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Skeletal Radiology
Erschienen in: Skeletal Radiology 9/2011

01.09.2011 | Special Issue: Jubilee

Benign notochordal lesions of the axial skeleton: a review and current appraisal

verfasst von: Michael Kyriakos

Erschienen in: Skeletal Radiology | Ausgabe 9/2011

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Abstract

At the 1996 meeting of the International Skeletal Society, an idea was put forth that there existed symptomatic lesions of the axial skeleton, morphologically different from chordoma, that were consistent with benign notochordal remnants (rests). A review of the embryological basis for this concept is made, along with an analysis of these lesions, termed giant notochordal rests or benign notochordal cell tumors, that have been reported in the intervening 15 years, with a commentary on their relationship, if any, to chordoma.
Fußnoten
1
Some of the following data include additional clinical information obtained in personal communication from Drs. Dorfman [45], McCarthy [37], and Reith [47] on their patients.
 
Literatur
1.
Mirra JM, Brien EW. Giant notochordal hamartoma of intraosseous origin: a newly reported benign entity to be distinguished from chordoma. Report of two cases. Skeletal Radiol. 2001;30:698–709.CrossRef
2.
Horwitz T. Chordal ectopia and its possible relation to chordoma. Arch Pathol. 1941;31:354–62.
3.
Horwitz T. The human notochord. A study of its development and regression, variations and pathologic derivative, chordoma. Indianapolis: Private printing; 1977.
4.
Steegmann AT. Notochordal tissue: its development and reactions. In: Minckler J, editor. Pathology of the nervous system, vol 1. New York: McGraw-Hill; 1968.
5.
Willis RA. The borderland of embryology and pathology. 2nd ed. London: Butterworths & Co.; 1962.
6.
Goto S, Uhthoff HK. Notochord action on spinal development. Acta Orthop Scand. 1985;57:85–90.CrossRef
7.
Götz W, Kasper M, Miosge N, Hughes RC. Detection and distribution of the carbohydrate binding protein galectin-3 in human notochord, intervertebral disc and chordoma. Differentiation. 1997;62:149–57.CrossRef
8.
Trout JJ, Buckwalter JA, Moore KC, Landas SK. Ultrastructure of the human intervertebral disc. I. Changes in notochordal cells with age. Tissue Cell. 1982;14:359–69.CrossRef
9.
Stewart MJ. Malignant sacrococcygeal chordoma. J Pathol Bacteriol. 1922;25:40–62.CrossRef
10.
Congdon CC. Proliferative lesions resembling chordoma following puncture of the nucleus pulposus in rabbits. J Natl Cancer Inst. 1952;12:893–907.PubMed
11.
Stewart MJ, Burrow J le F. Ecchordosis physaliphora spheno-occipitalis. J Neurol Psychopathol. 1923;4:218–20.CrossRef
12.
Salisbury JR. The pathology of the human notochord. J Pathol. 1993;171:253–5.CrossRef
13.
Sarasa JL, Fortes J. Ecchordosis physaliphora: an immunohistochemical study of two cases. Histopathology. 1991;18:273–5.CrossRef
14.
Willis RA. Pathology of tumours. 4th ed. New York: Appleton-Century-Crofts; 1967. p. 937–43.
15.
Wyatt RB, Schochet SS Jr, McCormick WF. Ecchordosis physaliphora. An electron microscopic study. J Neurosurg. 1971;34:672–7.CrossRef
16.
Ho K-L. Ecchordosis physaliphora and chordoma: a comparative ultrastructural study. Clin Neuropathol. 1985;4:77–86.PubMed
17.
Ng S-H, Ko S-F, Wan Y-L, Tang L-M, Ho Y-S. Case report. Cervical ecchordosis physaliphora: CT and MR features. Br J Radiol. 1998;71:329–31.CrossRef
18.
Stam FC, Kamphorst W. Ecchordosis physaliphora as a cause of fatal pontine hemorrhage. Eur Neurol. 1982;21:90–3.CrossRef
19.
Jaffe HL. Tumors and tumorous conditions of the bones and joints. Philadelphia: Lea and Febiger; 1958. p. 451–62.
20.
Beadle, OA. The intervertebral discs. Observations on their normal and morbid anatomy in relation to certain spinal deformities. His Majesty’s Stationery Office, Medical Research Council, Special Report Series No. 161; 1931.
21.
Musgrove J. Persistence of the notochord in the human subject. J Anat. 1891;25:386–9.
22.
Schmorl G, Junghanns H. The human spine in health and disease. New York: Grune and Stratton; 1959.
23.
Congdon CC. Benign and malignant chordomas. A clinico-anatomical study of twenty-two cases. Am J Pathol. 1952;28:793–821.PubMedPubMedCentral
24.
Ulich TR, Mirra JM. Ecchordosis physaliphora vertebralis. Clin Orthop Relat Res. 1982;163:282–9.
25.
Birrell JHW. Chordomata. A review of nineteen cases of chordomata including five vertebral cases. Aust NZ J Surg. 1953;22:258–67.CrossRef
26.
Bottles K, Beckstead JH. Enzyme histochemical characterization of chordomas. Am J Surg Pathol. 1984;8:443–7.CrossRef
27.
Hajdu SI. Thoughts about the cause of cancer. Cancer. 2006;106:1643–9.CrossRef
28.
McMaster ML, Goldstein AM, Bromley CM, Ishibe N, Parry DM. Chordoma: incidence and survival patterns in the United States, 1973–1995. Cancer Causes Control. 2001;12:1–11.CrossRef
29.
Folpe AL, Agoff SN, Willis J, Weiss SW. Parachordoma is immunohistochemically and cytogenetically distinct from axial chordoma and extraskeletal myxoid chondrosarcoma. Am J Surg Pathol. 1999;23:1059–67.CrossRef
30.
Nielsen GP, Mangham DC, Grimer RJ, Rosenberg AE. Chordoma periphericum. A case report. Am J Surg Pathol. 2001;25:263–7.CrossRef
31.
Shin HJC, Mackay B, Ichinose H, Ayala AG, Romsdahl MM. Parachordoma. Ultrastruct Pathol. 1994;18:249–56.CrossRef
32.
Koh JS, Chung JH, Lee SY, Cho K-J. Parachordoma of the tibia: report of a rare case. Pathol Res Pract. 2000;196:269–73.CrossRef
33.
Las Heras F, Pritzker KPH, Colgan TJ. Chordoma arising in a mature cystic teratoma of the ovary: A case report. Pathol Res Pract. 2007;203:467–71.CrossRef
34.
Riopelle JL. Teratoma of the ovary, with a segment of vertebral column and remnants of notochordal tissue. Am J Pathol. 1940;16:625–33.PubMedPubMedCentral
35.
Cassar-Pullicino VN, Darby AJ. Case 44. International Skeletal Society Meeting; Paris 1996.
36.
Darby AJ, Cassar-Pullicino VN, McCall IW, Jaffray DC. Vertebral intra-osseous chordoma or giant notochordal rest? Skeletal Radiol. 1999;28:342–6.CrossRef
37.
McCarthy E. Case 35. International Skeletal Society Meeting; Dublin 1998.
38.
Yamaguchi T, Iwata J, Sugihara S, et al. Distinguishing benign notochordal cell tumors from vertebral chordoma. Skeletal Radiol. 2008;37:291–9.CrossRef
39.
Yamaguchi T, Suzuki S, Ishiiwa H, Ueda Y. Intraosseous benign notochordal cell tumours: overlooked precursors of classic chordomas? Histopathology. 2004;44:597–602.CrossRef
40.
Mirra JM. Case 12. International Skeletal Society Meeting; Seattle 1999.
41.
Kyriakos M, Totty WG. Case 11. International Skeletal Society Meeting; Seattle 1999.
42.
Kyriakos M, Totty WG, Lenke LG. Giant vertebral notochordal rest. A lesion distinct from chordoma: discussion of an evolving concept. Am J Surg Pathol. 2003;27:396–406.CrossRef
43.
Chauvel A, Taillat F, Gille O, et al. Giant vertebral notochordal rest: a new entity distinct from chordoma. Histopathology. 2005;47:646–9.CrossRef
44.
Corsi A, De Maio F, Mancini F, Ippolito E, Riminucci M, Bianco P. Notochordal inclusions in the vertebral bone marrow. J Bone Miner Res. 2008;23:572–5.CrossRef
45.
Dorfman HD, Czerniak B. Bone tumors. St. Louis: Mosby; 1998. p. 977.
46.
Haasper C, Länger F, Rosenthal H, et al. Coccydynia due to a benign notochordal cell tumor. Spine. 2007;32:E394–6.CrossRef
47.
Knapik JA, Vlasak R, Reith JD. Notochordal hamartoma and its necessary distinction from chordoma (abstract). Mod Pathol. 2003;16:15A.
48.
Murakami H, Kawahara N, Gabata T, Nambu K, Tomita K. Vertebral body osteonecrosis without vertebral collapse. Spine. 2003;28:E323–8.CrossRef
49.
Murakami H, Kawahara N, Tomita K. Letter to the Editor. Spine. 2005;30:593–4.CrossRef
50.
Smith DS, French G, Miller M. Multifocal benign notochordal cell tumours. Histopathology. 2007;51:412–4.CrossRef
51.
Uglialoro AD, Beebe KS, Hameed M, Benevenia J. A rare case of intraosseous benign notochordal cell tumor of the coccyx. Orthopedics. 2009;32:445–9.CrossRef
52.
Yamaguchi T, Yamato M, Saotome K. First histologically confirmed case of a classic chordoma arising in a precursor benign notochordal lesion: differential diagnosis of benign and malignant notochordal lesions. Skeletal Radiol. 2002;31:413–8.CrossRef
53.
Deshpande V, Nielsen GP, Rosenthal DI, Rosenberg AE. Intraosseous benign notochord cell tumors (BNCT): further evidence supporting a relationship to chordoma. Am J Surg Pathol. 2007;31:1573–7.CrossRef
54.
Shen J, Li C-D, Yang H-L, et al. Classic chordoma coexisting with benign notochordal cell rest demonstrating different immunohistological expression patterns of brachyury and galectin-3. J Clin Neurosci. 2010;18:96–9.CrossRef
55.
Oner AY, Akpek S, Tali T, Ucar M. Giant vertebral notochordal rest: magnetic resonance and diffusion weighted imaging findings. Korean J Radiol. 2009;10:303–6.CrossRef
56.
Mirra JM. Bone tumors. Clinical, radiologic, and pathologic correlations. Philadelphia: Lea and Febiger; 1989. p. 648–72.
57.
Mulder JD, Schütte HE, Kroon HM, Taconis WK. Radiologic atlas of bone tumors. Amsterdam: Elsevier; 1993. p. 267–74.
58.
Unni KK, Inwards CY. Dahlin’s bone tumors. General aspects and data on 10,165 cases. 6th ed. Philadelphia: Lippincott Williams & Wilkins; 2010. p. 248–61.
59.
Coffin CM, Swanson PE, Wick MR, Dehner LP. An immunohistochemical comparison of chordoma with renal cell carcinoma, colorectal adenocarcinoma, and myxopapillary ependymoma: A potential diagnostic dilemma in the diminutive biopsy. Mod Pathol. 1993;6:531–8.PubMed
60.
Naka T, Iwamoto Y, Shinohara N, Chuman H, Fukui M, Tsuneyoshi M. Cytokeratin subtyping in chordomas and the fetal notochord: An immunohistochemical analysis of aberrant expression. Mod Pathol. 1997;10:545–51.PubMed
61.
O’Hara BJ, Paetau A, Miettinen M. Keratin subsets and monoclonal antibody HBME-1 in chordoma: immunohistochemical differential diagnosis between tumors simulating chordoma. Hum Pathol. 1998;29:119–26.CrossRef
62.
Jambhekar NA, Rekhi B, Thorat K, Dikshit R, Agrawal M, Puri A. Revisiting chordoma with brachyury, a “new age” marker. Analysis of a validation study on 51 cases. Arch Pathol Lab Med. 2010;134:1181–7.PubMed
63.
Vujovic S, Henderson S, Presneau N, et al. Brachyury, a crucial regulator of notochordal development, is a novel biomarker for chordomas. J Pathol. 2006;209:157–65.CrossRef
64.
Yamaguchi T, Suzuki S, Ishiiwa H, Shimizu K, Ueda Y. Benign notochordal cell tumors. A comparative histological study of benign notochordal tumors, classic chordomas, and notochordal vestiges of fetal intervertebral discs. Am J Surg Pathol. 2004;28:756–61.CrossRef
65.
Amer HZM, Hameed M. Intraosseous benign notochordal cell tumor. Arch Pathol Lab Med. 2010;134:283–8.PubMed
66.
Yamaguchi T, Watanabe-Ishiiwa H, Suzuki S, Igarashi Y, Ueda Y. Incipient chordoma: a report of two cases of early-stage chordoma arising from benign notochordal cell tumors. Mod Pathol. 2005;18:1005–10.CrossRef
67.
Götz W, Kasper M, Fischer G, Herken R. Intermediate filament typing of the human embryonic and fetal notochord. Cell Tissue Res. 1995;280:455–62.CrossRef
68.
Stosiek P, Kasper M, Karsten U. Expression of cytokeratin and vimentin in nucleus pulposus cells. Differentiation. 1988;39:78–81.CrossRef
69.
Wang W-L, Abramson JH, Ganguly A, Rosenberg AE. The surgical pathology of notochordal remnants in adult intervertebral disks. A report of 3 cases. Am J Surg Pathol. 2008;32:1123–9.CrossRef
70.
Kyriakos M. Chordoma in association with a benign appearing notochordal cell lesion (notochord rest). International Academy of Pathology Meeting; Athens 2008.
Metadaten
Titel
Benign notochordal lesions of the axial skeleton: a review and current appraisal
verfasst von
Michael Kyriakos
Publikationsdatum
01.09.2011
Verlag
Springer Berlin Heidelberg
Erschienen in
Skeletal Radiology / Ausgabe 9/2011
Print ISSN: 0364-2348
Elektronische ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-011-1167-6

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