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01.09.2010 | Case Report

Pulmonary arteriovenous malformation causing sudden death due to spontaneous hemothorax

verfasst von: Takaki Ishikawa, Stefan Pollak, René Pflugradt, Michael Bohnert, Markus Große Perdekamp, Annette Thierauf, Hitoshi Maeda

Erschienen in: International Journal of Legal Medicine | Ausgabe 5/2010

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Abstract

A sudden death due to hemothorax caused by spontaneous rupture of a congenital pulmonary arteriovenous malformation (AVM) is reported. A 44-year-old woman died unexpectedly with chest pain and dyspnea. The post-mortem examination revealed a massive right-sided hemothorax arising from a subpleural AVM of the upper lobe. There were multiple telangiectases in the tongue and the tonsils, as typically associated with Osler–Weber–Rendu disease (hereditary hemorrhagic telangiectasia, HHT). The post-mortem molecular genetic analysis proved the presence of a disease-causing mutation in the endoglin gene constituting a predisposition for pulmonary AVMs. According to the literature, almost half of the AVMs in the lung are seen in HHT patients. Based on the presented case and the relevant literature, the article addresses the forensic aspects of fatal hemothorax and the importance of detecting the source of bleeding.

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Titel: Pulmonary arteriovenous malformation causing sudden death due to spontaneous hemothorax
verfasst von: Takaki Ishikawa
Stefan Pollak
René Pflugradt
Michael Bohnert
Markus Große Perdekamp
Annette Thierauf
Hitoshi Maeda
Publikationsdatum: 01.09.2010
Verlag: Springer-Verlag
Erschienen in: International Journal of Legal Medicine / Ausgabe 5/2010
Print ISSN: 0937-9827
Elektronische ISSN: 1437-1596
DOI: https://doi.org/10.1007/s00414-009-0401-4

Springer Medizin

Pulmonary arteriovenous malformation causing sudden death due to spontaneous hemothorax

Abstract

Neu im Fachgebiet Rechtsmedizin

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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