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European Radiology

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01.11.2003 | Breast

Invasive breast cancer: correlation of dynamic MR features with prognostic factors

verfasst von: Botond K. Szabó, Peter Aspelin, Maria Kristoffersen Wiberg, Tibor Tot, Beata Boné

Erschienen in: European Radiology | Ausgabe 11/2003

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Abstract

The purpose of this exploratory study was to correlate kinetic and morphologic MR features with histologic prognostic factors in invasive breast cancer. Sixty-one women with invasive breast cancer underwent dynamic contrast-enhanced MR imaging at 1.5 T, using T1-weighted 3D fast low-angle shot technique. The MR characteristics were correlated with classical pathologic prognostic factors (tumor size, histologic type, grade and lymph node status) and immunohistochemically detected biomarkers [c-erbB-2, p53, Ki-67, and estrogen receptor (ER)]. Univariate and multivariate statistical analyses were performed. Presence of rim enhancement pattern, early maximal enhancement and washout phenomenon were independently associated with established predictors of poor prognosis (higher histologic grade, positive Ki-67, and negative ER status). Our results suggest that these MR signs are not only important in differentiating benign from malignant lesions, but may also be useful to noninvasively identify highly aggressive breast carcinomas.

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Titel: Invasive breast cancer: correlation of dynamic MR features with prognostic factors
verfasst von: Botond K. Szabó
Peter Aspelin
Maria Kristoffersen Wiberg
Tibor Tot
Beata Boné
Publikationsdatum: 01.11.2003
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 11/2003
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-003-2000-y

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