Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
European Archives of Oto-Rhino-Laryngology
Erschienen in: European Archives of Oto-Rhino-Laryngology 12/2016

16.03.2016 | Review Article

Antileukotrienes in adenotonsillar hypertrophy: a review of the literature

verfasst von: Murat Kar, Niyazi Altıntoprak, Nuray Bayar Muluk, Seckin Ulusoy, Sameer Ali Bafaqeeh, Cemal Cingi

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 12/2016

Einloggen, um Zugang zu erhalten

Abstract

We assessed the use of antileukotrienes for treating adenotonsillar hypertrophy. We reviewed the current literature on the anatomy of adenotonsillar tissue, adenotonsillar hypertrophy/hyperplasia (and the associated pathophysiology and symptoms), and the effects of antileukotrienes used to treat adenotonsillar hypertrophy. Leukotrienes (LTs) are inflammatory mediators produced by a number of cell types, including mast cells, eosinophils, basophils, macrophages, and monocytes. There are several types (e.g., LTA4, LTB4, LTC4, LTD4, and LTE4). By competitive binding to the cysLT1 receptor, LT-receptor antagonist drugs such as montelukast, zafirlukast, and pranlukast block the effects of cySHLTs, improving the symptoms of some chronic respiratory diseases. High numbers of LT receptors have been found in the tonsils of children with obstructive sleep apnea. Antileukotrienes reduce the apnea–hypopnea index and adenotonsillar inflammation. Antileukotrienes may be useful for children with adenotonsillar hypertrophy due to their anti-inflammatory effects, which help to reduce adenotonsillar inflammation.
Literatur
1.
Scadding G (2010) Non-surgical treatment of adenoidal hypertrophy: the role of treating IgE-mediated inflammation. Pediatr Allergy Immunol 21(8):1095–1106CrossRefPubMed
2.
Shine NP, Coates HL, Lannigan FJ (2005) Obstructive sleep apnea, morbid obesity, and adenotonsillar surgery: a review of the literature. Int J Pediatr Otorhinolaryngol 69:1475–1482CrossRefPubMed
3.
Friedman M, Wilson M, Lin HC, Chang HW (2009) Updated systematic review of tonsillectomy and adenoidectomy for treatment of pediatric obstructive sleep apnea/hypopnea syndrome. Otolaryngol Head Neck Surg 140:800–808CrossRefPubMed
4.
Nolan J, Brietzke SE (2011) Systematic review of pediatric tonsil size and polysomnogram-measured obstructive sleep apnea severity. Otolaryngol Head Neck Surg 144:844–850CrossRefPubMed
5.
Major MP, Flores-Mir C, Major PW (2006) Assessment of lateral cephalometric diagnosis of adenoid hypertrophy and posterior upper airway obstruction: a systematic review. Am J Orthod Dentofac Orthop 130:700–708CrossRef
6.
Feres MF, Hermann JS, Cappellette M Jr, Pignatari SS (2011) Lateral X-ray view of the skull for the diagnosis of adenoid hypertrophy: a systematic review. Int J Pediatr Otorhinolaryngol 75:1–11CrossRefPubMed
7.
8.
Wing YK, Hui SH, Pak WM, Ho CK, Cheung A et al (2003) A controlled study of sleep related disordered breathing in obese children. Arch Dis Child 88:1043–1047CrossRefPubMedPubMedCentral
9.
Tagaya M, Nakata S, Yasuma F, Miyazaki S, Sasaki F, Morinaga M et al (2012) Relationship between adenoid size and severity of obstructive sleep apnea in preschool children. Int J Pediatr Otorhinolaryngol 76:1827–1830CrossRefPubMed
10.
Dayyat E, Kheirandish-Gozal L, Sans Capdevila O, Maarafeya MM, Gozal D (2009) Obstructive sleep apnea in children: relative contributions of body mass index and adenotonsillar hypertrophy. Chest 136:137–144CrossRefPubMedPubMedCentral
11.
Kenna MA, Amin A (2009) Anatomy and physiology of the oral cavity. In: Snow JB, Wackym PA (eds) Ballenger’s otorhinolaryngology head and neck surgery, 17th edn. BC Decker Inc, Shelton, pp 769–774
12.
Susan S, Harold E, Jermiah CH, David J, Andrew W (2005) Pharynx (chapter 35). In: Susan S (ed) Gray’s anatomy: the anatomical basis of clinical practice, 39th edn. Elsevier, Philadelphia, pp 619–631
13.
Brodsky L (1999) Adenotonsillar disease in children. Pract Paediatr Otolaryngol Ch 2:15–39
14.
15.
Becker W, Nauman HH, Pfaltz CR, Behrbohm H, Nawka T (2009) Ear, Nose, and Throat Diseases. In: Behrbohm H, Kaschke O, Nawka T, Swift A (eds), 3rd edn. Thieme, New York, pp 307–309, 322–324
16.
17.
18.
Peterson J, Losek JD (2004) Post-tonsillectomy hemorrhage and pediatric emergency care. Clin Pediatr (Phila) 43(5):445–448CrossRef
19.
Stuck BA, Gotte K, Windfuhr JP, Genzwurker H, Schroten H, Tenenbaum T (2008) Tonsillectomy in children. Dtsch Arztebl Int 105(49):852–860PubMedPubMedCentral
20.
21.
Jeong JH, Lee DW, Ryu RA, Lee YS, Lee SH, Kang JO et al (2007) Bacteriologic comparison of tonsil core in recurrent tonsillitis and tonsillar hypertrophy. Laryngoscope 117(12):2146–2151CrossRefPubMed
22.
Serpero LD, Kheirandish-Gozal L, Dayyat E, Goldman JL, Kim J, Gozal D (2009) A mixed cell culture model for assessment of proliferation in tonsillar tissues from children with obstructive sleep apnea or recurrent tonsillitis. Laryngoscope 119(5):1005–1010CrossRefPubMedPubMedCentral
23.
Kelishadi R, Nilforoushan N, Okhovat A, Amra B, Poursafa P, Rogha M (2011) Effects of adenoidectomy on markers of endothelial function and inflammation in normal-weight and overweight prepubescent children with sleep apnea. J Res Med Sci. 16(Special Issue):386–394
24.
Brook I, Shah K, Jackson W (2000) Microbiology of healthy and diseased adenoids. Laryngoscope 110(6):994–999CrossRefPubMed
25.
Don DM, Goldstein NA, Crockett DM, Ward SD (2005) Antimicrobial therapy for children with adenotonsillar hypertrophy and obstructive sleep apnea: a prospective randomized trial comparing azithromycin vs placebo. Otolaryngol Head Neck Surg 133(4):562–568CrossRefPubMed
26.
Sclafani AP, Ginsburg J, Shah MK, Dolitsky JN (1998) Treatment of symptomatic chronic adenotonsillar hypertrophy with amoxicillin/clavulanate potassium: short- and long-term results. Pediatrics 101(4 Pt 1):675–681CrossRefPubMed
27.
Brouillette RT, Manoukian JJ, Ducharme FM, Oudjhane K, Earle LG, Ladan S et al (2001) Efficacy of fluticasone nasal spray for pediatric obstructive sleep apnea. J Pediatr 138(6):838–844CrossRefPubMed
28.
Demain JG, Goetz DW (1995) Pediatric adenoidal hypertrophy and nasal airway obstruction: reduction with aqueous nasal beclomethasone. Pediatrics 95(3):355–364PubMed
29.
Criscuoli G, D’Amora S, Ripa G, Cinquegrana G, Mansi N, Impagliazzo N et al (2003) Frequency of surgery among children who have adenotonsillar hypertrophy and improve after treatment with nasal beclomethasone. Pediatrics 111(3):e236–e238CrossRefPubMed
30.
Peters-Golden M, Canetti C, Mancuso P, Coffey MJ (2005) Leukotrienes:underappreciated mediators of innate immune responses. J Immunol 174:589–594CrossRefPubMed
31.
Serezani CH, Lewis C, Jancar S, Peters-Golden M (2011) Leukotriene B4 amplifies NF-κB activation in mouse macrophages by reducing SOCS1 inhibition of MyD88 expression. J Clin Invest 121:671–682CrossRefPubMedPubMedCentral
32.
Parnes SM (2003) The role of leukotriene inhibitors in patients with paranasal sinus disease. Curr Opin Otolaryngol Head Neck Surg 11:184–191CrossRefPubMed
33.
Hui Y, Cheng Y, Smalera I, Jian W, Goldhahn L, Fitzgerald GA et al (2004) Directed vascular expression of human cysteinyl leukotriene 2 receptor modulates endothelial permeability and systemic blood pressure. Circulation 110:3360–3366CrossRefPubMed
34.
Alobid I, Cardelús S, Picado C, Mullol J (2008) Antileukotrienes in rhinosinusitis and nasal polyposis. Expert Rev Clin Immunol 4(3):331–337CrossRefPubMed
35.
36.
37.
Tsaoussoglou M, Lianou L, Maragozidis P, Hatzinikolaou S, Mavromati M, Orologas N et al (2012) Cysteinyl leukotriene receptors in tonsillar B- and T-lymphocytes from children with obstructive sleep apnea. Sleep Med 13:879–885CrossRefPubMed
38.
Goldbart AD, Greenberg-Dotan S, Tal A (2012) Montelukast for children with obstructive sleep apnea: a double-blind, placebo-controlled study. Pediatrics 130:e575–e580CrossRefPubMed
39.
Cingi C, Oğhan F, Ünlü H, Tekat A, Okuyucu Ş (2011) Efficacy of montelukast and desloratadine combination in allergic rhinitis. J Med Updates 1(1):3–16
40.
Baççıoğlu A, Yorgancıoğlu A, Cingi C, Çuhadaroğlu Ç (2013) Role of leukotriene antagonists and antihistamines in treatment of allergic rhinitis and asthma comorbidity. J Med Updates 3(1):34–39CrossRef
41.
Goldbart AD, Goldman JL, Veling MC, Gozal D (2005) Leukotriene modifier therapy for mild sleep-disordered breathing in children. Am J Respir Crit Care Med 172:364CrossRefPubMedPubMedCentral
42.
43.
Kheirandish L, Goldbart AD, Gozal D (2006) Intranasal steroids and oral leukotriene modifier therapy in residual sleep-disordered breathing after tonsillectomy and adenoidectomy in children. Pediatrics 117:e61CrossRefPubMed
44.
Dayyat E, Serpero LD, Kheirandish-Gozal L, Goldman JL, Snow A, Bhattacharjee R et al (2009) Leukotriene pathways and in vitro adenotonsillar cell proliferation in children with obstructive sleep apnea. Chest 135(5):1142–1149CrossRefPubMed
45.
Kaditis AG, Ioannou MG, Chaidas K, Alexopoulos EI, Apostolidou M, Apostolidis T et al (2008) Cysteinyl leukotriene receptors are expressed by tonsillar T cells of children with obstructive sleep apnea. Chest 134(2):324–331CrossRefPubMed
46.
Goldbart AD, Goldman JL, Li RC, Brittian KR, Tauman R, Gozal D (2004) Differential expression of cysteinyl leukotriene receptors 1 and 2 in tonsils of children with obstructive sleep apnea syndrome or recurrent infection. Chest 126(1):13–18CrossRefPubMed
47.
Goldbart AD, Goldman JL, Veling MC, Gozal D (2005) Leukotriene modifier therapy for mild sleep-disordered breathing in children. Am J Respir Crit Care Med 172(3):364–370CrossRefPubMedPubMedCentral
48.
Goldbart AD, Krishna J, Li RC, Serpero LD, Gozal D (2006) Inflammatory mediators in exhaled breath condensate of children with obstructive sleep apnea syndrome. Chest 130(1):143–148CrossRefPubMed
Metadaten
Titel
Antileukotrienes in adenotonsillar hypertrophy: a review of the literature
verfasst von
Murat Kar
Niyazi Altıntoprak
Nuray Bayar Muluk
Seckin Ulusoy
Sameer Ali Bafaqeeh
Cemal Cingi
Publikationsdatum
16.03.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
European Archives of Oto-Rhino-Laryngology / Ausgabe 12/2016
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-016-3983-8

Weitere Artikel der Ausgabe 12/2016

European Archives of Oto-Rhino-Laryngology 12/2016 Zur Ausgabe

Rhinology

A modification of endoscopic endonasal approach for management of encephaloceles in sphenoid sinus lateral recess

Otology

Assessing residual vestibular function in adults with congenital hearing loss

Head and Neck

Cranial tonsillotomy for peritonsillar abscess: what a relief!

Head and Neck

Voice outcomes after thyroidectomy without superior and recurrent laryngeal nerve injury: VoiSS questionnaire and GRBAS tool assessment

Miscellaneous

Self-directed simulation-based training of emergency cricothyroidotomy: a route to lifesaving skills

Head and Neck

Core needle biopsy in the diagnosis of head and neck lesions: a retrospective study of 3 years

Neu im Fachgebiet HNO

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

25.04.2024 Allergien und Intoleranzreaktionen Nachrichten

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

HNO-Op. auch mit über 90?

16.04.2024 HNO-Chirurgie Nachrichten

Mit Blick auf das Risiko für Komplikationen nach elektiven Eingriffen im HNO-Bereich scheint das Alter der Patienten kein ausschlaggebender Faktor zu sein. Entscheidend ist offenbar, wie fit die Betroffenen tatsächlich sind.

Intrakapsuläre Tonsillektomie gewinnt an Boden

16.04.2024 Tonsillektomie Nachrichten

Gegenüber der vollständigen Entfernung der Gaumenmandeln hat die intrakapsuläre Tonsillektomie einige Vorteile, wie HNO-Fachleute aus den USA hervorheben. Sie haben die aktuelle Literatur zu dem Verfahren gesichtet.

Bilateraler Hörsturz hat eine schlechte Prognose

15.04.2024 Hörsturz Nachrichten

Die Mehrzahl der Menschen mit Hörsturz ist einseitig betroffen, doch auch ein beidseitiger Hörsturz ist möglich. Wie häufig solche Fälle sind und wie sich ihr Verlauf darstellt, hat eine HNO-Expertenrunde aus den USA untersucht.

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen
Bildnachweise