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European Archives of Oto-Rhino-Laryngology

Erschienen in:

22.11.2018 | Rhinology

Olfactory function and olfactory bulb volume in Wilson’s disease

verfasst von: Nazan Degirmenci, Bayram Veyseller, Hasmet Hanagasi, Basar Bilgic, Defne Gurbuz, Ali Toprak, Orhan Ozturan

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 1/2019

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Abstract

Purpose

To evaluate the olfactory function and the olfactory bulb (OB) volume changes in Wilson’s Disease (WD) patients.

Methods

A prospective, controlled, single-blinded study was planned. 12 patients with WD (Group 1) and 12 healthy subjects (Group 2) were included in the study. Connecticut Chemosensory Clinical Research Center (CCCRC) test was applied to evaluate olfactory functions. OB volumes were measured with a 1.5 T General Electric Signa Excite MRI scanner.

Results

There was a significant difference between the CCCRC scores of the two groups (p < 0.05). The difference of the OB volumes of the two groups was insignificant (p > 0.05).

Conclusions

WD patients are likely to experience olfactory dysfunction, so its assessment may be a useful tool to the follow-up care of these patients, although further studies are needed to evaluate correlations in WD evolution.

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Titel: Olfactory function and olfactory bulb volume in Wilson’s disease
verfasst von: Nazan Degirmenci
Bayram Veyseller
Hasmet Hanagasi
Basar Bilgic
Defne Gurbuz
Ali Toprak
Orhan Ozturan
Publikationsdatum: 22.11.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 1/2019
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-018-5216-9

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Olfactory function and olfactory bulb volume in Wilson’s disease