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Pediatric Radiology
Erschienen in: Pediatric Radiology 7/2016

01.06.2016 | Minisymposium: Pediatric MR Spectroscopy

Proton MRS imaging in pediatric brain tumors

verfasst von: Maria Zarifi, A. Aria Tzika

Erschienen in: Pediatric Radiology | Ausgabe 7/2016

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Abstract

Magnetic resonance (MR) techniques offer a noninvasive, non-irradiating yet sensitive approach to diagnosing and monitoring pediatric brain tumors. Proton MR spectroscopy (MRS), as an adjunct to MRI, is being more widely applied to monitor the metabolic aspects of brain cancer. In vivo MRS biomarkers represent a promising advance and may influence treatment choice at both initial diagnosis and follow-up, given the inherent difficulties of sequential biopsies to monitor therapeutic response. When combined with anatomical or other types of imaging, MRS provides unique information regarding biochemistry in inoperable brain tumors and can complement neuropathological data, guide biopsies and enhance insight into therapeutic options. The combination of noninvasively acquired prognostic information and the high-resolution anatomical imaging provided by conventional MRI is expected to surpass molecular analysis and DNA microarray gene profiling, both of which, although promising, depend on invasive biopsy. This review focuses on recent data in the field of MRS in children with brain tumors.
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Metadaten
Titel
Proton MRS imaging in pediatric brain tumors
verfasst von
Maria Zarifi
A. Aria Tzika
Publikationsdatum
01.06.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Pediatric Radiology / Ausgabe 7/2016
Print ISSN: 0301-0449
Elektronische ISSN: 1432-1998
DOI
https://doi.org/10.1007/s00247-016-3547-5

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