nach oben

Seminars in Immunopathology

Erschienen in:

01.06.2007 | Review

Regulatory T cells and regulatory natural killer (NK) cells play important roles in feto-maternal tolerance

verfasst von: Shigeru Saito, Arihiro Shiozaki, Yasushi Sasaki, Akitoshi Nakashima, Tomoko Shima, Mika Ito

Erschienen in: Seminars in Immunopathology | Ausgabe 2/2007

Einloggen, um Zugang zu erhalten

Abstract

In the early pregnancy decidua, lymphocytes express some activation markers on their surface, suggesting that maternal lymphocytes are activated and recognize the semiallograftic fetus. Therefore, the immunoregulation system must work to prevent fetus rejection. Recent data showed that parts of the immunoregulation system such as CD4⁺CD25⁺ regulatory T (Treg) cells, Th3 cells, Tr1 cells, regulatory NK cells, and a tryptophan-catabolizing enzyme, indolamine 2,3 deoxygenase, play very important roles in the maintenance of pregnancy. Not only Treg cells but also regulatory NK cells may inhibit maternal T cell or NK cell fetal attack.

Moffett-King A (2002) Natural killer cells and pregnancy. Nat Rev Immunol 2:656–663PubMedCrossRef

Tabiasco J, Rabot M, Aguerre-Girr M, El Costa H, Berrebi A, Parant O, Laskarin G, Juretic K, Bensussan A, Rukavina D, Le Bouteiller P (2006) Human decidual NK cells: unique phenotype and functional properties—a review. Placenta 27(Suppl A):S34–S39PubMedCrossRef

Hanna J, Goldman-Wohl D, Hamani Y, Avraham I, Greenfield C, Natanson-Yaron S, Prus D, Cohen-Daniel L, Arnon TI, Manaster I, Gazit R, Yutkin V, Benharroch D, Porgador A, Keshet E, Yagel S, Mandelboim O (2006) Decidual NK cells regulate key developmental processes at the human fetal–maternal interface. Nat Med 12:1065–1074PubMedCrossRef

Sakaguchi S (2004) Naturally arising CD4⁺ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 22:531–562PubMedCrossRef

Aluvihare VR, Kallikourdis M, Betz AG (2004) Regulatory T cells mediate maternal tolerance to the fetus. Nat Immunol 5:266–271PubMedCrossRef

Sasaki Y, Sakai M, Miyazaki S, Higuma S, Shiozaki A, Saito S (2004) Decidual and peripheral blood CD4⁺CD25⁺ regulatory T cells in early pregnancy subjects and spontaneous abortion cases. Mol Hum Reprod 10:347–353PubMedCrossRef

Somerset DA, Zheng Y, Kilby MD, Sansom DM, Drayson MT (2004) Normal human pregnancy is associated with an elevation in the immune suppressive CD4⁺CD25⁺ regulatory T-cell subset. Immunology 112:38–43PubMedCrossRef

Zenclussen AC, Gerlof K, Zenclussen ML, Sollwedel A, Bertoja AZ, Ritter T, Kotsch K, Leber J, Volk HD (2005) Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4⁺CD25⁺ T regulatory cells prevents fetal rejection in a murine abortion model. AmJ Pathol 166:811–822PubMed

Saito S, Nishikawa K, Morii T, Narita N, Enomoto M, Ichijo M (1992) Expression of activation antigens CD69, HLA-DR, interleukin-2 receptor-alpha (IL-2R alpha) and IL-2R beta on T cells of human decidua at an early stage of pregnancy. Immunology 75:710–712PubMed

10.

Wegmann TG, Lin H, Guilbert L, Mosmann TR (1993) Bidirectional cytokine interactions in the maternal–fetal relationship: is successful pregnancy a TH2 phenomenon? Immunol Today 14:353–356PubMedCrossRef

11.

Piccinni MP, Beloni L, Livi C, Maggi E, Scarselli G, Romagnani S (1998) Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions. Nat Med 4:1020–1024PubMedCrossRef

12.

Saito S, Tsukaguchi N, Hasegawa T, Michimata T, Tsuda H, Narita N (1999) Distribution of Th1, Th2, and Th0 and the Th1/Th2 cell ratios in human peripheral and endometrial T cells. Am J Reprod Immunol 42:240–245PubMed

13.

Chaouat G, Zourbas S, Ostojic S, Lappree-Delage G, Dubanchet S, Ledee N, Martal J (2002) A brief review of recent data on some cytokine expressions at the materno-fetal interface which might challenge the classical Th1/Th2 dichotomy. J Reprod Immunol 53:241–256PubMedCrossRef

14.

Saito S (2000) Cytokine network at the feto-maternal interface.J Reprod Immunol 47:87–103PubMedCrossRef

15.

Bluestone JA, Abbas AK (2003) Natural versus adaptive regulatory T cells. Nat Rev Immunol 3:253–257PubMedCrossRef

16.

Aluvihare VR, Betz AG (2006) The role of regulatory T cells in alloantigen tolerance. Immunol Rev 212:330–343PubMedCrossRef

17.

Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA (2001) CD4⁺CD25^high regulatory cells in human peripheral blood. J Immunol 167:1245–1253PubMed

18.

Saito S, Sasaki Y, Sakai M (2005) CD4⁺CD25^high regulatory T cells in human pregnancy. J Reprod Immunol 65:111–120PubMedCrossRef

19.

Hori S, Nomura T, Sakaguchi S (2003) Control of regulatory T cell development by the transcription factor Foxp3. Science 299:1057–1061PubMedCrossRef

20.

Zheng Y, Josefowicz SZ, Kas A, Chu TT, Gavin MA, Rudensky AY (2007) Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. Nature 445:936–940, DOI 10.1038/nature05563

21.

Marson A, Kretschmer K, Frampton GM, Jacobsen ES, Polansky JK, MacIsaac KD, Levine SS, Fraenkel E, von Boehmer H, Young RA (2007) Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature 445:931–935, DOI 10.1038/nature05478

22.

Nakamura K, Kitani A, Strober W (2001) Cell contact-dependent immunosuppression by CD4⁺CD25⁺ regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med 194:629–644PubMedCrossRef

23.

Piccirillo CA, Letterio JJ, Thornton AM, McHugh RS, Mamura M, Mizuhara H, Shevach EM (2002) CD4⁺CD25⁺ regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness. J Exp Med 196:237–246PubMedCrossRef

24.

Huang CT, Workman CJ, Flies D, Pan X, Marson AL, Zhou G, Hipkiss EL, Ravi S, Kowalski J, Levitsky HI, Powell JD, Pardoll DM, Drake CG, Vignali DA (2004) Role of LAG-3 in regulatory T cells. Immunity 21:503–513PubMedCrossRef

25.

Garin MI, Chu CC, Golshayan D, Cernuda-Morollon E, Wait R, Lechler RI (2007) Galectin-1: a key effector of regulation mediated by CD4⁺CD25⁺ T cells. Blood 109:2058–2065PubMedCrossRef

26.

Choe YS, Shim C, Choi D, Lee CS, Lee KK, Kim K (1997) Expression of galectin-1 mRNA in the mouse uterus is under the control of ovarian steroids during blastocyst implantation. Mol Reprod Dev 48:261–266PubMedCrossRef

27.

Polanczyk MJ, Hopke C, Vandenbark AA, Offner H (2006) Estrogen-mediated immunomodulation involves reduced activation of effector T cells, potentiation of Treg cells, and enhanced expression of the PD-1 costimulatory pathway. J Neurosci Res 84:370–378PubMedCrossRef

28.

Prieto GA, Rosenstein Y (2006) Oestradiol potentiates the suppressive function of human CD4⁺CD25⁺ regulatory T cells by promoting their proliferation. Immunology 118:58–65PubMedCrossRef

29.

Grohmann U, Orabona C, Fallarino F, Vacca C, Calcinaro F, Falorni A, Candeloro P, Belladonna ML, Bianchi R, Fioretti MC, Puccetti P (2002) CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat Immunol 3:1097–1101PubMedCrossRef

30.

Munn DH, Zhou M, Attwood JT, Bondarev I, Conway SJ, Marshall B, Brown C, Mellor AL (1998) Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 281:1191–1193PubMedCrossRef

31.

Miwa N, Hayakawa S, Miyazaki S, Myojo S, Sasaki Y, Sakai M, Takikawa O, Saito S (2005) IDO expression on decidual and peripheral blood dendritic cells and monocytes/macrophages after treatment with CTLA-4 or interferon-gamma increase in normal pregnancy but decrease in spontaneous abortion. Mol Hum Reprod 11:865–870PubMedCrossRef

32.

Darrasse-Jeze G, Klatzmann D, Charlotte F, Salomon BL, Cohen JL (2006) CD4⁺CD25⁺ regulatory/suppressor T cells prevent allogeneic fetus rejection in mice. Immunol Lett 102:106–109PubMedCrossRef

33.

Jasper MJ, Tremellen KP, Robertson SA (2006) Primary unexplained infertility is associated with reduced expression of the T-regulatory cell transcription factor Foxp3 in endometrial tissue. Mol Hum Reprod 12:301–308PubMedCrossRef

34.

Venturi GM, Conway RM, Steeber DA, Tedder TF (2007) CD25⁺CD4⁺ regulatory T cell migration requires L-selectin expression: L-selectin transcriptional regulation balances constitutive receptor turnover. J Immunol 178:291–300PubMed

35.

van den Heuvel M, Peralta C, Bashar S, Taylor S, Horrocks J, Croy BA (2005) Trafficking of peripheral blood CD56^bright cells to the decidualizing uterus—new tricks for old dogmas? J Reprod Immunol 67:21–34PubMedCrossRef

36.

Higuma-Myojo S, Sasaki Y, Miyazaki S, Sakai M, Siozaki A, Miwa N, Saito S (2005) Cytokine profile of natural killer cells in early human pregnancy. Am J Reprod Immunol 54:21–29PubMedCrossRef

37.

Lash GE, Schiessl B, Kirkley M, Innes BA, Cooper A, Searle RF, Robson SC, Bulmer JN (2006) Expression of angiogenic growth factors by uterine natural killer cells during early pregnancy. J Leukoc Biol 80:572–580PubMedCrossRef

38.

Levine RJ, Lam C, Qian C, Yu KF, Maynard SE, Sachs BP, Sibai BM, Epstein FH, Romero R, Thadhani R, Karumanchi SA (2006) Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med 355:992–1005PubMedCrossRef

39.

Beilke JN, Kuhl NR, Van Kaer L, Gill RG (2005) NK cells promote islet allograft tolerance via a perforin-dependent mechanism. Nat Med 11:1059–1065PubMedCrossRef

40.

Ranella A, Vassiliadis S, Mastora C, Valentina M, Dionyssopoulou E, Athanassakis I (2005) Constitutive intracellular expression of human leukocyte antigen (HLA)-DQ and HLA-DR but not HLA-DM in trophoblast cells. Hum Immunol 66:43–55PubMedCrossRef

41.

Adams KM, Yan Z, Stevens AM, Nelson JL (2007) The changing maternal “self” hypothesis: a mechanism for maternal tolerance of the fetus. Placenta, DOI 10.1016/j.placenta.2006.07.003

42.

Huppertz B, Kingdom J, Caniggia I, Desoye G, Black S, Korr H, Kaufmann P (2003) Hypoxia favours necrotic versus apoptotic shedding of placental syncytiotrophoblast into the maternal circulation. Placenta 24:181–190PubMedCrossRef

43.

Ebata K, Shimizu Y, Nakayama Y, Minemura M, Murakami J, Kato T, Yasumura S, Takahara T, Sugiyama T, Saito S (2006) Immature NK cells suppress dendritic cell functions during the development of leukemia in a mouse model. J Immunol 176:4113–4124PubMed

44.

Yu G, Xu X, Vu MD, Kilpatrick ED, Li XC (2006) NK cells promote transplant tolerance by killing donor antigen-presenting cells. J Exp Med 203:1851–1858PubMedCrossRef

Titel: Regulatory T cells and regulatory natural killer (NK) cells play important roles in feto-maternal tolerance
verfasst von: Shigeru Saito
Arihiro Shiozaki
Yasushi Sasaki
Akitoshi Nakashima
Tomoko Shima
Mika Ito
Publikationsdatum: 01.06.2007
Verlag: Springer-Verlag
Erschienen in: Seminars in Immunopathology / Ausgabe 2/2007
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-007-0067-2

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

25.04.2024 Allergien und Intoleranzreaktionen Nachrichten

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2007

UNK cells: their role in tissue re-modelling and preeclampsia

Neuroendocrine–immune disequilibrium and endometriosis: an interdisciplinary approach

The role of macrophage migration inhibitory factor in maintaining the immune privilege at the fetal–maternal interface

Neutrophil NETs: a novel contributor to preeclampsia-associated placental hypoxia?

The remission of rheumatoid arthritis during pregnancy