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29.10.2015 | Neuro

Neurite orientation dispersion and density imaging in the substantia nigra in idiopathic Parkinson disease

verfasst von: Koji Kamagata, Taku Hatano, Ayami Okuzumi, Yumiko Motoi, Osamu Abe, Keigo Shimoji, Kouhei Kamiya, Michimasa Suzuki, Masaaki Hori, Kanako K. Kumamaru, Nobutaka Hattori, Shigeki Aoki

Erschienen in: European Radiology | Ausgabe 8/2016

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Abstract

Objectives

We used neurite orientation dispersion and density imaging (NODDI) to quantify changes in the substantia nigra pars compacta (SNpc) and striatum in Parkinson disease (PD).

Methods

Diffusion-weighted magnetic resonance images were acquired from 58 PD patients and 36 age- and sex-matched controls. The intracellular volume fraction (Vic), orientation dispersion index (OD), and isotropic volume fraction (Viso) of the basal ganglia were compared between groups. Multivariate logistic regression analysis determined which diffusion parameters were independent predictors of PD. Receiver operating characteristic (ROC) analysis compared the diagnostic accuracies of the evaluated indices. Pearson coefficient analysis correlated each diffusional parameter with disease severity.

Results

Vic in the contralateral SNpc and putamen were significantly lower in PD patients than in healthy controls (P < 0.00058). Vic and OD in the SNpc and putamen showed significant negative correlations (P < 0.05) with disease severity. Multivariate logistic analysis revealed that Vic (P = 0.0000046) and mean diffusivity (P = 0.019) in the contralateral SNpc were the independent predictors of PD. In the ROC analysis, Vic in the contralateral SNpc showed the best diagnostic performance (mean cutoff, 0.62; sensitivity, 0.88; specificity, 0.83).

Conclusion

NODDI is likely to be useful for diagnosing PD and assessing its progression.

Key Points

• Neurite orientation dispersion and density imaging (NODDI) is a new diffusion MRI technique

• NODDI estimates neurite microstructure more specifically than diffusion tensor imaging

• By using NODDI, nigrostriatal alterations in PD can be evaluated in vivo

• NOODI is useful for diagnosing PD and assessing its disease progression

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Titel: Neurite orientation dispersion and density imaging in the substantia nigra in idiopathic Parkinson disease
verfasst von: Koji Kamagata
Taku Hatano
Ayami Okuzumi
Yumiko Motoi
Osamu Abe
Keigo Shimoji
Kouhei Kamiya
Michimasa Suzuki
Masaaki Hori
Kanako K. Kumamaru
Nobutaka Hattori
Shigeki Aoki
Publikationsdatum: 29.10.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 8/2016
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-015-4066-8

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Neurite orientation dispersion and density imaging in the substantia nigra in idiopathic Parkinson disease

Abstract

Objectives

Methods

Results

Conclusion

Key Points

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