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20.09.2022 | Original Article

Early detection of liver fibrosis with serum Mac-2 binding protein glycosylation-modified isomer (M2BPGi) during follow-up intestinal failure patients without intestinal failure-associated liver disease (IFALD)

verfasst von: Takehisa Ueno, Koki Takase, Koichi Deguchi, Kazunori Masahata, Motonari Nomura, Miho Watanabe, Masafumi Kamiyama, Yuko Tazuke, Kazuhiko Bessho, Hiroomi Okuyama

Erschienen in: Pediatric Surgery International | Ausgabe 12/2022

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Abstract

Purpose

Mac-2 binding protein glycosylation-modified isomer (M2BPGi) is a new marker for hepatic fibrosis progression. We examined the relationship between serum M2BPGi levels and liver histological findings in intestinal failure (IF) patients without IF-associated liver disease (IFALD).

Methods

This study included IF patients without IFALD followed at our hospital. All patients underwent routine liver biopsies per protocol every 1–2 years. We examined M2BPGi levels and histological findings in relation to aspartate aminotransferase (AST) to platelet ratio index, fibrosis-4 index, and AST/ALT ratio. Liver fibrosis was evaluated based on the METAVIR score.

Results

Total 18 liver biopsies out of eight patients were included. The median age was 11.5 years. Mean M2BPGi was 0.44 cutoff index (COI) in patients with F0 fibrosis, 0.78 COI in patients with F1 fibrosis and 1.63 COI in patients with F2 fibrosis. Mean M2BPGi was significantly higher in patients with F2 versus F1 or F0 fibrosis (P < 0.016 and P < 0.028, respectively). M2BPGi levels were more strongly correlated with fibrosis stage than with other conventional fibrosis markers.

Conclusion

Serum M2BPGi is a novel marker of liver fibrosis in patients with IF. It is useful for follow-up prior to IFALD. Serum M2BPGi levels can support the interpretation of liver status.

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Titel: Early detection of liver fibrosis with serum Mac-2 binding protein glycosylation-modified isomer (M2BPGi) during follow-up intestinal failure patients without intestinal failure-associated liver disease (IFALD)
verfasst von: Takehisa Ueno
Koki Takase
Koichi Deguchi
Kazunori Masahata
Motonari Nomura
Miho Watanabe
Masafumi Kamiyama
Yuko Tazuke
Kazuhiko Bessho
Hiroomi Okuyama
Publikationsdatum: 20.09.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Surgery International / Ausgabe 12/2022
Print ISSN: 0179-0358
Elektronische ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-022-05240-w

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Early detection of liver fibrosis with serum Mac-2 binding protein glycosylation-modified isomer (M2BPGi) during follow-up intestinal failure patients without intestinal failure-associated liver disease (IFALD)

Abstract

Purpose

Methods

Results

Conclusion

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Abstract

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