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Erschienen in: European Archives of Oto-Rhino-Laryngology 4/2007

01.04.2007 | Head and Neck

The effect of age on survival and quality of life in elderly head and neck cancer patients: a long-term prospective study

verfasst von: Marc P. van der Schroeff, Wynia Derks, Gerrit Jan Hordijk, Rob J. de Leeuw

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 4/2007

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Abstract

Little is known about long-term treatment outcome of elderly head and neck cancer patients and their quality of life (QOL). One hundred and eighteen older (≥70 years) and 148 younger (45–60 years) patients with head and neck cancer were followed up for 3–6 years. In the long-term follow-up 33 younger and 24 older patients completed the EORTC QLQ-C30 and H&N35 and a questionnaire about depression. The survival rate after 3–6 years for younger patients was 36%, as compared to 31% in the older patient group. Higher tumour stages, more co-morbidity and non-standard treatment showed to be independent prognostic factors for mortality. No independent prognostic value of age could be found. The global QOL score remains roughly comparable. Even up to 6 years after treatment, we found no significant differences in survival or overall QOL between older and younger head and neck cancer patients.
Literatur
1.
Zurück zum Zitat Samet J, Hunt WC, Key C, Humble CG, Goodwin JS (1986) Choice of cancer therapy varies with age of patient. JAMA 27(255):3385–3390 Samet J, Hunt WC, Key C, Humble CG, Goodwin JS (1986) Choice of cancer therapy varies with age of patient. JAMA 27(255):3385–3390
2.
Zurück zum Zitat Hirano M, Mori K (1998) Management of cancer in the elderly: therapeutic dilemmas. Otolaryngol Head Neck Surg 118:110–114CrossRef Hirano M, Mori K (1998) Management of cancer in the elderly: therapeutic dilemmas. Otolaryngol Head Neck Surg 118:110–114CrossRef
3.
Zurück zum Zitat Jones AS, Beasley N, Houghton D, Husband DJ (1998) The effects of age on survival and other parameters in squamous cell carcinoma of the oral cavity, pharynx and larynx. Clin Otolaryngol 23:51–56CrossRef Jones AS, Beasley N, Houghton D, Husband DJ (1998) The effects of age on survival and other parameters in squamous cell carcinoma of the oral cavity, pharynx and larynx. Clin Otolaryngol 23:51–56CrossRef
4.
Zurück zum Zitat Sarini J, Fournier C, Lefebre JL, Bonafos G, Van JT, Coche-Dequeant B (2001) Head and neck squamous cell carcinoma in elderly patients: a long term retrospective review of 273 cases. Arch Otolaryngol Head Neck Surg 127:1089–1092 Sarini J, Fournier C, Lefebre JL, Bonafos G, Van JT, Coche-Dequeant B (2001) Head and neck squamous cell carcinoma in elderly patients: a long term retrospective review of 273 cases. Arch Otolaryngol Head Neck Surg 127:1089–1092
5.
Zurück zum Zitat Derks W, de Leeuw JR, Hordijk GJ, Winnubst JA (2005) Reasons for non-standard treatment in elderly patients with advanced head and neck cancer. Eur Arch Otorhinolaryngol 262:21–26CrossRef Derks W, de Leeuw JR, Hordijk GJ, Winnubst JA (2005) Reasons for non-standard treatment in elderly patients with advanced head and neck cancer. Eur Arch Otorhinolaryngol 262:21–26CrossRef
6.
Zurück zum Zitat Bernardi D, Barzan L, Franchin G, Cinelli R, Balestreri L, Tirelli U, Vaccher E (2005) Treatment of head and neck cancer in elderly patients: state of the art and guidelines. Crit Rev Oncol Hematol 53:71–80 Bernardi D, Barzan L, Franchin G, Cinelli R, Balestreri L, Tirelli U, Vaccher E (2005) Treatment of head and neck cancer in elderly patients: state of the art and guidelines. Crit Rev Oncol Hematol 53:71–80
7.
Zurück zum Zitat Clayman GL, Eicher SA, Sicard MW, Razmpa E, Goepfert H (1998) Surgical outcomes in head and neck cancer patients 80 years of age and older. Head Neck 20:216–223CrossRef Clayman GL, Eicher SA, Sicard MW, Razmpa E, Goepfert H (1998) Surgical outcomes in head and neck cancer patients 80 years of age and older. Head Neck 20:216–223CrossRef
8.
Zurück zum Zitat Derks W, de Leeuw JR, Hordijk GJ (2003) Elderly patients with head and neck cancer: short-term effects of surgical treatment on quality of life. Clin Otolaryngol 28:399–405CrossRef Derks W, de Leeuw JR, Hordijk GJ (2003) Elderly patients with head and neck cancer: short-term effects of surgical treatment on quality of life. Clin Otolaryngol 28:399–405CrossRef
9.
Zurück zum Zitat Beausang ES, Ang EE, Lipa JE et al (2003) Microvascular free tissue transfer in elderly patients: the Toronto experience. Head Neck 25:549–553CrossRef Beausang ES, Ang EE, Lipa JE et al (2003) Microvascular free tissue transfer in elderly patients: the Toronto experience. Head Neck 25:549–553CrossRef
10.
Zurück zum Zitat Genden EM, Rinaldo A, Shaha A, Clayman GL, Werner JA, Suarez C, Ferlito A (2005) Treatment considerations for head and neck cancer in the elderly. J Laryngol Otol 119(3):169–74CrossRef Genden EM, Rinaldo A, Shaha A, Clayman GL, Werner JA, Suarez C, Ferlito A (2005) Treatment considerations for head and neck cancer in the elderly. J Laryngol Otol 119(3):169–74CrossRef
11.
Zurück zum Zitat Ribeiro KC, Kowalski LP, Latorre MR (2000) Impact of comorbidity, symptoms, and patients’ characteristics on the prognosis of oral carcinomas. Arch Otolaryngol Head Neck Surg 126:1079–1085 Ribeiro KC, Kowalski LP, Latorre MR (2000) Impact of comorbidity, symptoms, and patients’ characteristics on the prognosis of oral carcinomas. Arch Otolaryngol Head Neck Surg 126:1079–1085
12.
Zurück zum Zitat Reid BC, Alberg AJ, Klassen AC et al (2001) Comorbidity and survival of elderly head and neck carcinoma patients. Cancer 92:2109–2116CrossRef Reid BC, Alberg AJ, Klassen AC et al (2001) Comorbidity and survival of elderly head and neck carcinoma patients. Cancer 92:2109–2116CrossRef
13.
Zurück zum Zitat Hall SF, Groome PA, Rothwell D (2000) The impact of comorbidity on the survival of patients with squamous cell carcinoma of the head and neck. Head Neck 22:317–322CrossRef Hall SF, Groome PA, Rothwell D (2000) The impact of comorbidity on the survival of patients with squamous cell carcinoma of the head and neck. Head Neck 22:317–322CrossRef
14.
Zurück zum Zitat Piccirillo JF (2000) Importance of comorbidity in head and neck cancer. Laryngoscope 110:593–602CrossRef Piccirillo JF (2000) Importance of comorbidity in head and neck cancer. Laryngoscope 110:593–602CrossRef
15.
Zurück zum Zitat Sabin SL, Rosenfeld RM, Sundaram K et al (1999) The impact of comorbidity and age on survival with laryngeal cancer. Ear Nose Throat J 78:581–584 Sabin SL, Rosenfeld RM, Sundaram K et al (1999) The impact of comorbidity and age on survival with laryngeal cancer. Ear Nose Throat J 78:581–584
16.
Zurück zum Zitat Paleri V, Wight RG, Davies GR (2003) Impact of comorbidity on the outcome of laryngeal squamous cancer. Head Neck 25:1019–1026CrossRef Paleri V, Wight RG, Davies GR (2003) Impact of comorbidity on the outcome of laryngeal squamous cancer. Head Neck 25:1019–1026CrossRef
17.
Zurück zum Zitat Chen AY, Matson LK, Roberts D et al (2001) The significance of comorbidity in advanced laryngeal cancer. Head Neck 23:566–572CrossRef Chen AY, Matson LK, Roberts D et al (2001) The significance of comorbidity in advanced laryngeal cancer. Head Neck 23:566–572CrossRef
18.
Zurück zum Zitat Derks W, de Leeuw JR, Hordijk GJ, Winnubst JA (2004) Quality of life in elderly patients with head and neck cancer 1 year after diagnosis. Head Neck 26:1045–1052CrossRef Derks W, de Leeuw JR, Hordijk GJ, Winnubst JA (2004) Quality of life in elderly patients with head and neck cancer 1 year after diagnosis. Head Neck 26:1045–1052CrossRef
19.
Zurück zum Zitat De Graeff A, de Leeuw JR, Ros WJ, Hordijk GJ, Blijham GH, Winnubst JA (2000) Pretreatment factors predicting quality of life after treatment for head and neck cancer. Head Neck 22:398–407CrossRef De Graeff A, de Leeuw JR, Ros WJ, Hordijk GJ, Blijham GH, Winnubst JA (2000) Pretreatment factors predicting quality of life after treatment for head and neck cancer. Head Neck 22:398–407CrossRef
20.
Zurück zum Zitat Hammerlid E, Bjordal K, Ahlner-Elmqvist M et al (2001) A prospective study of quality of life in head and neck cancer patients. Part I: at diagnosis. Laryngoscope 111:669–680CrossRef Hammerlid E, Bjordal K, Ahlner-Elmqvist M et al (2001) A prospective study of quality of life in head and neck cancer patients. Part I: at diagnosis. Laryngoscope 111:669–680CrossRef
21.
Zurück zum Zitat Bjordal K, Ahlner-Elmqvist M, Hammerlid E et al (2001) A prospective study of quality of life in head and neck cancer patients. Part II: longitudinal data. Laryngoscope 111:1440–1452CrossRef Bjordal K, Ahlner-Elmqvist M, Hammerlid E et al (2001) A prospective study of quality of life in head and neck cancer patients. Part II: longitudinal data. Laryngoscope 111:1440–1452CrossRef
22.
Zurück zum Zitat Kaplan MH, Feinstein AR (1974) The importance of classifying initial co-morbidity in evaluating the outcome of diabetes mellitus. J Chronic Dis 27:387–404CrossRef Kaplan MH, Feinstein AR (1974) The importance of classifying initial co-morbidity in evaluating the outcome of diabetes mellitus. J Chronic Dis 27:387–404CrossRef
23.
Zurück zum Zitat Aaronson NK, Ahmedzai S, Bergman B et al (1993) The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85:365–376CrossRef Aaronson NK, Ahmedzai S, Bergman B et al (1993) The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85:365–376CrossRef
24.
Zurück zum Zitat Bjordal K, Ahlner-Elmqvist M, Tolleson E et al (1994) Development of a European Organization for Research and Treatment of Cancer (EORTC) questionnaire module to be used in quality of life assessments in head and neck cancer patients. EORTC Quality of Life Study Group. Acta Oncol 33:879–885 Bjordal K, Ahlner-Elmqvist M, Tolleson E et al (1994) Development of a European Organization for Research and Treatment of Cancer (EORTC) questionnaire module to be used in quality of life assessments in head and neck cancer patients. EORTC Quality of Life Study Group. Acta Oncol 33:879–885
25.
Zurück zum Zitat Radloff LS (1977) The CES-D Scale: a self-support depression scale for research in a general population. Appl Psychol Meas 1:385–401 Radloff LS (1977) The CES-D Scale: a self-support depression scale for research in a general population. Appl Psychol Meas 1:385–401
26.
Zurück zum Zitat Cassia Braga RK, Kowalski LP, Latorre MR (2003) Perioperative complications, comorbidities, and survival in oral or oropharyngeal cancer. Arch Otolaryngol Head Neck Surg 129:219–228 Cassia Braga RK, Kowalski LP, Latorre MR (2003) Perioperative complications, comorbidities, and survival in oral or oropharyngeal cancer. Arch Otolaryngol Head Neck Surg 129:219–228
27.
Zurück zum Zitat Kowalski LP, Alcantara PS, Magrin J, Parise JO (1994) A case-control study on complications and survival in elderly patients undergoing major head and neck surgery. Am J Surg 168:485–490CrossRef Kowalski LP, Alcantara PS, Magrin J, Parise JO (1994) A case-control study on complications and survival in elderly patients undergoing major head and neck surgery. Am J Surg 168:485–490CrossRef
28.
Zurück zum Zitat Barzan L, Veronesi A, Caruso G et al (1990) Head and neck cancer and ageing: a retrospective study in 438 patients. J Laryngol Otol 104:634–640 Barzan L, Veronesi A, Caruso G et al (1990) Head and neck cancer and ageing: a retrospective study in 438 patients. J Laryngol Otol 104:634–640
29.
Zurück zum Zitat Bhattacharyya N (2003) A matched survival analysis for squamous cell carcinoma of the head and neck in the elderly. Laryngoscope 113(2):368–72CrossRef Bhattacharyya N (2003) A matched survival analysis for squamous cell carcinoma of the head and neck in the elderly. Laryngoscope 113(2):368–72CrossRef
30.
Zurück zum Zitat De Graeff A, de Leeuw JR, Ros WJ, Hordijk GJ, Blijham GH, Winnubst JA (2000) Long-term quality of life of patients with head and neck cancer. Laryngoscope 110:98–106CrossRef De Graeff A, de Leeuw JR, Ros WJ, Hordijk GJ, Blijham GH, Winnubst JA (2000) Long-term quality of life of patients with head and neck cancer. Laryngoscope 110:98–106CrossRef
Metadaten
Titel
The effect of age on survival and quality of life in elderly head and neck cancer patients: a long-term prospective study
verfasst von
Marc P. van der Schroeff
Wynia Derks
Gerrit Jan Hordijk
Rob J. de Leeuw
Publikationsdatum
01.04.2007
Verlag
Springer-Verlag
Erschienen in
European Archives of Oto-Rhino-Laryngology / Ausgabe 4/2007
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-006-0203-y

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