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01.07.2013 | Review

Neutrophils in innate and adaptive immunity

verfasst von: Sébastien Jaillon, Maria Rosaria Galdiero, Davide Del Prete, Marco Antonio Cassatella, Cecilia Garlanda, Alberto Mantovani

Erschienen in: Seminars in Immunopathology | Ausgabe 4/2013

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Abstract

Neutrophils have long been viewed as short-lived cells crucial for the elimination of extracellular pathogens, possessing a limited role in the orchestration of the immune response. This dogma has been challenged by recent lines of evidence demonstrating the expression of an increasing number of cytokines and effector molecules by neutrophils. Moreover, in analogy with their “big brother” macrophages, neutrophils integrate the environmental signals and can be polarized towards an antitumoural or protumoural phenotype. Neutrophils are a major source of humoral fluid phase pattern recognition molecules and thus contribute to the humoral arm of innate immunity. Neutrophils cross talk and shape the maturation and effector functions of other leukocytes in a direct or indirect manner, through cell–cell contact or cytokine production, respectively. Therefore, neutrophils are integrated in the activation and regulation of the innate and adaptive immune system and play an important role in the resolution or exacerbation of diverse pathologies, including infections, chronic inflammation, autoimmunity and cancer.

Borregaard N (2010) Neutrophils, from marrow to microbes. Immunity 33(5):657–670PubMedCrossRef

Mantovani A, Cassatella MA, Costantini C, Jaillon S (2011) Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol 11(8):519–531PubMedCrossRef

Amulic B, Cazalet C, Hayes GL, Metzler KD, Zychlinsky A (2012) Neutrophil function: from mechanisms to disease. Annu Rev Immunol 30:459–489. doi:10.1146/annurev-immunol-020711-074942 PubMedCrossRef

Jaeger BN, Donadieu J, Cognet C, Bernat C, Ordonez-Rueda D et al (2012) Neutrophil depletion impairs natural killer cell maturation, function, and homeostasis. J Exp Med 209(3):565–580. doi:10.1084/jem.20111908 PubMedCrossRef

Costantini C, Calzetti F, Perbellini O, Micheletti A, Scarponi C et al (2011) Human neutrophils interact with both 6-sulfo LacNAc⁺ DC and NK cells to amplify NK-derived IFN{gamma}: role of CD18, ICAM-1, and ICAM-3. Blood 117(5):1677–1686. doi:10.1182/blood-2010-06-287243 PubMedCrossRef

Costantini C, Micheletti A, Calzetti F, Perbellini O, Pizzolo G et al (2010) Neutrophil activation and survival are modulated by interaction with NK cells. Int Immunol 22(10):827–838. doi:10.1093/intimm/dxq434 PubMedCrossRef

Griffin GK, Newton G, Tarrio ML, Bu DX, Maganto-Garcia E et al (2012) IL-17 and TNF-alpha sustain neutrophil recruitment during inflammation through synergistic effects on endothelial activation. J Immunol 188(12):6287–6299. doi:10.4049/jimmunol.1200385 PubMedCrossRef

Cua DJ, Tato CM (2010) Innate IL-17-producing cells: the sentinels of the immune system. Nat Rev Immunol 10(7):479–489PubMedCrossRef

Pelletier M, Maggi L, Micheletti A, Lazzeri E, Tamassia N et al (2010) Evidence for a cross-talk between human neutrophils and Th17 cells. Blood 115(2):335–343. doi:10.1182/blood-2009-04-216085 PubMedCrossRef

10.

Bottazzi B, Doni A, Garlanda C, Mantovani A (2010) An integrated view of humoral innate immunity: pentraxins as a paradigm. Annual Rev Immunol 28:157–183

11.

Takeuchi O, Akira S (2010) Pattern recognition receptors and inflammation. Cell 140(6):805–820PubMedCrossRef

12.

Nathan C (2006) Neutrophils and immunity: challenges and opportunities. Nat Rev Immunol 6(3):173–182PubMedCrossRef

13.

Segal AW (2005) How neutrophils kill microbes. Annu Rev Immunol 23:197–223PubMedCrossRef

14.

Hayashi F, Means TK, Luster AD (2003) Toll-like receptors stimulate human neutrophil function. Blood 102(7):2660–2669PubMedCrossRef

15.

Berger M, Hsieh CY, Bakele M, Marcos V, Rieber N et al (2012) Neutrophils express distinct RNA receptors in a non-canonical way. J Biol Chem 287(23):19409–19417. doi:10.1074/jbc.M112.353557 PubMedCrossRef

16.

Kennedy AD, Willment JA, Dorward DW, Williams DL, Brown GD et al (2007) Dectin-1 promotes fungicidal activity of human neutrophils. Eur J Immunol 37(2):467–478PubMedCrossRef

17.

Kerrigan AM, Dennehy KM, Mourao-Sa D, Faro-Trindade I, Willment JA et al (2009) CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils. J Immunol 182(7):4150–4157PubMedCrossRef

18.

Lee WB, Kang JS, Yan JJ, Lee MS, Jeon BY et al (2012) Neutrophils promote mycobacterial trehalose dimycolate-induced lung inflammation via the mincle pathway. PLoS Pathog 8(4):e1002614. doi:10.1371/journal.ppat.1002614 PubMedCrossRef

19.

Graham LM, Gupta V, Schafer G, Reid DM, Kimberg M et al (2012) The C-type lectin receptor CLECSF8 (CLEC4D) is expressed by myeloid cells and triggers cellular activation through Syk kinase. J Biol Chem 287(31):25964–25974. doi:10.1074/jbc.M112.384164 PubMedCrossRef

20.

Clarke TB, Davis KM, Lysenko ES, Zhou AY, Yu Y et al (2010) Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity. Nat Med 16(2):228–231PubMedCrossRef

21.

Tamassia N, Bazzoni F, Le Moigne V, Calzetti F, Masala C et al (2012) IFN-beta expression is directly activated in human neutrophils transfected with plasmid DNA and is further increased via TLR-4-mediated signaling. J Immunol 189(3):1500–1509. doi:10.4049/jimmunol.1102985 PubMedCrossRef

22.

Tamassia N, Le Moigne V, Rossato M, Donini M, McCartney S et al (2008) Activation of an immunoregulatory and antiviral gene expression program in poly(I:C)-transfected human neutrophils. J Immunol 181(9):6563–6573PubMed

23.

Greenblatt MB, Aliprantis A, Hu B, Glimcher LH (2010) Calcineurin regulates innate antifungal immunity in neutrophils. J Exp Med 207(5):923–931PubMedCrossRef

24.

Mankan AK, Dau T, Jenne D, Hornung V (2012) The NLRP3/ASC/Caspase-1 axis regulates IL-1beta processing in neutrophils. Eur J Immunol 42(3):710–715. doi:10.1002/eji.201141921 PubMedCrossRef

25.

Anand PK, Malireddi RK, Lukens JR, Vogel P, Bertin J et al (2012) NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens. Nature 488(7411):389–393. doi:10.1038/nature11250 PubMedCrossRef

26.

Tamassia N, Le Moigne V, Calzetti F, Donini M, Gasperini S et al (2007) The MyD88-independent pathway is not mobilized in human neutrophils stimulated via TLR4. J Immunol 178(11):7344–7356PubMed

27.

Liu X, Ma B, Malik AB, Tang H, Yang T et al (2012) Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases. Nat Immunol 13(5):457–464. doi:10.1038/ni.2258 PubMedCrossRef

28.

McDonald B, Pittman K, Menezes GB, Hirota SA, Slaba I et al (2010) Intravascular danger signals guide neutrophils to sites of sterile inflammation. Science (New York, NY) 330(6002):362–366. doi:10.1126/science.1195491 CrossRef

29.

Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T et al (2010) Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 464(7285):104–107PubMedCrossRef

30.

Jaillon S, Peri G, Delneste Y, Fremaux I, Doni A et al (2007) The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps. J Exp Med 204(4):793–804PubMedCrossRef

31.

Moalli F, Jaillon S, Inforzato A, Sironi M, Bottazzi B et al (2011) Pathogen recognition by the long pentraxin PTX3. J Biomed Biotechnol 2011:830421PubMedCrossRef

32.

Moalli F, Doni A, Deban L, Zelante T, Zagarella S et al (2010) Role of complement and Fc{gamma} receptors in the protective activity of the long pentraxin PTX3 against Aspergillus fumigatus. Blood 116(24):5170–5180PubMedCrossRef

33.

Jaillon S, Jeannin P, Hamon Y, Fremaux I, Doni A et al (2009) Endogenous PTX3 translocates at the membrane of late apoptotic human neutrophils and is involved in their engulfment by macrophages. Cell Death Differ 16(3):465–474PubMedCrossRef

34.

Deban L, Russo RC, Sironi M, Moalli F, Scanziani M et al (2010) Regulation of leukocyte recruitment by the long pentraxin PTX3. Nat Immunol 11(4):328–334PubMedCrossRef

35.

Dziarski R, Platt KA, Gelius E, Steiner H, Gupta D (2003) Defect in neutrophil killing and increased susceptibility to infection with nonpathogenic Gram-positive bacteria in peptidoglycan recognition protein-S (PGRP-S)-deficient mice. Blood 102(2):689–697PubMedCrossRef

36.

Rorvig S, Honore C, Larsson LI, Ohlsson S, Pedersen CC et al (2009) Ficolin-1 is present in a highly mobilizable subset of human neutrophil granules and associates with the cell surface after stimulation with fMLP. J Leukoc Biol 86(6):1439–1449PubMedCrossRef

37.

Cho JH, Fraser IP, Fukase K, Kusumoto S, Fujimoto Y et al (2005) Human peptidoglycan recognition protein S is an effector of neutrophil-mediated innate immunity. Blood 106(7):2551–2558PubMedCrossRef

38.

Kashyap DR, Wang M, Liu LH, Boons GJ, Gupta D et al (2011) Peptidoglycan recognition proteins kill bacteria by activating protein-sensing two-component systems. Nat Med 17(6):676–683. doi:10.1038/nm.2357 PubMedCrossRef

39.

Moreno-Amaral AN, Gout E, Danella-Polli C, Tabarin F, Lesavre P et al (2012) M-ficolin and leukosialin (CD43): new partners in neutrophil adhesion. J Leukoc Biol 91(3):469–474. doi:10.1189/jlb.0911460 PubMedCrossRef

40.

Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y et al (2004) Neutrophil extracellular traps kill bacteria. Science (New York, NY) 303(5663):1532–1535CrossRef

41.

Yousefi S, Mihalache C, Kozlowski E, Schmid I, Simon HU (2009) Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps. Cell Death Differ 16(11):1438–1444PubMedCrossRef

42.

Saitoh T, Komano J, Saitoh Y, Misawa T, Takahama M et al (2012) Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1. Cell Host Microbe 12(1):109–116. doi:10.1016/j.chom.2012.05.015 PubMedCrossRef

43.

Douda DN, Jackson R, Grasemann H, Palaniyar N (2011) Innate immune collectin surfactant protein D simultaneously binds both neutrophil extracellular traps and carbohydrate ligands and promotes bacterial trapping. J Immunol 187(4):1856–1865. doi:10.4049/jimmunol.1004201 PubMedCrossRef

44.

Menegazzi R, Decleva E, Dri P (2012) Killing by neutrophil extracellular traps: fact or folklore? Blood 119(5):1214–1216. doi:10.1182/blood-2011-07-364604 PubMedCrossRef

45.

Parker H, Albrett AM, Kettle AJ, Winterbourn CC (2012) Myeloperoxidase associated with neutrophil extracellular traps is active and mediates bacterial killing in the presence of hydrogen peroxide. J Leukoc Biol 91(3):369–376. doi:10.1189/jlb.0711387 PubMedCrossRef

46.

Yipp BG, Petri B, Salina D, Jenne CN, Scott BN et al (2012) Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo. Nat Med 18:1386–1393. doi:10.1038/nm.2847 PubMedCrossRef

47.

Hakkim A, Fuchs TA, Martinez NE, Hess S, Prinz H et al (2011) Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation. Nat Chem Biol 7(2):75–77PubMedCrossRef

48.

McInturff AM, Cody MJ, Elliott EA, Glenn JW, Rowley JW et al (2012) Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1 alpha. Blood 120:3118–3125. doi:10.1182/blood-2012-01-405993 PubMedCrossRef

49.

Fuchs TA, Abed U, Goosmann C, Hurwitz R, Schulze I et al (2007) Novel cell death program leads to neutrophil extracellular traps. J Cell Biol 176(2):231–241PubMedCrossRef

50.

Remijsen Q, Vanden Berghe T, Wirawan E, Asselbergh B, Parthoens E et al (2011) Neutrophil extracellular trap cell death requires both autophagy and superoxide generation. Cell Res 21(2):290–304PubMedCrossRef

51.

Li P, Li M, Lindberg MR, Kennett MJ, Xiong N et al (2010) PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps. J Exp Med 207(9):1853–1862PubMedCrossRef

52.

Papayannopoulos V, Metzler KD, Hakkim A, Zychlinsky A (2010) Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps. J Cell Biol 191(3):677–691PubMedCrossRef

53.

Metzler KD, Fuchs TA, Nauseef WM, Reumaux D, Roesler J et al (2011) Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity. Blood 117(3):953–959PubMedCrossRef

54.

Marcos V, Nussbaum C, Vitkov L, Hector A, Wiedenbauer EM et al (2009) Delayed but functional neutrophil extracellular trap formation in neonates. Blood 114(23):4908–4911, author reply 4911–4902PubMedCrossRef

55.

Yost CC, Cody MJ, Harris ES, Thornton NL, McInturff AM et al (2009) Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates. Blood 113(25):6419–6427PubMedCrossRef

56.

Gabriel C, McMaster WR, Girard D, Descoteaux A (2010) Leishmania donovani promastigotes evade the antimicrobial activity of neutrophil extracellular traps. J Immunol 185(7):4319–4327PubMedCrossRef

57.

Wartha F, Beiter K, Albiger B, Fernebro J, Zychlinsky A et al (2007) Capsule and d-alanylated lipoteichoic acids protect Streptococcus pneumoniae against neutrophil extracellular traps. Cell Microbiol 9(5):1162–1171PubMedCrossRef

58.

Beiter K, Wartha F, Albiger B, Normark S, Zychlinsky A et al (2006) An endonuclease allows Streptococcus pneumoniae to escape from neutrophil extracellular traps. Curr Biol 16(4):401–407PubMedCrossRef

59.

Buchanan JT, Simpson AJ, Aziz RK, Liu GY, Kristian SA et al (2006) DNase expression allows the pathogen group A Streptococcus to escape killing in neutrophil extracellular traps. Curr Biol 16(4):396–400PubMedCrossRef

60.

Young RL, Malcolm KC, Kret JE, Caceres SM, Poch KR et al (2011) Neutrophil extracellular trap (NET)-mediated killing of Pseudomonas aeruginosa: evidence of acquired resistance within the CF airway, independent of CFTR. PLoS One 6(9):e23637. doi:10.1371/journal.pone.0023637 PubMedCrossRef

61.

Cassatella MA (1999) Neutrophil-derived proteins: selling cytokines by the pound. Adv Immunol 73:369–509PubMedCrossRef

62.

Guma M, Ronacher L, Liu-Bryan R, Takai S, Karin M et al (2009) Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation. Arthritis Rheum 60(12):3642–3650. doi:10.1002/art.24959 PubMedCrossRef

63.

Rinchai D, Khaenam P, Kewcharoenwong C, Buddhisa S, Pankla R et al (2012) Production of interleukin-27 by human neutrophils regulates their function during bacterial infection. Eur J Immunol 42:3280–3290. doi:10.1002/eji.201242526 PubMedCrossRef

64.

Scapini P, Bazzoni F, Cassatella MA (2008) Regulation of B-cell-activating factor (BAFF)/B lymphocyte stimulator (BLyS) expression in human neutrophils. Immunol Lett 116(1):1–6. doi:10.1016/j.imlet.2007.11.009 PubMedCrossRef

65.

Puga I, Cols M, Barra CM, He B, Cassis L et al (2012) B cell-helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen. Nat Immunol 13(2):170–180. doi:10.1038/ni.2194 CrossRef

66.

Lefrancais E, Roga S, Gautier V, Gonzalez-de-Peredo A, Monsarrat B et al (2012) IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G. Proc Natl Acad Sci U S A 109(5):1673–1678. doi:10.1073/pnas.1115884109 PubMedCrossRef

67.

Benabid R, Wartelle J, Malleret L, Guyot N, Gangloff S et al (2012) Neutrophil elastase modulates cytokine expression: contribution to host defense against Pseudomonas aeruginosa-induced pneumonia. J Biol Chem 287:34883–34894. doi:10.1074/jbc.M112.361352 PubMedCrossRef

68.

Lin AM, Rubin CJ, Khandpur R, Wang JY, Riblett M et al (2011) Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis. J Immunol 187(1):490–500. doi:10.4049/jimmunol.1100123 PubMedCrossRef

69.

Moran EM, Heydrich R, Ng CT, Saber TP, McCormick J et al (2011) IL-17A expression is localised to both mononuclear and polymorphonuclear synovial cell infiltrates. PLoS One 6(8):e24048. doi:10.1371/journal.pone.0024048 PubMedCrossRef

70.

Cassatella MA, Locati M, Mantovani A (2009) Never underestimate the power of a neutrophil. Immunity 31(5):698–700PubMedCrossRef

71.

De Santo C, Arscott R, Booth S, Karydis I, Jones M et al (2010) Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A. Nat Immunol 11(11):1039–1046PubMedCrossRef

72.

Davey MS, Tamassia N, Rossato M, Bazzoni F, Calzetti F et al (2011) Failure to detect production of IL-10 by activated human neutrophils. Nat Immunol 12(11):1017–1018. doi:10.1038/ni.2111, author reply 1018–1020PubMedCrossRef

73.

Tsuda Y, Takahashi H, Kobayashi M, Hanafusa T, Herndon DN et al (2004) Three different neutrophil subsets exhibited in mice with different susceptibilities to infection by methicillin-resistant Staphylococcus aureus. Immunity 21(2):215–226PubMedCrossRef

74.

Zhang X, Majlessi L, Deriaud E, Leclerc C, Lo-Man R (2009) Coactivation of Syk kinase and MyD88 adaptor protein pathways by bacteria promotes regulatory properties of neutrophils. Immunity 31(5):761–771. doi:10.1016/j.immuni.2009.09.016 PubMedCrossRef

75.

Tosello Boari J, Amezcua Vesely MC, Bermejo DA, Ramello MC, Montes CL et al (2012) IL-17RA signaling reduces inflammation and mortality during Trypanosoma cruzi infection by recruiting suppressive IL-10-producing neutrophils. PLoS Pathog 8(4):e1002658. doi:10.1371/journal.ppat.1002658 PubMedCrossRef

76.

Tamassia N, Zimmermann M, Castellucci M, Ostuni R, Bruderek K et al (2013) Cutting edge: an inactive chromatin configuration at the IL-10 locus in human neutrophils. J Immunol 190:1921–1925. doi:10.4049/jimmunol.1203022 PubMedCrossRef

77.

Colotta F, Re F, Polentarutti N, Sozzani S, Mantovani A (1992) Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products. Blood 80(8):2012–2020PubMed

78.

Brandau S, Jakob M, Hemeda H, Bruderek K, Janeschik S et al (2010) Tissue-resident mesenchymal stem cells attract peripheral blood neutrophils and enhance their inflammatory activity in response to microbial challenge. J Leukoc Biol 88(5):1005–1015. doi:10.1189/jlb.0410207 PubMedCrossRef

79.

Cassatella MA, Mosna F, Micheletti A, Lisi V, Tamassia N et al. (2011) Toll-like receptor-3-activated human mesenchymal stromal cells significantly prolong the survival and function of neutrophils. Stem Cells 29:1001–1011

80.

van Gisbergen KP, Ludwig IS, Geijtenbeek TB, van Kooyk Y (2005) Interactions of DC-SIGN with Mac-1 and CEACAM1 regulate contact between dendritic cells and neutrophils. FEBS Lett 579(27):6159–6168PubMedCrossRef

81.

van Gisbergen KP, Sanchez-Hernandez M, Geijtenbeek TB, van Kooyk Y (2005) Neutrophils mediate immune modulation of dendritic cells through glycosylation-dependent interactions between Mac-1 and DC-SIGN. J Exp Med 201(8):1281–1292PubMedCrossRef

82.

Bennouna S, Bliss SK, Curiel TJ, Denkers EY (2003) Cross-talk in the innate immune system: neutrophils instruct recruitment and activation of dendritic cells during microbial infection. J Immunol 171(11):6052–6058PubMed

83.

Eken C, Gasser O, Zenhaeusern G, Oehri I, Hess C et al (2008) Polymorphonuclear neutrophil-derived ectosomes interfere with the maturation of monocyte-derived dendritic cells. J Immunol 180(2):817–824PubMed

84.

Gasser O, Schifferli JA (2004) Activated polymorphonuclear neutrophils disseminate anti-inflammatory microparticles by ectocytosis. Blood 104(8):2543–2548. doi:10.1182/blood-2004-01-0361 PubMedCrossRef

85.

Davey MS, Lin CY, Roberts GW, Heuston S, Brown AC et al (2011) Human neutrophil clearance of bacterial pathogens triggers anti-microbial gammadelta T cell responses in early infection. PLoS Pathog 7(5):e1002040. doi:10.1371/journal.ppat.1002040 PubMedCrossRef

86.

Himmel ME, Crome SQ, Ivison S, Piccirillo C, Steiner TS et al (2011) Human CD4⁺FOXP3⁺ regulatory T cells produce CXCL8 and recruit neutrophils. Eur J Immunol 41(2):306–312. doi:10.1002/eji.201040459 PubMedCrossRef

87.

Pelletier M, Micheletti A, Cassatella MA (2010) Modulation of human neutrophil survival and antigen expression by activated CD4⁺ and CD8⁺ T cells. J Leukoc Biol 88(6):1163–1170. doi:10.1189/jlb.0310172 PubMedCrossRef

88.

Abadie V, Badell E, Douillard P, Ensergueix D, Leenen PJ et al (2005) Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes. Blood 106(5):1843–1850. doi:10.1182/blood-2005-03-1281 PubMedCrossRef

89.

Abi Abdallah DS, Egan CE, Butcher BA, Denkers EY (2011) Mouse neutrophils are professional antigen-presenting cells programmed to instruct Th1 and Th17 T-cell differentiation. Int Immunol 23(5):317–326PubMedCrossRef

90.

Beauvillain C, Cunin P, Doni A, Scotet M, Jaillon S et al (2011) CCR7 is involved in the migration of neutrophils to lymph nodes. Blood 117(4):1196–1204. doi:10.1182/blood-2009-11-254490 PubMedCrossRef

91.

Beauvillain C, Delneste Y, Scotet M, Peres A, Gascan H et al (2007) Neutrophils efficiently cross-prime naive T cells in vivo. Blood 110(8):2965–2973PubMedCrossRef

92.

Chtanova T, Schaeffer M, Han SJ, van Dooren GG, Nollmann M et al (2008) Dynamics of neutrophil migration in lymph nodes during infection. Immunity 29(3):487–496. doi:10.1016/j.immuni.2008.07.012 PubMedCrossRef

93.

Yang CW, Strong BS, Miller MJ, Unanue ER (2010) Neutrophils influence the level of antigen presentation during the immune response to protein antigens in adjuvants. J Immunol 185(5):2927–2934. doi:10.4049/jimmunol.1001289 PubMedCrossRef

94.

Alfaro C, Suarez N, Onate C, Perez-Gracia JL, Martinez-Forero I et al (2011) Dendritic cells take up and present antigens from viable and apoptotic polymorphonuclear leukocytes. PLoS One 6(12):e29300. doi:10.1371/journal.pone.0029300 PubMedCrossRef

95.

Morel C, Badell E, Abadie V, Robledo M, Setterblad N et al (2008) Mycobacterium bovis BCG-infected neutrophils and dendritic cells cooperate to induce specific T cell responses in humans and mice. Eur J Immunol 38(2):437–447. doi:10.1002/eji.200737905 PubMedCrossRef

96.

Blomgran R, Ernst JD (2011) Lung neutrophils facilitate activation of naive antigen-specific CD4⁺ T cells during Mycobacterium tuberculosis infection. J Immunol 186(12):7110–7119. doi:10.4049/jimmunol.1100001 PubMedCrossRef

97.

Blomgran R, Desvignes L, Briken V, Ernst JD (2012) Mycobacterium tuberculosis inhibits neutrophil apoptosis, leading to delayed activation of naive CD4 T cells. Cell Host Microbe 11(1):81–90. doi:10.1016/j.chom.2011.11.012 PubMedCrossRef

98.

Ordonez-Rueda D, Jonsson F, Mancardi DA, Zhao W, Malzac A et al (2012) A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia. Eur J Immunol 42(9):2395–2408. doi:10.1002/eji.201242589 PubMedCrossRef

99.

Costantini C, Cassatella MA (2011) The defensive alliance between neutrophils and NK cells as a novel arm of innate immunity. J Leukoc Biol 89(2):221–233. doi:10.1189/jlb.0510250 PubMedCrossRef

100.

Bhatnagar N, Hong HS, Krishnaswamy JK, Haghikia A, Behrens GM et al (2010) Cytokine-activated NK cells inhibit PMN apoptosis and preserve their functional capacity. Blood 116(8):1308–1316. doi:10.1182/blood-2010-01-264903 PubMedCrossRef

101.

Thoren FB, Riise RE, Ousback J, Della Chiesa M, Alsterholm M et al (2012) Human NK cells induce neutrophil apoptosis via an NKp46- and Fas-dependent mechanism. J Immunol 188(4):1668–1674. doi:10.4049/jimmunol.1102002 PubMedCrossRef

102.

Michel ML, Keller AC, Paget C, Fujio M, Trottein F et al (2007) Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia. J Exp Med 204(5):995–1001. doi:10.1084/jem.20061551 PubMedCrossRef

103.

Emoto M, Emoto Y, Yoshizawa I, Kita E, Shimizu T et al (2010) Alpha-GalCer ameliorates listeriosis by accelerating infiltration of Gr-1⁺ cells into the liver. Eur J Immunol 40(5):1328–1341. doi:10.1002/eji.200939594 PubMedCrossRef

104.

Wintermeyer P, Cheng CW, Gehring S, Hoffman BL, Holub M et al (2009) Invariant natural killer T cells suppress the neutrophil inflammatory response in a mouse model of cholestatic liver damage. Gastroenterology 136(3):1048–1059. doi:10.1053/j.gastro.2008.10.027 PubMedCrossRef

105.

Wingender G, Hiss M, Engel I, Peukert K, Ley K et al (2012) Neutrophilic granulocytes modulate invariant NKT cell function in mice and humans. J Immunol 188(7):3000–3008. doi:10.4049/jimmunol.1101273 PubMedCrossRef

106.

Cassatella MA (2006) On the production of TNF-related apoptosis-inducing ligand (TRAIL/Apo-2L) by human neutrophils. J Leukoc Biol 79(6):1140–1149. doi:10.1189/jlb.1005558 PubMedCrossRef

107.

McGrath EE, Marriott HM, Lawrie A, Francis SE, Sabroe I et al (2011) TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation. J Leukoc Biol 90(5):855–865. doi:10.1189/jlb.0211062 PubMedCrossRef

108.

Conway KL, Goel G, Sokol H, Manocha M, Mizoguchi E et al (2012) p40phox expression regulates neutrophil recruitment and function during the resolution phase of intestinal inflammation. J Immunol 189(7):3631–3640. doi:10.4049/jimmunol.1103746 PubMedCrossRef

109.

Serhan CN, Chiang N, Van Dyke TE (2008) Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol 8(5):349–361PubMedCrossRef

110.

Chiang N, Fredman G, Backhed F, Oh SF, Vickery T et al (2012) Infection regulates pro-resolving mediators that lower antibiotic requirements. Nature 484(7395):524–528. doi:10.1038/nature11042 PubMedCrossRef

111.

Spite M, Norling LV, Summers L, Yang R, Cooper D et al (2009) Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature 461(7268):1287–1291. doi:10.1038/nature08541 PubMedCrossRef

112.

Krishnamoorthy S, Recchiuti A, Chiang N, Yacoubian S, Lee CH et al (2010) Resolvin D1 binds human phagocytes with evidence for proresolving receptors. Proc Natl Acad Sci U S A 107(4):1660–1665PubMedCrossRef

113.

Arita M, Ohira T, Sun YP, Elangovan S, Chiang N et al (2007) Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation. J Immunol 178(6):3912–3917PubMed

114.

Serhan CN, Yang R, Martinod K, Kasuga K, Pillai PS et al (2009) Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions. J Exp Med 206(1):15–23. doi:10.1084/jem.20081880 PubMedCrossRef

115.

Oh SF, Pillai PS, Recchiuti A, Yang R, Serhan CN (2011) Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation. J Clin Invest 121(2):569–581. doi:10.1172/JCI42545 PubMedCrossRef

116.

Jeannin P, Jaillon S, Delneste Y (2008) Pattern recognition receptors in the immune response against dying cells. Curr Opin Immunol 20(5):530–537PubMedCrossRef

117.

Filardy AA, Pires DR, Nunes MP, Takiya CM, Freire-de-Lima CG et al (2010) Proinflammatory clearance of apoptotic neutrophils induces an IL-12(low)IL-10(high) regulatory phenotype in macrophages. J Immunol 185(4):2044–2050PubMedCrossRef

118.

Dalli J, Serhan C (2012) Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators. Blood 120:e60–e72. doi:10.1182/blood-2012-04-423525 PubMedCrossRef

119.

El Kebir D, Gjorstrup P, Filep JG (2012) Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation. Proc Natl Acad Sci U S A 109(37):14983–14988. doi:10.1073/pnas.1206641109 PubMedCrossRef

120.

Ren Y, Xie Y, Jiang G, Fan J, Yeung J et al (2008) Apoptotic cells protect mice against lipopolysaccharide-induced shock. J Immunol 180(7):4978–4985PubMed

121.

Ariel A, Fredman G, Sun YP, Kantarci A, Van Dyke TE et al (2006) Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression. Nat Immunol 7(11):1209–1216PubMedCrossRef

122.

Cassatella MA, Meda L, Gasperini S, Calzetti F, Bonora S (1994) Interleukin 10 (IL-10) upregulates IL-1 receptor antagonist production from lipopolysaccharide-stimulated human polymorphonuclear leukocytes by delaying mRNA degradation. J Exp Med 179(5):1695–1699PubMedCrossRef

123.

Bourke E, Cassetti A, Villa A, Fadlon E, Colotta F et al (2003) IL-1 beta scavenging by the type II IL-1 decoy receptor in human neutrophils. J Immunol 170(12):5999–6005PubMed

124.

Steinwede K, Maus R, Bohling J, Voedisch S, Braun A et al (2012) Cathepsin G and neutrophil elastase contribute to lung-protective immunity against mycobacterial infections in mice. J Immunol 188(9):4476–4487. doi:10.4049/jimmunol.1103346 PubMedCrossRef

125.

Berry MP, Graham CM, McNab FW, Xu Z, Bloch SA et al (2010) An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis. Nature 466(7309):973–977. doi:10.1038/nature09247 PubMedCrossRef

126.

Nandi B, Behar SM (2011) Regulation of neutrophils by interferon-gamma limits lung inflammation during tuberculosis infection. J Exp Med 208(11):2251–2262. doi:10.1084/jem.20110919 PubMedCrossRef

127.

Fridlender ZG, Albelda SM (2012) Tumor-associated neutrophils: friend or foe? Carcinogenesis 33(5):949–955. doi:10.1093/carcin/bgs123 PubMedCrossRef

128.

Trevelin SC, Alves-Filho JC, Sonego F, Turato W, Nascimento DC et al (2012) Toll-like receptor 9 activation in neutrophils impairs chemotaxis and reduces sepsis outcome. Crit Care Med 40(9):2631–2637. doi:10.1097/CCM.0b013e318258fb70 PubMedCrossRef

129.

Alves-Filho JC, Sonego F, Souto FO, Freitas A, Verri WA Jr et al (2010) Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection. Nat Med 16(6):708–712PubMedCrossRef

130.

Le HT, Tran VG, Kim W, Kim J, Cho HR et al (2012) IL-33 priming regulates multiple steps of the neutrophil-mediated anti-Candida albicans response by modulating TLR and dectin-1 signals. J Immunol 189(1):287–295. doi:10.4049/jimmunol.1103564 PubMedCrossRef

131.

Bian Z, Guo Y, Ha B, Zen K, Liu Y (2012) Regulation of the inflammatory response: enhancing neutrophil infiltration under chronic inflammatory conditions. J Immunol 188(2):844–853. doi:10.4049/jimmunol.1101736 PubMedCrossRef

132.

Braber S, Thio M, Blokhuis BR, Henricks PA, Koelink PJ et al (2012) An association between neutrophils and immunoglobulin free light chains in the pathogenesis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 185(8):817–824. doi:10.1164/rccm.201104-0761OC PubMedCrossRef

133.

Snelgrove RJ, Jackson PL, Hardison MT, Noerager BD, Kinloch A et al (2010) A critical role for LTA₄H in limiting chronic pulmonary neutrophilic inflammation. Science (New York, NY) 330(6000):90–94. doi:10.1126/science.1190594 CrossRef

134.

Weathington NM, van Houwelingen AH, Noerager BD, Jackson PL, Kraneveld AD et al (2006) A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation. Nat Med 12(3):317–323. doi:10.1038/nm1361 PubMedCrossRef

135.

Gaggar A, Jackson PL, Noerager BD, O'Reilly PJ, McQuaid DB et al (2008) A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation. J Immunol 180(8):5662–5669PubMed

136.

Corti A, Franzini M, Cianchetti S, Bergamini G, Lorenzini E et al (2012) Contribution by polymorphonucleate granulocytes to elevated gamma-glutamyltransferase in cystic fibrosis sputum. PLoS One 7(4):e34772. doi:10.1371/journal.pone.0034772 PubMedCrossRef

137.

Bennett L, Palucka AK, Arce E, Cantrell V, Borvak J et al (2003) Interferon and granulopoiesis signatures in systemic lupus erythematosus blood. J Exp Med 197(6):711–723PubMedCrossRef

138.

Hakkim A, Furnrohr BG, Amann K, Laube B, Abed UA et al (2010) Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis. Proc Natl Acad Sci U S A 107(21):9813–9818PubMedCrossRef

139.

Leffler J, Martin M, Gullstrand B, Tyden H, Lood C et al (2012) Neutrophil extracellular traps that are not degraded in systemic lupus erythematosus activate complement exacerbating the disease. J Immunol 188(7):3522–3531. doi:10.4049/jimmunol.1102404 PubMedCrossRef

140.

Villanueva E, Yalavarthi S, Berthier CC, Hodgin JB, Khandpur R et al (2011) Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus. J Immunol 187(1):538–552. doi:10.4049/jimmunol.1100450 PubMedCrossRef

141.

Garcia-Romo GS, Caielli S, Vega B, Connolly J, Allantaz F et al (2011) Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus. Sci Transl Med 3(73):73ra20. doi:10.1126/scitranslmed.3001201 PubMedCrossRef

142.

Lande R, Ganguly D, Facchinetti V, Frasca L, Conrad C et al (2011) Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus. Sci Transl Med 3(73):73ra19. doi:10.1126/scitranslmed.3001180 PubMedCrossRef

143.

Dwivedi N, Upadhyay J, Neeli I, Khan S, Pattanaik D et al (2012) Felty’s syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps. Arthritis Rheum 64(4):982–992. doi:10.1002/art.33432 PubMedCrossRef

144.

Denny MF, Yalavarthi S, Zhao W, Thacker SG, Anderson M et al (2010) A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I IFNs. J Immunol 184(6):3284–3297. doi:10.4049/jimmunol.0902199 PubMedCrossRef

145.

Gomez-Puerta JA, Bosch X (2009) Anti-neutrophil cytoplasmic antibody pathogenesis in small-vessel vasculitis: an update. Am J Pathol 175(5):1790–1798PubMedCrossRef

146.

Clark SR, Ma AC, Tavener SA, McDonald B, Goodarzi Z et al (2007) Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat Med 13(4):463–469PubMedCrossRef

147.

Xu J, Zhang X, Pelayo R, Monestier M, Ammollo CT et al (2009) Extracellular histones are major mediators of death in sepsis. Nat Med 15(11):1318–1321PubMedCrossRef

148.

4Saffarzadeh M, Juenemann C, Queisser MA, Lochnit G, Barreto G et al (2012) Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones. PLoS One 7(2):e32366. doi:10.1371/journal.pone.0032366 PubMedCrossRef

149.

Kessenbrock K, Krumbholz M, Schonermarck U, Back W, Gross WL et al (2009) Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med 15(6):623–625PubMedCrossRef

150.

Hidalgo A, Chang J, Jang JE, Peired AJ, Chiang EY et al (2009) Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury. Nat Med 15(4):384–391. doi:10.1038/nm.1939 PubMedCrossRef

151.

Caudrillier A, Looney MR (2012) Platelet–neutrophil interactions as a target for prevention and treatment of transfusion-related acute lung injury. Curr Pharm Des 18(22):3260–3266PubMedCrossRef

152.

Thomas GM, Carbo C, Curtis BR, Martinod K, Mazo IB et al (2012) Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice. Blood 119(26):6335–6343. doi:10.1182/blood-2012-01-405183 PubMedCrossRef

153.

Massberg S, Grahl L, von Bruehl ML, Manukyan D, Pfeiler S et al (2010) Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases. Nat Med 16(8):887–896. doi:10.1038/nm.2184 PubMedCrossRef

154.

Fuchs TA, Brill A, Duerschmied D, Schatzberg D, Monestier M et al (2010) Extracellular DNA traps promote thrombosis. Proc Natl Acad Sci U S A 107(36):15880–15885PubMedCrossRef

155.

Demers M, Krause DS, Schatzberg D, Martinod K, Voorhees JR et al (2012) Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis. Proc Natl Acad Sci U S A 109(32):13076–13081. doi:10.1073/pnas.1200419109 PubMedCrossRef

156.

Brill A, Fuchs TA, Savchenko AS, Thomas GM, Martinod K et al (2012) Neutrophil extracellular traps promote deep vein thrombosis in mice. J Thromb Haemost 10(1):136–144. doi:10.1111/j.1538-7836.2011.04544.x PubMedCrossRef

157.

Chou RC, Kim ND, Sadik CD, Seung E, Lan Y et al (2010) Lipid–cytokine–chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis. Immunity 33(2):266–278. doi:10.1016/j.immuni.2010.07.018 PubMedCrossRef

158.

Wang JX, Bair AM, King SL, Shnayder R, Huang YF et al (2012) Ly6G ligation blocks recruitment of neutrophils via a beta2-integrin-dependent mechanism. Blood 120(7):1489–1498. doi:10.1182/blood-2012-01-404046 PubMedCrossRef

159.

Elliott ER, Van Ziffle JA, Scapini P, Sullivan BM, Locksley RM et al (2011) Deletion of Syk in neutrophils prevents immune complex arthritis. J Immunol 187(8):4319–4330. doi:10.4049/jimmunol.1100341 PubMedCrossRef

160.

Liu L, Belkadi A, Darnall L, Hu T, Drescher C et al (2010) CXCR2-positive neutrophils are essential for cuprizone-induced demyelination: relevance to multiple sclerosis. Nat Neurosci 13(3):319–326. doi:10.1038/nn.2491 PubMedCrossRef

161.

Carlson T, Kroenke M, Rao P, Lane TE, Segal B (2008) The Th17-ELR⁺ CXC chemokine pathway is essential for the development of central nervous system autoimmune disease. J Exp Med 205(4):811–823. doi:10.1084/jem.20072404 PubMedCrossRef

162.

Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646–674. doi:10.1016/j.cell.2011.02.013 PubMedCrossRef

163.

Sica A, Mantovani A (2012) Macrophage plasticity and polarization: in vivo veritas. J Clin Invest 122(3):787–795. doi:10.1172/JCI59643 PubMedCrossRef

164.

Kuang DM, Zhao Q, Wu Y, Peng C, Wang J et al. (2011) Peritumoral neutrophils link inflammatory response to disease progression by fostering angiogenesis in hepatocellular carcinoma. J Hepatol 54:948–955

165.

Jensen HK, Donskov F, Marcussen N, Nordsmark M, Lundbeck F et al (2009) Presence of intratumoral neutrophils is an independent prognostic factor in localized renal cell carcinoma. J Clin Oncol 27(28):4709–4717PubMedCrossRef

166.

Wislez M, Rabbe N, Marchal J, Milleron B, Crestani B et al (2003) Hepatocyte growth factor production by neutrophils infiltrating bronchioloalveolar subtype pulmonary adenocarcinoma: role in tumor progression and death. Cancer Res 63(6):1405–1412PubMed

167.

Bellocq A, Antoine M, Flahault A, Philippe C, Crestani B et al (1998) Neutrophil alveolitis in bronchioloalveolar carcinoma: induction by tumor-derived interleukin-8 and relation to clinical outcome. Am J Pathol 152(1):83–92PubMed

168.

Rao HL, Chen JW, Li M, Xiao YB, Fu J et al (2012) Increased intratumoral neutrophil in colorectal carcinomas correlates closely with malignant phenotype and predicts patients’ adverse prognosis. PLoS One 7(1):e30806. doi:10.1371/journal.pone.0030806 PubMedCrossRef

169.

Trellakis S, Bruderek K, Dumitru CA, Gholaman H, Gu X et al (2011) Polymorphonuclear granulocytes in human head and neck cancer: enhanced inflammatory activity, modulation by cancer cells and expansion in advanced disease. Int J Cancer 129(9):2183–2193. doi:10.1002/ijc.25892 PubMedCrossRef

170.

Caruso RA, Bellocco R, Pagano M, Bertoli G, Rigoli L et al (2002) Prognostic value of intratumoral neutrophils in advanced gastric carcinoma in a high-risk area in northern Italy. Mod Pathol 15(8):831–837. doi:10.1097/01.MP.0000020391.98998.6B PubMedCrossRef

171.

Huh SJ, Liang S, Sharma A, Dong C, Robertson GP (2010) Transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis development. Cancer Res 70(14):6071–6082PubMedCrossRef

172.

Fridlender ZG, Sun J, Kim S, Kapoor V, Cheng G et al (2009) Polarization of tumor-associated neutrophil phenotype by TGF-beta: “N1” versus “N2” TAN. Cancer Cell 16(3):183–194PubMedCrossRef

173.

Keeley EC, Mehrad B, Strieter RM (2010) CXC chemokines in cancer angiogenesis and metastases. Adv Cancer Res 106:91–111PubMedCrossRef

174.

Ijichi H, Chytil A, Gorska AE, Aakre ME, Bierie B et al (2011) Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma. J Clin Invest 121(10):4106–4117. doi:10.1172/JCI42754 PubMedCrossRef

175.

Keane MP, Belperio JA, Xue YY, Burdick MD, Strieter RM (2004) Depletion of CXCR2 inhibits tumor growth and angiogenesis in a murine model of lung cancer. J Immunol 172(5):2853–2860PubMed

176.

Jamieson T, Clarke M, Steele CW, Samuel MS, Neumann J et al (2012) Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis. J Clin Invest 122(9):3127–3144. doi:10.1172/JCI61067 PubMedCrossRef

177.

Clark RA, Klebanoff SJ (1975) Neutrophil-mediated tumor cell cytotoxicity: role of the peroxidase system. J Exp Med 141(6):1442–1447PubMedCrossRef

178.

Pekarek LA, Starr BA, Toledano AY, Schreiber H (1995) Inhibition of tumor growth by elimination of granulocytes. J Exp Med 181(1):435–440PubMedCrossRef

179.

Houghton AM, Rzymkiewicz DM, Ji H, Gregory AD, Egea EE et al (2010) Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth. Nat Med 16(2):219–223PubMedCrossRef

180.

Mittendorf EA, Alatrash G, Qiao N, Wu Y, Sukhumalchandra P et al (2012) Breast cancer cell uptake of the inflammatory mediator neutrophil elastase triggers an anticancer adaptive immune response. Cancer Res 72(13):3153–3162. doi:10.1158/0008-5472.CAN-11-4135 PubMedCrossRef

181.

Queen MM, Ryan RE, Holzer RG, Keller-Peck CR, Jorcyk CL (2005) Breast cancer cells stimulate neutrophils to produce oncostatin M: potential implications for tumor progression. Cancer Res 65(19):8896–8904PubMedCrossRef

182.

Grenier A, Chollet-Martin S, Crestani B, Delarche C, El Benna J et al (2002) Presence of a mobilizable intracellular pool of hepatocyte growth factor in human polymorphonuclear neutrophils. Blood 99(8):2997–3004PubMedCrossRef

183.

Imai Y, Kubota Y, Yamamoto S, Tsuji K, Shimatani M et al (2005) Neutrophils enhance invasion activity of human cholangiocellular carcinoma and hepatocellular carcinoma cells: an in vitro study. J Gastroenterol Hepatol 20(2):287–293PubMedCrossRef

184.

Granot Z, Henke E, Comen EA, King TA, Norton L et al (2011) Tumor entrained neutrophils inhibit seeding in the premetastatic lung. Cancer Cell 20(3):300–314. doi:10.1016/j.ccr.2011.08.012 PubMedCrossRef

185.

Scapini P, Morini M, Tecchio C, Minghelli S, Di Carlo E et al (2004) CXCL1/macrophage inflammatory protein-2-induced angiogenesis in vivo is mediated by neutrophil-derived vascular endothelial growth factor-A. J Immunol 172(8):5034–5040PubMed

186.

Nozawa H, Chiu C, Hanahan D (2006) Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis. Proc Natl Acad Sci U S A 103(33):12493–12498PubMedCrossRef

187.

Dumitru CA, Fechner MK, Hoffmann TK, Lang S, Brandau S (2012) A novel p38-MAPK signaling axis modulates neutrophil biology in head and neck cancer. J Leukoc Biol 91(4):591–598. doi:10.1189/jlb.0411193 PubMedCrossRef

188.

Jablonska J, Leschner S, Westphal K, Lienenklaus S, Weiss S (2010) Neutrophils responsive to endogenous IFN-beta regulate tumor angiogenesis and growth in a mouse tumor model. J Clin Invest 120(4):1151–1164PubMedCrossRef

189.

Shojaei F, Singh M, Thompson JD, Ferrara N (2008) Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression. Proc Natl Acad Sci U S A 105(7):2640–2645PubMedCrossRef

190.

Shojaei F, Wu X, Zhong C, Yu L, Liang XH et al (2007) Bv8 regulates myeloid-cell-dependent tumour angiogenesis. Nature 450(7171):825–831. doi:10.1038/nature06348 PubMedCrossRef

191.

Shojaei F, Wu X, Qu X, Kowanetz M, Yu L et al (2009) G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models. Proc Natl Acad Sci U S A 106(16):6742–6747. doi:10.1073/pnas.0902280106 PubMedCrossRef

192.

Weitzman SA, Weitberg AB, Clark EP, Stossel TP (1985) Phagocytes as carcinogens: malignant transformation produced by human neutrophils. Science (New York, NY) 227(4691):1231–1233CrossRef

193.

Sandhu JK, Privora HF, Wenckebach G, Birnboim HC (2000) Neutrophils, nitric oxide synthase, and mutations in the mutatect murine tumor model. Am J Pathol 156(2):509–518PubMedCrossRef

194.

Gungor N, Knaapen AM, Munnia A, Peluso M, Haenen GR et al (2010) Genotoxic effects of neutrophils and hypochlorous acid. Mutagenesis 25(2):149–154PubMedCrossRef

195.

Tazawa H, Okada F, Kobayashi T, Tada M, Mori Y et al (2003) Infiltration of neutrophils is required for acquisition of metastatic phenotype of benign murine fibrosarcoma cells: implication of inflammation-associated carcinogenesis and tumor progression. Am J Pathol 163(6):2221–2232PubMedCrossRef

196.

Campregher C, Luciani MG, Gasche C (2008) Activated neutrophils induce an hMSH2-dependent G2/M checkpoint arrest and replication errors at a (CA)13-repeat in colon epithelial cells. Gut 57(6):780–787PubMedCrossRef

197.

Welch DR, Schissel DJ, Howrey RP, Aeed PA (1989) Tumor-elicited polymorphonuclear cells, in contrast to “normal” circulating polymorphonuclear cells, stimulate invasive and metastatic potentials of rat mammary adenocarcinoma cells. Proc Natl Acad Sci U S A 86(15):5859–5863PubMedCrossRef

198.

Gabrilovich DI, Ostrand-Rosenberg S, Bronte V (2012) Coordinated regulation of myeloid cells by tumours. Nat Rev Immunol 12(4):253–268. doi:10.1038/nri3175 PubMedCrossRef

199.

Rodriguez PC, Ernstoff MS, Hernandez C, Atkins M, Zabaleta J et al (2009) Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes. Cancer Res 69(4):1553–1560PubMedCrossRef

200.

Schmielau J, Finn OJ (2001) Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of T-cell function in advanced cancer patients. Cancer Res 61(12):4756–4760PubMed

201.

Cortez-Retamozo V, Etzrodt M, Newton A, Rauch PJ, Chudnovskiy A et al (2012) Origins of tumor-associated macrophages and neutrophils. Proc Natl Acad Sci U S A 109(7):2491–2496. doi:10.1073/pnas.1113744109 PubMedCrossRef

202.

Brandau S, Trellakis S, Bruderek K, Schmaltz D, Steller G et al (2011) Myeloid-derived suppressor cells in the peripheral blood of cancer patients contain a subset of immature neutrophils with impaired migratory properties. J Leukoc Biol 89(2):311–317. doi:10.1189/jlb.0310162 PubMedCrossRef

203.

Solito S, Falisi E, Diaz-Montero CM, Doni A, Pinton L et al (2011) A human promyelocytic-like population is responsible for the immune suppression mediated by myeloid-derived suppressor cells. Blood 118(8):2254–2265. doi:10.1182/blood-2010-12-325753 PubMedCrossRef

204.

Youn JI, Collazo M, Shalova IN, Biswas SK, Gabrilovich DI (2012) Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice. J Leukoc Biol 91(1):167–181. doi:10.1189/jlb.0311177 PubMedCrossRef

205.

Fridlender ZG, Sun J, Mishalian I, Singhal S, Cheng G et al (2012) Transcriptomic analysis comparing tumor-associated neutrophils with granulocytic myeloid-derived suppressor cells and normal neutrophils. PLoS One 7(2):e31524. doi:10.1371/journal.pone.0031524 PubMedCrossRef

Titel: Neutrophils in innate and adaptive immunity
verfasst von: Sébastien Jaillon
Maria Rosaria Galdiero
Davide Del Prete
Marco Antonio Cassatella
Cecilia Garlanda
Alberto Mantovani
Publikationsdatum: 01.07.2013
Verlag: Springer-Verlag
Erschienen in: Seminars in Immunopathology / Ausgabe 4/2013
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-013-0374-8

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