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European Journal of Nutrition

Erschienen in:

01.02.2011 | Original Contribution

Effects of high-fat and low-fat diets rich in monounsaturated fatty acids on serum lipids, LDL size and indices of lipid peroxidation in healthy non-obese men and women when consumed under controlled conditions

verfasst von: Sarah Egert, Mario Kratz, Frank Kannenberg, Manfred Fobker, Ursel Wahrburg

Erschienen in: European Journal of Nutrition | Ausgabe 1/2011

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Abstract

Objective

To study the effects of the dietary fat content on cardiovascular disease risk factors in humans when the fatty acid composition and types of carbohydrates are kept constant.

Methods

A controlled dietary study in healthy volunteers with 2 dietary groups and a parallel design consisting of 2 dietary periods was conducted. First, participants received a 2-week wash-in diet rich in saturated fatty acids (SFA; 47% of total fatty acids) and were then randomly assigned to either a high-fat (40% of energy) or a low-fat diet (29% of energy) for 4 weeks. Both diets were isocaloric, rich in monounsaturated fatty acids (MUFA; 51% of total fatty acids) and had similar fatty acid and carbohydrate compositions.

Results

Compared to the wash-in diet, the high-fat and low-fat diets significantly lowered LDL-cholesterol (−0.34 and −0.41 mmol/l, respectively; P < 0.001 for time effect in RM-ANOVA), and HDL-cholesterol (−0.13 and −0.18 mmol/l, respectively; P < 0.001 for time), without any differences between the high-fat and low-fat diets (P = 0.112 and P = 0.085 for time × group interaction in RM-ANOVA, respectively). The size of the major LDL fraction, the LDL susceptibility to oxidation and the plasma concentrations of oxidized LDL (ox-LDL) were significantly reduced by both the high-fat and low-fat diet, again without significant differences between the diets. The ratio of ox-LDL/LDL-cholesterol, serum triacylglycerols and urinary F2-isoprostanes were not significantly affected by the diets.

Conclusion

A high-fat and a low-fat diet, both rich in MUFA, had similar effects on lipid-related cardiovascular disease risk factors in metabolically healthy men and women.

Mackay J, Mensah GA (2004) The atlas of heart disease and stroke. World Health Organization (WHO), Geneva

Glass CK, Witztum JL (2001) Atherosclerosis: the road ahead. Cell 104:503–516CrossRef

Kratz M, Cullen P, Wahrburg U (2002) The impact of dietary mono- and polyunsaturated fatty acids on risk factors for atherosclerosis in humans. Eur J Lipid Sci Technol 104:300–311CrossRef

Lapointe A, Couillard C, Lemieux S (2006) Effects of dietary factors on oxidation of low-density lipoprotein particles. J Nutr Biochem 17:645–658CrossRef

Erkkilä A, de Mello VD, Risérus U, Laaksonen DE (2008) Dietary fatty acids and cardiovascular disease: an epidemiological approach. Prog Lipid Res 47:172–187CrossRef

Jakobsen MU, O’Reilly EJ, Heitmann BL, Pereira MA, Balter K, Fraser GE, Goldbourt U, Hallmans G, Knekt P, Liu S, Pietinen P, Spiegelman D, Stevens J, Virtamo J, Willett WC, Ascherio A (2009) Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies. Am J Clin Nutr 89:1425–1432CrossRef

Siri-Tarino PW, Sun Q, Hu FB, Krauss RM (2010) Saturated fat, carbohydrate, and cardiovascular disease. Am J Clin Nutr 91:502–509CrossRef

National Cholesterol Education Program (NCEP) (2001) Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults. Executive summary of the third report of the Expert Panel (Adult Treatment Panel III). JAMA 285:2486–2497CrossRef

Lichtenstein AH, Appel LJ, Brands M, Carnethon M, Daniels S, Franch HA, Franklin B, Kris-Etherton P, Harris WS, Howard B, Karanja N, Lefevre M, Rudel L, Sacks F, Van Horn L, Winston M, Wylie-Rosett J (2006) Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee. Circulation 114:82–96CrossRef

10.

World Health Organization (WHO) (2003) Diet, nutrition and the prevention of chronic diseases: Report of a Joint WHO/FAO Expert Consultation (WHO Technical Report Series Vol. 916). World Health Organization (WHO). WHO Technical Report Series 916. World Health Organization (WHO), Geneva

11.

Willet WC (2002) Dietary fat plays a major role in obesity: no. Obes Rev 3:59–68CrossRef

12.

Sanders TA (2003) High- versus low-fat diets in human diseases. Curr Opin Clin Nutr Metab Care 6:151–155CrossRef

13.

Katan MB, Grundy SM, Willett WC (1997) Should a low-fat, high-carbohydrate diet be recommended for everyone? Beyond low-fat diets. N Engl J Med 337:563–566

14.

Astrup A, Astrup A, Buemann B, Flint A, Raben A (2002) Low-fat diets and energy balance: how does the evidence stand in 2002? Proc Nutr Soc 61:299–309CrossRef

15.

Pieke B, von Eckardstein A, Gülbahçe E, Chirazi A, Schulte H, Assmann G, Wahrburg U (2000) Treatment of hypertriglyceridemia by two diets rich either in unsaturated fatty acids or in carbohydrates: effects on lipoprotein subclasses, lipolytic enzymes, lipid transfer proteins, insulin and leptin. Int J Obes Relat Metab Disord 24:1286–1296CrossRef

16.

Siri-Tarino PW, Sun Q, Hu FB, Krauss RM (2010) Saturated fat, carbohydrate, and cardiovascular disease. Am J Clin Nutr 91:502–509

17.

Mozaffarian D (2005) Effects of dietary fats versus carbohydrates on coronary heart disease: a review of the evidence. Curr Atheroscler Rep 7:435–445CrossRef

18.

Kratz M, Gülbahçe E, von Eckardstein A, Cullen P, Cignarella A, Assmann G, Wahrburg U (2002) Dietary mono- and polyunsaturated fatty acids similarly affect LDL size in healthy men and women. J Nutr 132:715–718

19.

Egert S, Somoza V, Kannenberg F, Fobker M, Krome K, Erbersdobler HF, Wahrburg U (2007) Influence of three rapeseed oil-rich diets, fortified with alpha-linolenic acid, eicosapentaenoic acid or docosahexaenoic acid on the composition and oxidizability of low-density lipoproteins: results of a controlled study in healthy volunteers. Eur J Clin Nutr 61:314–325CrossRef

20.

Esterbauer H, Striegl G, Puhl H, Rotheneder M (1989) Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Radic Res Commun 6:67–75CrossRef

21.

Jacobs B, Angelis-Schierbaum G, Egert S, Assmann G, Kratz M (2004) Individual serum triglyceride responses to high-fat and low-fat diets differ in men with modest and severe hypertriglyceridemia. J Nutr 134:1400–1405

22.

Mensink RP, de Groot MJ, van den Broeke LT, Severijnen-Nobels AP, Demacker PN, Katan MB (1989) Effects of monounsaturated fatty acids v complex carbohydrates on serum lipoproteins and apoproteins in healthy men and women. Metabolism 38:172–178CrossRef

23.

Mensink RP, Katan MB (1987) Effect of monounsaturated fatty acids versus complex carbohydrates on high-density lipoproteins in healthy men and women. Lancet 1:122–125CrossRef

24.

Dreon DM, Fernstrom HA, Miller B, Krauss RM (1995) Apolipoprotein E isoform phenotype and LDL subclass response to a reduced-fat diet. Arterioscler Thromb Vasc Biol 15:105–111

25.

Krauss RM, Dreon DM (1995) Low-density-lipoprotein subclasses and response to a low-fat diet in healthy men. Am J Clin Nutr 62:478S–487S

26.

Campos H, Dreon DM, Krauss RM (1995) Associations of hepatic and lipoprotein lipase activities with changes in dietary composition and low density lipoprotein subclasses. J Lipid Res 36:462–472

27.

Grundy SM, Florentin L, Nix D, Whelan MF (1988) Comparison of monounsaturated fatty acids and carbohydrates for reducing raised levels of plasma cholesterol in man. Am J Clin Nutr 47:965–969

28.

Sirtori CR, Tremoli E, Gatti E, Montanari G, Sirtori M, Colli S, Gianfranceschi G, Maderna P, Dentone CZ, Testolin G (1986) Controlled evaluation of fat intake in the Mediterranean diet: comparative activities of olive oil and corn oil on plasma lipids and platelets in high-risk patients. Am J Clin Nutr 44:635–642

29.

Kris-Etherton PM, Pearson TA, Wan Y, Hargrove RL, Moriarty K, Fishell V, Etherton TD (1999) High-monounsaturated fatty acid diets lower both plasma cholesterol and triacylglycerol concentrations. Am J Clin Nutr 70:1009–1015

30.

Wahrburg U, Martin H, Sandkamp M, Schulte H, Assmann G (1992) Comparative effects of a recommended lipid-lowering diet vs a diet rich in monounsaturated fatty acids on serum lipid profiles in healthy young adults. Am J Clin Nutr 56:678–683

31.

Kratz M, Cullen P, Kannenberg F, Kassner A, Fobker M, Abuja PM, Assmann G, Wahrburg U (2002) Effects of dietary fatty acids on the composition and oxidizability of low-density lipoprotein. Eur J Clin Nutr 56:72–81CrossRef

32.

Ginsberg HN, Kris-Etherton P, Dennis B, Elmer PJ, Ershow A, Lefevre M, Pearson T, Roheim P, Ramakrishnan R, Reed R, Stewart K, Stewart P, Phillips K, Anderson N (1998) Effects of reducing dietary saturated fatty acids on plasma lipids and lipoproteins in healthy subjects: the DELTA Study, protocol 1. Arterioscler Thromb Vasc Biol 18:441–449

33.

Mensink RP, Zock PL, Kester AD, Katan MB (2003) Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am J Clin Nutr 77:1146–1155

34.

Mensink RP, Katan MB (1992) Effect of dietary fatty acids on serum lipids and lipoproteins. A meta-analysis of 27 trials. Arterioscler Thromb 12:911–919

35.

Gardner CD, Kraemer HC (1995) Monounsaturated versus polyunsaturated dietary fat and serum lipids. A meta-analysis. Arterioscler Thromb Vasc Biol 15:1917–1927

36.

Kris-Etherton PM, Kris-Etherton PM, Binkoski AE, Zhao G, Coval SM, Clemmer KF, Hecker KD, Jacques H, Etherton TD (2002) Dietary fat: assessing the evidence in support of a moderate-fat diet; the benchmark based on lipoprotein metabolism. Proc Nutr Soc 61:287–298CrossRef

37.

Hargrove RL, Etherton TD, Pearson TA, Harrison EH, Kris-Etherton PM (2001) Low fat and high monounsaturated fat diets decrease human low density lipoprotein oxidative susceptibility in vitro. J Nutr 131:1758–1763

38.

O’Bryne DJ, O’Keefe SF, Shireman RB (1998) Low-fat, monounsaturate-rich diets reduce susceptibility of low density lipoproteins to peroxidation ex vivo. Lipids 33:149–157CrossRef

39.

Ylä-Herttuala S, Palinski W, Rosenfeld ME, Parthasarathy S, Carew TE, Butler S, Witztum JL, Steinberg D (1989) Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. J Clin Invest 84:1086–1095CrossRef

40.

Morrow JD (2005) Quantification of isoprostanes as indices of oxidant stress and the risk of atherosclerosis in humans. Arterioscler Thromb Vasc Biol 25:279–286CrossRef

41.

Lamarche B, Lemieux I, Despres JP (1999) The small, dense LDL phenotype and the risk of coronary heart disease: epidemiology, patho-physiology and therapeutic aspects. Diabetes Metab 25:199–211

42.

Groener JE, van Ramshorst EM, Katan MB, Mensink RP, van Tol A (1991) Diet-induced alteration in the activity of plasma lipid transfer protein in normolipidemic human subjects. Atherosclerosis 87:221–226CrossRef

43.

Jansen S, Lopez-Miranda J, Castro P, Lopez-Segura F, Marin C, Ordovas JM, Paz E, Jimenez-Pereperez J, Fuentes F, Perez-Jimenez F (2000) Low-fat and high-monounsaturated fatty acid diets decrease plasma cholesterol ester transfer protein concentrations in young, healthy, normolipemic men. Am J Clin Nutr 72:36–41

44.

Chung BH, Segrest JP, Franklin F (1998) In vitro production of beta-very low density lipoproteins and small, dense low density lipoproteins in mildly hypertriglyceridemic plasma: role of activities of lecithin:cholester acyltransferase, cholesterylester transfer proteins and lipoprotein lipase. Atherosclerosis 141:209–225CrossRef

Titel: Effects of high-fat and low-fat diets rich in monounsaturated fatty acids on serum lipids, LDL size and indices of lipid peroxidation in healthy non-obese men and women when consumed under controlled conditions
verfasst von: Sarah Egert
Mario Kratz
Frank Kannenberg
Manfred Fobker
Ursel Wahrburg
Publikationsdatum: 01.02.2011
Verlag: Springer-Verlag
Erschienen in: European Journal of Nutrition / Ausgabe 1/2011
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-010-0116-9

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