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Skeletal Radiology

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01.05.2003 | Review Article

Adamantinoma, osteofibrous dysplasia and differentiated adamantinoma

verfasst von: Leonard B. Kahn

Erschienen in: Skeletal Radiology | Ausgabe 5/2003

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Abstract

For just over 100 years, adamantinoma has been recognized as a primary bone tumor with epithelial characteristics and predominantly involving the tibia. Osteofibrous dysplasia is a fibro-osseous lesion also predominantly confined to the tibia with radiologic features similar to those of adamantinoma. This lesion has been shown by immunohistochemical studies to frequently contain cytokeratin-positive epithelial cells. More recently, a third group of cases with clinical and radiologic features similar to those of osteofibrous dysplasia have demonstrated more overt strands of epithelial cells within a fibro-osseous background and have been categorized as "differentiated", "regressive", "juvenile intracortical" or "osteofibrous dysplasia-like" adamantinoma. Cytokeratin subset immunohistochemical stains and cytogenetic studies performed in recent years suggest a common histogenesis for these three entities. This article reviews the clinical, radiologic and pathologic features of these entities as well as their prognostic significance. It also reviews the results of the immunohistochemical and cytogenetic studies which establish a common histogenetic relationship.

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Titel: Adamantinoma, osteofibrous dysplasia and differentiated adamantinoma
verfasst von: Leonard B. Kahn
Publikationsdatum: 01.05.2003
Verlag: Springer-Verlag
Erschienen in: Skeletal Radiology / Ausgabe 5/2003
Print ISSN: 0364-2348
Elektronische ISSN: 1432-2161
DOI: https://doi.org/10.1007/s00256-003-0624-2

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