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28.01.2019 | Oncology

Fat-free muscle area measured by magnetic resonance imaging predicts overall survival of patients undergoing radioembolization of colorectal cancer liver metastases

verfasst von: Anton Faron, Claus C. Pieper, Frederic C. Schmeel, Alois M. Sprinkart, Daniel L. R. Kuetting, Rolf Fimmers, Jonel Trebicka, Hans H. Schild, Carsten Meyer, Daniel Thomas, Julian A. Luetkens

Erschienen in: European Radiology | Ausgabe 9/2019

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Abstract

Objectives

To investigate the clinical potential of fat-free muscle area (FFMA) to predict outcome in patients with liver-predominant metastatic colorectal cancer (mCRC) undergoing radioembolization (RE) with ⁹⁰Yttrium microspheres.

Methods

Patients with mCRC who underwent RE in our center were included in this retrospective study. All patients received liver magnetic resonance imaging including standard T2-weighted images. The total erector spinae muscle area and the intramuscular adipose tissue area were measured at the level of the origin of the superior mesenteric artery and subtracted to calculate FFMA. Cutoff values for definition of low FFMA were 3644 mm² in men and 2825 mm² in women. The main outcome was overall survival (OS). For survival analysis, the Kaplan-Meier method and Cox regressions comparing various clinic-oncological parameters which potentially may affect OS were performed.

Results

Seventy-seven patients (28 female, mean age 60 ± 11 years) were analyzed. Mean time between MRI and the following RE was 17 ± 31 days. Median OS after RE was 178 days. Patients with low FFMA had significantly shortened OS compared to patients with high FFMA (median OS: 128 vs. 273 days, p = 0.017). On multivariate Cox regression analysis, OS was best predicted by FFMA (hazard ratio (HR) 2.652; p < 0.001). Baseline bilirubin (HR 1.875; p = 0.030), pattern of tumor manifestation (HR 1.679; p = 0.001), and model of endstage liver disease (MELD) score (HR 1.164; p < 0.001) were also significantly associated with OS.

Conclusions

FFMA was associated with OS in patients receiving RE for treatment of mCRC and might be a new prognostic biomarker for survival prognosis.

Key Points

• Fat-free muscle area (FFMA) as a measure of lean muscle area predicts survival in metastatic colorectal liver cancer following radioembolization.

• FFMA can easily be assessed from routine pre-interventional liver magnetic resonance imaging.

• FFMA might be a new promising biomarker for assessment of sarcopenia.

Siegel RL, Miller KD, Fedewa SA et al (2017) Colorectal cancer statistics, 2017. CA Cancer J Clin 67:177–193CrossRefPubMed

Dendy MS, Ludwig JM, Kim HS (2017) Predictors and prognosticators for survival with Yttrium-90 radioembolization therapy for unresectable colorectal cancer liver metastasis. Oncotarget 8:37912–37922CrossRefPubMedPubMedCentral

Ahmadzadehfar H, Biersack HJ, Ezziddin S (2010) Radioembolization of liver tumors with yttrium-90 microspheres. Semin Nucl Med 40:105–121CrossRefPubMed

Garden OJ, Rees M, Poston GJ et al (2006) Guidelines for resection of colorectal cancer liver metastases. Gut 55(Suppl 3):1–8

Boas FE, Bodei L, Sofocleous CT (2017) Radioembolization of colorectal liver metastases: indications, technique, and outcomes. J Nucl Med 58(Suppl 2):104S–111SCrossRefPubMedPubMedCentral

Schmeel FC, Simon B, Sabet A et al (2017) Diffusion-weighted magnetic resonance imaging predicts survival in patients with liver-predominant metastatic colorectal cancer shortly after selective internal radiation therapy. Eur Radiol 27:966–975CrossRefPubMed

Barabasch A, Heinzel A, Bruners P, Kraemer NA, Kuhl CK (2018) Diffusion-weighted MRI is superior to PET/CT in predicting survival of patients undergoing Y radioembolization of hepatic metastases. Radiology 288:764–773CrossRefPubMed

Chang KV, Chen JD, Wu WT, Huang KC, Hsu CT, Han DS (2017) Association between loss of skeletal muscle mass and mortality and tumor recurrence in hepatocellular carcinoma: a systematic review and meta-analysis. Liver Cancer 87:90–103

Martin L, Birdsell L, Macdonald N et al (2013) Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index. J Clin Oncol 31:1539–1547CrossRefPubMed

10.

Praktiknjo M, Book M, Luetkens J et al (2018) Fat-free muscle mass in magnetic resonance imaging predicts acute-on-chronic liver failure and survival in decompensated cirrhosis. Hepatology 67:1014–1026CrossRefPubMed

11.

Yamashima M, Miyaaki H, Honda T et al (2017) Significance of psoas muscle thickness as an indicator of muscle atrophy in patients with hepatocellular carcinoma treated with sorafenib. Mol Clin Oncol 7:449–453CrossRefPubMedPubMedCentral

12.

Cruz-Jentoft AJ, Landi F, Schneider SM et al (2014) Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS). Age Ageing 43:748–759CrossRefPubMedPubMedCentral

13.

Xiao J, Caan BJ, Weltzien E et al (2018) Associations of pre-existing co-morbidities with skeletal muscle mass and radiodensity in patients with non-metastatic colorectal cancer. J Cachexia Sarcopenia Muscle 9:654–663CrossRefPubMedPubMedCentral

14.

Nattenmüller J, Hoegenauer H, Boehm J et al (2016) CT-based compartmental quantification of adipose tissue versus body metrics in colorectal cancer patients. Eur Radiol 26:4131–4140CrossRef

15.

Nattenmüller J, Rom J, Buckner T et al (2018) Visceral abdominal fat measured by computer tomography as a prognostic factor for gynecological malignancies? Oncotarget 9:16330–16342CrossRefPubMedPubMedCentral

16.

Miyamoto Y, Baba Y, Sakamoto Y et al (2015) Negative impact of skeletal muscle loss after systemic chemotherapy in patients with unresectable colorectal cancer. PLoS One 10:e0129742CrossRefPubMedPubMedCentral

17.

van Vledder MG, Levolger S, Ayez N, Verhoef C, Tran TC, Ijzermans JN (2012) Body composition and outcome in patients undergoing resection of colorectal liver metastases. Br J Surg 99:550–557CrossRefPubMed

18.

Levolger S, van Vugt JL, De Bruin RW, IJzermans JN (2015) Systematic review of sarcopenia in patients operated on for gastrointestinal and hepatopancreatobiliary malignancies. Br J Surg 102:1448–1458CrossRefPubMed

19.

Buckinx F, Landi F, Cesari M et al (2018) Pitfalls in the measurement of muscle mass: a need for a reference standard. J Cachexia Sarcopenia Muscle 9:269–278CrossRefPubMedPubMedCentral

20.

Dunfee BL, Riaz A, Lewandowski RJ et al (2010) Yttrium-90 radioembolization for liver malignancies: prognostic factors associated with survival. J Vasc Interv Radiol 21:90–95CrossRefPubMed

21.

Cruz-Jentoft AJ, Baeyens JP, Bauer JM et al (2010) Sarcopenia: European consensus on definition and diagnosis. Age Ageing 39:412–423CrossRefPubMedPubMedCentral

22.

Lewandowski RJ, Thurston KG, Goin JE et al (2005) 90Y microsphere (TheraSphere) treatment for unresectable colorectal cancer metastases of the liver: response to treatment at targeted doses of 135-150 Gy as measured by [18F]fluorodeoxyglucose positron emission tomography and computed tomographic imaging. J Vasc Interv Radiol 16:1641–1651CrossRefPubMed

23.

Peng PD, van Vledder MG, Tsai S et al (2011) Sarcopenia negatively impacts short-term outcomes in patients undergoing hepatic resection for colorectal liver metastasis. HPB (Oxford) 13:439–446

24.

Kalantar-Zadeh K, Horwich TB, Oreopoulos A et al (2007) Risk factor paradox in wasting diseases. Curr Opin Clin Nutr Metab Care 10:433–442CrossRefPubMed

25.

Imbeault P, Tremblay A, Simoneau JA, Joanisse DR (2002) Weight loss-induced rise in plasma pollutant is associated with reduced skeletal muscle oxidative capacity. Am J Physiol Endocrinol Metab 282:E574–E579CrossRefPubMed

26.

Fromer MW, Aloia TA, Gaughan JP, Atabek UM, Spitz FR (2016) The utility of the MELD score in predicting mortality following liver resection for metastasis. Eur J Surg Oncol 42:1568–1575CrossRefPubMed

27.

Pan CC, Kavanagh BD, Dawson LA et al (2010) Radiation-associated liver injury. Int J Radiat Oncol Biol Phys 76(Suppl 3):94–100CrossRef

28.

Kennedy AS, Ball D, Cohen SJ et al (2017) Baseline hemoglobin and liver function predict tolerability and overall survival of patients receiving radioembolization for chemotherapy-refractory metastatic colorectal cancer. J Gastrointest Oncol 8:70–80CrossRefPubMedPubMedCentral

29.

Grimm A, Meyer H, Nickel MD et al (2018) A comparison between 6-point DIXON MRI and MR spectroscopy to quantify muscle fat in the thigh of subjects with sarcopenia. J Frailty Aging. https://doi.org/10.14283/jfa.2018.16

30.

Schlaeger S, Inhuber S, Rohrmeier A et al (2018) Association of paraspinal muscle water–fat MRI-based measurements with isometric strength measurements. Eur Radiol. https://doi.org/10.1007/s00330-018-5631-8

31.

Wasan HS, Gibbs P, Sharma NK et al (2017) First-line selective internal radiotherapy plus chemotherapy versus chemotherapy alone in patients with liver metastases from colorectal cancer (FOXFIRE, SIRFLOX, and FOXFIRE-global): a combined analysis of three multicentre, randomised, phase 3 trials. Lancet Oncol 18:1159–1171CrossRefPubMedPubMedCentral

32.

van Hazel GA, Heinemann V, Sharma NK et al (2016) SIRFLOX: randomized phase III trial comparing first-line mFOLFOX6 (plus or minus bevacizumab) versus mFOLFOX6 (plus or minus bevacizumab) plus selective internal radiation therapy in patients with metastatic colorectal cancer. J Clin Oncol 34:1723–1731CrossRefPubMed

Titel: Fat-free muscle area measured by magnetic resonance imaging predicts overall survival of patients undergoing radioembolization of colorectal cancer liver metastases
verfasst von: Anton Faron
Claus C. Pieper
Frederic C. Schmeel
Alois M. Sprinkart
Daniel L. R. Kuetting
Rolf Fimmers
Jonel Trebicka
Hans H. Schild
Carsten Meyer
Daniel Thomas
Julian A. Luetkens
Publikationsdatum: 28.01.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 9/2019
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-018-5976-z

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Fat-free muscle area measured by magnetic resonance imaging predicts overall survival of patients undergoing radioembolization of colorectal cancer liver metastases

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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