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Erschienen in:
16.09.2015 | Paediatric
Intravoxel incoherent motion magnetic resonance imaging to predict vesicoureteral reflux in children with urinary tract infection
Erschienen in: European Radiology | Ausgabe 6/2016
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Objectives
To compare the diffusion parameters of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) between the “reflux” and the “non-reflux” kidneys, and to evaluate the feasibility of using IVIM DWI to predict vesicoureteral reflux (VUR) in children with a urinary tract infection (UTI).
Methods
Eighty-three kidneys from 57 pediatric patients with a UTI were classified into “reflux” and “non-reflux” groups according to voiding cystourethrography (VCUG) results. The apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudo-diffusion coefficient (D*), and perfusion fraction (PF) were measured and compared in the renal pelvis of both groups. Four indices (D*/ADC, PF/ADC, D*/D, and PF/D) were calculated and receiver operating characteristic (ROC) curve analyses were performed.
Results
VURs were detected on VCUG in 21 kidneys. PF and D* were significantly higher in the “reflux” group than in the “non-reflux” group. The indices were all significantly higher. The PF/D index showed the best diagnostic performance in predicting VUR in children with UTI (Az = 0.864).
Conclusion
PF and D* were significantly higher in the "reflux" kidney than in the "non-reflux" kidney. Our new index (PF/D) could prove useful for predicting VUR.
Key Points
• IVIM DWI is both radiation-free and contrast media-free.
• IVIM DWI index is easily calculated by combining diffusion parameters.
• IVIM DWI may help predict VUR in children with UTI.
• PF is significantly higher in the “reflux” than the “non-reflux” kidneys.
• A new VUR index, PF/D could prove useful for predicting VUR.