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15.06.2018 | Original Contribution

Diet as moderator in the association of adiposity with inflammatory biomarkers among adolescents in the HELENA study

verfasst von: Aline Arouca, Luis A. Moreno, Esther M. Gonzalez-Gil, Ascensión Marcos, Kurt Widhalm, Dénes Molnár, Yannis Manios, Frederic Gottrand, Anthony Kafatos, Mathilde Kersting, Michael Sjöström, Francisco J. Amaro-Gahete, Marika Ferrari, Inge Huybrechts, Marcela Gonzalez-Gross, Stefaan De Henauw, Nathalie Michels

Erschienen in: European Journal of Nutrition | Ausgabe 5/2019

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Abstract

Aim

Our aim is to demonstrate that a healthy diet might reduce the relation between adiposity and inflammation, whereas an unhealthy diet may increase the effect of adiposity on inflammatory biomarkers.

Methods

In 618 adolescents (13–17 years) of the European HELENA study, data were available on body composition, a set of inflammation markers, and food intake determined by a self-administered computerized 24-h recall. A 9-point Mediterranean diet score and an antioxidant-rich diet score were used as dietary parameters and tested as moderator. Total body fat was represented by the sum of six skinfold thicknesses and central adiposity by waist circumference. A set of inflammation-related biomarkers was used as outcome: a pro/anti-inflammatory interleukins ratio, TGFβ-1, C-reactive protein, TNF-α, 3 cell adhesion molecules, and 3 types of immune cells; gamma-glutamyltransferase (GGT) and homocysteine were used as cardiovascular disease risk biomarkers, and alanine transaminase (ALT) as liver dysfunction biomarker. Multiple linear regression analyses tested moderation by diet in the adiposity-inflammation association and were adjusted for age, sex, country, puberty, socioeconomic status.

Results

Both the Mediterranean and antioxidant-rich diet, and overall and central adiposity, were important in the moderation. Diet was a significant protective moderator in the effect of adiposity on the pro/anti-inflammatory interleukins ratio, TGFβ-1, GGT, and ALT.

Conclusion

In conclusion, in some cases, a diet rich in antioxidants and essential nutrients may attenuate the concentration of inflammatory biomarkers caused by adiposity, whereas a poor diet appears to contribute to the onset of early oxidative stress signs.

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Titel: Diet as moderator in the association of adiposity with inflammatory biomarkers among adolescents in the HELENA study
verfasst von: Aline Arouca
Luis A. Moreno
Esther M. Gonzalez-Gil
Ascensión Marcos
Kurt Widhalm
Dénes Molnár
Yannis Manios
Frederic Gottrand
Anthony Kafatos
Mathilde Kersting
Michael Sjöström
Francisco J. Amaro-Gahete
Marika Ferrari
Inge Huybrechts
Marcela Gonzalez-Gross
Stefaan De Henauw
Nathalie Michels
Publikationsdatum: 15.06.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 5/2019
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-018-1749-3

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Diet as moderator in the association of adiposity with inflammatory biomarkers among adolescents in the HELENA study

Abstract