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European Radiology

Erschienen in:

01.04.2012 | Chest

Tumour heterogeneity in non-small cell lung carcinoma assessed by CT texture analysis: a potential marker of survival

verfasst von: Balaji Ganeshan, Elleny Panayiotou, Kate Burnand, Sabina Dizdarevic, Ken Miles

Erschienen in: European Radiology | Ausgabe 4/2012

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Abstract

Purpose

To establish the potential for tumour heterogeneity in non-small cell lung cancer (NSCLC) as assessed by CT texture analysis (CTTA) to provide an independent marker of survival for patients with NSCLC.

Materials and methods

Tumour heterogeneity was assessed by CTTA of unenhanced images of primary pulmonary lesions from 54 patients undergoing ¹⁸F-fluorodeoxyglucose (FDG) PET-CT for staging of NSCLC. CTTA comprised image filtration to extract fine, medium and coarse features with quantification of the distribution of pixel values (uniformity) within the filtered images. Receiver operating characteristics identified thresholds for PET and CTTA parameters that were related to patient survival using Kaplan-Meier analysis.

Results

The median (range) survival was 29.5 (1–38) months. 24, 10, 14 and 6 patients had tumour stages I, II, III and IV respectively. PET stage and tumour heterogeneity assessed by CTTA were significant independent predictors of survival (PET stage: Odds ratio 3.85, 95% confidence limits 0.9–8.09, P = 0.002; CTTA: Odds ratio 56.4, 95% confidence limits 4.79–666, p = 0.001). SUV was not a significantly associated with survival.

Conclusion

Assessment of tumour heterogeneity by CTTA of non-contrast enhanced images has the potential for to provide a novel, independent predictor of survival for patients with NSCLC.

Key Points

• Computed tomography is a routine staging procedure in non-small cell lung cancer

• CT texture analysis (CTTA) can quantify heterogeneity within these lung tumours

• CTTA seems to offer a novel independent predictor of survival for NSCLC

• CTTA could contribute to disease risk-stratification for patients with NSCLC

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Titel: Tumour heterogeneity in non-small cell lung carcinoma assessed by CT texture analysis: a potential marker of survival
verfasst von: Balaji Ganeshan
Elleny Panayiotou
Kate Burnand
Sabina Dizdarevic
Ken Miles
Publikationsdatum: 01.04.2012
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 4/2012
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-011-2319-8

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Tumour heterogeneity in non-small cell lung carcinoma assessed by CT texture analysis: a potential marker of survival

Abstract

Purpose

Materials and methods

Results

Conclusion

Key Points

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