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01.11.2005 | Original Article

Haplotyping of STR cluster DXS6801–DXS6809–DXS6789 on Xq21 provides a powerful tool for kinship testing

verfasst von: Reinhard Szibor, Sandra Hering, Eberhard Kuhlisch, Ines Plate, Susanne Demberger, Michael Krawczak, Jeanett Edelmann

Erschienen in: International Journal of Legal Medicine | Ausgabe 6/2005

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Abstract

Short tandem repeat (STR) markers DXS6801 (GATA41B11), DXS6809 (GATA69B129) and DXS6789 (GATA31F01) are located in a 3-Mb region on human chromosome Xq21, spanning approximately 3–6 cM. Theoretically, this cluster could give rise to 1,144 different haplotypes in the German population. In fact, genotyping of 806 males revealed the presence of 207 different haplotypes. Since the three STRs have been shown to be in strong linkage disequilibrium (LD), haplotype frequencies cannot be computed on the basis of single locus allele frequencies alone, but have to be estimated directly instead. In this work, we present data on linkage, haplotype frequencies and LD in the German population. To highlight the potential of the STR cluster for forensic analysis, we also report two examples of its successful application in pedigree-based kinship testing.

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Titel: Haplotyping of STR cluster DXS6801–DXS6809–DXS6789 on Xq21 provides a powerful tool for kinship testing
verfasst von: Reinhard Szibor
Sandra Hering
Eberhard Kuhlisch
Ines Plate
Susanne Demberger
Michael Krawczak
Jeanett Edelmann
Publikationsdatum: 01.11.2005
Verlag: Springer-Verlag
Erschienen in: International Journal of Legal Medicine / Ausgabe 6/2005
Print ISSN: 0937-9827
Elektronische ISSN: 1437-1596
DOI: https://doi.org/10.1007/s00414-005-0550-z

Springer Medizin

Haplotyping of STR cluster DXS6801–DXS6809–DXS6789 on Xq21 provides a powerful tool for kinship testing

Abstract

Neu im Fachgebiet Rechtsmedizin

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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