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Erschienen in: Pediatric Radiology 8/2009

01.08.2009 | Review

Microcephaly: a radiological review

verfasst von: Ailbhe Tarrant, Catherine Garel, David Germanaud, Thierry Billette de Villemeur, Cyril Mignot, Marion Lenoir, Hubert Ducou le Pointe

Erschienen in: Pediatric Radiology | Ausgabe 8/2009

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Abstract

Microcephaly results from inadequate brain growth during development. It may develop in utero, and therefore be present at birth, or may develop later as a result of perinatal events or postnatal conditions. The aetiology of microcephaly may be congenital (secondary to cerebral malformations or metabolic abnormalities) or acquired, most frequently following an ischaemic insult. This distinct radiological and pathological entity is reviewed with a specific focus on aetiology.
Literatur
1.
Zurück zum Zitat Watemberg N, Silver S, Harel S et al (2002) Significance of microcephaly among children with developmental disabilities. J Child Neurol 17:117–122PubMedCrossRef Watemberg N, Silver S, Harel S et al (2002) Significance of microcephaly among children with developmental disabilities. J Child Neurol 17:117–122PubMedCrossRef
2.
Zurück zum Zitat Russell SA, McHugo J, Pilling D (2007) Cranial abnormalities. In: Twining P, McHugo J, Pilling D (eds) Textbook of fetal abnormalities. Churchill Livingstone, Edinburgh, pp 95–141 Russell SA, McHugo J, Pilling D (2007) Cranial abnormalities. In: Twining P, McHugo J, Pilling D (eds) Textbook of fetal abnormalities. Churchill Livingstone, Edinburgh, pp 95–141
3.
Zurück zum Zitat Salomon LJ, Duyme M, Crequat J et al (2006) French fetal biometry: reference equations and comparison with other charts. Ultrasound Obstet Gynecol 28:193–198PubMedCrossRef Salomon LJ, Duyme M, Crequat J et al (2006) French fetal biometry: reference equations and comparison with other charts. Ultrasound Obstet Gynecol 28:193–198PubMedCrossRef
4.
Zurück zum Zitat Garel C (2005) Fetal cerebral biometry: normal parenchymal findings and ventricular size. Eur Radiol 15:809–813PubMedCrossRef Garel C (2005) Fetal cerebral biometry: normal parenchymal findings and ventricular size. Eur Radiol 15:809–813PubMedCrossRef
5.
6.
Zurück zum Zitat Cnossen JS, Morris RK, ter Riet G et al (2008) Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis. CMAJ 178:701–711PubMed Cnossen JS, Morris RK, ter Riet G et al (2008) Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis. CMAJ 178:701–711PubMed
7.
Zurück zum Zitat Malinger G, Lev D, Zahalka N et al (2003) Fetal cytomegalovirus infection of the brain: the spectrum of sonographic findings. AJNR 24:28–32PubMed Malinger G, Lev D, Zahalka N et al (2003) Fetal cytomegalovirus infection of the brain: the spectrum of sonographic findings. AJNR 24:28–32PubMed
8.
Zurück zum Zitat Walkinshaw SA (2007) Viral infections in pregnancy. In: Twining P, McHugo J, Pilling D (eds) Textbook of fetal abnormalities. Churchill Livingstone, Edinburgh, pp 427–442 Walkinshaw SA (2007) Viral infections in pregnancy. In: Twining P, McHugo J, Pilling D (eds) Textbook of fetal abnormalities. Churchill Livingstone, Edinburgh, pp 427–442
9.
Zurück zum Zitat Sugimoto T, Yasuhara A, Nishida N et al (1993) MRI of the head in the evaluation of microcephaly. Neuropediatrics 24:4–7PubMedCrossRef Sugimoto T, Yasuhara A, Nishida N et al (1993) MRI of the head in the evaluation of microcephaly. Neuropediatrics 24:4–7PubMedCrossRef
10.
Zurück zum Zitat Chao CP, Zaleski CG, Patton AC (2006) Neonatal hypoxic-ischemic encephalopathy: multimodality imaging findings. Radiographics 26(Suppl 1):S159–172PubMedCrossRef Chao CP, Zaleski CG, Patton AC (2006) Neonatal hypoxic-ischemic encephalopathy: multimodality imaging findings. Radiographics 26(Suppl 1):S159–172PubMedCrossRef
11.
Zurück zum Zitat Verloes A (2004) Microcéphalie isolée congénitale. Orphanet Encyclopedia, p ORPHA2512 Verloes A (2004) Microcéphalie isolée congénitale. Orphanet Encyclopedia, p ORPHA2512
12.
Zurück zum Zitat de Vries LS, Gunardi H, Barth PG et al (2004) The spectrum of cranial ultrasound and magnetic resonance imaging abnormalities in congenital cytomegalovirus infection. Neuropediatrics 35:113–119PubMedCrossRef de Vries LS, Gunardi H, Barth PG et al (2004) The spectrum of cranial ultrasound and magnetic resonance imaging abnormalities in congenital cytomegalovirus infection. Neuropediatrics 35:113–119PubMedCrossRef
13.
Zurück zum Zitat Lago EG, Baldisserotto M, Hoefel Filho JR et al (2007) Agreement between ultrasonography and computed tomography in detecting intracranial calcifications in congenital toxoplasmosis. Clin Radiol 62:1004–1011PubMedCrossRef Lago EG, Baldisserotto M, Hoefel Filho JR et al (2007) Agreement between ultrasonography and computed tomography in detecting intracranial calcifications in congenital toxoplasmosis. Clin Radiol 62:1004–1011PubMedCrossRef
14.
Zurück zum Zitat Dahlgren L, Wilson RD (2001) Prenatally diagnosed microcephaly: a review of etiologies. Fetal Diagn Ther 16:323–326PubMedCrossRef Dahlgren L, Wilson RD (2001) Prenatally diagnosed microcephaly: a review of etiologies. Fetal Diagn Ther 16:323–326PubMedCrossRef
15.
Zurück zum Zitat Bronsteen R, Lee W, Vettraino IM et al (2004) Second-trimester sonography and trisomy 18. J Ultrasound Med 23:233–240PubMed Bronsteen R, Lee W, Vettraino IM et al (2004) Second-trimester sonography and trisomy 18. J Ultrasound Med 23:233–240PubMed
16.
Zurück zum Zitat Twining P (2007) Chromosomal abnormalities. In: Twining P, McHugo J, Pilling D (eds) Textbook of fetal abnormalities. Churchill Livingstone, Edinburgh, pp 327–359 Twining P (2007) Chromosomal abnormalities. In: Twining P, McHugo J, Pilling D (eds) Textbook of fetal abnormalities. Churchill Livingstone, Edinburgh, pp 327–359
17.
18.
Zurück zum Zitat Steinlin M (2007) The cerebellum in cognitive processes: supporting studies in children. Cerebellum 6:237–241PubMedCrossRef Steinlin M (2007) The cerebellum in cognitive processes: supporting studies in children. Cerebellum 6:237–241PubMedCrossRef
19.
Zurück zum Zitat Uhl M, Pawlik H, Laubenberger J et al (1998) MR findings in pontocerebellar hypoplasia. Pediatr Radiol 28:547–551PubMedCrossRef Uhl M, Pawlik H, Laubenberger J et al (1998) MR findings in pontocerebellar hypoplasia. Pediatr Radiol 28:547–551PubMedCrossRef
20.
Zurück zum Zitat Ghai S, Fong KW, Toi A et al (2006) Prenatal US and MR imaging findings of lissencephaly: review of fetal cerebral sulcal development. Radiographics 26:389–405PubMedCrossRef Ghai S, Fong KW, Toi A et al (2006) Prenatal US and MR imaging findings of lissencephaly: review of fetal cerebral sulcal development. Radiographics 26:389–405PubMedCrossRef
21.
Zurück zum Zitat Desir J, Abramowicz M, Tunca Y (2006) Novel mutations in prenatal diagnosis of primary microcephaly. Prenat Diagn 26:989PubMedCrossRef Desir J, Abramowicz M, Tunca Y (2006) Novel mutations in prenatal diagnosis of primary microcephaly. Prenat Diagn 26:989PubMedCrossRef
22.
Zurück zum Zitat Yelgec S, Ozturk MH, Aydingoz U et al (1998) CT and MRI of microcephalia vera. Neuroradiology 40:332–334PubMedCrossRef Yelgec S, Ozturk MH, Aydingoz U et al (1998) CT and MRI of microcephalia vera. Neuroradiology 40:332–334PubMedCrossRef
23.
Zurück zum Zitat Virkola K, Lappalainen M, Valanne L et al (1997) Radiological signs in newborns exposed to primary Toxoplasma infection in utero. Pediatr Radiol 27:133–138PubMedCrossRef Virkola K, Lappalainen M, Valanne L et al (1997) Radiological signs in newborns exposed to primary Toxoplasma infection in utero. Pediatr Radiol 27:133–138PubMedCrossRef
24.
Zurück zum Zitat Mari G, Deter RL, Carpenter RL (2003) Noninvasive diagnosis by Doppler ultrasonography of fetal anemia due to maternal red-cell alloimmunization. N Engl J Med 342:9–14CrossRef Mari G, Deter RL, Carpenter RL (2003) Noninvasive diagnosis by Doppler ultrasonography of fetal anemia due to maternal red-cell alloimmunization. N Engl J Med 342:9–14CrossRef
25.
Zurück zum Zitat van der Knaap MS, Vermeulen G, Barkhof F et al (2004) Pattern of white matter abnormalities at MR imaging: use of polymerase chain reaction testing of Guthrie cards to link pattern with congenital cytomegalovirus infection. Radiology 230:529–536PubMedCrossRef van der Knaap MS, Vermeulen G, Barkhof F et al (2004) Pattern of white matter abnormalities at MR imaging: use of polymerase chain reaction testing of Guthrie cards to link pattern with congenital cytomegalovirus infection. Radiology 230:529–536PubMedCrossRef
26.
Zurück zum Zitat Degani S (2006) Sonographic findings in fetal viral infections: a systematic review. Obstet Gynecol Surv 61:329–336PubMedCrossRef Degani S (2006) Sonographic findings in fetal viral infections: a systematic review. Obstet Gynecol Surv 61:329–336PubMedCrossRef
27.
Zurück zum Zitat Garel C, Delezoide AL, Elmaleh-Berges M et al (2004) Contribution of fetal MR imaging in the evaluation of cerebral ischemic lesions. AJNR 25:1563–1568PubMed Garel C, Delezoide AL, Elmaleh-Berges M et al (2004) Contribution of fetal MR imaging in the evaluation of cerebral ischemic lesions. AJNR 25:1563–1568PubMed
28.
Zurück zum Zitat Smith AP (2007) Abnormalities of twin pregnancies. In: Twining P, McHugo J, Pilling D (eds) Textbook of fetal abnormalities. Churchill Livingstone, Edinburgh, pp 405–426 Smith AP (2007) Abnormalities of twin pregnancies. In: Twining P, McHugo J, Pilling D (eds) Textbook of fetal abnormalities. Churchill Livingstone, Edinburgh, pp 405–426
29.
Zurück zum Zitat Beattie RB, Rich DA (2007) Disorders of amniotic fluid, placenta, and membranes. In: Twining P, McHugo J, Pilling D (eds) Textbook of fetal abnormalities. Churchill Livingstone, Edinburgh, pp 75–94 Beattie RB, Rich DA (2007) Disorders of amniotic fluid, placenta, and membranes. In: Twining P, McHugo J, Pilling D (eds) Textbook of fetal abnormalities. Churchill Livingstone, Edinburgh, pp 75–94
30.
Zurück zum Zitat Nikas I, Dermentzoglou V, Theofanopoulou M et al (2008) Parasagittal lesions and ulegyria in hypoxic-ischemic encephalopathy: neuroimaging findings and review of the pathogenesis. J Child Neurol 23:51–58PubMedCrossRef Nikas I, Dermentzoglou V, Theofanopoulou M et al (2008) Parasagittal lesions and ulegyria in hypoxic-ischemic encephalopathy: neuroimaging findings and review of the pathogenesis. J Child Neurol 23:51–58PubMedCrossRef
31.
Zurück zum Zitat Hoon AH Jr (2005) Neuroimaging in cerebral palsy: patterns of brain dysgenesis and injury. J Child Neurol 20:936–939PubMedCrossRef Hoon AH Jr (2005) Neuroimaging in cerebral palsy: patterns of brain dysgenesis and injury. J Child Neurol 20:936–939PubMedCrossRef
32.
Zurück zum Zitat Levy HL, Lobbregt D, Barnes PD et al (1996) Maternal phenylketonuria: magnetic resonance imaging of the brain in offspring. J Pediatr 128:770–775PubMedCrossRef Levy HL, Lobbregt D, Barnes PD et al (1996) Maternal phenylketonuria: magnetic resonance imaging of the brain in offspring. J Pediatr 128:770–775PubMedCrossRef
33.
Zurück zum Zitat Maillot F, Cook P, Lilburn M et al (2007) A practical approach to maternal phenylketonuria management. J Inherit Metab Dis 30:198–201PubMedCrossRef Maillot F, Cook P, Lilburn M et al (2007) A practical approach to maternal phenylketonuria management. J Inherit Metab Dis 30:198–201PubMedCrossRef
34.
Zurück zum Zitat Pennell PB (2002) Pregnancy in the woman with epilepsy: maternal and fetal outcomes. Semin Neurol 22:299–308PubMedCrossRef Pennell PB (2002) Pregnancy in the woman with epilepsy: maternal and fetal outcomes. Semin Neurol 22:299–308PubMedCrossRef
35.
Zurück zum Zitat Nulman I, Rovet J, Altmann D et al (1994) Neurodevelopment of adopted children exposed in utero to cocaine. CMAJ 151:1591–1597PubMed Nulman I, Rovet J, Altmann D et al (1994) Neurodevelopment of adopted children exposed in utero to cocaine. CMAJ 151:1591–1597PubMed
36.
Zurück zum Zitat Spadoni AD, McGee CL, Fryer SL et al (2007) Neuroimaging and fetal alcohol spectrum disorders. Neurosci Biobehav Rev 31:239–245PubMedCrossRef Spadoni AD, McGee CL, Fryer SL et al (2007) Neuroimaging and fetal alcohol spectrum disorders. Neurosci Biobehav Rev 31:239–245PubMedCrossRef
37.
Zurück zum Zitat Volpe JJ (1992) Effect of cocaine use on the fetus. N Engl J Med 327:399–407PubMed Volpe JJ (1992) Effect of cocaine use on the fetus. N Engl J Med 327:399–407PubMed
38.
Zurück zum Zitat Yalnizoglu D, Haliloglu G, Turanli G et al (2007) Neurologic outcome in patients with MRI pattern of damage typical for neonatal hypoglycemia. Brain Dev 29:285–292PubMedCrossRef Yalnizoglu D, Haliloglu G, Turanli G et al (2007) Neurologic outcome in patients with MRI pattern of damage typical for neonatal hypoglycemia. Brain Dev 29:285–292PubMedCrossRef
39.
Zurück zum Zitat Rolig RL, McKinnon PJ (2000) Linking DNA damage and neurodegeneration. Trends Neurosci 23:417–424PubMedCrossRef Rolig RL, McKinnon PJ (2000) Linking DNA damage and neurodegeneration. Trends Neurosci 23:417–424PubMedCrossRef
40.
Zurück zum Zitat Leroy-Malherbe V, Bonnier C, Papiernik E et al (2006) The association between developmental handicaps and traumatic brain injury during pregnancy: an issue that deserves more systematic evaluation. Brain Inj 20:1355–1365PubMedCrossRef Leroy-Malherbe V, Bonnier C, Papiernik E et al (2006) The association between developmental handicaps and traumatic brain injury during pregnancy: an issue that deserves more systematic evaluation. Brain Inj 20:1355–1365PubMedCrossRef
41.
Zurück zum Zitat Lo TY, McPhillips M, Minns RA et al (2003) Cerebral atrophy following shaken impact syndrome and other non-accidental head injury (NAHI). Pediatr Rehabil 6:47–55PubMedCrossRef Lo TY, McPhillips M, Minns RA et al (2003) Cerebral atrophy following shaken impact syndrome and other non-accidental head injury (NAHI). Pediatr Rehabil 6:47–55PubMedCrossRef
Metadaten
Titel
Microcephaly: a radiological review
verfasst von
Ailbhe Tarrant
Catherine Garel
David Germanaud
Thierry Billette de Villemeur
Cyril Mignot
Marion Lenoir
Hubert Ducou le Pointe
Publikationsdatum
01.08.2009
Verlag
Springer-Verlag
Erschienen in
Pediatric Radiology / Ausgabe 8/2009
Print ISSN: 0301-0449
Elektronische ISSN: 1432-1998
DOI
https://doi.org/10.1007/s00247-009-1266-x

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