nach oben

International Journal of Legal Medicine

Erschienen in:

01.08.2004 | Original Article

Entomotoxicology for the forensic toxicologist: much ado about nothing?

verfasst von: A. Tracqui, C. Keyser-Tracqui, P. Kintz, B. Ludes

Erschienen in: International Journal of Legal Medicine | Ausgabe 4/2004

Einloggen, um Zugang zu erhalten

Abstract

We present a series of 29 necropsies in which organic compounds (including benzodiazepines, barbiturates, antidepressants, phenothiazine, opiates, cannabinoids, meprobamate, digoxin and nefopam) were detected in arthropod larvae sampled on human corpses. No correlation was observed between drug concentrations in the larvae versus human samples. When tested, inter-larvae and inter-site variations of drug concentrations (i.e., within larvae when analyzed separately, and within anatomic sites when larvae were grouped according to their site of sampling) were enormous and not reproducible from one case to another, confirming that arthropod larvae are unreliable for quantitative toxicological analysis. Since drugs identified in maggots are always detectable in the cadaver too, we conclude that larvae analysis is of almost no interest for practical forensic casework.

Beyer JC, Enos WF, Stajic M (1980) Drug identification through analysis of maggots. J Forensic Sci 25:411–412PubMed

Levine B, Golle M, Smialek JE (2000) An unusual drug death involving maggots. Am J Forensic Med Pathol 21:59–61CrossRefPubMed

Sadler DW, Chuter G, Seneveratne C, Pounder DJ (1997) Barbiturates and analgesics in Calliphora vicina larvae. J Forensic Sci 42:1214–1215

Carvalho LM, Linhares AX, Trigo JR (2001) Determination of drug levels and the effect of diazepam on the growth of necrophagous flies of forensic importance in southeastern Brazil. Forensic Sci Int 120:140–144PubMed

Sadler DW, Fuke C, Court F, Pounder DJ (1995) Drug accumulation and elimination in Calliphora vicina larvae. Forensic Sci Int 71:191–197CrossRefPubMed

Wilson Z, Hubbard S, Pounder DJ (1993) Drug analysis in fly larvae. Am J Forensic Med Pathol 14:118–120PubMed

Miller ML, Lord WD, Goff ML, Donnelly B, McDonough ET, Alexis JC (1994) Isolation of amitriptyline and nortriptyline from fly puparia (Phoridae) and beetle exuviae (Dermestidae) associated with mummified human remains. J Forensic Sci 39:1305–1313

Sadler DW, Richardson J, Haigh S, Bruce G, Pounder DJ (1997) Amitriptyline accumulation and elimination in Calliphora vicina larvae. Am J Forensic Med Pathol 18:397–403CrossRefPubMed

Goff ML, Brown WA, Omori AI, LaPointe DA (1993) Preliminary observations of the effects of amitriptyline in decomposing tissues on the development of Parasarcophaga ruficornis (Diptera: Sarcophagidae) and implications of this effect to estimation of postmortem interval. J Forensic Sci 38:316–322PubMed

10.

Introna F, Lo Dico C, Caplan YH, Smialek JE (1990) Opiate analysis in cadaveric blowfly larvae as an indicator of narcotic intoxication. J Forensic Sci 35:118–122PubMed

11.

Goff ML, Brown WA, Hewadikaram KA, Omori AI (1991) Effect of heroin in decomposing tissues on the development rate of Boettcherisca peregrina (Diptera, Sarcophagidae) and implications of this effect on estimation of postmortem intervals using arthropod development patterns. J Forensic Sci 36:537–542PubMed

12.

Hedouin V, Bourel B, Martin-Bouyer L, Becart A, Tournel G, Deveaux M, Gosset D (1999) Morphine perfused rabbits: a tool for experiments in forensic entomotoxicology. J Forensic Sci 44:347–350PubMed

13.

Hedouin V, Bourel B, Martin-Bouyer L, Becart A, Tournel G, Deveaux M, Gosset D (1999) Determination of drug levels in larvae of Lucilia sericata (Diptera: Calliphoridae) reared on rabbit carcasses containing morphine. J Forensic Sci 44:351–353PubMed

14.

Bourel B, Tournel G, Hedouin V, Deveaux M, Goff ML, Gosset D (2001) Morphine extraction in necrophagous insects remains for determining ante-mortem opiate intoxication. Forensic Sci Int 120:127–131CrossRefPubMed

15.

Bourel B, Fleurisse L, Hedouin V, Cailliez JC, Creusy C, Gosset D, Goff ML (2001) Immunohistochemical contribution to the study of morphine metabolism in Calliphoridae larvae and implications in forensic entomotoxicology. J Forensic Sci 46:596–599PubMed

16.

Bourel B, Tournel G, Hedouin V, Goff ML, Gosset D (2001) Determination of drug levels in two species of necrophagous Coleoptera reared on substrates containing morphine. J Forensic Sci 46:600–603PubMed

17.

Goff ML, Miller ML, Paulson JD, Lord WD, Richards E, Omori AI (1997) Effects of 3,4-methylenedioxymethamphetamine in decomposing tissues on the development of Parasarcophaga ruficornis (Diptera: Sarcophagidae) and detection of the drug in postmortem blood, liver tissue, larvae, and puparia. J Forensic Sci 42:276–280PubMed

18.

Manhoff DT, Hood I, Caputo F, Perry J, Rosen S, Mirchandani HG (1991) Cocaine in decomposed human remains. J Forensic Sci 36:1732–1735PubMed

19.

Nolte KB, Pinder RD, Lord WD (1992) Insect larvae used to detect cocaine poisoning in a decomposed body. J Forensic Sci 37:1179–1185PubMed

20.

Goff ML, Omori AI, Goodbrod JR (1989) Effect of cocaine in tissues on the development rate of Boettcherisca peregrina (Diptera: Sarcophagidae). J Med Entomol 26:91–93PubMed

21.

Gunatilake K, Goff ML (1989) Detection of organophosphate poisoning in a putrefying body by analyzing arthropod larvae. J Forensic Sci 34:714–716PubMed

22.

Tracqui A, Kintz P, Godelar B, Mangin P, Lugnier AA, Chaumont AJ (1989) Etude toxicologique de la faune des cadavres: application aux larves de mouche. J Med Leg Droit Med 32:259–262

23.

Campobasso CP, Gherardi M, Caligara M, Sironi L, Introna F (2004) Drug analysis in blowfly larvae and in human tissues: a comparative study DOI: s00414-004-0448-1

24.

O’Brien C, Turner B (2004) Impact of paracetamol on Calliphora vicina larval development. DOI: s00414-004-0440-9

25.

Pien K, Laloup M, Pipeleers-Marichal M et al. (2004) Toxicological data and growth characteristics of single post-feeding larvae and puparia of Calliphora vicina (Diptera: Calliphoridae) obtained from a controlled nordiazepam study DOI: s00414-004-0441-8

Titel: Entomotoxicology for the forensic toxicologist: much ado about nothing?
verfasst von: A. Tracqui
C. Keyser-Tracqui
P. Kintz
B. Ludes
Publikationsdatum: 01.08.2004
Verlag: Springer-Verlag
Erschienen in: International Journal of Legal Medicine / Ausgabe 4/2004
Print ISSN: 0937-9827
Elektronische ISSN: 1437-1596
DOI: https://doi.org/10.1007/s00414-004-0442-7

Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

Springer Medizin

Entomotoxicology for the forensic toxicologist: much ado about nothing?

Abstract

Neu im Fachgebiet Rechtsmedizin

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2004

Decomposition of carrion in the marine environment in British Columbia, Canada

Calliphora vicina larvae grow at different rates on different body tissues.

Forensic Anthropology Society of Europe

Segmental vertebral motion in the assessment of neck range of motion in whiplash patients

Drug analysis in blowfly larvae and in human tissues: a comparative study

Entomofauna of buried bodies in northern France

Neu im Fachgebiet Rechtsmedizin

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie