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01.01.2013 | Interventional

Early diffuse recurrence of hepatocellular carcinoma after percutaneous radiofrequency ablation: analysis of risk factors

verfasst von: Hee Young Lee, Hyunchul Rhim, Min Woo Lee, Young-sun Kim, Dongil Choi, Min Jung Park, Young Kon Kim, Seong Hyun Kim, Hyo Keun Lim

Erschienen in: European Radiology | Ausgabe 1/2013

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Abstract

Objective

To evaluate the risk factors affecting early diffuse recurrence within 1 year of percutaneous ultrasound-guided radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC).

Methods

Out of 146 patients who received transcatheter arterial chemoembolisation (TACE) for treatment of recurrent HCC after percutaneous ultrasound-guided RFA, we selected 23 patients with early diffuse recurrence. Early diffuse recurrence was defined as three or more new recurrent HCCs within 1 year of initial RFA. As a control group, we selected 23 patients, matched exactly for age and sex, in which there was no local tumour progression or new recurrence after RFA. To analyse the risk factors, we examined patient factors and tumour factors.

Results

Recurrent tumours occurred from 30 to 365 days after RFA (median time, 203 days). Univariate analysis indicated that larger tumour size and poorly defined margin were significant risk factors (P < 0.05). Multivariate analysis indicated that poorly defined margin was a significant risk factor (P < 0.05).

Conclusion

Larger tumour size and poorly defined margin may be risk factors for early diffuse recurrence of HCC within 1 year of RFA. Tumours with such risk factors should be treated with a combination of TACE to minimise the potential for therapeutic failure.

Key Points

• Ultrasound-guided radiofrequency ablation (RFA) is widely used for hepatocellular carcinoma (HCC).

• Early diffuse recurrence after RFA is an important prognostic factor

• The risk factors for recurrence are larger tumour size and poorly defined margins

• Tumours with such risk factors should be treated with transarterial chemoembolisation.

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Titel: Early diffuse recurrence of hepatocellular carcinoma after percutaneous radiofrequency ablation: analysis of risk factors
verfasst von: Hee Young Lee
Hyunchul Rhim
Min Woo Lee
Young-sun Kim
Dongil Choi
Min Jung Park
Young Kon Kim
Seong Hyun Kim
Hyo Keun Lim
Publikationsdatum: 01.01.2013
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 1/2013
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-012-2561-8

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Early diffuse recurrence of hepatocellular carcinoma after percutaneous radiofrequency ablation: analysis of risk factors

Abstract

Objective

Methods

Results

Conclusion

Key Points

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Springer Medizin

Abstract

Objective

Methods

Results

Conclusion

Key Points

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