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Virchows Archiv

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01.07.2004 | Review Article

Fibrosis of the pancreas: the initial tissue damage and the resulting pattern

verfasst von: Günter Klöppel, Sönke Detlefsen, Bernd Feyerabend

Erschienen in: Virchows Archiv | Ausgabe 1/2004

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Abstract

Fibrosis in the pancreas is caused by such processes as necrosis/apoptosis, inflammation or duct obstruction. The initial event that induces fibrogenesis in the pancreas is an injury that may involve the interstitial mesenchymal cells, the duct cells and/or the acinar cells. Damage to any one of these tissue compartments of the pancreas is associated with cytokine-triggered transformation of resident fibroblasts/pancreatic stellate cells into myofibroblasts and the subsequent production and deposition of extracellular matrix. Depending on the site of injury in the pancreas and the involved tissue compartment, predominantly inter(peri)lobular fibrosis (as in alcoholic chronic pancreatitis), periductal fibrosis (as in hereditary pancreatitis), periductal and interlobular fibrosis (as in autoimmune pancreatitis) or diffuse inter- and intralobular fibrosis (as in obstructive chronic pancreatitis) develops.

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Titel: Fibrosis of the pancreas: the initial tissue damage and the resulting pattern
verfasst von: Günter Klöppel
Sönke Detlefsen
Bernd Feyerabend
Publikationsdatum: 01.07.2004
Verlag: Springer-Verlag
Erschienen in: Virchows Archiv / Ausgabe 1/2004
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-004-1021-5

Springer Medizin

Fibrosis of the pancreas: the initial tissue damage and the resulting pattern

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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