nach oben

Erschienen in:

01.01.2006 | Magnetic Resonance

¹³C imaging—a new diagnostic platform

verfasst von: Sven Månsson, Edvin Johansson, Peter Magnusson, Chun-Ming Chai, Georg Hansson, J. Stefan Petersson, Freddy Ståhlberg, Klaes Golman

Erschienen in: European Radiology | Ausgabe 1/2006

Einloggen, um Zugang zu erhalten

Abstract

The evolution of magnetic resonance imaging (MRI) has been astounding since the early 1980s, and a broad range of applications has emerged. To date, clinical imaging of nuclei other than protons has been precluded for reasons of sensitivity. However, with the recent development of hyperpolarization techniques, the signal from a given number of nuclei can be increased as much as 100,000 times, sufficient to enable imaging of nonproton nuclei. Technically, imaging of hyperpolarized nuclei offers several unique properties, such as complete lack of background signal and possibility for local and permanent destruction of the signal by means of radio frequency (RF) pulses. These properties allow for improved as well as new techniques within several application areas. Diagnostically, the injected compounds can visualize information about flow, perfusion, excretory function, and metabolic status. In this review article, we explain the concept of hyperpolarization and the techniques to hyperpolarize ¹³C. An overview of results obtained within angiography, perfusion, and catheter tracking is given, together with a discussion of the particular advantages and limitations. Finally, possible future directions of hyperpolarized ¹³C MRI are pointed out.

Bloch F, Hansen WW, Packard M (1946) The nuclear induction experiment. Phys Rev 70:474–485CrossRef

Purcell EM, Torrey HC, Pound RV (1946) Resonance absorption by nuclear magnetic moments in a solid. Phys Rev 69:37–38CrossRef

Lauterbur PC (1973) Image formation by induced local interactions: examples employing nuclear magnetic resonance. Nature 242:190–191

Shulman RG, Rothman DL (2001) 13C NMR of intermediary metabolism: implications for systemic physiology. Annu Rev Physiol 63:15–48CrossRefPubMed

Albert MS, Balamore D (1998) Development of hyperpolarized noble gas MRI. Nucl Instrum Methods Phys Res A 402:441–453PubMed

Albert MS, Cates GD, Driehuys B, Happer W, Saam B, Springer CS Jr, Wishnia A (1994) Biological magnetic resonance imaging using laser-polarized ¹²⁹Xe. Nature 370:199–201CrossRefPubMed

Middleton H, Black RD, Saam B, Cates GD, Cofer GP, Guenther R, Happer W, Hedlund LW, Johnson GA, Juvan K et al (1995) MR imaging with hyperpolarized ³He gas. Magn Reson Med 33:271–275PubMed

Kauczor H, Surkau R, Roberts T (1998) MRI using hyperpolarized noble gases. Eur Radiol 8:820–827PubMed

Kauczor HU (2003) Hyperpolarized helium-3 gas magnetic resonance imaging of the lung. Top Magn Reson Imaging 14:223–230PubMed

10.

van Beek EJ, Wild JM, Kauczor HU, Schreiber W, Mugler JP III, de Lange EE (2004) Functional MRI of the lung using hyperpolarized 3-helium gas. J Magn Reson Imaging 20:540–554PubMed

11.

Jóhannesson H, Axelsson O, Karlsson M (2004) Transfer of para-hydrogen spin order into polarization by diabatic field cycling. C R Physique 5:315–324

12.

Ardenkjaer-Larsen JH, Fridlund B, Gram A, Hansson G, Hansson L, Lerche MH, Servin R, Thaning M, Golman K (2003) Increase in signal-to-noise ratio of >10,000 times in liquid-state NMR. Proc Natl Acad Sci U S A 100:10158–10163PubMed

13.

Campeau NG, Huston J III, Bernstein MA, Lin C, Gibbs GF (2001) Magnetic resonance angiography at 3.0 Tesla: initial clinical experience. Top Magn Reson Imaging 12:183–204PubMed

14.

Ardenkjaer-Larsen JH, Axelsson O, Golman K, Wistrand LG, Hansson G, Leunbach I, Petersson JS (1999) Method of magnetic resonance investigation. International patent application no. WO 99/35508

15.

Frossati G (1998) Polarization of ³He, D₂ (and possibly ¹²⁹Xe) using cryogenic techniques. Nucl Instrum Meth A 402:479–483

16.

Abragam A, Goldman M (1978) Principles of dynamic nuclear polarisation. Rep Prog Phys 41:395–467

17.

Bowers CR, Weitekamp DP (1986) Transformation of symmetrization order to nuclear-spin magnetization by chemical reaction and nuclear magnetic resonance. Phys Rev Lett 57:2645–2648PubMed

18.

Bowers CR, Weitekamp DP (1987) Parahydrogen and synthesis allow dramatically enhanced nuclear alignment. J Am Chem Soc 109:5541–5542

19.

Golman K, Axelsson O, Jóhannesson H, Månsson S, Olofsson C, Petersson JS (2001) Parahydrogen-induced polarization in imaging: subsecond ¹³C angiography. Magn Reson Med 46:1–5PubMed

20.

Jóhannesson H, Axelsson O, Karlsson M, Goldman M (2004) Methods to convert para-hydrogen spin order into hetero nuclei polarization for in vivo detection. In: Proc 21st Annual Meeting ESMRMB:144

21.

Prince MR, Yucel EK, Kaufman JA, Harrison DC, Geller SC (1993) Dynamic gadolinium-enhanced three-dimensional abdominal MR arteriography. J Magn Reson Imaging 3:877–881

22.

Merbach A, Tóth É (2001) The chemistry of contrast agents in medical magnetic resonance imaging. John Wiley & Sons, Chichester

23.

Nishimura DG, Macovski A, Pauly JM (1986) Magnetic resonance angiography. IEEE Trans Med Imaging 5:140–151

24.

Maki JH, Chenevert TL, Prince MR (1996) Three-dimensional contrast-enhanced MR angiography. Top Magn Reson Imaging 8:322–344PubMed

25.

Golman K, Ardenkjaer-Larsen JH, Petersson JS, Månsson S, Leunbach I (2003) Molecular imaging with endogenous substances. Proc Natl Acad Sci U S A 100:10435–10439PubMed

26.

Golman K, Ardenkjaer-Larsen JH, Svensson J, Axelsson O, Hansson G, Hansson L, Johannesson H, Leunbach I, Månsson S, Petersson JS, Pettersson G, Servin R, Wistrand LG (2002) ¹³C-angiography. Acad Radiol 9(Suppl 2):S507–S510PubMed

27.

Markstaller K, Eberle B, Schreiber WG, Weiler N, Thelen M, Kauczor HU (2000) Flip angle considerations in (3)helium-MRI. NMR Biomed 13:190–193PubMed

28.

Zhao L, Albert MS (1998) Biomedical imaging using hyperpolarized noble gas MRI: pulse sequence considerations. Nucl Instrum Methods Phys Res A 402:454–460PubMed

29.

Svensson J, Månsson S, Johansson E, Petersson JS, Olsson LE (2003) Hyperpolarized ¹³C MR angiography using trueFISP. Magn Reson Med 50:256–262PubMed

30.

Kiselev VG (2001) On the theoretical basis of perfusion measurements by dynamic susceptibility contrast MRI. Magn Reson Med 46:1113–1122PubMed

31.

Larsson HB, Fritz-Hansen T, Rostrup E, Sondergaard L, Ring P, Henriksen O (1996) Myocardial perfusion modeling using MRI. Magn Reson Med 35:716–726PubMed

32.

Johansson E, Månsson S, Wirestam R, Svensson J, Petersson JS, Golman K, Ståhlberg F (2004) Cerebral perfusion assessment by bolus tracking using hyperpolarized ¹³C. Magn Reson Med 51:464–472PubMed

33.

Johansson E (2003) NMR imaging of flow and perfusion using hyperpolarized nuclei. Thesis, Lund University, Sweden

34.

Johansson E, Magnusson P, Chai C-M, Petersson J, Golman K, Wirestam R, Ståhlberg F (2004) Assessing myocardial perfusion using hyperpolarized ¹³C. In: Proc 21st Annual Meeting ESMRMB:117

35.

Johansson E, Olsson LE, Mansson S, Petersson JS, Golman K, Ståhlberg F, Wirestam R (2004) Perfusion assessment with bolus differentiation: a technique applicable to hyperpolarized tracers. Magn Reson Med 52:1043–1051PubMed

36.

Uematsu H, Ohno Y, Hatabu H (2003) Recent advances in magnetic resonance perfusion imaging of the lung. Top Magn Reson Imaging 14:245–251PubMed

37.

West JB, Wagner PD (1997) Ventilation-perfusion relationships. In: Crystal RG, West JB, Barnes PJ, Weibel ER (eds) The lung: scientific foundations. Lippincott Williams & Wilkins, Philadelphia, pp 1693–1709

38.

Kearon C (2003) Diagnosis of pulmonary embolism. CMAJ 168:183–194PubMed

39.

Wagner PD, Saltzman HA, West JB (1974) Measurement of continuous distributions of ventilation-perfusion ratios: theory. J Appl Physiol 36:588–599PubMed

40.

Robertson HT, Glenny RW, Stanford D, McInnes LM, Luchtel DL, Covert D (1997) High-resolution maps of regional ventilation utilizing inhaled fluorescent microspheres. J Appl Physiol 82:943–953PubMed

41.

Edelman RR, Hatabu H, Tadamura E, Li W, Prasad PV (1996) Noninvasive assessment of regional ventilation in the human lung using oxygen-enhanced magnetic resonance imaging. Nat Med 2:1236–1239

42.

Ohno Y, Hatabu H, Takenaka D, Adachi S, Van Cauteren M, Sugimura K (2001) Oxygen-enhanced MR ventilation imaging of the lung: preliminary clinical experience in 25 subjects. Am J Roentgenol 177:185–194

43.

Simon BA, Marcucci C, Fung M, Lele SR (1998) Parameter estimation and confidence intervals for Xe-CT ventilation studies: a Monte Carlo approach. J Appl Physiol 84:709–716PubMed

44.

Peters DC, Lederman RJ, Dick AJ, Raman VK, Guttman MA, Derbyshire JA, McVeigh ER (2003) Undersampled projection reconstruction for active catheter imaging with adaptable temporal resolution and catheter-only views. Magn Reson Med 49:216–222PubMed

45.

Serfaty JM, Yang X, Aksit P, Quick HH, Solaiyappan M, Atalar E (2000) Toward MRI-guided coronary catheterization: visualization of guiding catheters, guidewires, and anatomy in real time. J Magn Reson Imaging 12:590–594PubMed

46.

Wildermuth S, Dumoulin CL, Pfammatter T, Maier SE, Hofmann E, Debatin JF (1998) MR-guided percutaneous angioplasty: assessment of tracking safety, catheter handling and functionality. Cardiovasc Intervent Radiol 21:404–410PubMed

47.

Zimmermann-Paul GG, Ladd ME, Pfammatter T, Hilfiker PR, Quick HH, Debatin JF (1998) MR versus fluoroscopic guidance of a catheter/guidewire system: in vitro comparison of steerability. J Magn Reson Imaging 8:1177–1181PubMed

48.

Bakker CJ, Hoogeveen RM, Hurtak WF, van Vaals JJ, Viergever MA, Mali WP (1997) MR-guided endovascular interventions: susceptibility-based catheter and near-real-time imaging technique. Radiology 202:273–276PubMed

49.

Green JD, Omary RA, Finn JP, Tang R, Li Y, Carr J, Li D (2002) Passive catheter tracking using MRI: comparison of conventional and magnetization-prepared FLASH. J Magn Reson Imaging 16:104–109PubMed

50.

Magnusson P, Månsson S, Petersson J, Chai C-M, Hansson G, Johansson E (2004) Passive catheter tracking using MRI and hyperpolarized 13C. In: Proc 21st Annual Meeting ESMRMB:143

51.

Ross B, Michaelis T (1994) Clinical applications of magnetic resonance spectroscopy. Magn Reson Q 10:191–247PubMed

52.

Cousins JP (1995) Clinical MR spectroscopy: fundamentals, current applications, and future potential. Am J Roentgenol 164:1337–1347

53.

Henriksen O (1994) MR spectroscopy in clinical research. Acta Radiol 35:96–116PubMed

54.

Sonnewald U, Gribbestad IS, Westergaard N, Nilsen G, Unsgard G, Schousboe A, Petersen SB (1994) Nuclear magnetic resonance spectroscopy: biochemical evaluation of brain function in vivo and in vitro. Neurotoxicology 15:579–590PubMed

55.

Kety SS, Schmidt CF (1948) The nitrous oxide method for the quantitative determination of cerebral blood flow in man: theory, procedure and normal values. J Clin Invest 27:476–483

Titel: 13C imaging—a new diagnostic platform
verfasst von: Sven Månsson
Edvin Johansson
Peter Magnusson
Chun-Ming Chai
Georg Hansson
J. Stefan Petersson
Freddy Ståhlberg
Klaes Golman
Publikationsdatum: 01.01.2006
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 1/2006
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-005-2806-x

Neu im Fachgebiet Radiologie

23.04.2024 | Pankreaskarzinom | Nachrichten

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

¹³C imaging—a new diagnostic platform

Abstract

Neu im Fachgebiet Radiologie

S3-Leitlinie zu Pankreaskrebs aktualisiert

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

Wie toxische Männlichkeit der Gesundheit von Männern schadet

Update Radiologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2006

Evaluation of a semiautomatic software tool for left ventricular function analysis with 16-slice computed tomography

Coronary magnetic resonance imaging: visualization of the vessel lumen and the vessel wall and molecular imaging of arteriothrombosis

The reproducibility of left ventricular volume and mass measurements: a comparison between dual-inversion-recovery black-blood sequence and SSFP

Assessment of reproducibility and stability of different breath-hold maneuvres by dynamic MRI: comparison between healthy adults and patients with pulmonary hypertension

Ankylosing Spondylitis: an unusual cause for complete heart block (2005: 10b)

Fractional anisotropy and mean diffusivity measurements on normal human brain: comparison between low- and high-resolution diffusion tensor imaging sequences

Neu im Fachgebiet Radiologie

S3-Leitlinie zu Pankreaskrebs aktualisiert

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

Wie toxische Männlichkeit der Gesundheit von Männern schadet

Update Radiologie