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22.11.2022 | COVID-19 | Research

Longitudinal Cardiac Outcomes of Multisystem Inflammatory Syndrome in Children: A Systematic Review and Meta-Analysis

verfasst von: Jun Yasuhara, Kaihei Masuda, Kae Watanabe, Takuro Shirasu, Hisato Takagi, Naokata Sumitomo, Simon Lee, Toshiki Kuno

Erschienen in: Pediatric Cardiology | Ausgabe 4/2023

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Abstract

There is a paucity of longitudinal data on cardiac outcomes in multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19. We aimed to investigate the longitudinal cardiovascular outcomes in MIS-C. PubMed and EMBASE were searched through May 2022. Observational studies were included, reporting mid-term (≥ 3 months) outcomes in children (aged < 21) with MIS-C. Data were extracted by two researchers. Longitudinal outcomes were synthesized by a one-group meta-analysis using a random-effects model. Eleven studies with a follow-up period (3 months to 1 year) were identified, including 547 MIS-C patients. The mortality was 2.5% (95% CI 1.3–4.9). The majority of left ventricular (LV) systolic dysfunction present in 46.8% (95% CI 32.7–61.3) in the acute phase resolved by 3 months, and the prevalence of LV systolic dysfunction was 1.7% (95% CI 0.5–5.7) and 2.1% (95% CI 0.8–5.4) at 3 month and 6 month follow-up, respectively. Additionally, the persistent LV systolic dysfunction in the small population was mild. However, coronary abnormalities such as coronary artery dilatation or aneurysms, seen in 23.7% (95% CI 17.7–31.1) at baseline, persisted in 4.7% (95% CI 1.5–14.3) at 3 months and 5.2% (95% CI 3.0–8.9) at 6 months. Mitral regurgitation (MR), which was observed in 56.6% (95% CI 27.7–81.6) at baseline, also persisted in 7.5% at 6 months. In conclusion, our study demonstrated largely favorable cardiac outcomes, suggesting resolution of LV systolic dysfunction in the majority of cases. However, coronary abnormalities and MR persisted in a subset of patients at mid-term follow-up.

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Yasuhara J, Kuno T, Takagi H, Sumitomo N (2020) Clinical characteristics of COVID-19 in children: a systematic review. Pediatr Pulmonol 55:2565–2575PubMedCrossRef

Whittaker E, Bamford A, Kenny J, Kaforou M, Jones CE, Shah P, Ramnarayan P, Fraisse A, Miller O, Davies P, Kucera F, Brierley J, McDougall M, Carter M, Tremoulet A, Shimizu C, Herberg J, Burns JC, Lyall H, Levin M (2020) Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2. JAMA 324:259–269PubMedPubMedCentralCrossRef

Riphagen S, Gomez X, Gonzalez-Martinez C, Wilkinson N, Theocharis P (2020) Hyperinflammatory shock in children during COVID-19 pandemic. Lancet 395:1607–1608PubMedPubMedCentralCrossRef

Dufort EM, Koumans EH, Chow EJ, Rosenthal EM, Muse A, Rowlands J, Barranco MA, Maxted AM, Rosenberg ES, Easton D, Udo T, Kumar J, Pulver W, Smith L, Hutton B, Blog D, Zucker H (2020) Multisystem inflammatory syndrome in children in New York state. N Engl J Med 383:347–358PubMedCrossRef

Feldstein LR, Rose EB, Horwitz SM, Collins JP, Newhams MM, Son MBF, Newburger JW, Kleinman LC, Heidemann SM, Martin AA, Singh AR, Li S, Tarquinio KM, Jaggi P, Oster ME, Zackai SP, Gillen J, Ratner AJ, Walsh RF, Fitzgerald JC, Keenaghan MA, Alharash H, Doymaz S, Clouser KN, Giuliano JS Jr, Gupta A, Parker RM, Maddux AB, Havalad V, Ramsingh S, Bukulmez H, Bradford TT, Smith LS, Tenforde MW, Carroll CL, Riggs BJ, Gertz SJ, Daube A, Lansell A, Coronado Munoz A, Hobbs CV, Marohn KL, Halasa NB, Patel MM, Randolph AG (2020) Multisystem inflammatory syndrome in US. children and adolescents. N Engl J Med 383:334–346PubMedCrossRef

Cheung EW, Zachariah P, Gorelik M, Boneparth A, Kernie SG, Orange JS, Milner JD (2020) Multisystem inflammatory syndrome related to COVID-19 in previously healthy children and adolescents in New York City. JAMA 24:294–296CrossRef

Dionne A, Mah DY, Son MBF, Lee PY, Henderson L, Baker AL, de Ferranti SD, Fulton DR, Newburger JW, Friedman KG (2020) Atrioventricular block in children with multisystem inflammatory syndrome. Pediatrics. https://doi.org/10.1542/peds.2020-009704CrossRefPubMed

Theocharis P, Wong J, Pushparajah K, Mathur SK, Simpson JM, Pascall E, Cleary A, Stewart K, Adhvaryu K, Savis A, Kabir SR, Uy MP, Heard H, Peacock K, Miller O (2021) Multimodality cardiac evaluation in children and young adults with multisystem inflammation associated with COVID-19. Eur Heart J Cardiovasc Imaging 22:896–903PubMedCrossRef

Valverde I, Singh Y, Sanchez-de-Toledo J, Theocharis P, Chikermane A, Di Filippo S, Kuciñska B, Mannarino S, Tamariz-Martel A, Gutierrez-Larraya F, Soda G, Vandekerckhove K, Gonzalez-Barlatay F, McMahon CJ, Marcora S, Napoleone CP, Duong P, Tuo G, Deri A, Nepali G, Ilina M, Ciliberti P, Miller O (2021) Acute cardiovascular manifestations in 286 children with multisystem inflammatory syndrome associated with COVID-19 infection in Europe. Circulation 143:21–32PubMedCrossRef

10.

Yasuhara J, Watanabe K, Takagi H, Sumitomo N, Kuno T (2021) COVID-19 and multisystem inflammatory syndrome in children: a systematic review and meta-analysis. Pediatr Pulmonol 56(5):837–848PubMedPubMedCentralCrossRef

11.

Capone CA, Subramony A, Sweberg T, Schneider J, Shah S, Rubin L, Schleien C, Epstein S, Johnson JC, Kessel A, Misra N, Mitchell E, Palumbo N, Rajan S, Rocker J, Williamson K, Davidson KW (2020) Characteristics, cardiac involvement, and outcomes of multisystem inflammatory disease of childhood (MIS-C) associated with SARS-CoV-2 infection. J Pediatr 224:141–145PubMedPubMedCentralCrossRef

12.

Feldstein LR, Tenforde MW, Friedman KG, Newhams M, Rose EB, Dapul H, Soma VL, Maddux AB, Mourani PM, Bowens C, Maamari M, Hall MW, Riggs BJ, Giuliano JS Jr, Singh AR, Li S, Kong M, Schuster JE, McLaughlin GE, Schwartz SP, Walker TC, Loftis LL, Hobbs CV, Halasa NB, Doymaz S, Babbitt CJ, Hume JR, Gertz SJ, Irby K, Clouser KN, Cvijanovich NZ, Bradford TT, Smith LS, Heidemann SM, Zackai SP, Wellnitz K, Nofziger RA, Horwitz SM, Carroll RW, Rowan CM, Tarquinio KM, Mack EH, Fitzgerald JC, Coates BM, Jackson AM, Young CC, Son MBF, Patel MM, Newburger JW, Randolph AG, Overcoming C-I (2021) Characteristics and outcomes of US children and adolescents with multisystem inflammatory syndrome in children (MIS-C) compared with severe acute COVID-19. JAMA 325:1074–1087PubMedCrossRef

13.

Matsubara D, Kauffman HL, Wang Y, Calderon-Anyosa R, Nadaraj S, Elias MD, White TJ, Torowicz DL, Yubbu P, Giglia TM, Hogarty AN, Rossano JW, Quartermain MD, Banerjee A (2020) Echocardiographic findings in pediatric multisystem inflammatory syndrome associated with COVID-19 in the United States. J Am Coll Cardiol 76(17):1947–1961PubMedPubMedCentralCrossRef

14.

Belhadjer Z, Méot M, Bajolle F, Khraiche D, Legendre A, Abakka S, Auriau J, Grimaud M, Oualha M, Beghetti M, Wacker J, Ovaert C, Hascoet S, Selegny M, Malekzadeh-Milani S, Maltret A, Bosser G, Giroux N, Bonnemains L, Bordet J, Di Filippo S, Mauran P, Falcon-Eicher S, Thambo JB, Lefort B, Moceri P, Houyel L, Renolleau S, Bonnet D (2020) Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic. Circulation 142(5):429–436PubMedCrossRef

15.

Penner J, Abdel-Mannan O, Grant K, Maillard S, Kucera F, Hassell J, Eyre M, Berger Z, Hacohen Y, Moshal K (2021) 6-month multidisciplinary follow-up and outcomes of patients with paediatric inflammatory multisystem syndrome (PIMS-TS) at a UK tertiary paediatric hospital: a retrospective cohort study. Lancet Child Adolesc Health 5:473–482PubMedCrossRef

16.

Farooqi KM, Chan A, Weller RJ, Mi J, Jiang P, Abrahams E, Ferris A, Krishnan US, Pasumarti N, Suh S, Shah AM, DiLorenzo MP, Zachariah P, Milner JD, Rosenzweig EB, Gorelik M, Anderson BR (2021) Longitudinal outcomes for multisystem inflammatory syndrome in children. Pediatrics. https://doi.org/10.1542/peds.2021-051155CrossRefPubMed

17.

Davies P, du Pré P, Lillie J, Kanthimathinathan HK (2021) One-year outcomes of critical care patients post-COVID-19 multisystem inflammatory syndrome in children. JAMA Pediatr 175:1281–1283PubMedPubMedCentralCrossRef

18.

Capone CA, Misra N, Ganigara M, Epstein S, Rajan S, Acharya SS, Hayes DA, Kearney MB, Romano A, Friedman RA, Blaufox AD, Cooper R, Schleien C, Mitchell E (2021) Six month follow-up of patients with multi-system inflammatory syndrome in children. Pediatrics. https://doi.org/10.1542/peds.2021-050973CrossRefPubMed

19.

Barris DM, Keelan J, Ahluwalia N, Jhaveri S, Cohen J, Stern K, Seiden HS, Glass L (2022) Midterm outcomes and cardiac magnetic resonance imaging following multisystem inflammatory syndrome in children. J Pediatr 241:237-241.e231PubMedCrossRef

20.

Kucera F, Laurence C, Simmonds J, Gavela J, Bodnar T, Brogan P, Hoskote A, Skellett S, Moshal K, Bamford A, Khambadkone S (2021) Cardiac outcomes in severe acute respiratory syndrome coronavirus-2-associated multisystem inflammatory syndrome at a tertiary paediatric hospital. Cardiol Young 32(10):1585–1591PubMedCrossRef

21.

Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol 62:e1-34PubMedCrossRef

22.

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hróbjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Stewart LA, Thomas J, Tricco AC, Welch VA, Whiting P, Moher D (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ (Clinical Research Ed) 372:n71PubMed

23.

Centers for Disease Control and Prevention. (2020) Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19).

24.

Royal College of Paediatrics and Child Health. (2020) Paediatric multisystem inflammatory syndrome temporally associated with COVID-19 (PIMS) – guidance for clinicians.

25.

McCrindle BW, Rowley AH, Newburger JW, Burns JC, Bolger AF, Gewitz M, Baker AL, Jackson MA, Takahashi M, Shah PB, Kobayashi T, Wu MH, Saji TT, Pahl E (2017) Diagnosis, treatment, and long-term management of kawasaki disease: a scientific statement for health professionals from the american heart association. Circulation 135:e927–e999PubMedCrossRef

26.

Stang A (2010) Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 25:603–605PubMedCrossRef

27.

Matsubara D, Chang J, Kauffman HL, Wang Y, Nadaraj S, Patel C, Paridon SM, Fogel MA, Quartermain MD, Banerjee A (2022) Longitudinal assessment of cardiac outcomes of multisystem inflammatory syndrome in children associated with COVID-19 infections. J Am Heart Assoc 11:e023251PubMedPubMedCentralCrossRef

28.

Mitchell EC, Romano A, Capone CA, Cooper R, Epstein S, Hayes DA, Parness IA, Schleien C, Misra N (2022) Multisystem inflammatory syndrome in children: salient echocardiogram findings in the acute phase and longitudinal follow-up. Prog Pediatr Cardiol. https://doi.org/10.1016/j.ppedcard.2022.101492CrossRef

29.

Awasthi P, Kumar V, Naganur S, Nallasamy K, Angurana SK, Bansal A, Manoj RK, Jayashree M (2022) Multisystem inflammatory syndrome in children: follow-up of a Cohort from North India. Am J Trop Med Hyg 106:1108–1112PubMedPubMedCentralCrossRef

30.

Dove ML, Oster ME, Hashemi S, Slesnick TC (2022) Cardiac magnetic resonance findings after multisystem inflammatory syndrome in children. J Pediatr: https://doi.org/10.1016/j.jpeds.2022.02.049CrossRefPubMed

31.

Aziz OA, Sadiq M, Qureshi AU, Hyder N, Kazmi U, Batool A, Naz S, Mushtaq A, Bari A, Rashid J (2022) Short to midterm follow-up of multi-system inflammatory syndrome in children with special reference to cardiac involvement. Cardiol Young: https://doi.org/10.1017/S1047951122000828CrossRefPubMedPubMedCentral

32.

Sanil Y, Misra A, Safa R, Blake JM, Eddine AC, Balakrishnan P, Garcia RU, Taylor R, Dentel JN, Ang J, Cashen K, Heidemann SM, Bauerfield C, Sethuraman U, Farooqi A, Aggarwal S, Singh G (2021) Echocardiographic indicators associated with adverse clinical course and cardiac sequelae in multisystem inflammatory syndrome in children with coronavirus disease 2019. J Am Soc Echocardiogr. https://doi.org/10.1016/j.echo.2021.04.018CrossRefPubMedPubMedCentral

33.

Rowley AH (2020) Understanding SARS-CoV-2-related multisystem inflammatory syndrome in children. Nat Rev Immunol 20:453–454PubMedPubMedCentralCrossRef

34.

Jhaveri S, Ahluwalia N, Kaushik S, Trachtman R, Kowalsky S, Aydin S, Stern K (2021) Longitudinal echocardiographic assessment of coronary arteries and left ventricular function following multisystem inflammatory syndrome in children. J Pediatr 228:290-293.e291PubMedCrossRef

35.

Blondiaux E, Parisot P, Redheuil A, Tzaroukian L, Levy Y, Sileo C, Schnuriger A, Lorrot M, Guedj R, Ducou le Pointe H (2020) Cardiac MRI of children with multisystem inflammatory syndrome (MIS-C) associated with COVID-19: case series. Radiology 297(3):E283–E288PubMedCrossRef

36.

Sengelov M, Jorgensen PG, Jensen JS, Bruun NE, Olsen FJ, Fritz-Hansen T, Nochioka K, Biering-Sorensen T (2015) Global longitudinal strain is a superior predictor of all-cause mortality in heart failure with reduced ejection fraction. JACC Cardiovasc Imaging 8:1351–1359PubMedCrossRef

37.

Krupickova S, Bautista-Rodriguez C, Hatipoglu S, Kang H, Fraisse A, Di Salvo G, Piccinelli E, Rowlinson G, Lane M, Altamar Bermejo I, Moscatelli S, Wage R, Mohiaddin R, Pennell DJ, Voges I (2022) Myocardial deformation assessed by CMR in children after multisystem inflammatory syndrome (MIS-C). Int J Cardiol 346:105–106PubMedCrossRef

38.

Law YM, Lal AK, Chen S, Čiháková D, Cooper LT Jr, Deshpande S, Godown J, Grosse-Wortmann L, Robinson JD, Towbin JA (2021) Diagnosis and management of myocarditis in children: a scientific statement from the american heart association. Circulation 144:e123–e135PubMedCrossRef

39.

Shaykh R, Leftin S, Suh S, Spencer R, Gorelik M, Wilson PT, Diamond R (2021) Reversible coronary artery aneurysm with delayed anti-inflammatory therapy in multisystem inflammatory syndrome in children. JACC Case Rep 3:550–554PubMedPubMedCentralCrossRef

40.

Villacis-Nunez DS, Hashemi S, Nelson MC, Flanagan E, Thakral A, Rodriguez F 3rd, Jaggi P, Oster ME, Prahalad S, Rouster-Stevens KA (2021) Giant coronary aneurysms in multisystem inflammatory syndrome in children associated with SARS-CoV-2 infection. JACC Case Rep 3:1499–1508PubMedPubMedCentralCrossRef

41.

Bautista-Rodriguez C, Sanchez-de-Toledo J, Clark BC, Herberg J, Bajolle F, Randanne PC, Salas-Mera D, Foldvari S, Chowdhury D, Munoz R, Bianco F, Singh Y, Levin M, Bonnet D, Fraisse A (2021) Multisystem inflammatory syndrome in children: an international survey. Pediatrics. https://doi.org/10.1542/peds.2020-024554CrossRefPubMed

42.

Hasan MR, Al Zubaidi K, Diab K, Hejazi Y, Bout-Tabaku S, Al-Adba B, Al Maslamani E, Janahi M, Roscoe D, Lopez AP, Tang P (2021) COVID-19 related multisystem inflammatory syndrome in children (MIS-C): a case series from a tertiary care pediatric hospital in Qatar. BMC Pediatr 21:267PubMedPubMedCentralCrossRef

43.

Elias MD, McCrindle BW, Larios G, Choueiter NF, Dahdah N, Harahsheh AS, Jain S, Manlhiot C, Portman MA, Raghuveer G, Giglia TM, Dionne A (2020) Management of multisystem inflammatory syndrome in children associated with COVID-19: a survey from the international Kawasaki disease registry. CJC Open 2:632–640PubMedPubMedCentralCrossRef

44.

Ogata S, Tremoulet AH, Sato Y, Ueda K, Shimizu C, Sun X, Jain S, Silverstein L, Baker AL, Tanaka N, Ogihara Y, Ikehara S, Takatsuki S, Sakamoto N, Kobayashi T, Fuse S, Matsubara T, Ishii M, Saji T, Newburger JW, Burns JC (2013) Coronary artery outcomes among children with Kawasaki disease in the United States and Japan. Int J Cardiol 168:3825–3828PubMedPubMedCentralCrossRef

45.

Friedman KG, Gauvreau K, Hamaoka-Okamoto A, Tang A, Berry E, Tremoulet AH, Mahavadi VS, Baker A, deFerranti SD, Fulton DR, Burns JC, Newburger JW (2016) Coronary artery aneurysms in Kawasaki Disease: risk factors for progressive disease and adverse cardiac events in the US population. J Am Heart Assoc. https://doi.org/10.1161/JAHA.116.003289CrossRefPubMedPubMedCentral

46.

Kato H, Sugimura T, Akagi T, Sato N, Hashino K, Maeno Y, Kazue T, Eto G, Yamakawa R (1996) Long-term consequences of Kawasaki disease. A 10- to 21-year follow-up study of 594 patients. Circulation 94:1379–1385PubMedCrossRef

47.

Dionne A, Newburger JW (2021) The electrocardiogram in multisystem inflammatory syndrome in children: mind your Ps and Qs. J Pediatr 234:10–11PubMedPubMedCentralCrossRef

48.

Regan W, O’Byrne L, Stewart K, Miller O, Pushparajah K, Theocharis P, Wong J, Rosenthal E (2021) Electrocardiographic changes in children with multisystem inflammation associated with COVID-19: associated with Coronavirus disease 2019. J Pediatr 234:27-32.e22PubMedPubMedCentralCrossRef

49.

Choi NH, Fremed M, Starc T, Weller R, Cheung E, Ferris A, Silver ES, Liberman L (2020) MIS-C and cardiac conduction abnormalities. Pediatrics. https://doi.org/10.1542/peds.2020-009738CrossRefPubMedPubMedCentral

50.

Hallberg TC, Bjorklund AR, Slusher TM, Rodgers N (2021) Sinus bradycardia in a toddler with multisystem inflammatory syndrome in children (MIS-C) related to COVID-19. BMJ Case Rep. https://doi.org/10.1136/bcr-2021-242058CrossRefPubMedPubMedCentral

51.

Tomlinson LG, Cohen MI, Levorson RE, Tzeng MB (2021) COVID-19-associated multisystem inflammatory syndrome in children presenting uniquely with sinus node dysfunction in the setting of shock. Cardiol Young 31:1202–1204PubMedCrossRef

52.

Clark BC, Sanchez-de-Toledo J, Bautista-Rodriguez C, Choueiter N, Lara D, Kang H, Mohsin S, Fraisse A, Cesar S, Sattar Shaikh A, Escobar-Diaz MC, Hsu DT, Randanne PC, Aslam N, Kleinmahon J, Lamour JM, Johnson JN, Sarquella-Brugada G, Chowdhury D (2020) Cardiac abnormalities seen in pediatric patients during the SARS-CoV2 pandemic: an international experience. J Am Heart Assoc 9:e018007PubMedPubMedCentralCrossRef

53.

Tseng YS, Herron C, Garcia R, Cashen K (2021) Sustained ventricular tachycardia in a paediatric patient with acute COVID-19 myocarditis. Cardiol Young 31:1510–1512PubMedCrossRef

54.

Ouldali N, Toubiana J, Antona D, Javouhey E, Madhi F, Lorrot M, Léger PL, Galeotti C, Claude C, Wiedemann A, Lachaume N, Ovaert C, Dumortier M, Kahn JE, Mandelcwajg A, Percheron L, Biot B, Bordet J, Girardin ML, Yang DD, Grimaud M, Oualha M, Allali S, Bajolle F, Beyler C, Meinzer U, Levy M, Paulet AM, Levy C, Cohen R, Belot A, Angoulvant F (2021) Association of intravenous immunoglobulins plus methylprednisolone vs immunoglobulins alone with course of fever in multisystem inflammatory syndrome in children. JAMA 325:855–864PubMedCrossRef

55.

Son MBF, Murray N, Friedman K, Young CC, Newhams MM, Feldstein LR, Loftis LL, Tarquinio KM, Singh AR, Heidemann SM, Soma VL, Riggs BJ, Fitzgerald JC, Kong M, Doymaz S, Giuliano JS Jr, Keenaghan MA, Hume JR, Hobbs CV, Schuster JE, Clouser KN, Hall MW, Smith LS, Horwitz SM, Schwartz SP, Irby K, Bradford TT, Maddux AB, Babbitt CJ, Rowan CM, McLaughlin GE, Yager PH, Maamari M, Mack EH, Carroll CL, Montgomery VL, Halasa NB, Cvijanovich NZ, Coates BM, Rose CE, Newburger JW, Patel MM, Randolph AG (2021) Multisystem inflammatory syndrome in children—initial therapy and outcomes. N Engl J Med 385:23–34PubMedCrossRef

56.

McArdle AJ, Vito O, Patel H, Seaby EG, Shah P, Wilson C, Broderick C, Nijman R, Tremoulet AH, Munblit D, Ulloa-Gutierrez R, Carter MJ, De T, Hoggart C, Whittaker E, Herberg JA, Kaforou M, Cunnington AJ, Levin M (2021) Treatment of multisystem inflammatory syndrome in children. N Engl J Med 385:11–22PubMedCrossRef

57.

Henderson LA, Canna SW, Friedman KG, Gorelik M, Lapidus SK, Bassiri H, Behrens EM, Ferris A, Kernan KF, Schulert GS, Seo P, Son MBF, Tremoulet AH, Yeung RSM, Mudano AS, Turner AS, Karp DR, Mehta JJ (2021) American college of rheumatology clinical guidance for multisystem inflammatory syndrome in children associated with SARS-CoV-2 and hyperinflammation in pediatric COVID-19: version 2. Arthritis Rheumatol 73:e13–e29PubMedPubMedCentralCrossRef

58.

Henderson LA, Canna SW, Friedman KG, Gorelik M, Lapidus SK, Bassiri H, Behrens EM, Kernan KF, Schulert GS, Seo P, Son MBF, Tremoulet AH, VanderPluym C, Yeung RSM, Mudano AS, Turner AS, Karp DR, Mehta JJ (2022) American college of rheumatology clinical guidance for multisystem inflammatory syndrome in children associated with SARS-CoV-2 and hyperinflammation in pediatric COVID-19: version 3. Arthritis Rheumatol 74(4):e1–e20PubMedPubMedCentralCrossRef

59.

Harwood R, Allin B, Jones CE, Whittaker E, Ramnarayan P, Ramanan AV, Kaleem M, Tulloh R, Peters MJ, Almond S, Davis PJ, Levin M, Tometzki A, Faust SN, Knight M, Kenny S (2021) A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a national Delphi process. Lancet Child Adolesc Health 5:133–141PubMedCrossRef

60.

Chiotos K, Hayes M, Kimberlin DW, Jones SB, James SH, Pinninti SG, Yarbrough A, Abzug MJ, MacBrayne CE, Soma VL, Dulek DE, Vora SB, Waghmare A, Wolf J, Olivero R, Grapentine S, Wattier RL, Bio L, Cross SJ, Dillman NO, Downes KJ, Oliveira CR, Timberlake K, Young J, Orscheln RC, Tamma PD, Schwenk HT, Zachariah P, Aldrich ML, Goldman DL, Groves HE, Rajapakse NS, Lamb GS, Tribble AC, Hersh AL, Thorell EA, Denison MR, Ratner AJ, Newland JG, Nakamura MM (2021) Multicenter interim guidance on use of antivirals for children with Coronavirus disease 2019/severe acute respiratory syndrome coronavirus 2. J Pediatric Infect Dis Soc 10:34–48PubMedCrossRef

61.

Bansal N, Azeka E, Neunert C, Kim JS, Murray J, May L, Kirk C, Lorts A, Rosenthal D, VanderPluym C (2021) Multisystem inflammatory syndrome associated with COVID-19 anti-thrombosis guideline of care for children by action. Pediatr Cardiol 42:1635–1639PubMedPubMedCentralCrossRef

Titel: Longitudinal Cardiac Outcomes of Multisystem Inflammatory Syndrome in Children: A Systematic Review and Meta-Analysis
verfasst von: Jun Yasuhara
Kaihei Masuda
Kae Watanabe
Takuro Shirasu
Hisato Takagi
Naokata Sumitomo
Simon Lee
Toshiki Kuno
Publikationsdatum: 22.11.2022
Verlag: Springer US
Schlagwort: COVID-19
Erschienen in: Pediatric Cardiology / Ausgabe 4/2023
Print ISSN: 0172-0643
Elektronische ISSN: 1432-1971
DOI: https://doi.org/10.1007/s00246-022-03052-2

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Longitudinal Cardiac Outcomes of Multisystem Inflammatory Syndrome in Children: A Systematic Review and Meta-Analysis

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“A Good Death”: Role of Shared Decision Making and Palliative Care in Children with Cardiac Disease

Sudden Cardiac Arrest During a Sedated Cardiac Magnetic Resonance Study in a Nonsyndromic Child with Evolving Supravalvar Aortic Stenosis Due to Familial ELN Mutation

Third Trimester Umbilical Arterial Pulsatility Index is Associated with Neurodevelopmental Outcomes at 2-Years in Major Congenital Heart Disease

Correction to: Association Between Birth Weight Z-Scores and Early Outcomes Following Truncus Arteriosus Repair

Incidence, Predictors, and Outcomes of Cardiac Perforation During Pediatric Cardiac Catheterization: a Retrospective Observational Study from the Congenital Cardiac Interventional Study Consortium (CCISC)

Neu im Fachgebiet Kardiologie

„Jeder Fall von plötzlichem Tod muss obduziert werden!“

Hirnblutung unter DOAK und VKA ähnlich bedrohlich

Schlechtere Vorhofflimmern-Prognose bei kleinem linken Ventrikel

Semaglutid bei Herzinsuffizienz: Wie erklärt sich die Wirksamkeit?

Update Kardiologie