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Erschienen in:

01.02.2015

Physical Activity and the Frequency of Acute Exacerbations in Patients with Chronic Obstructive Pulmonary Disease

verfasst von: M. Schönmann, N. A. Sievi, C. F. Clarenbach, T. Brack, M. Brutsche, M. Frey, S. Irani, J. D. Leuppi, J. Ruediger, O. Senn, R. Thurnheer, M. Kohler

Erschienen in: Lung | Ausgabe 1/2015

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Abstract

Purpose

Acute exacerbations (AE) in patients with COPD are associated with a decline in lung function, increased risk of hospitalization, and mortality. In this cross-sectional study we tested whether the level of objectively measured daily physical activity and exercise capacity are associated with the number of COPD exacerbations.

Methods

In 210 patients with COPD (67 % men; mean (SD) age: 63 (8) years) enrolled in The Obstructive Pulmonary Disease Outcomes Cohort of Switzerland (TOPDOCS) physical activity (PA) (steps per day, physical activity level, (PAL)), exercise capacity (6-min walking distance, (6MWD)), comorbidities, lung function, and medication were assessed. Differences between COPD patients with frequent (≥2 year) and infrequent (0–1 year) exacerbations were assessed. Univariate and multivariate analyses were performed to investigate whether the level of objectively measured daily physical activity and exercise capacity are associated with the number of COPD exacerbations.

Results

Patients with frequent AE had a significantly lower FEV₁ and 6MWD compared to patients with infrequent AE. In univariate analysis, the number of exacerbations was inversely associated with FEV₁, 6MWD, BMI, and smoking status while there was a positive association with RV/TLC and combined inhaled medication. However, there was no significant association with PAL and steps per day. In multivariate analysis, FEV₁ and the use of combined inhaled medication were independently associated with the number of AE, after correction for covariates.

Conclusions

The findings of this study imply that FEV₁, independent of inhaled medication, is significantly associated with COPD exacerbations. Neither physical activity nor exercise capacity was independently associated with COPD exacerbations.

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Titel: Physical Activity and the Frequency of Acute Exacerbations in Patients with Chronic Obstructive Pulmonary Disease
verfasst von: M. Schönmann
N. A. Sievi
C. F. Clarenbach
T. Brack
M. Brutsche
M. Frey
S. Irani
J. D. Leuppi
J. Ruediger
O. Senn
R. Thurnheer
M. Kohler
Publikationsdatum: 01.02.2015
Verlag: Springer US
Erschienen in: Lung / Ausgabe 1/2015
Print ISSN: 0341-2040
Elektronische ISSN: 1432-1750
DOI: https://doi.org/10.1007/s00408-014-9673-7

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Physical Activity and the Frequency of Acute Exacerbations in Patients with Chronic Obstructive Pulmonary Disease