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30.11.2016 | General Gynecology

Endometrial preparation with Dienogest before hysteroscopic surgery: a systematic review

verfasst von: Antonio Simone Laganà, Salvatore Giovanni Vitale, Vincenzo Muscia, Paola Rossetti, Massimo Buscema, Onofrio Triolo, Agnese Maria Chiara Rapisarda, Loretta Giunta, Vittorio Palmara, Roberta Granese, Helena Ban Frangež, Andrea Romano

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 3/2017

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Abstract

Purpose

Hysteroscopic surgery is considered the gold standard for the minimal invasive treatment of many endouterine diseases such as endometrial polyps or submucous myomas. Recently, many studies have evaluated the effect of preoperative administration of a number of drugs to reduce endometrial thickness and achieve important intraoperative advantages. The purpose of this systematic review is to summarize the available evidence about the use of Dienogest, an orally administrable progestin, for endometrial preparation before hysteroscopic surgery.

Methods

All studies published on this topic and indexed on PubMed/MEDLINE, Embase or Google scholar databases were retrieved and analysed.

Results

We retrieved five studies about this topic. Considered together, the published data analyses allow us to conclude that Dienogest is effective in reducing the thickness of the endometrium, the severity of bleeding and also of operative time, with a lower number of side effects compared with other pharmacological preparations or no treatment.

Conclusion

Administration of Dienogest may be an effective and safe treatment for endometrial thinning before operative hysteroscopy. However, this conclusion is based on few reports and further studies to prove or disprove it are warranted.

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Titel: Endometrial preparation with Dienogest before hysteroscopic surgery: a systematic review
verfasst von: Antonio Simone Laganà
Salvatore Giovanni Vitale
Vincenzo Muscia
Paola Rossetti
Massimo Buscema
Onofrio Triolo
Agnese Maria Chiara Rapisarda
Loretta Giunta
Vittorio Palmara
Roberta Granese
Helena Ban Frangež
Andrea Romano
Publikationsdatum: 30.11.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 3/2017
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-016-4244-1

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Endometrial preparation with Dienogest before hysteroscopic surgery: a systematic review