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Seminars in Immunopathology

Erschienen in:

01.03.2005 | Original Article

Surveillance B lymphocytes and mucosal immunoregulation

verfasst von: Peter Velázquez, Bo Wei, Jonathan Braun

Erschienen in: Seminars in Immunopathology | Ausgabe 4/2005

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Abstract

Mucosal lymphocyte homeostasis involves the dynamic interaction of enteric microbiota, the intestinal host epithelium, and the mucosal immune system. Dysregulation of mucosal lymphocyte homeostasis results in a variety of intestinal disorders, notably inflammatory bowel diseases like ulcerative colitis and Crohn’s disease. One key cellular component regulating homeostasis are B lymphocytes that reside in gut-associated lymphoid tissue. This compartment includes Peyer’s patches, isolated lymphoid follicles, lamina propria, and mesenteric lymph nodes. Recent data have pointed to two new and exciting aspects of B cells in the gut. First, there has been progress on identification and functional analysis of abundant isolated lymphoid follicle B cells that are key mediators of IgA genesis. Second, several groups have now clarified the functional identification and characterization of immunoregulatory B cells in the gut. This review examines the novel aspects of these B cells, and examines how each plays a role in mediating mucosal homeostasis in this bacteria-laden compartment.

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Titel: Surveillance B lymphocytes and mucosal immunoregulation
verfasst von: Peter Velázquez
Bo Wei
Jonathan Braun
Publikationsdatum: 01.03.2005
Verlag: Springer-Verlag
Erschienen in: Seminars in Immunopathology / Ausgabe 4/2005
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-004-0189-8

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