nach oben

Erschienen in:

01.04.2004 | Case Report

Irregular connexin43 expressed in a rare cardiac hamartoma containing adipose tissue in the crista terminalis

verfasst von: Pao-Hsien Chu, Hung-I. Yeh, Shih-Ming Jung, Li-Ying Chien, Nai-Feng Cheng, Hsueh-Hua Wu, Jaw-Ji Chu, Chuen Hsueh, Ying-Shiung Lee

Erschienen in: Virchows Archiv | Ausgabe 4/2004

Einloggen, um Zugang zu erhalten

Abstract

Cardiac hamartomas are very rare and are demarcated masses of enlarged, hypertrophied, mature myocytes and collagen tissue. Cardiac hamartomas are generally circumscribed in the right ventricle or atrium, but not reported in the crista terminalis (CRT). The CRT is crucial in electrophysiology, is related to arrhythmogenesis, and is targeted by radiofrequency catheter procedures. Previous works only described the benign natures of prominent CRT using non-invasive methods. This study describes an unusual cardiac hamartoma originating from the CRT and extending toward the tricuspid valve. Microscopically, this hamartoma comprised dense collagen and adipose tissue, mixed with hypertrophy, but with disarrayed cardiomyocytes. An irregular gap junction, connexin43, was demonstrated in this cardiac hamartoma.

Alam M, Sun I, Smith S (1991) Transesophageal echocardiographic evaluation of right atrial mass lesions. J Am Soc Echocardiogr 4:331–337PubMed

Burkes A, Virmani R (1996) Tumors of the heart and great vessels. In: (eds) AFIP Atlas of Tumor Pathology, AFIP, Washington, pp 63–67

Elderkin RA, Radford DJ (2002) Primary cardiac tumours in a paediatric population. J Paediatr Child Health 38:173–177CrossRefPubMed

Lukas A, Antzelevitch C (1989) Reflected reentry, delayed conduction, and electrotonic inhibition in segmentally depressed atrial tissues. Can J Physiol Pharmacol 67:757–764PubMed

McMahon CJ, Nihill MR, Kovalchin JP, Lewin MB (2000) Echocardiographic features of Chiari’s network in association with tricuspid atresia. Tex Heart Inst J 27:312–313PubMed

Meier RA, Hartnell GG (1994) MRI of right atrial pseudomass: is it really a diagnostic problem? J Comput Assist Tomogr 18:398–401PubMed

Mirowitz SA, Gutierrez FR (1992) Fibromuscluar elements of the right atrium: pseudomass at MR imaging. Radiology 182:231–233PubMed

Pharr JR, Figueredo VM (2002) Lipomatus hypertrophy of the atrial septum and prominent crista terminalis appearing as a right atrial mass. Eur J Echocardiogr 3:159–161CrossRefPubMed

Pharr JR, West MB, Kusumoto FM, Figueredo VM (2002) Prominent crista terminalis appearing as a right atrial mass on transthoracic echocardiogram. J Am Soc Echocardiogr 15:753–755CrossRefPubMed

10.

Saffitz JE, Kanter HL, Green KG, Tolley TK, Beyer EC (1994) Tissue-specific determinants of anisotropic conduction velocity in canine atrial and ventricular myocardium. Circ Res 74:1065–1070PubMed

11.

Sanchez-Quintana D, Anderson RH, Cabrera JA, Climent V, Martin R, Farre J, Ho SY (2002) The terminal crest: morphological features relevant to electrophysiology. Heart 88:406–411CrossRefPubMed

12.

Severs NJ, Rothery S, Dupont E, Coppen SR, Yeh HI, Ko YS, Matsushita T, Kaba R, Halliday D (2001) Immunocytochemical analysis of connexin expression in the healthy and diseased cardiovascular system. Microsc Res Tech 52:301–322PubMed

13.

Sturtz CL, Abt AB, Leuenberger UA, Damiano R (1998) Hamartoma of mature cardiac myocytes: a case report. Mod Pathol 11:496–469PubMed

14.

ten Velde I, de Jonge B, Verheijck EE, van Kempen MJ, Analbers L, Gros D, Jongsma HJ (1995) Spatial distribution of connexin43, the major cardiac gap junction protein, visualizes the cellular network for impulse propagation from sinoatrial node to atrium. Circ Res 76:802–811PubMed

15.

Vander Salm TJ (2000) Unusual primary tumors of the heart. Semin Thorac Cardiovasc Surg 12:89–100PubMed

16.

Yeh HI, Lai YJ, Lee SH, Lee YN, Ko YS, Chen SA, Severs NJ, Tsai CH (2001) Heterogeneity of myocardial sleeve morphology and gap junctions in canine superior vena cava. Circulation 104:3152–3157PubMed

Titel: Irregular connexin43 expressed in a rare cardiac hamartoma containing adipose tissue in the crista terminalis
verfasst von: Pao-Hsien Chu
Hung-I. Yeh
Shih-Ming Jung
Li-Ying Chien
Nai-Feng Cheng
Hsueh-Hua Wu
Jaw-Ji Chu
Chuen Hsueh
Ying-Shiung Lee
Publikationsdatum: 01.04.2004
Verlag: Springer-Verlag
Erschienen in: Virchows Archiv / Ausgabe 4/2004
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-003-0960-6

Springer Medizin

Irregular connexin43 expressed in a rare cardiac hamartoma containing adipose tissue in the crista terminalis

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2004

Brain involvement in multicentric Epstein–Barr virus-associated smooth muscle tumours in a child after kidney transplantation

Subcutaneous lymphoid hyperplasia arising at site of ethnic scarifications and mimicking subcutaneous panniculitis-like T-cell lymphoma: a subcuticular T-cell lymphoid dyscrasia

Confocal microscope analysis and tridimensional reconstruction of papillary thyroid carcinoma nuclei

Pattern of p63 expression in squamous cell carcinoma of the oral cavity

Regeneration in chronic sialadenitis: an analysis of proliferation and apoptosis based on double immunohistochemical labelling

Ectopic micronodular thymoma with lymphoid stroma

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie