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Erschienen in: European Journal of Nutrition 1/2013

01.02.2013 | Original Contribution

Metabolic syndrome and quality of life in the elderly: age and gender differences

verfasst von: Alice Laudisio, Emanuele Marzetti, Livia Antonica, Francesco Pagano, Davide L. Vetrano, Roberto Bernabei, Giuseppe Zuccalà

Erschienen in: European Journal of Nutrition | Ausgabe 1/2013

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Abstract

Purpose

The metabolic syndrome (MetS) is highly prevalent in Western older populations. MetS is an intriguing entity, because it includes potentially reversible risk factors. Some studies have suggested an inverse correlation between MetS and health-related quality of life (HRQoL), but data regarding older subjects are scanty and conflicting. The aim of this study was to assess the association between HRQoL and MetS in older, unselected community-dwelling subjects.

Methods

We analyzed data of 356 subjects aged 75+ living in Tuscania (Italy). HRQoL was assessed using the Health Utilities Index, Mark 3. Diagnosis of MetS was defined according to the National Cholesterol Education Program’s ATP-III criteria.

Results

MetS was reported by 137 (38%) participants. According to linear regression analysis, MetS was associated with significantly better HRQoL in men (B = 0.19 95% CI = 0.06–0.32; p = 0.006), but not in women. Also, when the regression model was analyzed in men, MetS was associated with better HRQoL (B = 0.17, 95% CI = 0.01–0.32; p = 0.035) only among participants aged 80+. No significant associations were found in men between HRQoL and any of the single components of MetS.

Conclusions

MetS is not associated with worse HRQoL among community-dwelling elderly; it is associated with significantly better HRQoL among the oldest men.
Literatur
1.
Zurück zum Zitat Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC Jr, Lenfant C, American Heart Association; National Heart, Lung, and Blood Institute (2004) Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 109(3):433–438CrossRef Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC Jr, Lenfant C, American Heart Association; National Heart, Lung, and Blood Institute (2004) Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 109(3):433–438CrossRef
2.
Zurück zum Zitat Cameron AJ, Shaw JE, Zimmet PZ (2004) The metabolic syndrome: prevalence in worldwide populations. Endocrinol Metab Clin North Am 33(2):351–375CrossRef Cameron AJ, Shaw JE, Zimmet PZ (2004) The metabolic syndrome: prevalence in worldwide populations. Endocrinol Metab Clin North Am 33(2):351–375CrossRef
3.
Zurück zum Zitat Gutierrez DA, Puglisi MJ, Hasty AH (2009) Impact of increased adipose tissue mass on inflammation, insulin resistance, and dyslipidemia. Curr Diab Rep 9:26–32CrossRef Gutierrez DA, Puglisi MJ, Hasty AH (2009) Impact of increased adipose tissue mass on inflammation, insulin resistance, and dyslipidemia. Curr Diab Rep 9:26–32CrossRef
4.
Zurück zum Zitat Qiao Q, Gao W, Zhang L, Nyamdorj R, Tuomilehto J (2007) Metabolic syndrome and cardiovascular disease. Ann Clin Biochem 44(Pt3):232–263CrossRef Qiao Q, Gao W, Zhang L, Nyamdorj R, Tuomilehto J (2007) Metabolic syndrome and cardiovascular disease. Ann Clin Biochem 44(Pt3):232–263CrossRef
5.
Zurück zum Zitat Thomas GN, Schooling CM, McGhee SM, Ho SY, Cheung BM, Wat NM, Janus ED, Lam KS, Lam TH, Hong Kong Cardiovascular Risk Factor Prevalence Study Steering Committee (2007) Metabolic syndrome increases all-cause and vascular mortality: the Hong Kong Cardiovascular Risk Factor Study. Clin Endocrinol 66(5):666–671CrossRef Thomas GN, Schooling CM, McGhee SM, Ho SY, Cheung BM, Wat NM, Janus ED, Lam KS, Lam TH, Hong Kong Cardiovascular Risk Factor Prevalence Study Steering Committee (2007) Metabolic syndrome increases all-cause and vascular mortality: the Hong Kong Cardiovascular Risk Factor Study. Clin Endocrinol 66(5):666–671CrossRef
6.
Zurück zum Zitat Smith KJ, Hsu HE, Roberts MS, Kramer MK, Orchard TJ, Piatt GA, Seidel MC, Zgibor JC, Bryce CL (2010) Cost-effectiveness analysis of efforts to reduce risk of type 2 diabetes and cardiovascular disease in southwestern Pennsylvania, 2005–2007. Prev Chronic Dis 7(5):A109 Smith KJ, Hsu HE, Roberts MS, Kramer MK, Orchard TJ, Piatt GA, Seidel MC, Zgibor JC, Bryce CL (2010) Cost-effectiveness analysis of efforts to reduce risk of type 2 diabetes and cardiovascular disease in southwestern Pennsylvania, 2005–2007. Prev Chronic Dis 7(5):A109
7.
Zurück zum Zitat Tziallas D, Kastanioti C, Kostapanos MS, Skapinakis P, Elisaf MS, Mavreas V (2011) The impact of the metabolic syndrome on health-related quality of life: a cross-sectional study in Greece. Eur J Cardiovasc Nurs, Mar 11 Tziallas D, Kastanioti C, Kostapanos MS, Skapinakis P, Elisaf MS, Mavreas V (2011) The impact of the metabolic syndrome on health-related quality of life: a cross-sectional study in Greece. Eur J Cardiovasc Nurs, Mar 11
8.
Zurück zum Zitat Park SS, Yoon YS, Oh SW (2005) Health-related quality of life in metabolic syndrome: the Korea National Health and Nutrition Examination Survey 2005. Diabetes Res Clin Pract 91(3):381–388CrossRef Park SS, Yoon YS, Oh SW (2005) Health-related quality of life in metabolic syndrome: the Korea National Health and Nutrition Examination Survey 2005. Diabetes Res Clin Pract 91(3):381–388CrossRef
9.
Zurück zum Zitat Amiri P, Hosseinpanah F, Rambod M, Montazeri A, Azizi F (2010) Metabolic syndrome predicts poor health-related quality of life in women but not in men: Tehran Lipid and Glucose Study. J Womens Health (Larchmt) 19(6):1201–1207CrossRef Amiri P, Hosseinpanah F, Rambod M, Montazeri A, Azizi F (2010) Metabolic syndrome predicts poor health-related quality of life in women but not in men: Tehran Lipid and Glucose Study. J Womens Health (Larchmt) 19(6):1201–1207CrossRef
10.
Zurück zum Zitat Sohn YJ, Sohn HS, Kwon JW (2011) Gender differences among middle-aged Koreans for health-related quality of life related to metabolic syndrome. Qual Life Res 20(4):583–592CrossRef Sohn YJ, Sohn HS, Kwon JW (2011) Gender differences among middle-aged Koreans for health-related quality of life related to metabolic syndrome. Qual Life Res 20(4):583–592CrossRef
11.
Zurück zum Zitat Ferraroni M, Decarli A, Franceschi S, La Vecchia C, Enard L, Negri E, Parpinel M, Salvini S (1996) Validity and reproducibility of alcohol consumption in Italy. Int J Epidemiol 25(4):775–782CrossRef Ferraroni M, Decarli A, Franceschi S, La Vecchia C, Enard L, Negri E, Parpinel M, Salvini S (1996) Validity and reproducibility of alcohol consumption in Italy. Int J Epidemiol 25(4):775–782CrossRef
12.
Zurück zum Zitat Zuccalà G, Onder G, Pedone C, Cesari M, Landi F, Bernabei R, Cocchi A, Gruppo Italiano di Farmacoepidemiologia nell’Anziano Investigators (2001) Dose-related impact of alcohol consumption on cognitive function in advanced age: results of a multicenter survey. Alcohol Clin Exp Res 25(12):1743–1748CrossRef Zuccalà G, Onder G, Pedone C, Cesari M, Landi F, Bernabei R, Cocchi A, Gruppo Italiano di Farmacoepidemiologia nell’Anziano Investigators (2001) Dose-related impact of alcohol consumption on cognitive function in advanced age: results of a multicenter survey. Alcohol Clin Exp Res 25(12):1743–1748CrossRef
13.
Zurück zum Zitat Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW (1963) Studies of illness in the aged: the index of ADL: a standardized measure of biological and psychosocial function. JAMA 185:414–419CrossRef Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW (1963) Studies of illness in the aged: the index of ADL: a standardized measure of biological and psychosocial function. JAMA 185:414–419CrossRef
14.
Zurück zum Zitat Lawton MP, Brody EM (1969) Assessment of older: self-maintaining and instrumental activities of daily living. Gerontologist 9(3):179–186CrossRef Lawton MP, Brody EM (1969) Assessment of older: self-maintaining and instrumental activities of daily living. Gerontologist 9(3):179–186CrossRef
15.
Zurück zum Zitat Nardi B, De Rosa M, Paciaroni G, Marchesi GF, Bonaiuto S, Luciani P, Turtù F, Giannandrea E (1991) Clinical investigation on depression on a randomized and stratified sample in an elderly population. Minerva Psichiatr 32(3):135–144 Nardi B, De Rosa M, Paciaroni G, Marchesi GF, Bonaiuto S, Luciani P, Turtù F, Giannandrea E (1991) Clinical investigation on depression on a randomized and stratified sample in an elderly population. Minerva Psichiatr 32(3):135–144
16.
Zurück zum Zitat Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, Adey M, Leirer VO (1982–1983) Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res 17(1):37–49 Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, Adey M, Leirer VO (1982–1983) Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res 17(1):37–49
17.
Zurück zum Zitat Hodkinson HM (1972) Evaluation of a mental test score for assessment of mental impairment in the elderly. Age Ageing 1(4):233–238CrossRef Hodkinson HM (1972) Evaluation of a mental test score for assessment of mental impairment in the elderly. Age Ageing 1(4):233–238CrossRef
18.
Zurück zum Zitat Rocca WA, Bonaiuto S, Lippi A, Luciani P, Pistarelli T, Grandinetti A, Cavarzeran F, Amaducci L (1992) Validation of the Hodkinson abbreviated mental test as a screening instrument for dementia in an Italian population. Neuroepidemiology 11(4–6):288–295CrossRef Rocca WA, Bonaiuto S, Lippi A, Luciani P, Pistarelli T, Grandinetti A, Cavarzeran F, Amaducci L (1992) Validation of the Hodkinson abbreviated mental test as a screening instrument for dementia in an Italian population. Neuroepidemiology 11(4–6):288–295CrossRef
19.
Zurück zum Zitat PHS–HCFA (1980) International classification of diseases, 9th rev. 1980 Public Health Service—Health Care Financing Administration, Washington, DC PHS–HCFA (1980) International classification of diseases, 9th rev. 1980 Public Health Service—Health Care Financing Administration, Washington, DC
20.
Zurück zum Zitat Deyo RA, Cherkin DC, Ciol MA (1992) Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol 45(6):613–619CrossRef Deyo RA, Cherkin DC, Ciol MA (1992) Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol 45(6):613–619CrossRef
21.
Zurück zum Zitat Feeny D, Furlong W, Torrance GW, Goldsmith CH, Zhu Z, DePauw S, Denton M, Boyle M (2002) Multiattribute and single-attribute utility functions for the health utilities index mark 3 system. Med Care 40(2):113–128CrossRef Feeny D, Furlong W, Torrance GW, Goldsmith CH, Zhu Z, DePauw S, Denton M, Boyle M (2002) Multiattribute and single-attribute utility functions for the health utilities index mark 3 system. Med Care 40(2):113–128CrossRef
22.
Zurück zum Zitat Eckel RH, Grundy SM, Zimmet PZ (2005) The metabolic syndrome. Lancet 365(9468):1415–1428CrossRef Eckel RH, Grundy SM, Zimmet PZ (2005) The metabolic syndrome. Lancet 365(9468):1415–1428CrossRef
23.
Zurück zum Zitat Ford ES, Li C (2008) Metabolic syndrome and health-related quality of life among U.S. adults. Ann Epidemiol 18(3):165–171CrossRef Ford ES, Li C (2008) Metabolic syndrome and health-related quality of life among U.S. adults. Ann Epidemiol 18(3):165–171CrossRef
24.
Zurück zum Zitat Rich MW, Nease RF (1999) Cost-effectiveness analysis in clinical practice: the case of heart failure. Arch Intern Med 159(15):1690–1700CrossRef Rich MW, Nease RF (1999) Cost-effectiveness analysis in clinical practice: the case of heart failure. Arch Intern Med 159(15):1690–1700CrossRef
25.
Zurück zum Zitat Katano S, Nakamura Y, Nakamura A, Suzukamo Y, Murakami Y, Tanaka T, Okayama A, Miura K, Okamura T, Fukuhara S, Ueshima H (2001) Relationship between health-related quality of life and clustering of metabolic syndrome diagnostic components. Qual Life Res [Epub ahead of print] Katano S, Nakamura Y, Nakamura A, Suzukamo Y, Murakami Y, Tanaka T, Okayama A, Miura K, Okamura T, Fukuhara S, Ueshima H (2001) Relationship between health-related quality of life and clustering of metabolic syndrome diagnostic components. Qual Life Res [Epub ahead of print]
26.
Zurück zum Zitat Dupuy AM, Jaussent I, Lacroux A, Durant R, Cristol JP, Delcourt C (2007) Waist circumference adds to the variance in plasma C-reactive protein levels in elderly patients with metabolic syndrome. Gerontology 53(6):329–339CrossRef Dupuy AM, Jaussent I, Lacroux A, Durant R, Cristol JP, Delcourt C (2007) Waist circumference adds to the variance in plasma C-reactive protein levels in elderly patients with metabolic syndrome. Gerontology 53(6):329–339CrossRef
27.
Zurück zum Zitat Lai MM, Li CI, Kardia SL, Liu CS, Lin WY, Lee YD, Chang PC, Lin CC, Li TC (2010) Sex difference in the association of metabolic syndrome with high sensitivity C-reactive protein in a Taiwanese population. BMC Public Health 10:429CrossRef Lai MM, Li CI, Kardia SL, Liu CS, Lin WY, Lee YD, Chang PC, Lin CC, Li TC (2010) Sex difference in the association of metabolic syndrome with high sensitivity C-reactive protein in a Taiwanese population. BMC Public Health 10:429CrossRef
28.
Zurück zum Zitat Laudisio A, Marzetti E, Pagano F, Pozzi G, Bernabei R, Zuccalà G (2009) Depressive symptoms and metabolic syndrome: selective association in older women. J Geriatr Psychiatry Neurol 22(4):215–222CrossRef Laudisio A, Marzetti E, Pagano F, Pozzi G, Bernabei R, Zuccalà G (2009) Depressive symptoms and metabolic syndrome: selective association in older women. J Geriatr Psychiatry Neurol 22(4):215–222CrossRef
29.
Zurück zum Zitat Kalantar-Zadeh K, Block G, Horwich T, Fonarow GC (2004) Reverse epidemiology of conventional cardiovascular risk factors in patients with chronic heart failure. J Am Coll Cardiol 43(8):1439–1444CrossRef Kalantar-Zadeh K, Block G, Horwich T, Fonarow GC (2004) Reverse epidemiology of conventional cardiovascular risk factors in patients with chronic heart failure. J Am Coll Cardiol 43(8):1439–1444CrossRef
Metadaten
Titel
Metabolic syndrome and quality of life in the elderly: age and gender differences
verfasst von
Alice Laudisio
Emanuele Marzetti
Livia Antonica
Francesco Pagano
Davide L. Vetrano
Roberto Bernabei
Giuseppe Zuccalà
Publikationsdatum
01.02.2013
Verlag
Springer-Verlag
Erschienen in
European Journal of Nutrition / Ausgabe 1/2013
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-012-0337-1

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