated for each participant.

Results

The statistical result showed significantly lower connectivity in dMPFC and MTL subsystems in the BC group. In addition, the partial correlation analysis result indicated that the low connectivity of some brain regions in MTL subsystem was correlated with attention dysfunction following BC chemotherapy.

Conclusion

These results suggest that the functional disconnection in MTL subsystem of the DMN may have association with attention function of BC after chemotherapy.

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Titel: Functional connectivity change of brain default mode network in breast cancer patients after chemotherapy
verfasst von: Hui Miao
Xingui Chen
Yunwen Yan
Xiaoxuan He
Sheng Hu
Jian Kong
Meiqi Wu
Yarui Wei
Yawen Zhou
Lu Wang
Kai Wang
Bensheng Qiu
Publikationsdatum: 09.06.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Neuroradiology / Ausgabe 9/2016
Print ISSN: 0028-3940
Elektronische ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-016-1708-8

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Functional connectivity change of brain default mode network in breast cancer patients after chemotherapy

Abstract

Introduction

Methods

Results

Conclusion

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Abstract

Introduction

Methods

Results

Conclusion

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