nach oben

Erschienen in:

01.06.2013 | Original Contribution

Neonatal overfeeding causes higher adrenal catecholamine content and basal secretion and liver dysfunction in adult rats

verfasst von: E. P. S. Conceição, E. G. Moura, I. H. Trevenzoli, N. Peixoto-Silva, C. R. Pinheiro, V. Younes-Rapozo, E. Oliveira, P. C. Lisboa

Erschienen in: European Journal of Nutrition | Ausgabe 4/2013

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Rats that are overfed during lactation exhibit neonatal hyperleptinemia and higher visceral adiposity, hypertension, higher liver oxidative stress and insulin resistance in the liver as adults. Previously, we demonstrated that neonatal hyperleptinemia is associated with adrenal medullary hyperfunction, hypertension and liver steatosis in adulthood. Therefore, we hypothesised that adrenal and liver functions are altered in adult obese rats that were overfed during lactation, which would underlie their hypertension and liver alterations.

Methods

The litter size was reduced from ten to three male pups on the third day of lactation until weaning (SL) to induce early overfeeding in Wistar rats. The control group had ten rats per litter (NL). Rats had free access to standard diet, and water after weaning until the rats were 180 days old.

Results

The SL group exhibited higher adrenal catecholamine content (absolute: +35% and relative: +40%), tyrosine hydroxylase (+31%) and DOPA decarboxylase (+90%) protein contents and basal catecholamine secretion in vitro (+57%). However, the hormones of the hypothalamic-pituitary-adrenal cortex axis were unchanged. β₃-adrenergic receptor content in visceral adipose tissue was unchanged in SL rats, but the β₂-adrenergic receptor content in the liver was lower in this group (−45%). The SL group exhibited higher glycogen and triglycerides contents in the liver (+79 and +49%, respectively), which suggested microesteatosis.

Conclusions

Neonatal overfeeding led to higher adrenomedullary function, but the liver β₂-adrenergic receptor content was reduced. These results may contribute to the hepatic dysfunction characteristic of liver obesity complications.

Barker DJ (2004) The developmental origins of adult disease. J Am Coll Nutr 23:588S–595S

de Moura EG, Lisboa PC, Passos MC (2008) Neonatal programming of neuroimmunomodulation–role of adipocytokines and neuropeptides. NeuroImmunoModulation 15:176–188CrossRef

Gluckman PD, Hanson MA (2007) Developmental plasticity and human disease: research directions. J Intern Med 261:461–471CrossRef

Plagemann A, Harder T, Rake A, Voits M, Fink H, Rohde W, Dörner G (1999) Perinatal elevation of hypothalamic insulin, acquired malformation of hypothalamic galaninergic neurons, and syndrome x-like alterations in adulthood of neonatally overfed rats. Brain Res 836:146–155CrossRef

Rodrigues AL, de Moura EG, Passos MC, Dutra SC, Lisboa PC (2009) Postnatal early overnutrition changes the leptin signalling pathway in the hypothalamic-pituitary-thyroid axis of young and adult rats. J Physiol 587:2647–2661CrossRef

Plagemann A, Harder T, Rake A, Waas T, Melchior K, Ziska T, Rohde W, Dörner G (1999) Observations on the orexigenic hypothalamic neuropeptide Y-system in neonatally overfed weanling rats. J Neuroendocrinol 7:541–546

Davidowa H, Plagemann A (2000) Decreased inhibition by leptin of hypothalamic arcuate neurons in neonatally overfed young rats. NeuroReport 21:2795–2798CrossRef

Davidowa H, Plagemann A (2001) Inhibition by insulin of hypothalamic VMN neurons in rats overweight due to postnatal overfeeding. NeuroReport 29:3201–3204CrossRef

Rodrigues AL, de Moura EG, Passos MC, Trevenzoli IH, da Conceição EP, Bonono IT, Neto JF, Lisboa PC (2011) Postnatal early overfeeding induces hypothalamic higher SOCS3 expression and lower STAT3 activity in adult rats. J Nutr Biochem 22:109–117CrossRef

10.

Ferretti S, Fornari A, Pedrazzi P, Pellegrini M, Zoli M (2011) Developmental overfeeding alters hypothalamic neuropeptide mRNA levels and response to a high-fat diet in adult mice. Peptides 32:1371–1383CrossRef

11.

Reilly JJ, Kelly J (2011) Long-term impact of overweight and obesity in childhood and adolescence on morbidity and premature mortality in adulthood: systematic review. Int J Obes (Lond) 35:891–898CrossRef

12.

Trevenzoli IH, Valle MM, Machado FB, Garcia RM, Passos MC, Lisboa PC, Moura EG (2007) Neonatal hyperleptinaemia programmes adrenal medullary function in adult rats: effects on cardiovascular parameters. J Physiol 580:629–637CrossRef

13.

Trevenzoli IH, Rodrigues AL, Oliveira E, Thole AA, Carvalho L, Figueiredo MS, Toste FP, Neto JF, Passos MC, Lisboa PC et al (2010) Leptin treatment during lactation programs leptin synthesis, intermediate metabolism, and liver microsteatosis in adult rats. Horm Metab Res 42:483–490CrossRef

14.

Young JB (2002) Effects of litter size on sympathetic activity in young adult rats. Am J Physiol Regul Integr Comp Physiol 282:1113–1121

15.

Plagemann A, Heidrich I, Götz F, Rohde W, Dörner G (1992) Obesity and enhanced diabetes and cardiovascular risk in adult rats due to early postnatal overfeeding. Exp Clin Endocrinol 99:154–158CrossRef

16.

Peng YX, Shan J, Qi XY, Zhang SJ, Ma SP, Wang N, Li JP, Xue H, Wu M (2006) The catecholamine-beta-adrenoreceptor-cAMP system and prediction of cardiovascular events in hypertension. Clin Exp Pharmacol Physiol 33:227–231CrossRef

17.

Conceição EPS, Franco JG, Oliveira E, Resende AC, Amaral TAS, Peixoto-Silva N, Passos MCF, Moura EG, Lisboa PC (2012) Oxidative stress programming in a rat model of postnatal early overnutrition—role of insulin resistance. J Nutr Biochem. doi:10.1016/j.jnutbio.2012.02.010

18.

Nonogaki K (2000) New insights into sympathetic regulation of glucose and fat metabolism. Diabetologia 43:533–549CrossRef

19.

Blaak EE, van Baak MA, Kempen KPG, Saris WHM (1993) Role of α- and β-adrenoceptors in sympathetically mediated thermogenesis. Am J Physiol 264:E11–E17

20.

Yorek MA, Rufo GA Jr, Ray PD (1980) Gluconeogenesis in rabbit liver. III. The influences of glucagon, epinephrine, alpha- and beta-adrenergic agents on gluconeogenesis in isolated hepatocytes. Biochim Biophys Acta 632:517–526CrossRef

21.

Djouder N, Tuerk RD, Suter M, Salvioni P, Thali RF, Scholz R, Vaahtomeri K, Auchli Y, Rechsteiner H, Brunisholz RA et al (2010) PKA phosphorylates and inactivates AMPKalpha to promote efficient lipolysis. EMBO J 29:469–481CrossRef

22.

Campbell JE, Peckett AJ, D’souza AM, Hawke TJ, Riddell MC (2011) Adipogenic and lipolytic effects of chronic glucocorticoid exposure. Am J Physiol 300:198–209CrossRef

23.

Ross ME, Evinger MJ, Hyman SE, Carroll JM, Mucke L, Comb M, Reis DJ, Joh TH, Goodman HM (1990) Identification of a functional glucocorticoid response element in the phenylethanolamine N-methyltransferase promoter using fusion genes introduced into chromaffin cells in primary cultures. J Neurosci 10:520–530

24.

Cornett LE, Hiller FC, Jacobi SE, Cao W, McGraw DW (1998) Identification of a glucocorticoid response element in the rat beta2-adrenergic receptor gene. Mol Pharmacol 54:1016–1023

25.

Pasquali R, Cantobelli S, Casimirri F, Capelli M, Bortoluzzi L, Flamia R, Labate AMM, Barabara L (1993) The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution. J Clin Endocrinol Metab 77:341–346CrossRef

26.

Mastorakos G, Zapanti E (2004) The hypothalamic-pituitary-adrenal axis in the neuroendocrine regulation of food intake and obesity: the role of corticotropin releasing hormone. Nutr Neurosci 7:271–280CrossRef

27.

Boullu-Ciocca S, Dutour A, Guillaume V, Achard V, Oliver C, Grino M (2005) Postnatal diet-induced obesity in rats upregulates systemic and adipose tissue glucocorticoid metabolism during development and in adulthood: its relationship with the metabolic syndrome. Diabetes 54:197–203CrossRef

28.

Spencer SJ, Tilbrook A (2009) Neonatal overfeeding alters adult anxiety and stress responsiveness. Psychoneuroendocrinology 34:1133–1143CrossRef

29.

Kahan E, Rosen M (1984) The influence of litter size and favourable conditions on mortality and weaning weights in rats. Lab Anim 18:247–251CrossRef

30.

Scherle W (1970) A simple method for volumetry of organs in quantitative stereology. Mikroskopie 26:57–60

31.

Yin FCP, Spurgeon HA, Rakusan K, Weisfeldt ML, Lakatta EG (1982) Use of tibial length to quantify cardiac hypertrophy: application in the ageing rat. Am J Physiol 243:H941–H947

32.

Paxinos G, Watson C (1998) The rat brain in stereotaxic coordinates. Academic Press, New York

33.

Trevenzoli IH, Pinheiro CR, Conceição EPS, Oliveira E, Passos MCF, Lisboa PC, Moura EG (2010) Programming of rat adrenal medulla by neonatal hyperleptinemia: adrenal morphology, catecholamine secretion, and leptin signaling pathway. Am J Physiol Endocrinol Metab 298:941–949CrossRef

34.

Oliveira E, Pinheiro CR, Santos-Silva AP, Trevenzoli IH, Abreu-Villaça Y, Nogueira Neto JF, Reis AM, Passos MC, Moura EG, Lisboa PC (2010) Nicotine exposure affects mother’s and pup’s nutritional, biochemical, and hormonal profiles during lactation in rats. J Endocrinol 205:159–170CrossRef

35.

Folch J, Lees M, Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226:497–509

36.

Catta-Preta M, Mendonca LS, Fraulob-Aquino J, Aguila MB, Mandarim-de-Lacerda CA (2011) A critical analysis of three quantitative methods of assessment of hepatic steatosis in liver biopsies. Virchows Arch 459:477–485CrossRef

37.

Bancroft JD, Stevens A (1990) Theory and practice of histological techniques. Churchill Livingstone, Edinburgh

38.

Conceição EPS, Trevenzoli IH, Oliveira E, Franco JG, Carlos AS, Nascimento-Saba CC, Moura EG, Lisboa PC (2011) Higher white adipocyte area and lower leptin production in adult rats overfed during lactation. Horm Metab Res 43:513–516CrossRef

39.

Plagemann A, Roepke K, Harder T, Brunn M, Harder A, Wittrock-Staar M, Ziska T, Schellong K, Rodekamp E, Melchior K, Dudenhausen JW (2010) Epigenetic malprogramming of the insulin receptor promoter due to developmental overfeeding. J Perinat Med 38:393–400

40.

Shah NS, Lila A (2011) Childhood cushing disease: a challenge in diagnosis and management. Horm Res Paediatr 76:65–70CrossRef

41.

Rosmond R, Dallman MF, Björntorp P (1998) Stress-related cortisol secretion in men: relationship with abdominal obesity and endocrine, metabolic and hemodynamic abnormalities. J Clin Endocrinol Metab 83:1853–1859CrossRef

42.

Salehi M, Ferenczi A, Zumoff B (2005) Obesity and cortisol status. Horm Metab Res 37:193–197CrossRef

43.

Velkoska E, Cole TJ, Morris MJ (2005) Early dietary intervention: long-term effects on blood pressure, brain neuropeptide Y, and adiposity markers. Am J Physiol Endocrinol Metab 288:1236–1243CrossRef

44.

Edgerton DS, Basu R, Ramnanan CJ, Farmer TD, Neal D, Scott M, Jacobson P, Rizza RA, Cherrington AD (2010) Effect of 11 beta-hydroxysteroid dehydrogenase-1 inhibition on hepatic glucose metabolism in the conscious dog. Am J Physiol Endocrinol Metab 298:1019–1026CrossRef

45.

Perelló M, Moreno G, Gaillard RC, Spinedi E (2004) Glucocorticoid-dependency of increased adiposity in a model of hypothalamic obesity. Neuro Endocrinol Lett 25(1–2):119–126

46.

Tokuyama K, Himms-Hagen J (1989) Adrenalectomy prevents obesity in glutamate-treated mice. Am J Physiol 257(2 Pt 1):E139–E144

47.

Auvinen HE, Romijn JA, Biermasz NR, Havekes LM, Smit JW, Rensen PC, Pereira AM (2011) Effects of high fat diet on the Basal activity of the hypothalamus-pituitary-adrenal axis in mice: a systematic review. Horm Metab Res 43(13):899–906CrossRef

48.

Auvinen HE, Romijn JA, Biermasz NR, Pijl H, Havekes LM, Smit JW, Rensen PC, Pereira AM (2012) The effects of high fat diet on the basal activity of the hypothalamus-pituitary-adrenal axis in mice. J Endocrinol 214(2):191–197CrossRef

49.

Martins AC, Souza KL, Shio MT, Mathias PC, Lelkes PI, Garcia RM (2004) Adrenal medullary function and expression of catecholamine-synthesising enzymes in mice with hypothalamic obesity. Life Sci 74(26):3211–3222CrossRef

50.

Collins S, Daniel KW, Rohlfs EM (1999) Depressed expression of adipocyte beta-adrenergic receptors is a common feature of congenital and diet-induced obesity in rodents. Int J Obes Relat Metab Disord 23:669–677CrossRef

51.

Xu XF, Björntorp P (1990) Effects of dexamethasone on multiplication and differentiation of rat adipose precursor cells. Exp Cell Res 189:247–252CrossRef

52.

Fried SK, Russell CD, Grauso NL, Brolin RE (1993) Lipoprotein lipase regulation by insulin and glucocorticoid in subcutaneous and omental adipose tissue of obese women and men. J Clin Invest 92:2191–2198CrossRef

53.

Raddatz D, Ramadori G (2007) Carbohydrate metabolism and the liver: actual aspects from physiology and disease. Z Gastroenterol 45:51–62CrossRef

54.

Li J, Huang J, Li JS, Chen H, Huang K, Zheng L (2011) Accumulation of endoplasmic reticulum stress and lipogenesis in the liver through generational effects of high fat diets. J Hepatol PMID: 22173165

55.

Dudley KJ, Sloboda DM, Connor KL, Beltrand J, Vickers MH (2011) Offspring of mothers fed a high fat diet display hepatic cell cycle inhibition and associated changes in gene expression and DNA methylation. PLoS ONE 6:e21662CrossRef

56.

Hodis J, Kutinová-Canová N, Potmesil P, Kameníková L, Kmonícková E, Zídek Z, Farghali H (2007) The role of adrenergic agonists on glycogenolysis in rat hepatocyte cultures and possible involvement of NO. Phys Res 56:419–425

57.

Chakrabarti S, Guria S, Samanta I, Das M (2007) Thyroid dysfunction modulates glucoregulatory mechanism in rat. Indian J Exp Biol 45:549–553

58.

Hou M, Liu Y, Zhu L, Sun B, Guo M, Burén J, Li X (2011) Neonatal overfeeding induced by small litter rearing causes altered glucocorticoid metabolism in rats. PLoS ONE 6:e25726CrossRef

59.

Baudrand R, Domínguez JM, Carvajal CA, Riquelme A, Campino C, Macchiavello S, Bozinovic M, Morales M, Pizarro M, Solis N et al (2011) Overexpression of hepatic 5α-reductase and 11β-hydroxysteroid dehydrogenase type 1 in visceral adipose tissue is associated with hyperinsulinemia in morbidly obese patients. Metabolism 60:1775–1780CrossRef

60.

Duff DA, Snell K (1982) Effect of altered neonatal nutrition on the development of enzymes of lipid and carbohydrate metabolism in the rat. J Nutr 112:1057–1066

61.

Jakobsen MU, Berentzen T, Sørensen TI, Overvad K (2007) Abdominal obesity and fatty liver. Epidemiol Rev 29:77–87CrossRef

62.

Pietiläinen KH, Rissanen A, Kaprio J, Mäkimattila S, Häkkinen AM, Westerbacka J, Sutinen J, Vehkavaara S, Yki-Järvinen H (2005) Acquired obesity is associated with increased liver fat, intra-abdominal fat, and insulin resistance in young adult monozygotic twins. Am J Phys Metab 288:768–774

63.

Oben JA, Mouralidarane A, Samuelsson AM, Matthews PJ, Morgan ML, McKee C, Soeda J, Fernandez-Twinn DS, Martin-Gronert MS, Ozanne SE et al (2010) Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice. J Hepatol 52:913–920CrossRef

64.

Bouanane S, Merzouk H, Benkalfat NB, Soulimane N, Merzouk SA, Gresti J, Tessier C, Narce M (2010) Hepatic and very low-density lipoprotein fatty acids in obese offspring of overfed dams. Metabolism 59:1701–1709CrossRef

Titel: Neonatal overfeeding causes higher adrenal catecholamine content and basal secretion and liver dysfunction in adult rats
verfasst von: E. P. S. Conceição
E. G. Moura
I. H. Trevenzoli
N. Peixoto-Silva
C. R. Pinheiro
V. Younes-Rapozo
E. Oliveira
P. C. Lisboa
Publikationsdatum: 01.06.2013
Verlag: Springer-Verlag
Erschienen in: European Journal of Nutrition / Ausgabe 4/2013
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-012-0448-8

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

25.04.2024 Allergien und Intoleranzreaktionen Nachrichten

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2013

Dietary acrylamide intake of adults in the European Prospective Investigation into Cancer and Nutrition differs greatly according to geographical region

Time of ingestion relative to meal intake determines gastrointestinal responses to a plant sterol–containing yoghurt drink

Trans-fatty acids, dangerous bonds for health? A background review paper of their use, consumption, health implications and regulation in France

Krill oil versus fish oil in modulation of inflammation and lipid metabolism in mice transgenic for TNF-α

Modulation of the nuclear factor-kappa B (NF-κB) signalling pathway by glutamine in peritoneal macrophages of a murine model of protein malnutrition