Clinical Feasibility of 3D Automated Coronary Atherosclerotic Plaque Quantification Algorithm on Coronary Computed Tomography Angiography: Comparison with Intravascular Ultrasound | springermedizin.de

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European Radiology

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01.10.2015 | Cardiac

Clinical Feasibility of 3D Automated Coronary Atherosclerotic Plaque Quantification Algorithm on Coronary Computed Tomography Angiography: Comparison with Intravascular Ultrasound

verfasst von: Hyung-Bok Park, Byoung Kwon Lee, Sanghoon Shin, Ran Heo, Reza Arsanjani, Pieter H. Kitslaar, Alexander Broersen, Jouke Dijkstra, Sung Gyun Ahn, James K. Min, Hyuk-Jae Chang, Myeong-Ki Hong, Yangsoo Jang, Namsik Chung

Erschienen in: European Radiology | Ausgabe 10/2015

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Abstract

Objective

To evaluate the diagnostic performance of automated coronary atherosclerotic plaque quantification (QCT) by different users (expert/non-expert/automatic).

Methods

One hundred fifty coronary artery segments from 142 patients who underwent coronary computed tomography angiography (CCTA) and intravascular ultrasound (IVUS) were analyzed. Minimal lumen area (MLA), maximal lumen area stenosis percentage (%AS), mean plaque burden percentage (%PB), and plaque volume were measured semi-automatically by expert, non-expert, and fully automatic QCT analyses, and then compared to IVUS.

Results

Between IVUS and expert QCT analysis, the correlation coefficients (r) for the MLA, %AS, %PB, and plaque volume were excellent: 0.89 (p < 0.001), 0.84 (p < 0.001), 0.91 (p < 0.001), and 0.94 (p < 0.001), respectively. There were no significant differences in the mean parameters (all p values >0.05) except %AS (p = 0.01). The automatic QCT analysis showed comparable performance to non-expert QCT analysis, showing correlation coefficients (r) of the MLA (0.80 vs. 0.82), %AS (0.82 vs. 0.80), %PB (0.84 vs. 0.73), and plaque volume (0.84 vs. 0.79) when they were compared to IVUS, respectively.

Conclusion

Fully automatic QCT analysis showed clinical utility compared with IVUS, as well as a compelling performance when compared with semiautomatic analyses.

Key Points

• Coronary CTA enables the assessment of coronary atherosclerotic plaque.

• High-risk plaque characteristics and overall plaque burden can predict future cardiac events.

• Coronary atherosclerotic plaque quantification is currently unfeasible in practice.

• Quantitative computed tomography coronary plaque analysis software (QCT) enables feasible plaque quantification.

• Fully automatic QCT analysis shows excellent performance.

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Titel: Clinical Feasibility of 3D Automated Coronary Atherosclerotic Plaque Quantification Algorithm on Coronary Computed Tomography Angiography: Comparison with Intravascular Ultrasound
verfasst von: Hyung-Bok Park
Byoung Kwon Lee
Sanghoon Shin
Ran Heo
Reza Arsanjani
Pieter H. Kitslaar
Alexander Broersen
Jouke Dijkstra
Sung Gyun Ahn
James K. Min
Hyuk-Jae Chang
Myeong-Ki Hong
Yangsoo Jang
Namsik Chung
Publikationsdatum: 01.10.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 10/2015
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-015-3698-z

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