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Erschienen in: Child's Nervous System 1/2016

01.01.2016 | Original Paper

Minimizing blood transfusions in the surgical correction of craniosynostosis: a 10-year single-center experience

verfasst von: Christopher M. Bonfield, Julia Sharma, D. Douglas Cochrane, Ash Singhal, Paul Steinbok

Erschienen in: Child's Nervous System | Ausgabe 1/2016

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Abstract

Introduction

Our center previously reported low transfusion rates for craniosynostosis surgery by two experienced neurosurgeons using standard intraoperative techniques and acceptance of low hemoglobin levels. This study evaluated whether low rates were maintained over the last 10 years and if a less experienced neurosurgeon, trained in and practicing in the same environment, could achieve similar outcomes.

Methods

All craniosynostosis operations performed in children between 2004 and 2015 were reviewed retrospectively. Transfusion rates were calculated. Analyses examined the relationship of transfusion to craniosynostosis type, surgical procedure, redo operation, surgeon, and perioperative hemoglobin levels.

Results

Two hundred eighteen patients were included: 71 open sagittal, 28 endoscopic-assisted sagittal, 32 unicoronal, 14 bicoronal, 42 metopic, and 31 multisuture. Median age at operation was 9.1 months. Overall transfusion rate was 24 %: 17 % open sagittal, 7 % endoscopic-assisted sagittal, 6 % unicoronal, 21 % bicoronal, 45 % metopic, and 45 % multisuture. The timing of transfusions were 75, 21, and 4 % for intraoperative, postoperative, and both, respectively. Patients not receiving transfusion had a mean lowest hemoglobin of 87 g/l (range 61–111) intraoperatively and 83 g/l (range 58–115) postoperatively. Mean lowest hemoglobin values were significantly lower in those necessitating intraoperative (75 g/l, range 54–102) or postoperative (59 g/l, range 51–71) transfusions. There was no significant difference in transfusion rate between less and more experienced surgeons. There were no cardiovascular complications or mortalities.

Conclusion

In craniosynostosis surgery, reproducible, long-term low blood transfusion rates were able to be maintained at a single center by careful intraoperative technique and acceptance of low intraoperative and postoperative hemoglobin levels in hemodynamically stable patients. Furthermore, low rates were also achieved by an inexperienced neurosurgeon in the group. This suggests that these results may be achievable by other neurosurgeons, who follow a similar protocol.
Literatur
1.
Zurück zum Zitat Ali A, Basaran B, Yornuk M, Altun D, Aydoseli A, Sencer A, Akinci IO (2013) Factors influencing blood loss and postoperative morbidity in children undergoing craniosynostosis surgery: a retrospective study. Pediatr Neurosurg 49:339–46CrossRefPubMed Ali A, Basaran B, Yornuk M, Altun D, Aydoseli A, Sencer A, Akinci IO (2013) Factors influencing blood loss and postoperative morbidity in children undergoing craniosynostosis surgery: a retrospective study. Pediatr Neurosurg 49:339–46CrossRefPubMed
2.
Zurück zum Zitat Cochrane DD, Woerdeman PA (2016) Sagittal Synostosis Repair Surgery. In Cohen AR (ed) Pediatric Neurosurgery: Tricks of the trade, Thieme, New York, pp 119–124 (forthcoming) Cochrane DD, Woerdeman PA (2016) Sagittal Synostosis Repair Surgery. In Cohen AR (ed) Pediatric Neurosurgery: Tricks of the trade, Thieme, New York, pp 119–124 (forthcoming)
3.
Zurück zum Zitat Cortellazzi P, Caldiroli D, Lamperti M, Bricchi M, Valentini L (2009) Early transfusion and crystalloid infusion strategy in infants undergoing cranioplasty surgery. Paediatr Anaesth 19:1251–2CrossRefPubMed Cortellazzi P, Caldiroli D, Lamperti M, Bricchi M, Valentini L (2009) Early transfusion and crystalloid infusion strategy in infants undergoing cranioplasty surgery. Paediatr Anaesth 19:1251–2CrossRefPubMed
4.
Zurück zum Zitat Crantford JC, Wood BC, Claiborne JR, Ririe DG, Couture DE, Thompson JT, David LR (2015) Evaluating the safety and efficacy of tranexamic acid administration in pediatric cranial vault reconstruction. J Craniofac Surg 26:104–7CrossRefPubMed Crantford JC, Wood BC, Claiborne JR, Ririe DG, Couture DE, Thompson JT, David LR (2015) Evaluating the safety and efficacy of tranexamic acid administration in pediatric cranial vault reconstruction. J Craniofac Surg 26:104–7CrossRefPubMed
5.
Zurück zum Zitat D’Errico CC, Munro HM, Buchman SR, Wagner D, Muraszko KM (2003) Efficacy of aprotinin in children undergoing craniofacial surgery. J Neurosurg 99:287–90CrossRefPubMed D’Errico CC, Munro HM, Buchman SR, Wagner D, Muraszko KM (2003) Efficacy of aprotinin in children undergoing craniofacial surgery. J Neurosurg 99:287–90CrossRefPubMed
6.
Zurück zum Zitat Dadure C, Sauter M, Bringuier S, Bigorre M, Raux O, Rochette A, Canaud N, Capdevila X (2011) Intraoperative tranexamic acid reduces blood transfusion in children undergoing craniosynostosis surgery: a randomized double-blind study. Anesthesiology 114:856–61CrossRefPubMed Dadure C, Sauter M, Bringuier S, Bigorre M, Raux O, Rochette A, Canaud N, Capdevila X (2011) Intraoperative tranexamic acid reduces blood transfusion in children undergoing craniosynostosis surgery: a randomized double-blind study. Anesthesiology 114:856–61CrossRefPubMed
7.
Zurück zum Zitat Deva AK, Hopper RA, Landecker A, Flores R, Weiner H, McCarthy JG (2002) The use of intraoperative autotransfusion during cranial vault remodeling for craniosynostosis. Plast Reconstr Surg 109:58–63CrossRefPubMed Deva AK, Hopper RA, Landecker A, Flores R, Weiner H, McCarthy JG (2002) The use of intraoperative autotransfusion during cranial vault remodeling for craniosynostosis. Plast Reconstr Surg 109:58–63CrossRefPubMed
8.
Zurück zum Zitat Di Rocco C, Tamburrini G, Pietrini D (2004) Blood sparing in craniosynostosis surgery. Semin Pediatr Neurol 11:278–87CrossRefPubMed Di Rocco C, Tamburrini G, Pietrini D (2004) Blood sparing in craniosynostosis surgery. Semin Pediatr Neurol 11:278–87CrossRefPubMed
9.
Zurück zum Zitat Duncan C, Richardson D, May P, Thiruchelvam J, Shong DC, Potter F, Grogan J, Caswell M (2008) Reducing blood loss in synostosis surgery: the Liverpool experience. J Craniofac Surg 19:1424–30CrossRefPubMed Duncan C, Richardson D, May P, Thiruchelvam J, Shong DC, Potter F, Grogan J, Caswell M (2008) Reducing blood loss in synostosis surgery: the Liverpool experience. J Craniofac Surg 19:1424–30CrossRefPubMed
10.
Zurück zum Zitat Durán de la Fuente P, García-Fernández J, Pérez-López C, Carceller F, Gilsanz Rodríguez F (2003) Usefulness of tranexamic acid in cranial remodeling surgery. Rev Esp Anestesiol Reanim 50:388–94PubMed Durán de la Fuente P, García-Fernández J, Pérez-López C, Carceller F, Gilsanz Rodríguez F (2003) Usefulness of tranexamic acid in cranial remodeling surgery. Rev Esp Anestesiol Reanim 50:388–94PubMed
11.
Zurück zum Zitat Faberowski LW, Black S, Mickle JP (1999) Blood loss and transfusion practice in the perioperative management of craniosynostosis repair. J Neurosurg Anesthesiol 11:167–72CrossRefPubMed Faberowski LW, Black S, Mickle JP (1999) Blood loss and transfusion practice in the perioperative management of craniosynostosis repair. J Neurosurg Anesthesiol 11:167–72CrossRefPubMed
12.
Zurück zum Zitat Fearon JA (2004) Reducing allogenic blood transfusions during pediatric cranial vault surgical procedures: a prospective analysis of blood recycling. Plast Reconstr Surg 113:1126–30CrossRefPubMed Fearon JA (2004) Reducing allogenic blood transfusions during pediatric cranial vault surgical procedures: a prospective analysis of blood recycling. Plast Reconstr Surg 113:1126–30CrossRefPubMed
13.
Zurück zum Zitat Fearon JA, Cook TK, Herbert M (2014) Effects of hypotensive anesthesia on blood transfusion rates in craniosynostosis corrections. Plast Reconstr Surg 133:1133–6CrossRefPubMed Fearon JA, Cook TK, Herbert M (2014) Effects of hypotensive anesthesia on blood transfusion rates in craniosynostosis corrections. Plast Reconstr Surg 133:1133–6CrossRefPubMed
14.
Zurück zum Zitat Fearon JA, Weinthal J (2002) The use of recombinant erythropoietin in the reduction of blood transfusion rates in craniosynostosis repair in infants and children. Plast Reconstr Surg 109:2190–6CrossRefPubMed Fearon JA, Weinthal J (2002) The use of recombinant erythropoietin in the reduction of blood transfusion rates in craniosynostosis repair in infants and children. Plast Reconstr Surg 109:2190–6CrossRefPubMed
15.
Zurück zum Zitat Gault DT, Renier D, Marchac D, Jones BM (1992) Intracranial pressure and intracranial volume in children with craniosynostosis. Plast Reconstr Surg 90:377–81CrossRefPubMed Gault DT, Renier D, Marchac D, Jones BM (1992) Intracranial pressure and intracranial volume in children with craniosynostosis. Plast Reconstr Surg 90:377–81CrossRefPubMed
16.
Zurück zum Zitat Goobie SM, Meier PM, Pereira LM, McGowan FX, Prescilla RP, Scharp LA, Rogers GF, Proctor MR, Meara JG, Soriano SG, Zurakowski D, Sethna NF (2011) Efficacy of tranexamic acid in pediatric craniosynostosis surgery: a double-blind, placebo-controlled trial. Anesthesiology 114:862–71CrossRefPubMed Goobie SM, Meier PM, Pereira LM, McGowan FX, Prescilla RP, Scharp LA, Rogers GF, Proctor MR, Meara JG, Soriano SG, Zurakowski D, Sethna NF (2011) Efficacy of tranexamic acid in pediatric craniosynostosis surgery: a double-blind, placebo-controlled trial. Anesthesiology 114:862–71CrossRefPubMed
17.
Zurück zum Zitat Goodman AM, Pollack MM, Patel KM, Luban NL (2003) Pediatric red blood cell transfusions increase resource use. J Pediatr 142:123–7CrossRefPubMed Goodman AM, Pollack MM, Patel KM, Luban NL (2003) Pediatric red blood cell transfusions increase resource use. J Pediatr 142:123–7CrossRefPubMed
18.
19.
Zurück zum Zitat Gunnarsson I, Hlynsson BÖ, Rosmundsson T, Thorsteinsson A (2011) Haemostatic effect of aprotinin during craniosynostotic surgery in children. Acta Anaesthesiol Scand 55:1010–4CrossRefPubMed Gunnarsson I, Hlynsson BÖ, Rosmundsson T, Thorsteinsson A (2011) Haemostatic effect of aprotinin during craniosynostotic surgery in children. Acta Anaesthesiol Scand 55:1010–4CrossRefPubMed
20.
Zurück zum Zitat Haas T, Goobie S, Spielmann N, Weiss M, Schmugge M (2014) Improvements in patient blood management for pediatric craniosynostosis surgery using a ROTEM(®) -assisted strategy - feasibility and costs. Paediatr Anaesth 24:774–80CrossRefPubMedCentralPubMed Haas T, Goobie S, Spielmann N, Weiss M, Schmugge M (2014) Improvements in patient blood management for pediatric craniosynostosis surgery using a ROTEM(®) -assisted strategy - feasibility and costs. Paediatr Anaesth 24:774–80CrossRefPubMedCentralPubMed
21.
Zurück zum Zitat Hans P, Collin V, Bonhomme V, Damas F, Born JD, Lamy M (2000) Evaluation of acute normovolemic hemodilution for surgical repair of craniosynostosis. J Neurosurg Anesthesiol 12:33–6CrossRefPubMed Hans P, Collin V, Bonhomme V, Damas F, Born JD, Lamy M (2000) Evaluation of acute normovolemic hemodilution for surgical repair of craniosynostosis. J Neurosurg Anesthesiol 12:33–6CrossRefPubMed
22.
Zurück zum Zitat Hebert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G, Tweeddale M, Schweitzer I, Yetisir E (1999) A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 340:409–17CrossRefPubMed Hebert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G, Tweeddale M, Schweitzer I, Yetisir E (1999) A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 340:409–17CrossRefPubMed
23.
Zurück zum Zitat Helfaer MA, Carson BS, James CS, Gates J, Della-Lana D, Vander Kolk C (1998) Increased hematocrit and decreased transfusion requirements in children given erythropoietin before undergoing craniofacial surgery. J Neurosurg 88:704–8CrossRefPubMed Helfaer MA, Carson BS, James CS, Gates J, Della-Lana D, Vander Kolk C (1998) Increased hematocrit and decreased transfusion requirements in children given erythropoietin before undergoing craniofacial surgery. J Neurosurg 88:704–8CrossRefPubMed
24.
Zurück zum Zitat Hentschel S, Steinbok P, Cochrane DD, Kestle J (2002) Reduction of transfusion rates in the surgical correction of sagittal synostosis. J Neurosurg 97:503–9CrossRefPubMed Hentschel S, Steinbok P, Cochrane DD, Kestle J (2002) Reduction of transfusion rates in the surgical correction of sagittal synostosis. J Neurosurg 97:503–9CrossRefPubMed
25.
Zurück zum Zitat Howe PW, Cooper MG (2012) Blood loss and replacement for paediatric cranioplasty in Australia - a prospective national audit. Anaesth Intensive Care 40:107–13PubMed Howe PW, Cooper MG (2012) Blood loss and replacement for paediatric cranioplasty in Australia - a prospective national audit. Anaesth Intensive Care 40:107–13PubMed
26.
Zurück zum Zitat Jimenez DF, Barone CM (1995) Intraoperative autologous blood transfusion in the surgical correction of craniosynostosis. Neurosurgery 37:1075–9CrossRefPubMed Jimenez DF, Barone CM (1995) Intraoperative autologous blood transfusion in the surgical correction of craniosynostosis. Neurosurgery 37:1075–9CrossRefPubMed
27.
Zurück zum Zitat Jimenez DF, Barone CM (2012) Endoscopic technique for sagittal synostosis. Childs Nerv Syst 28:1333–9CrossRefPubMed Jimenez DF, Barone CM (2012) Endoscopic technique for sagittal synostosis. Childs Nerv Syst 28:1333–9CrossRefPubMed
28.
Zurück zum Zitat Krajewski K, Ashley RK, Pung N, Wald S, Lazareff J, Kawamoto HK, Bradley JP (2008) Successful blood conservation during craniosynostotic correction with dual therapy using procrit and cell saver. J Craniofac Surg 19:101–5PubMed Krajewski K, Ashley RK, Pung N, Wald S, Lazareff J, Kawamoto HK, Bradley JP (2008) Successful blood conservation during craniosynostotic correction with dual therapy using procrit and cell saver. J Craniofac Surg 19:101–5PubMed
29.
Zurück zum Zitat Martin DT, Gries H, Diggs BS, Koh JL, Selden NR, Schreiber MA, Kuang AA (2014) Implementation of tranexamic acid to reduce blood loss during cranial vault remodeling for craniosynostosis at a single institution. Plast Reconstr Surg 134(4 Suppl 1):22CrossRef Martin DT, Gries H, Diggs BS, Koh JL, Selden NR, Schreiber MA, Kuang AA (2014) Implementation of tranexamic acid to reduce blood loss during cranial vault remodeling for craniosynostosis at a single institution. Plast Reconstr Surg 134(4 Suppl 1):22CrossRef
30.
Zurück zum Zitat Massimi L, Tamburrini G, Caldarelli M, Di Rocco C (2007) Effectiveness of a limited invasive scalp approach in the correction of sagittal craniosynostosis. Childs Nerv Syst 23:1389–401CrossRefPubMed Massimi L, Tamburrini G, Caldarelli M, Di Rocco C (2007) Effectiveness of a limited invasive scalp approach in the correction of sagittal craniosynostosis. Childs Nerv Syst 23:1389–401CrossRefPubMed
31.
Zurück zum Zitat Maugans TA, Martin D, Taylor J, Salisbury S, Istaphanous G (2011) Comparative analysis of tranexamic acid use in minimally invasive versus open craniosynostosis procedures. J Craniofac Surg 22:1772–8CrossRefPubMed Maugans TA, Martin D, Taylor J, Salisbury S, Istaphanous G (2011) Comparative analysis of tranexamic acid use in minimally invasive versus open craniosynostosis procedures. J Craniofac Surg 22:1772–8CrossRefPubMed
32.
Zurück zum Zitat Meara JG, Smith EM, Harshbarger RJ, Farlo JN, Matar MM, Levy ML (2005) Blood-conservation techniques in craniofacial surgery. Ann Plast Surg 54:525–9CrossRefPubMed Meara JG, Smith EM, Harshbarger RJ, Farlo JN, Matar MM, Levy ML (2005) Blood-conservation techniques in craniofacial surgery. Ann Plast Surg 54:525–9CrossRefPubMed
33.
Zurück zum Zitat Meneghini L, Zadra N, Aneloni V, Metrangolo S, Faggin R, Giusti F (2003) Erythropoietin therapy and acute preoperative normovolaemic haemodilution in infants undergoing craniosynostosis surgery. Paediatr Anaesth 13:392–6CrossRefPubMed Meneghini L, Zadra N, Aneloni V, Metrangolo S, Faggin R, Giusti F (2003) Erythropoietin therapy and acute preoperative normovolaemic haemodilution in infants undergoing craniosynostosis surgery. Paediatr Anaesth 13:392–6CrossRefPubMed
34.
Zurück zum Zitat Meyer P, Renier D, Arnaud E, Jarreau MM, Charron B, Buy E, Buisson C, Barrier G (1993) Blood loss during repair of craniosynostosis. Br J Anaesth 71:854–7CrossRefPubMed Meyer P, Renier D, Arnaud E, Jarreau MM, Charron B, Buy E, Buisson C, Barrier G (1993) Blood loss during repair of craniosynostosis. Br J Anaesth 71:854–7CrossRefPubMed
35.
Zurück zum Zitat Nguyen TT, Hill S, Austin TM, Whitney GM, Wellons JC 3rd, Lam HV (2015) Use of blood-sparing surgical techniques and transfusion algorithms: association with decreased blood administration in children undergoing primary open craniosynostosis repair. J Neurosurg Pediatr 31:1–8 Nguyen TT, Hill S, Austin TM, Whitney GM, Wellons JC 3rd, Lam HV (2015) Use of blood-sparing surgical techniques and transfusion algorithms: association with decreased blood administration in children undergoing primary open craniosynostosis repair. J Neurosurg Pediatr 31:1–8
36.
Zurück zum Zitat Oppenheimer AJ, Ranganathan K, Levi B, Strahle JM, Kapurch J, Muraszko KM, Buchman SR (2014) Minimizing transfusions in primary cranial vault remodeling: the role of aminocaproic acid. J Craniofac Surg 25:82–6CrossRefPubMed Oppenheimer AJ, Ranganathan K, Levi B, Strahle JM, Kapurch J, Muraszko KM, Buchman SR (2014) Minimizing transfusions in primary cranial vault remodeling: the role of aminocaproic acid. J Craniofac Surg 25:82–6CrossRefPubMed
37.
Zurück zum Zitat Orliaguet GA, Bruyere M, Meyer PG, Blanot S, Renier D, Carli PA (2003) Comparison of perioperative blood salvage and postoperative reinfusion of drained blood during surgical correction of craniosynostosis in infants. Paediatr Anaesth 13:797–804CrossRefPubMed Orliaguet GA, Bruyere M, Meyer PG, Blanot S, Renier D, Carli PA (2003) Comparison of perioperative blood salvage and postoperative reinfusion of drained blood during surgical correction of craniosynostosis in infants. Paediatr Anaesth 13:797–804CrossRefPubMed
38.
Zurück zum Zitat Pieters BJ, Conley L, Weiford J, Hamilton M, Wicklund B, Booser A, Striker A, Whitney S, Singhal V (2015) Prophylactic versus reactive transfusion of thawed plasma in patients undergoing surgical repair of craniosynostosis: a randomized clinical trial. Paediatr Anaesth 25:279–87CrossRefPubMed Pieters BJ, Conley L, Weiford J, Hamilton M, Wicklund B, Booser A, Striker A, Whitney S, Singhal V (2015) Prophylactic versus reactive transfusion of thawed plasma in patients undergoing surgical repair of craniosynostosis: a randomized clinical trial. Paediatr Anaesth 25:279–87CrossRefPubMed
39.
Zurück zum Zitat Seal SK, Steinbok P, Courtemanche DJ (2015) Cranial orbital buttress technique for nonsyndromic unicoronal and metopic craniosynostosis. Neurosurg Focus 38:E4CrossRefPubMed Seal SK, Steinbok P, Courtemanche DJ (2015) Cranial orbital buttress technique for nonsyndromic unicoronal and metopic craniosynostosis. Neurosurg Focus 38:E4CrossRefPubMed
40.
Zurück zum Zitat Seruya M, Oh AK, Rogers GF, Han KD, Boyajian MJ, Myseros JS, Yaun AL, Keating RF (2012) Blood loss estimation during fronto-orbital advancement: implications for blood transfusion practice and hospital length of stay. J Craniofac Surg 23:1314–7CrossRefPubMed Seruya M, Oh AK, Rogers GF, Han KD, Boyajian MJ, Myseros JS, Yaun AL, Keating RF (2012) Blood loss estimation during fronto-orbital advancement: implications for blood transfusion practice and hospital length of stay. J Craniofac Surg 23:1314–7CrossRefPubMed
41.
Zurück zum Zitat Stainsby D, Jones H, Wells AW, Gibson B, Cohen H, SHOT Steering Group (2008) Adverse outcomes of blood transfusion in children: analysis of UK reports to the serious hazards of transfusion scheme 1996–2005. Br J Haematol 141:73–79CrossRefPubMed Stainsby D, Jones H, Wells AW, Gibson B, Cohen H, SHOT Steering Group (2008) Adverse outcomes of blood transfusion in children: analysis of UK reports to the serious hazards of transfusion scheme 1996–2005. Br J Haematol 141:73–79CrossRefPubMed
42.
Zurück zum Zitat Steinbok P (2016) Techniques for limiting blood loss and blood transfusions in pediatric neurosurgery. In Cohen AR (ed) Pediatric Neurosurgery: Tricks of the trade, Thieme, New York, pp 867–873 (forthcoming) Steinbok P (2016) Techniques for limiting blood loss and blood transfusions in pediatric neurosurgery. In Cohen AR (ed) Pediatric Neurosurgery: Tricks of the trade, Thieme, New York, pp 867–873 (forthcoming)
43.
Zurück zum Zitat Steinbok P, Heran N, Hicdonmez T, Cochrane DD, Price A (2004) Minimizing blood transufusions in the surgical correction of coronal and metopic craniosynostosis. Childs Nerv Syst 20:445–52PubMed Steinbok P, Heran N, Hicdonmez T, Cochrane DD, Price A (2004) Minimizing blood transufusions in the surgical correction of coronal and metopic craniosynostosis. Childs Nerv Syst 20:445–52PubMed
44.
Zurück zum Zitat Stricker PA, Fiadjoe JE, Kilbaugh TJ, Pruitt EY, Taylor JA, Bartlett SP, McCloskey JJ (2012) Effect of transfusion guidelines on postoperative transfusion in children undergoing craniofacial reconstruction surgery. Pediatr Crit Care Med 13:e357–62CrossRefPubMed Stricker PA, Fiadjoe JE, Kilbaugh TJ, Pruitt EY, Taylor JA, Bartlett SP, McCloskey JJ (2012) Effect of transfusion guidelines on postoperative transfusion in children undergoing craniofacial reconstruction surgery. Pediatr Crit Care Med 13:e357–62CrossRefPubMed
45.
Zurück zum Zitat Stricker PA, Shaw TL, Desouza DG, Hernandez SV, Bartlett SP, Friedman DF, Sesok-Pizzini DA, Jobes DR (2010) Blood loss, replacement, and associated morbidity in infants and children undergoing craniofacial surgery. Paediatr Anaesth 20:150–9CrossRefPubMed Stricker PA, Shaw TL, Desouza DG, Hernandez SV, Bartlett SP, Friedman DF, Sesok-Pizzini DA, Jobes DR (2010) Blood loss, replacement, and associated morbidity in infants and children undergoing craniofacial surgery. Paediatr Anaesth 20:150–9CrossRefPubMed
46.
Zurück zum Zitat Székely A, Cserép Z, Sápi E, Breuer T, Nagy CA, Vargha P, Hartyánszky I, Szatmári A, Treszl A (2009) Risks and predictors of blood transfusion in pediatric patients undergoing open heart operations. Ann Thorac Surg 87:187–97CrossRefPubMed Székely A, Cserép Z, Sápi E, Breuer T, Nagy CA, Vargha P, Hartyánszky I, Szatmári A, Treszl A (2009) Risks and predictors of blood transfusion in pediatric patients undergoing open heart operations. Ann Thorac Surg 87:187–97CrossRefPubMed
47.
Zurück zum Zitat van Uitert A, Megens JH, Breugem CC, Stubenitsky BM, Han KS, de Graaff JC (2011) Factors influencing blood loss and allogeneic blood transfusion practice in craniosynostosis surgery. Paediatr Anaesth 21:1192–7CrossRefPubMed van Uitert A, Megens JH, Breugem CC, Stubenitsky BM, Han KS, de Graaff JC (2011) Factors influencing blood loss and allogeneic blood transfusion practice in craniosynostosis surgery. Paediatr Anaesth 21:1192–7CrossRefPubMed
48.
Zurück zum Zitat Vega RA, Lyon C, Kierce JF, Tye GW, Ritter AM, Rhodes JL (2014) Minimizing transfusion requirements children undergoing craniosynostosis repair: the CHoR protocol. J Neurosurg Pediatr 30:1–6 Vega RA, Lyon C, Kierce JF, Tye GW, Ritter AM, Rhodes JL (2014) Minimizing transfusion requirements children undergoing craniosynostosis repair: the CHoR protocol. J Neurosurg Pediatr 30:1–6
49.
Zurück zum Zitat White N, Bayliss S, Moore D (2015) Systematic review of interventions for minimizing perioperative blood transfusion for surgery for craniosynostosis. J Craniofac Surg 26:26–36CrossRefPubMed White N, Bayliss S, Moore D (2015) Systematic review of interventions for minimizing perioperative blood transfusion for surgery for craniosynostosis. J Craniofac Surg 26:26–36CrossRefPubMed
50.
Zurück zum Zitat White N, Carver ED, Rodrigues D, Dover S, Magdum S, Nishikawa H, Solanki G (2009) Calvarial remodelling for sagittal synostosis: does fibrin glue (Tisseel) reduce post-operative blood transfusion requirements? Childs Nerv Syst 25:867–9CrossRefPubMed White N, Carver ED, Rodrigues D, Dover S, Magdum S, Nishikawa H, Solanki G (2009) Calvarial remodelling for sagittal synostosis: does fibrin glue (Tisseel) reduce post-operative blood transfusion requirements? Childs Nerv Syst 25:867–9CrossRefPubMed
51.
Zurück zum Zitat White N, Marcus R, Dover S, Solanki G, Nishikawa H, Millar C, Carver ED (2009) Predictors of blood loss in fronto-orbital advancement and remodeling. J Craniofac Surg 20:378–81CrossRefPubMed White N, Marcus R, Dover S, Solanki G, Nishikawa H, Millar C, Carver ED (2009) Predictors of blood loss in fronto-orbital advancement and remodeling. J Craniofac Surg 20:378–81CrossRefPubMed
Metadaten
Titel
Minimizing blood transfusions in the surgical correction of craniosynostosis: a 10-year single-center experience
verfasst von
Christopher M. Bonfield
Julia Sharma
D. Douglas Cochrane
Ash Singhal
Paul Steinbok
Publikationsdatum
01.01.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Child's Nervous System / Ausgabe 1/2016
Print ISSN: 0256-7040
Elektronische ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-015-2900-6

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Karpaltunnelsyndrom BDC Leitlinien Webinare
CME: 2 Punkte

Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis
Berufsverband der Deutschen Chirurgie e.V.

S2e-Leitlinie „Distale Radiusfraktur“

Radiusfraktur BDC Leitlinien Webinare
CME: 2 Punkte

Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske
Dr. med. Benjamin Meyknecht
Berufsverband der Deutschen Chirurgie e.V.

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

Appendizitis BDC Leitlinien Webinare
CME: 2 Punkte

Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric
Berufsverband der Deutschen Chirurgie e.V.