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01.04.2012 | Original Article

A prospective, randomized, double-blind study comparing the efficacy of diltiazem, glyceryl trinitrate, and lidocaine for the treatment of anal fissure in children

verfasst von: Muazez Cevik, Mehmet Emin Boleken, Ibrahim Koruk, Servet Ocal, Mehmet Emin Balcioglu, Asim Aydinoglu, Cetin Ali Karadag

Erschienen in: Pediatric Surgery International | Ausgabe 4/2012

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Abstract

Purpose

Anal fissure (AF) is a common perianal condition in children. Although adult patients with AF have been treated successfully using diltiazem, it has not been studied in children. The present randomized, prospective, double-blind study assessed the response, side effects, and recurrence of diltiazem.

Methods

Ninety-three children with AF were randomly divided into three groups. Each group received topical ointment. Group GTN received 0.2% glyceryl trinitrate, group L received 10% lidocaine, and group D received 2% diltiazem ointment.

Results

Eighty-two patients completed the 12-month study. At the end of the first 8-week course, the healing rate in group D was significantly higher than that of the other groups (p < 0.0001, χ ² = 19.82). Nonresponders received a second course of the same treatment. Group D showed significantly higher healing rates than the other groups (p < 0.05, χ ² = 7.227) at the end of the second 8-week course. The group D recurrence rate was significantly different than that of the other groups (p < 0. 002, χ ² = 12.79).

Conclusion

Diltiazem application is effective and safe for the treatment of AF in children, and has a low recurrence rate. The smooth dose–concentration curve causes minimal side effects.

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Titel: A prospective, randomized, double-blind study comparing the efficacy of diltiazem, glyceryl trinitrate, and lidocaine for the treatment of anal fissure in children
verfasst von: Muazez Cevik
Mehmet Emin Boleken
Ibrahim Koruk
Servet Ocal
Mehmet Emin Balcioglu
Asim Aydinoglu
Cetin Ali Karadag
Publikationsdatum: 01.04.2012
Verlag: Springer-Verlag
Erschienen in: Pediatric Surgery International / Ausgabe 4/2012
Print ISSN: 0179-0358
Elektronische ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-011-3048-4

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A prospective, randomized, double-blind study comparing the efficacy of diltiazem, glyceryl trinitrate, and lidocaine for the treatment of anal fissure in children