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European Archives of Oto-Rhino-Laryngology

Erschienen in:

01.02.2015 | Rhinology

The effect of nasal structure on olfactory function in patients with OSA

verfasst von: Dan Fu, Jayant M. Pinto, Li Wang, Guowei Chen, Xiaojun Zhan, Yongxiang Wei

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 2/2015

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Abstract

The aim of this study was to investigate the relationship between nasal structure and olfactory function in patients with obstructive sleep apnea (OSA). Olfaction and nasal structure of 76 adults with OSA diagnosed by polysomnography were measured using acoustic rhinometry and the Sniffin, Sticks (SS) smell test at Anzhen Hospital, a major academic center in Beijing, China. We tested the hypothesis that nasal structure in these patients would correlate with objectively measured olfactory performance. Minimum cross-sectional area (MCA) of the nose was significantly correlated with SS composite score (r = 0.434, p < 0.001), a result that was driven by two of the test’s three components: olfactory threshold (OT) (r = 0.385, p = 0.001) and olfactory discrimination (OD) (r = 0.370, p = 0.001) but not olfactory identification (OI) (p > 0.05). Additionally, nasal volume (NV) was associated with composite SS score (r = 0.350, p = 0.002), a finding driven by OT (r = 0.283, p = 0.014). These data suggest that nasal structure affects parameters of olfactory function, likely via alterations in nasal airflow. Thus, anatomic abnormalities and diseases involving airflow (such as OSA) may cause, in part, olfactory dysfunction that is amenable to treatment. We speculate that surgery that alters nasal volume and MCA may improve olfactory performance.

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Ahlstrom R, Berglund B, Berglund U, Engen T, Lindvall T (1987) A comparison of odor perception in smokers, nonsmokers, and passive smokers. Am J Otolaryngol 8:1–6PubMedCrossRef

Allison AC (1953) The morphology of the olfactory system in the vertebrates. Biol Rev 28:195–244CrossRef

Banabilh SM, Suzina AH, Mohamad H, Dinsuhaimi S, Samsudin AR, Singh GD (2010) Assessment of 3-D nasal airway morphology in Southeast Asian adults with obstructive sleep apnea using acoustic rhinometry. Clin Oral Investig 14:491–498PubMedCrossRef

Berry RB, Budhiraja R, Gottlieb DJ, Gozal D, Iber C, Kapur VK, Marcus CL, Mehra R, Parthasarathy S, Quan SF, Redline S, Strohl KP, Davidson WS, Tangredi MM (2012) Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events. Deliberations of the Sleep Apnea Definitions Task Force of the American Academy of Sleep Medicine. J Clin Sleep Med 8:597–619PubMedCentralPubMed

Cain WS, Gent JF (1991) Olfactory sensitivity: reliability, generality, and association with aging. J Exp Psychol Hum Percept Perform 17:382–391PubMedCrossRef

Cakmak O, Tarhan E, Coskun M, Cankurtaran M, Celik H (2005) Acoustic rhinometry: accuracy and ability to detect changes in passage area at different locations in the nasal cavity. Ann Otol Rhinol Laryngol 114:949–957PubMedCrossRef

Cankurtaran M, Celik H, Coskun M, Hizal E, Cakmak O (2007) Acoustic rhinometry in healthy humans: accuracy of area estimates and ability to quantify certain anatomic structures in the nasal cavity. Ann Otol Rhinol Laryngol 116:906–916PubMedCrossRef

Chaaban M, Corey JP (2011) Assessing nasal air flow: options and utility. Proc Am Thorac Soc 8:70–78PubMedCrossRef

Clement PA, Gordts F (2005) Consensus report on acoustic rhinometry and rhinomanometry. Rhinology 43:169–179PubMed

10.

Damm M, Vent J, Schmidt M, Theissen P, Eckel HE, Lotsch J, Hummel T (2002) Intranasal volume and olfactory function. Chem Senses 27:831–839PubMedCrossRef

11.

Farmer MN, Raddin RS, Roberts JD (2009) The relationship between taste, olfaction, and nutrition in the cancer population. J Support Oncol 7:70–72PubMed

12.

Ferris BJ, Mead J, Opie LH (1964) Partitioning of respiratory flow resistance in man. J Appl Physiol 19:653–658PubMed

13.

Georgalas C (2011) The role of the nose in snoring and obstructive sleep apnoea: an update. Eur Arch Otorhinolaryngol 268:1365–1373PubMedCentralPubMedCrossRef

14.

Hornung DE, Leopold DA (1999) Relationship between uninasal anatomy and uninasal olfactory ability. Arch Otolaryngol Head Neck Surg 125:53–58PubMedCrossRef

15.

Horth L (2007) Sensory genes and mate choice: evidence that duplications, mutations, and adaptive evolution alter variation in mating cue genes and their receptors. Genomics 90:159–175PubMedCrossRef

16.

Houser SM, Mamikoglu B, Aquino BF, Moinuddin R, Corey JP (2002) Acoustic rhinometry findings in patients with mild sleep apnea. Otolaryngol Head Neck Surg 126:475–480PubMedCrossRef

17.

Huang ZL, Wang DY, Zhang PC, Dong F, Yeoh KH (2001) Evaluation of nasal cavity by acoustic rhinometry in Chinese, Malay and Indian ethnic groups. Acta Otolaryngol 121:844–848PubMedCrossRef

18.

Hubert HB, Fabsitz RR, Feinleib M, Brown KS (1980) Olfactory sensitivity in humans: genetic versus environmental control. Science 208:607–609PubMedCrossRef

19.

Hummel T, Barz S, Pauli E, Kobal G (1998) Chemosensory event-related potentials change with age. Electroencephalogr Clin Neurophysiol 108:208–217PubMedCrossRef

20.

Hummel T, Kobal G, Gudziol H, Mackay-Sim A (2007) Normative data for the “Sniffin’ Sticks” including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects. Eur Arch Otorhinolaryngol 264:237–243PubMedCrossRef

21.

Hummel T, Nordin S (2005) Olfactory disorders and their consequences for quality of life. Acta Otolaryngol 125:116–121PubMedCrossRef

22.

Jun BC, Song SW, Kim BG, Kim BY, Seo JH, Kang JM, Park YJ, Cho JH (2010) A comparative analysis of intranasal volume and olfactory function using a three-dimensional reconstruction of paranasal sinus computed tomography, with a focus on the airway around the turbinates. Eur Arch Otorhinolaryngol 267:1389–1395PubMedCrossRef

23.

Katotomichelakis M, Balatsouras D, Tripsianis G, Davris S, Maroudias N, Danielides V, Simopoulos C (2007) The effect of smoking on the olfactory function. Rhinology 45:273–280PubMed

24.

Keverne EB (2004) Importance of olfactory and vomeronasal systems for male sexual function. Physiol Behav 83:177–187PubMedCrossRef

25.

Kjaergaard T, Cvancarova M, Steinsvag SK (2009) Relation of nasal air flow to nasal cavity dimensions. Arch Otolaryngol Head Neck Surg 135:565–570PubMedCrossRef

26.

Kobal G, Klimek L, Wolfensberger M, Gudziol H, Temmel A, Owen CM, Seeber H, Pauli E, Hummel T (2000) Multicenter investigation of 1,036 subjects using a standardized method for the assessment of olfactory function combining tests of odor identification, odor discrimination, and olfactory thresholds. Eur Arch Otorhinolaryngol 257:205–211PubMedCrossRef

27.

Kotecha BT, Hall AC (2014) Role of surgery in adult obstructive sleep apnoea. Sleep Med Rev 1-9

28.

Kunkel M, Hochban W (1994) Acoustic rhinometry: rationale and perspectives. J Craniomaxillofac Surg 22:244–249PubMedCrossRef

29.

Leopold DA (1988) The relationship between nasal anatomy and human olfaction. Laryngoscope 98:1232–1238PubMedCrossRef

30.

Malhotra A, White DP (2002) Obstructive sleep apnoea. Lancet 360:237–245PubMedCrossRef

31.

Murphy C (1983) Age-related effects on the threshold, psychophysical function, and pleasantness of menthol. J Gerontol 38:217–222PubMedCrossRef

32.

Niewoehner DE, Kleinerman J, Rice DB (1974) Pathologic changes in the peripheral airways of young cigarette smokers. N Engl J Med 291:755–758PubMedCrossRef

33.

Pinto JM (2011) Olfaction. Proc Am Thorac Soc 8:46PubMedCrossRef

34.

Pinto JM, Assanasen P, Baroody FM, Naureckas E, Solway J, Naclerio RM (2004) Treatment of nasal inflammation decreases the ability of subjects with asthma to condition inspired air. Am J Respir Crit Care Med 170:863–869PubMedCrossRef

35.

Rolet A, Magnin E, Millot JL, Berger E, Vidal C, Sileman G, Rumbach L (2013) Olfactory dysfunction in multiple sclerosis: evidence of a decrease in different aspects of olfactory function. Eur Neurol 69:166–170PubMedCrossRef

36.

Schriever VA, Reither N, Gerber J, Iannilli E, Hummel T (2013) Olfactory bulb volume in smokers. Exp Brain Res 225:153–157PubMedCrossRef

37.

Sivam A, Jeswani S, Reder L, Wang J, DeTineo M, Taxy J, Baroody FM, Naclerio RM, Pinto JM (2010) Olfactory cleft inflammation is present in seasonal allergic rhinitis and is reduced with intranasal steroids. Am J Rhinol Allergy 24:286–290PubMedCrossRef

38.

Vennemann MM, Hummel T, Berger K (2008) The association between smoking and smell and taste impairment in the general population. J Neurol 255:1121–1126PubMedCrossRef

39.

Verse T, Hormann K (2011) The surgical treatment of sleep-related upper airway obstruction. Dtsch Arztebl Int 108:216–221PubMedCentralPubMed

40.

Willander J, Larsson M (2007) Olfaction and emotion: the case of autobiographical memory. Mem Cogn 35:1659–1663CrossRef

41.

Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S (1993) The occurrence of sleep-disordered breathing among middle-aged adults. New Engl J Med 328:1230–1235PubMedCrossRef

42.

Yousem DM, Maldjian JA, Hummel T, Alsop DC, Geckle RJ, Kraut MA, Doty RL (1999) The effect of age on odor-stimulated functional MR imaging. AJNR Am J Neuroradiol 20:600–608PubMed

43.

Zhao K, Dalton P, Yang GC, Scherer PW (2006) Numerical modeling of turbulent and laminar airflow and odorant transport during sniffing in the human and rat nose. Chem Senses 31:107–118PubMedCrossRef

44.

Zhao K, Scherer PW, Hajiloo SA, Dalton P (2004) Effect of anatomy on human nasal air flow and odorant transport patterns: implications for olfaction. Chem Senses 29:365–379PubMedCrossRef

45.

Zhou BF (2002) Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults–study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Biomed Environ Sci 15:83–96PubMed

Titel: The effect of nasal structure on olfactory function in patients with OSA
verfasst von: Dan Fu
Jayant M. Pinto
Li Wang
Guowei Chen
Xiaojun Zhan
Yongxiang Wei
Publikationsdatum: 01.02.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 2/2015
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-014-3096-1

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The effect of nasal structure on olfactory function in patients with OSA

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