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01.07.2006 | Original Article

Genetic similarities and differences between lobular in situ neoplasia (LN) and invasive lobular carcinoma of the breast

verfasst von: Luca Morandi, Gianluca Marucci, Maria P. Foschini, Maria G. Cattani, Annalisa Pession, Cristina Riva, Vincenzo Eusebi

Erschienen in: Virchows Archiv | Ausgabe 1/2006

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Abstract

One of the most controversial issues in breast pathology is whether lobular neoplasia (LN) is a risk factor or a precursor lesion of invasive lobular carcinoma (ILC). This is consequent to the fact that no conclusive data on the biology of LN exist. Molecular studies of LN and ILC are scanty, variable, and not consistent. Clonality of 12 cases of LN and ILC present simultaneously in the same block has been studied. Cells from both lesions were obtained by microdissection and were studied for mitochondrial DNA (mtDNA), D-loop sequencing, and neighbor-joining trees. Eight of the same cases were studied with comparative genomic hybridization (CGH) array to have additional data consistent with mtDNA. In all cases, loss of heterozygosity was studied for D16S496,locus 16q22.1 related to e-cadherin. It appears that no fewer than eight cases were genetically very similar (clonal) with mtDNA. Seven of these cases appeared also clonal with CGH array. It is concluded that in the present series, LN and ILC are genetically related lesions in the majority of cases and that LN might be the precursor of ILC.

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Titel: Genetic similarities and differences between lobular in situ neoplasia (LN) and invasive lobular carcinoma of the breast
verfasst von: Luca Morandi
Gianluca Marucci
Maria P. Foschini
Maria G. Cattani
Annalisa Pession
Cristina Riva
Vincenzo Eusebi
Publikationsdatum: 01.07.2006
Verlag: Springer-Verlag
Erschienen in: Virchows Archiv / Ausgabe 1/2006
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-006-0192-7

Springer Medizin

Genetic similarities and differences between lobular in situ neoplasia (LN) and invasive lobular carcinoma of the breast

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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