nach oben

Erschienen in:

04.03.2021 | Original Contribution

Associations between maternal vitamin D status during three trimesters and cord blood 25(OH)D concentrations in newborns: a prospective Shanghai birth cohort study

verfasst von: Xirui Wang, Xianting Jiao, Ying Tian, Jun Zhang, Yue Zhang, Juan Li, Fan Yang, Mingqing Xu, Xiaodan Yu, for the Shanghai Birth Cohort Study

Erschienen in: European Journal of Nutrition | Ausgabe 6/2021

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Prenatal vitamin D (VitD) deficiency influences children’s health in later life. We aimed to test the associations between maternal VitD status in each of the three trimesters of pregnancy and cord blood 25(OH)D concentrations in newborns.

Methods

Participants were pregnant women recruited from the Shanghai Birth Cohort (SBC) (n = 1100). Of all the participants, 946 completed the collection of venous blood at early (< 16 weeks, T1), mid- (24–28 weeks, T2), and late (32–34 weeks, T3) pregnancy as well as the corresponding cord blood in the newborns. Maternal serum 25(OH)D concentrations were measured by LC–MS/MS, and the information on confounding factors was obtained through a standardized questionnaire.

Results

The mean 25(OH)D concentrations at time points T1, T2, T3 in maternal blood and cord blood of the newborns were 26.31 ng/mL, 31.92 ng/mL, 35.62 ng/mL, and 19.77 ng/mL, respectively. Neonatal 25(OH)D level in cord blood was positively correlated with maternal serum 25(OH)D levels at each trimester, and the strongest correlation was found at time point T3.

Conclusion

Maternal 25(OH)D concentrations at each trimester were positively associated with neonatal VitD status in cord blood, and the strongest correlation was found in the late stage of pregnancy, which could be considered as a sensitive time window. Attention should be paid to the nutritional status of VitD during pregnancy to better prevent the VitD deficiency in neonates.

Chang SW, Lee HC (2019) Vitamin D and health—the missing vitamin in humans. Pediatr Neonatol 60(3):237–244. https://doi.org/10.1016/j.pedneo.2019.04.007CrossRefPubMed

Wheeler BJ, Taylor BJ, de Lange M et al (2018) A longitudinal study of 25-hydroxy vitamin D and parathyroid hormone status throughout pregnancy and exclusive lactation in New Zealand mothers and their infants at 45°S. Nutrients 10(1):E86. https://doi.org/10.3390/nu10010086CrossRefPubMed

Magnus MC, Miliku K, Bauer A et al (2018) Vitamin D and risk of pregnancy related hypertensive disorders: mendelian randomisation study. BMJ 361:k2167. https://doi.org/10.1136/bmj.k2167CrossRefPubMedPubMedCentral

Zhao X, Fang R, Yu R et al (2017) Maternal Vitamin D Status in the late second trimester and the risk of severe Preeclampsia in Southeastern China. Nutrients 9(2):138. https://doi.org/10.3390/nu9020138CrossRefPubMedCentral

Xia J, Song Y, Rawal S et al (2019) Vitamin D status during pregnancy and the risk of gestational diabetes mellitus: a longitudinal study in a multiracial cohort. Diabetes Obes Metab 21(8):1895–1905. https://doi.org/10.1111/dom.13748CrossRefPubMedPubMedCentral

Pérez-López FR, Pasupuleti V, Mezones-Holguin E et al (2015) Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials. Fertil Steril 103(5):1278–1288. https://doi.org/10.1016/j.fertnstert.2015.02.019CrossRefPubMed

Wang Y, Li H, Zheng M et al (2018) Maternal vitamin D deficiency increases the risk of adverse neonatal outcomes in the Chinese population: a prospective cohort study. PLoS ONE 13(4):e0195700. https://doi.org/10.1371/journal.pone.0195700CrossRefPubMedPubMedCentral

Kiely M, O’Donovan SM, Kenny LC et al (2017) Vitamin D metabolite concentrations in umbilical cord blood serum and associations with clinical characteristics in large prospective mother-infant cohort in Ireland. J Steroid Biochem Mol Biol 167:162–168. https://doi.org/10.1016/j.jsbmb.2016.12.006CrossRefPubMed

Hollis BW, Wagner CL (2017) New insights into the vitamin D requirements during pregnancy. Bone Res 5:17030. https://doi.org/10.1038/boneres.2017.30CrossRefPubMedPubMedCentral

10.

Shen SY, Xiao WQ, Lu JH et al (2018) Early life vitamin D status and asthma and wheeze: a systematic review and meta-analysis. BMC Pulm Med 18(1):120. https://doi.org/10.1186/s12890-018-0679-4CrossRefPubMedPubMedCentral

11.

Miller KM, Hart PH, de Klerk NH et al (2017) Are low sun exposure and/or vitamin D risk factors for type 1 diabetes? Photochem Photobiol Sci 16(3):381–398. https://doi.org/10.1039/c6pp00294cCrossRefPubMed

12.

Larqué E, Morales E, Leis R et al (2018) Maternal and foetal health implications of vitamin D status during pregnancy. Ann Nutr Metab 72(3):179–192. https://doi.org/10.1159/000487370CrossRefPubMed

13.

Courbebaisse M, Souberbielle JC, Baptiste A et al (2019) Vitamin D status during pregnancy and in cord blood in a large prospective French cohort. Clin Nutr 38(5):2136–2144. https://doi.org/10.1016/j.clnu.2018.08.035CrossRefPubMed

14.

Wierzejska R, Jarosz M, Sawicki W et al (2017) Vitamin D concentration in maternal and umbilical cord blood by season. Int J Environ Res Public Health 14(10):E1121. https://doi.org/10.3390/ijerph14101121CrossRefPubMed

15.

Zhang J, Tian Y, Wang W et al (2019) Cohort profile: the Shanghai Birth Cohort. Int J Epidemiol 48(1):21–21g. https://doi.org/10.1093/ije/dyy277CrossRefPubMed

16.

Jiao X, Yuan Y, Wang X et al (2020) Development of a sensitive HPLC-MS/MS method for 25-hydroxyvitamin D(2) and D(3) measurement in capillary blood. J Clin Lab Anal 34(10):e23451. https://doi.org/10.1002/jcla.23451CrossRefPubMedPubMedCentral

17.

Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium; Ross AC, Taylor CL, Yaktine AL, Del Valle HB, editors. Dietary Reference Intakes for Calcium and Vitamin D. Washington (DC): National Academies Press (US) (2011)

18.

Holick MF, Binkley NC, Bischoff-Ferrari HA et al (2011) Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96(7):1911–1930. https://doi.org/10.1210/jc.2011-0385CrossRefPubMed

19.

Baca KM, Simhan HN, Platt RW et al (2016) Low maternal 25-hydroxyvitamin D concentration increases the risk of severe and mild preeclampsia. Ann Epidemiol 26(12):853–857. https://doi.org/10.1016/j.annepidem.2016.09.015CrossRefPubMedPubMedCentral

20.

Andersen LB, Jørgensen JS, Jensen TK et al (2015) Vitamin D insufficiency is associated with increased risk of first-trimester miscarriage in the Odense Child Cohort. Am J Clin Nutr 102(3):633–638. https://doi.org/10.3945/ajcn.114.103655CrossRefPubMed

21.

Miliku K, Vinkhuyzen A, Blanken LM et al (2016) Maternal vitamin D concentrations during pregnancy, fetal growth patterns, and risks of adverse birth outcomes. Am J Clin Nutr 103(6):1514–1522. https://doi.org/10.3945/ajcn.115.123752CrossRefPubMed

22.

Zhu P, Tong SL, Hu WB et al (2015) Cord Blood 25-hydroxyvitamin D and Fetal Growth in the China-Anhui Birth Cohort Study. Sci Rep 5:14930. https://doi.org/10.1038/srep14930CrossRefPubMedPubMedCentral

23.

Tao RX, Meng DH, Li JJ et al (2018) Current Recommended vitamin D prenatal supplementation and fetal growth: results from the china-anhui birth cohort study. J Clin Endocrinol Metab 103(1):244–252. https://doi.org/10.1210/jc.2017-00850CrossRefPubMed

24.

Tao M, Shao H, Gu J et al (2012) Vitamin D status of pregnant women in Shanghai, China. J Matern Fetal Neonatal Med 25:237–239. https://doi.org/10.3109/14767058.2011.569613CrossRefPubMed

25.

Yun C, Chen J, He Y et al (2017) Vitamin D deficiency prevalence and risk factors among pregnant Chinese women. Public Health Nutr 20(10):1746–1754. https://doi.org/10.1017/S1368980015002980CrossRefPubMed

26.

Bouillon R, Assche FAV, Baelen HV, et al (1981) Influence of the vitamin D-binding protein on the serum concentration of 1,25-dihydroxyvitamin D3. Significance of the free 1,25-dihydroxyvitamin D3 concentration. J Clin Invest 67(3):589–596. https://doi.org/https://doi.org/10.1172/JCI110072.

27.

Halicioglu O, Aksit S, Koc F, et al (2012) Vitamin D deficiency in pregnant women and their neonates in spring time in western Turkey. Paediatr Perinat Epidemiol 26(1):53–60. https://doi.org/10.1111/j.1365-3016.2011.01238.x

28.

Roth DE, Morris SK, Zlotkin S et al (2018) Vitamin D Supplementation in Pregnancy and Lactation and Infant Growth. N Engl J Med 379(6):535–546. https://doi.org/10.1056/NEJMoa1800927CrossRefPubMedPubMedCentral

29.

von Websky K, Hasan AA, Reichetzeder C et al (2018) Impact of vitamin D on pregnancy-related disorders and on offspring outcome. J Steroid Biochem Mol Biol 180:51–64. https://doi.org/10.1016/j.jsbmb.2017.11.008CrossRef

30.

van der Pligt P, Willcox J, Szymlek-Gay EA et al (2018) Associations of maternal vitamin D deficiency with pregnancy and neonatal complications in developing countries: a systematic review. Nutrients 10(5):E640. https://doi.org/10.3390/nu10050640CrossRefPubMed

31.

Park H, Brannon PM, West AA, et al (2016) Vitamin D metabolism varies among women in different reproductive states consuming the same intakes of vitamin D and related nutrients. J Nutr 146: 1537–1545. https://doi.org/https://doi.org/10.3945/jn.116.229971

32.

Karras SN, Wagner CL, Castracane VD (2018) Understanding vitamin D metabolism in pregnancy: from physiology to pathophysiology and clinical outcomes. Metabolism 86:112–123. https://doi.org/10.1016/j.metabol.2017.10.001CrossRefPubMed

33.

Chawla D, Daniels JL, Benjamin-Neelon SE et al (2019) Racial and ethnic differences in predictors of vitamin D among pregnant women in south-eastern USA. J Nutr Sci 8:e8. https://doi.org/10.1017/jns.2019.4CrossRefPubMedPubMedCentral

34.

Gould JF, Anderson AJ, Yelland LN et al (2017) Association of cord blood vitamin D with early childhood growth and neurodevelopment. J Paediatr Child Health 53(1):75–83. https://doi.org/10.1111/jpc.13308CrossRefPubMed

35.

Song HB, Xu Y, Yang XW et al (2018) High prevalence of vitamin D deficiency in pregnant women and its relationship with adverse pregnancy outcomes in Guizhou. China J Int Med Res 46(11):4500–4505. https://doi.org/10.1177/0300060518781477CrossRef

36.

March KM, Chen NN, Karakochuk CD, et al (2015) Maternal vitamin D3 supplementation at 50 mug/d protects against low serum 25- hydroxyvitamin D in infants at 8 wk of age: a randomized controlled trial of 3 doses of vitamin D beginning in gestation and continued in lactation. Am J Clin Nutr 102:402–10. https://doi.org/10.3945/ajcn.114.106385.

37.

O’Callaghan KM, Hennessy A, Hull GLJ et al (2018) Estimation of the maternal vitamin D intake that maintains circulating 25-hydroxyvitamin D in late gestation at a concentration sufficient to keep umbilical cord sera ≥ 25–30 nmol/L: a dose-response, double-blind, randomized placebo-controlled trial in pregnant women at northern latitude. Am J Clin Nutr 108(1):77–91. https://doi.org/10.1093/ajcn/nqy064CrossRefPubMedPubMedCentral

38.

Grant CC, Stewart AW, Scragg R, et al (2014) Vitamin D during pregnancy and infancy and infant serum 25-hydroxyvitamin D concentration. Pediatrics 133:e143–53. https://doi.org/10.1542/peds.2013-2602.

Titel: Associations between maternal vitamin D status during three trimesters and cord blood 25(OH)D concentrations in newborns: a prospective Shanghai birth cohort study
verfasst von: Xirui Wang
Xianting Jiao
Ying Tian
Jun Zhang
Yue Zhang
Juan Li
Fan Yang
Mingqing Xu
Xiaodan Yu
for the Shanghai Birth Cohort Study
Publikationsdatum: 04.03.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 6/2021
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-021-02528-w

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Associations between maternal vitamin D status during three trimesters and cord blood 25(OH)D concentrations in newborns: a prospective Shanghai birth cohort study